The Ketamine StartUp Podcast

Ketamine StartUp
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Welcome to the Ketamine StartUp Podcast! This is the FIRST podcast dedicated to entrepreneurial medical professionals who want to learn more about providing ketamine therapy, run a business, marketing, and more. We are Sam and Kim Ko, two board certified physicians who have ventured into the ketamine therapy world. We’ve learned a lot of lessons, taught many clinicians like yourself, and luckily made a few friends along the way. In this podcast we share our experience and knowledge, plus that of the ketamine industry pioneers and leaders in our interviews. If you’re ready to boldly go where a few medical professionals have gone before, download and listen to our podcast today

  1. Episode 048 - Does a Physician Need to Be Present During Ketamine Infusions?

    22H AGO

    Episode 048 - Does a Physician Need to Be Present During Ketamine Infusions?

    Welcome back to the Ketamine Startup Podcast! It's great to be back with you for our first new episode of 2026. After sharing a couple episodes from the vault in December, we are excited to dive back into fresh content. In this episode, we tackle the most frequently asked question we get: "Do I need to be present in the room during every ketamine infusion?" This isn't just about regulations. It's about balancing autonomy, patient safety, business scalability, and your personal values as you transition from traditional healthcare to private practice. We explore the complex regulatory landscape across different states, the tension between wanting professional freedom and providing exemplary patient care, and the practical considerations every clinic owner must navigate. We share our own philosophy and approach while acknowledging the legitimate business and personal factors that influence these critical decisions. What You'll Learn: ・The "loved one test" for making staffing decisions: a simple framework to determine your comfort level and standards ・State by state regulatory variations: why Texas, Utah, and California have different requirements and what that means for you ・The business reality of scaling vs. safety: how to balance growth aspirations with quality patient care ・Building reputation in a small community: why integrity matters more than short term profit in the ketamine field Episode 48 show notes: 00:00 Teaser - The most common question… 02:25 The "loved one test": What would you want for your family member receiving treatment? 04:23 Balancing autonomy vs. quality care: The tension clinicians face 06:32 Federal vs. state regulatory landscape: How regulations vary across different states 09:37 Scope of practice considerations and corporate practice of medicine laws 12:01 Philosophy behind practice decisions: What's right for you and your patients 13:28 Sam's approach: Why he's always present and recommends starting that way 16:56 Balancing physician wellbeing with high-quality patient care 19:26 State-specific research requirements: Medical board, legal, and insurance considerations 21:05 Malpractice insurance requirements and how they affect your practice decisions 23:03 Final recommendations: The decision framework based on your values 24:44 Closing thoughts: What would you want for your loved one? Thanks for listening Want to go deeper on some of these topics? Check out these related episodes: Episode 007 - Who Can Open A Ketamine Therapy Clinic? Episode 034 - Ketamine Clinic Insurance: Expert Insights with Canyon Clifton Follow us on Linkedin Ketamine StartUp Website YouTube 🚀 Want to fast track launching your ketamine clinic? If so, download our free checklist.

    27 min
  2. Episode 047 - What You Should Tell Your Ketamine Patients: 4 Things To Expect During Their Infusion (Episodes from the Vault)

    12/22/2025

    Episode 047 - What You Should Tell Your Ketamine Patients: 4 Things To Expect During Their Infusion (Episodes from the Vault)

    We're continuing our holiday break from regularly scheduled programming to bring you another foundational resource: the patient communication strategies that transform ketamine therapy from a clinical procedure into a truly healing experience. This episode originally came from one of our mastermind sessions with students from our Ketamine Startup 101 course, where we dove deep into patient preparation and emotional safety protocols. It's become one of our most popular episodes.. Whether you're building a ketamine practice, looking to elevate your current patient communication, or trying to understand what separates exceptional clinics from those that simply provide treatment, this episode gives you the complete framework.  This is part of our "Episodes from the Vault" series, bringing back content that continues to serve as the go-to resource for healthcare providers focused on patient experience excellence.  For those who may recall, this was originally released as Episode 33. The mastermind format allowed us to go deep on each communication strategy while keeping everything immediately actionable for real-world implementation. This episode is especially valuable if you're training staff members, standardizing patient communication protocols, or seeking to create the kind of trust and safety that enables true therapeutic transformation. The strategies we share bridge clinical excellence with emotional intelligence which is exactly what ketamine therapy demands. What You'll Learn in This Episode  • The four essential communications every ketamine patient needs before treatment • Specific language and techniques for normalizing anxiety and fostering trust • How to prepare patients for non-ordinary experiences while ensuring emotional safety Episode 47 show notes: 00:00 Teaser - Why presence matters 00:49 Episode introduction  01:59 The Patient Communication Framework - The four essential things patients need to know and why therapeutic experience begins before treatment 06:14 #1: Feeling Nervous is Normal - Acknowledging patient anxiety, pre-framing concepts, and diving board metaphor for first treatments 10:59 #2: They May See, Feel, or Realize Big Things - Preparing patients for non-ordinary states of consciousness and ensuring they understand experiences will end 15:08 #3: Physical Sensations May Happen - Managing nausea, dizziness, and physical side effects with proactive medical interventions 17:31 #4: Emotional Releases Are Possible - Creating safe space for tears, anger, and grief while normalizing emotional expression 27:31 Practical Implementation Tips - Team training strategies, consistent language protocols, and creating emotionally safe clinical environments 30:19 Episode wrap-up Selected Links From the Episode: This book link in these show notes is an Amazon affiliate link. If you purchase through these links, we may earn a small commission at no additional cost to you. 📗Book mentioned  - Never Split The Difference by Chris Voss  If you’re interested in learning more about creating a healing and therapeutic space definitely check out these other episodes: • Episode 20 - Unlocking Transformation: Exploring Set, Setting, and Integration in Ketamine Therapy • Episode 9 - Healing Journeys: Ayahuasca, Ketamine Therapy, & Spirituality With Dr. Joe Tafur Follow us on Linkedin Ketamine StartUp Website YouTube 🚀Want to fast track launching your ketamine clinic? If so, download our free checklist. Disclaimer: This podcast is for educational purposes only and is not intended as medical or business advice. Always consult with qualified professionals for your specific situation.

    32 min
  3. Episode 046 - The Clinician's Guide to Ketamine Therapy (Episodes from the Vault)

    12/09/2025

    Episode 046 - The Clinician's Guide to Ketamine Therapy (Episodes from the Vault)

    We're taking a break from our regularly scheduled programming for the holidays to bring you something a bit different: a foundational episode that covers everything you need to know about ketamine therapy in one comprehensive resource. Sam originally delivered this presentation to the UCLA and Betty Ford Addiction Medicine Fellowship, and it's become one of those episodes that medical professionals, curious physicians, and anyone seriously exploring this field have come back to. It covers ketamine's complete story, from its fascinating medical history to current research and real-world implementation protocols. Whether you're considering ketamine therapy for your own practice, trying to understand this rapidly evolving field, or just want a solid clinical foundation, this is your starting point. We bridge the gap between academic research and practical clinical application, breaking down complex pharmacology and patient selection in a way that's actually accessible. This is part of our "Episodes from the Vault" series, bringing back content that continues to serve as a go-to resource for healthcare providers across specialties. For those who may recall, this was originally released as Episode 31. The presentation format lets us go deep on each topic while keeping everything practically relevant for actual clinical decision-making. This episode is especially valuable if you're evaluating ketamine therapy integration, seeking to understand the evidence base, or looking to enhance your patient education and staff training. What You'll Learn in This Episode ・Ketamine's journey from battlefield anesthetic to breakthrough mental health treatment ・Evidence-based mechanisms of action and clinical research findings ・Practical patient selection criteria, dosing protocols, and safety considerations for clinical practice Episode 46 show notes: 00:00 - Teaser - Mental health crisis statistics and ketamine's role 00:27 - Introduction to Episodes from the Vault series 01:19 - Sam's presentation introduction and off-label use disclosure 01:52 - Presentation Overview: Three-part structure: mental health/history, mechanisms/studies, patient selection/protocols 02:19 - Part 1: Current State of Mental Health - Depression, PTSD, anxiety statistics and the need for ketamine therapy 04:07 - The Need for More Treatment Options: Healthcare arsenal expansion with ketamine 04:20 - A Brief History of Ketamine: From phencyclidine to FDA approval and Vietnam War battlefield use 09:36 - Part 2: How Ketamine Works - NMDA receptor mechanisms and neuroplasticity effects 12:11 - Types of Patient Ketamine Experiences: Four levels of non-ordinary states of consciousness 14:49 - A Review of Scientific Studies: Yale study through recent research and meta-analyses 22:43 - Part 3: Ideal Patient Selection, Dosing & Scheduling: Contraindications, protocols, and safety considerations 32:33 - Episode wrap-up with YouTube resources, and more Thanks for listening Selected Related Links: ・For original Youtube version featuring slides during the presentation, go to https://youtu.be/u9XOQ2xnwsg ・For references and studies mentioned in this episode, go to www.ketaminestartup.com/podcast/episode-046 Follow us on Linkedin Ketamine StartUp Website YouTube 🚀Want to fast track launching your ketamine clinic? If so, download our free checklist.

    35 min
  4. Episode 045 - From Emergency Medicine to Psychospiritual Healing: Dr. Randy Frederick's Ketamine Clinic Journey

    11/24/2025

    Episode 045 - From Emergency Medicine to Psychospiritual Healing: Dr. Randy Frederick's Ketamine Clinic Journey

    Dr. Randy Frederick isn't your typical ketamine provider. As a former military flight surgeon and EM physician, he's spent nearly several years developing a "psychospiritual" approach to ketamine therapy. And his perspective challenges a lot of the conventional thinking in this field. In this conversation, Randy shares his evolution from following traditional clinical protocols to building something completely different. He talks openly about viewing ketamine as a catalyst rather than a cure, and why that distinction fundamentally changes how he works with patients. What makes this episode different? Randy doesn't just talk theory. He shares his own transformation journey. From losing his spiritual connection in college to rediscovering it through his own healing work, he's transparent about how his personal growth directly shapes the way he cares for patients. His focus on mind-body-spirit integration and helping patients reconfigure their relationship with their own minds comes from lived experience, not just clinical training. What You'll Learn in This Episode ・ Why ketamine should be viewed as a catalyst, not a cure and how that philosophy changes everything about treatment ・ The real challenges and rewards of transitioning from physician employee to clinic owner ・ How meditation and awareness practices actually complement ketamine therapy Episode 45 show notes: 00:00 - Teaser - Ketamine is not a cure… 00:28 - Episode introduction 01:43 - Welcome Dr. Frederick to the show 02:30 - Dr. Frederick’s background: ER medicine, social media discovery moment, initial research phase 05:20 - The stories that convinced Dr. Frederick: patient transformations and life-saving impact 08:00 - Dr. Frederick’s evolution from clinical to psychospiritual approach over the years 12:00 - Why ketamine is a facilitator/catalyst, not a cure - the consciousness perspective 16:30 - Dr. Frederick’s personal spiritual journey: losing faith in college, rediscovering spirituality 19:30 - Military background: Navy flight surgeon, Iraq deployment, veteran mental health insights 22:30 - The broader psychedelic landscape: psilocybin, MDMA, stakeholder challenges 26:30 - Harvard Law School psychedelic summit and Zero L course experience 29:30 - Reality of clinic ownership: wearing many hats, constant challenges, HR difficulties 34:30 - The five types of wealth: choosing time and lifestyle over maximum income 37:30 - Bombing story discussion, perspective shifts, and choosing growth over victimhood 42:00 - Mind-body-spirit integration: ego dissolution, mindfulness practice, meditation 49:00 - Advice for aspiring clinic owners: having your why, mentorship, team building 50:30 - Rapid fire questions: desert island choices, relaxation rituals, hidden talents 57:00 - Contact information and closing remarks Thanks for listening Connect with Dr. Frederick at: Website Instagram Meta Selected Links From the Episode:  These book links in these show notes are Amazon affiliate links. If you purchase through these links, we may earn a small commission at no additional cost to you. 📗 The 5 Types of Wealth: A Transformative Guide to Design Your Dream Life by Sahil Bloom    📘 Being Ram Dass by Ram Dass Follow us on Linkedin Ketamine StartUp Website YouTube 🚀Want to fast track launching your ketamine clinic? If so, download our free checklist.

    1h 2m
  5. Episode 044 - Building a Trauma-Informed Ketamine Practice with Dr. Jack Hay & Dr. Harry Pepper

    11/12/2025

    Episode 044 - Building a Trauma-Informed Ketamine Practice with Dr. Jack Hay & Dr. Harry Pepper

    What happens when an ER physician and a psychologist both hit burnout at the same time? In Dr. Jack Hay and Dr. Harry Pepper's case, they decided to build something different together. In this episode, Dr. Hay and Dr. Pepper share the real story behind opening Oberlin Ketamine Clinic in Ohio. Including their unique physician-psychologist partnership model, how they've made personalized music a core part of their ketamine therapy approach, and why they're so intentional about trauma-informed care. This isn't a polished success story. They walk us through their first-year challenges, the difference between integration coaching and traditional therapy (and why that distinction matters), and their philosophy of empowering patients to choose their own music playlists instead of prescribing one-size-fits-all soundtracks. What really stood out? How they've built their practice around their core values instead of just copying what other clinics are doing. What you’ll gain 🔹 How to maintain passion, patience, and perseverance through inevitable obstacles 🔹 Simple techniques that create profound patient experiences (whiteboard intentions, personalized playlists) 🔹 How to distinguish between coaching and therapy in integration work  Episode 44 show notes: 00:00 - Teaser - A shamanic transfer of energy 00:26 - Episode Introduction 02:30 - Dr. Hay's background: Emergency medicine to ketamine therapy journey, COVID burnout experience 05:20 - Dr. Pepper's background: 30 years in psychology, psychedelic therapy insights 08:45 - Pivotal moments: Dr. Pepper's continuing education revelation and personal experience with long COVID 12:15 - Dr. Hay's decision point: Leaving ED directorship, timing with Harry's proposal 15:30 - Major obstacles faced: Timeline underestimation, patient education challenges, Midwest ketamine awareness 21:40 - Safety protocols and patient process: First contact approach, trauma-informed care, continuous monitoring 26:50 - Integration coaching philosophy: Present-moment forward orientation vs traditional therapy 32:20 - Music curation innovation: Challenging conventional wisdom, personalized playlists, patient choice 40:30 - Intention setting technique: Colored whiteboard process, embodiment practices 44:15 - Advice for new clinicians: Dr. Hay's "Three P's" - passion, patience, perseverance 47:30 - Dr. Pepper's advice: Don't give up, staying connected to values during challenges 50:45 - Personal questions begin: Desert island books/movies/food 56:20 - Hidden talents: Dr. Pepper's music performance background, Dr. Hay's artistic abilities 1:00:30 - Time travel question: Future space exploration vs MLK's "I Have a Dream" speech 1:02:45 - Contact information and closing remarks Thanks for listening Connect with Dr. Hay and Dr. Pepper at: Oberlin Ketamine Website Instagram Meta Infinite Leadership Selected Links From the Episode: These book links in these show notes are Amazon affiliate links. If you purchase through these links, we may earn a small commission at no additional cost to you. 📕The Elevated Leader: Level Up Your Leadership Through Vertical Development by Ryan Gottfredson 📗The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma by Bessel van der Kolk 📘You Are Enough: Revealing the Soul to Discover Your Power, Potential, and Possibility by Panache Desai 🎶Explore more about music in Episode 032 - Music & Psychedelic Therapy: A Conversation with Author Steve Gelberg Follow us on Linkedin Ketamine StartUp Website YouTube 🚀Want to fast track launching your ketamine clinic? If so, download our free checklist.

    1h 7m
  6. Episode 043 - What Licenses Do You Need to Open a Ketamine Clinic?

    10/28/2025

    Episode 043 - What Licenses Do You Need to Open a Ketamine Clinic?

    Remember when you were a hospital employee and licensing was just... someone else's problem? Yeah, those days are over. When you open a ketamine clinic, you're suddenly responsible for every license, permit, and regulatory checkbox that used to magically get handled by administrators. And here's the thing, get this stuff wrong and you can expect delays. In this episode, we break down the exact licenses and permits you need to open a ketamine clinic, the specific order to tackle them (yes, order matters), and why trying to DIY this process is a terrible idea. We share what we learned opening Reset Ketamine in Southern California plus insights from helping dozens of physicians navigate licensing requirements across different states. Because here's what we've learned: every state is different, and the details matter more than you think. What You'll Learn in This Episode: ・The medical licenses you probably already have - and why you might need a second DEA license ・Business permits that confuse physicians - FNP vs DBA and when you can skip them ・The order of operations - 10 sequential steps that prevent costly delays ・Why AI and Google aren't enough - the critical role of state-specific professional guidance Episode 43 show notes: 00:00 Teaser - The DEA License Address Rule 00:30 Episode Introduction 01:42 Why You Need Professional Guidance 03:48 Active Medical License & NPI 04:50 DEA License: The Tricky One 07:03 Order of Operation - The Foundation: Entity & Location 09:11 City Business License 10:22 Fictitious Name Permit (FNP) 12:33 DBA (Doing Business As) 15:27 EIN (Employer Identification Number) 16:39 Summary: The Complete Order of Operations 17:28 Key Takeaways & Closing Advice 18:30 The Medical Consult Analogy 20:50 Closing & Resources Thanks for listening Selected Links From the Episode: Get your DEA related questions answered in Episode 023 - Mastering Clinic Compliance: Insights from Retired DEA Agent Dennis Wichern Follow us on Linkedin Ketamine StartUp Website YouTube 🚀 Want to fast track launching your ketamine clinic? If so, download our free checklist.

    22 min
  7. Episode 042 - Essential Risk Management: DEA Compliance & Insurance for Ketamine Clinics

    10/14/2025

    Episode 042 - Essential Risk Management: DEA Compliance & Insurance for Ketamine Clinics

    Running a ketamine clinic? Clinical skills alone won't cut it. You also need to protect your practice from regulatory and financial landmines. In this compilation episode, two experts break down the complex world of DEA compliance and insurance coverage for ketamine clinics. Whether you're about to open your doors or already treating patients, understanding what triggers regulatory scrutiny and how to properly protect your practice isn't optional - it's critical. Our guests reveal the most common mistakes clinics make and share practical strategies to keep your practice safe, compliant, and protected. We've combined insights from two full-length episodes to give you concentrated wisdom on the business foundations every ketamine clinic needs. DISCLAIMER:  This episode is for educational and informational purposes only. The views expressed by our guests do not constitute legal, regulatory, or professional insurance advice for your specific practice. Insurance and compliance requirements vary significantly by state and individual circumstances. Always consult with qualified professionals before making decisions for your business or medical practice. Featured Experts Dennis Wichern - Retired DEA Special Agent in Charge and founder of Prescription Drug Consulting. Dennis spent over three decades with the DEA, including ten years focused specifically on pharmaceutical controlled substance compliance. He now helps healthcare providers understand DEA regulations and maintain proper compliance. Canyon Clifton - CEO of Clifton Insurance Agency, a professional liability and high-risk niche market insurance corporation founded in 1982. Canyon has spent over two decades designing elaborate professional liability and medical malpractice policies for healthcare providers across the US. What You'll Learn in This Episode: ・The 3 red flags that trigger DEA audits and how to avoid them ・The #1 insurance mistake ketamine clinics make (and how to verify coverage) ・Real claims data: What actually happens when things go wrong Episode 42 show notes: 00:00 Teaser - The DEA are Humans too. 00:20 Introduction & Episode Overview 01:51 Dennis Wichern 02:01 The 3 Red Flags That Trigger DEA Audits 05:16 State-Level DEA Enforcement Differences 08:37 Biannual Inventory Requirements & What to Do If You Missed Them 09:39 The DEA's Human Side 10:48 Witnessing Requirements for Small Clinics 13:47 Canyon Clifton 13:57 The #1 Insurance Mistake Ketamine Clinics Make 14:59 Where to Find Coverage Details in Your Policy 17:03 Why Insurance Applications Matter (They Become Part of Your Policy) 18:39 How the Insurance Landscape Has Changed for Ketamine Therapy 20:00 Admitted vs. Non-Admitted Insurance Carriers Explained 23:29 The Top Insurances Your Ketamine Clinic Needs 25:54 Ending & Resources Thanks for listening Listen to each of their full conversations: Episode 023 - Mastering Clinic Compliance: Insights from Retired DEA Agent Dennis Wichern Episode 034 - Ketamine Clinic Insurance: Expert Insights with Canyon Clifton Connect with the experts: Prescription Drug Consulting Website LinkedIn Email: dennis.wichern@prescriptiondrugconsulting.com Phone: (312) 859-2430 Clifton Insurance Agency Website - Mention “Ketamine StartUp” and receive FREE quotes & exclusive policy discounts. Phone: 877-212-4368 Clifton Insurance Agency | LinkedIn Clifton Insurance Agency | Instagram  Follow us on Linkedin Ketamine StartUp Website YouTube 🚀Want to fast track launching your ketamine clinic? If so, download our free checklist.

    27 min
  8. Episode 041 - Pioneers Who Challenged Medical Orthodoxy: Howard Kornfeld, Joe Tafur & Mel Herbert

    09/29/2025

    Episode 041 - Pioneers Who Challenged Medical Orthodoxy: Howard Kornfeld, Joe Tafur & Mel Herbert

    Starting a ketamine clinic can mean challenging the status quo - and that can feel isolating when colleagues question your vision or patients don't understand the treatment. But here's what's reassuring: every major breakthrough in medicine started with physicians who were willing to stand alone and persist through doubt. In this compilation episode, we're featuring three remarkable doctors who faced the exact same resistance you might be experiencing. Each was told their ideas wouldn't work. Each had colleagues who doubted them. And each proved that individual practitioners can create massive change when they refuse to take "no" for an answer. Dr. Howard Kornfeld revolutionized addiction medicine by advocating for buprenorphine years before anyone believed in it. Dr. Joe Tafur bridges traditional healing with modern ketamine therapy despite skepticism from both sides. And Dr. Mel Herbert transformed global medical education from a single idea that everyone initially dismissed. These aren't just inspiring stories - they're road maps for how to navigate the challenges in the medical space. If you're building a practice or considering taking the leap, their experiences will show you that the resistance you face isn't a sign you're wrong - it's often a sign you're onto something important. What You'll Learn in This Episode ・ How medical pioneers overcome institutional resistance and persist through years of colleagues doubting their vision ・  Revolutionary approaches to addiction medicine including Dr. Kornfeld's early advocacy for buprenorphine treatment ・ Bridging traditional and modern healing through Dr. Tafur's integration of ceremonial medicine with ketamine therapy ・ Global medical education transformation and how Dr. Herbert built a company impacting training in 160+ countries despite never wanting to be an entrepreneur Episode 41 show notes: 00:00 Teaser - “I didn’t want to be an entrepreneur…” 00:23 Welcome To The Podcast 01:36 Dr. Howard Kornfeld: The Power of Small Groups & Early Mentorship 02:37 Buprenorphine Breakthrough & Early Adoption 13:09 Dr. Joe Tafur: His perspective on colleague resistance 21:11 Bridging Worlds: First Ketamine Ceremony 21:34 Dr. Mel Herbert: The Birth of EM:RAP Vision 22:51 Overcoming Initial Rejections 23:21 Building Global Impact 30:01 Finding Meaning in Simple Medicine 30:23 Ending & Resources Thanks for listening Listen to each of their full conversations: 🛡️Episode 039 - Pain, Addiction, and Medical Practice with Dr. Howard Kornfeld 🌿Episode 009 - Healing Journeys: Ayahuasca, Ketamine Therapy, & Spirituality With Dr. Joe Tafur 🎓Episode 025 - Breaking the Stigma: Ketamine, Forgiveness, & Mental Health with Dr. Mel Herbert Follow us on Linkedin Ketamine StartUp Website YouTube ✅ Want to fast track launching your ketamine clinic? If so, download our free checklist.

    31 min
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About

Welcome to the Ketamine StartUp Podcast! This is the FIRST podcast dedicated to entrepreneurial medical professionals who want to learn more about providing ketamine therapy, run a business, marketing, and more. We are Sam and Kim Ko, two board certified physicians who have ventured into the ketamine therapy world. We’ve learned a lot of lessons, taught many clinicians like yourself, and luckily made a few friends along the way. In this podcast we share our experience and knowledge, plus that of the ketamine industry pioneers and leaders in our interviews. If you’re ready to boldly go where a few medical professionals have gone before, download and listen to our podcast today

Information

  • Creator
    Ketamine StartUp
  • Years Active
    2024 - 2026
  • Episodes
    48
  • Rating
    Clean
  • Copyright
    ©️ 2024 Ketamine StartUp All Rights Reserved
  • Show Website
    The Ketamine StartUp Podcast

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