The Daily Apple Podcast

Prime Health Associates - Kevin White, MD

We dive into all topics regarding the science of longevity along with some other subjects we find of interest with the hopes to provide useful information for everyone. This stems from our personal interest to optimize the human condition to not just live longer, but live better.

  1. Aug 18

    Your Labs Are Graded on the World's Easiest Curve

    Most people treat a clean lab report as a verdict. Nothing flagged, nothing to do. Brian Kennedy has spent three decades explaining why that reading is generous. He trained at MIT, led the Buck Institute for Research on Aging, and now directs the Centre for Healthy Longevity at the National University of Singapore. His view is that medicine learned to define disease and never got around to defining health, so the ranges on your lab report mark the minimum that keeps you alive and the maximum that doesn't kill you. Everything in between gets called normal. Dr. Kevin White sits down with Brian to talk about what belongs in that space. Kennedy's team went looking for the people who are aging unusually well and found their numbers cluster in a far tighter band than the one your lab prints. He is 59, has nothing on his chart, and treats his own numbers anyway. They also get into why waiting for a diagnosis is a bad trade, what he takes and why, and what his lab found when it bought 16 supplement brands and measured what was actually in the bottles. "If somebody says they can tell you exactly what to do to make you 10 years younger, they're lying to you or they're lying to themselves."                                       - Brian Kennedy If you've ever been handed a normal lab report and wondered what it actually bought you, this conversation gives you something better to aim at. Learn more about Brian Kennedy's research at medicine.nus.edu.sg/sites/briankennedylab, find Rejuvant at rejuvant.com, and look up his longevity solutions company, Live Beyond. Follow The Daily Apple for weekly conversations on longevity, performance, prevention, nutrition, exercise, and the science of living well. If you enjoyed this episode, please subscribe, leave a review, and share it with someone who's committed to living a longer, healthier life. www.primehealthassociates.com Instagram: @KevinWhiteMD YouTube: @KevinWhiteMD Prime Health Associates

  2. Aug 11

    NAD, Rapamycin & the Stories We Tell About Longevity (with Matt Kaeberlein)

    A 27 year old woman went to a longevity clinic in the Bronx for an NAD IV drip. Minutes later she was in cardiac arrest. She died a few hours after that. The person who ran the clinic held a medical license from the Dominican Republic, not the United States. Dr. Kevin White talks with Dr. Matt Kaeberlein, a researcher who studies why and how we age, about what that story actually tells us. His answer isn't really about NAD. It's about certainty. Kaeberlein has never seen evidence that NAD infusions help anyone, and the field's founding claim, that NAD declines with age and needs replacing, is now being questioned by the same scientists who study it. Clinics keep selling it with total confidence anyway. That same pattern shows up everywhere they go in this conversation. Kaeberlein now chairs Montana's expanded Right To Try review board, which lets biotech companies test experimental therapies on real patients once they clear a phase one safety bar, outside the usual FDA process. He explains why that could produce safety data the field has never had, and why he'd reject any therapy pitched without a real scientific rationale behind it, no matter how confidently it's sold. "You don't want to listen to the people who are telling you with a hundred percent certainty, do this. And by the way, you know, buy my longevity latte."                                                     — Matt Kaeberlein They also compare LinAge2, a biological age calculator built from standard bloodwork with decades of mortality data behind it, to the consumer epigenetic age tests sold directly to the public. Kaeberlein's problem with the popular tests has nothing to do with the underlying science. It's that nobody selling them will publish the error bars, so a 20 year gap on your result could mean everything or nothing. You can't run statistics on a number you're not allowed to check. Along the way they cover why rapamycin, the drug most associated with Kaeberlein's name, might not even be his top pick anymore. A company spun out of his lab, Aura Biomedical, has found longevity molecules that also protect against radiation damage. And a new epigenetic instability test from Irena Conboy's company, Generation Lab, measures something closer to biological chaos than biological age. Follow The Daily Apple and leave a review to help more people find the show.   Instagram: @KevinWhiteMD YouTube: @KevinWhiteMD Prime Health Associates

  3. Aug 5

    Can Rapamycin Reverse Brain Aging? Dr. Veronica Galvan on the Alzheimer's Research Surprising Even Her

    In this episode, Dr. Kevin White sits down with Dr. Veronica Galvan, Presidential Professor at the University of Oklahoma Health Sciences Center and Director of the Oklahoma Nathan Shock Center on Aging. Most people think Alzheimer's is caused by a buildup of "bad" proteins in the brain. The real story is more complicated, and more hopeful. Galvan has spent her career studying what actually drives Alzheimer's disease, and her research has uncovered something surprising: a common, decades-old drug may be able to reverse brain damage that was thought to be permanent. Together they explore: What's really happening in the brain during Alzheimer's, and why the "bad protein" explanation is incompleteWhy aging itself, not genetics, is the single biggest risk factor for Alzheimer's diseaseWhat your APOE gene type (2, 3, or 4) actually means for your riskHow rapamycin, a drug originally used for organ transplants, reversed brain damage in animal studies"It wasn't improving. It was restoring." — Dr. Veronica GalvanWhy some people's brains show significant Alzheimer's damage on scans but never lose their memory or functionThe simplest, most overlooked factor that can change your brain's trajectory as you ageAlong the way, Galvan shares what pulled her from virology into Alzheimer's research, why she believes large-scale human trials on rapamycin are long overdue, and what she'd study next if funding were no object. Whether you have a family history of dementia, want to understand the research behind the headlines, or are simply thinking ahead about how to protect your brain, this episode offers a clearer picture of where the science actually stands. Guest  Dr. Veronica Galvan  Presidential Professor, University of Oklahoma Health Sciences Center  Director, Oklahoma Nathan Shock Center on Aging Follow The Daily Apple for weekly conversations on longevity, performance, prevention, nutrition, exercise, and the science of living well. If you enjoyed this episode, please subscribe, leave a review, and share it with someone who's committed to living a longer, healthier life. www.primehealthassociates.com Instagram: @KevinWhiteMD YouTube: @KevinWhiteMD Prime Health Associates

  4. Jun 24

    Train Smarter. Age Better. Strength, Stability & Longevity with Andie Emmett, PT, DPT

    Train Smarter. Age Better. Most people don't lose their health overnight. They lose it one movement, one habit, and one missed opportunity at a time. In this episode, Dr. Kevin White sits down with physical therapist Andie Emmett, PT, DPT, whose one-on-one approach to movement, strength, and recovery has made her one of Oklahoma's most sought-after physical therapists. This isn't just a conversation about pain. It's about building a body that stays strong, capable, and resilient for decades. Together they explore: • Why strength and stability matter more than you think • The hidden movement patterns behind chronic pain • Why weak glutes can lead to back problems • How to protect your shoulders before injuries happen • The importance of resistance training after 40 • Walking, CrossFit, Hyrox, and training intelligently • What separates people who thrive in their 70s and 80s from those who don't Along the way, Andie shares why she left the traditional high-volume healthcare model to create a practice centered around something increasingly rare: time, attention, and truly personalized care. Whether you're recovering from an injury, trying to perform at a higher level, or simply want to age with strength and independence, this episode offers practical insights you can start using today. Guest Andie Emmett, PT, DPT Whole Wellness Nichols Hills Plaza Oklahoma City Follow The Daily Apple for weekly conversations on longevity, performance, prevention, nutrition, exercise, and the science of living well. If you enjoyed this episode, please subscribe, leave a review, and share it with someone who's committed to living a longer, healthier life. Find Andie Emmett at Whole Wellness, Nichols Hills Plaza, Oklahoma City.  www.facebook.com/WholeWellnessLLC Follow The Daily Apple and leave a review to help more people find the show.  www.primehealthassociates.com Instagram: @KevinWhiteMD YouTube: @KevinWhiteMD Prime Health Associates

  5. Jun 16

    The Microplastics Problem Is Bigger Than Your Water Bottle

    Most people worried about microplastics are focused on the wrong things. The receipts, the water bottles, the plastic cutting boards. Dr. Matt Campen has spent his career actually measuring what ends up in the human body, and the picture that's emerging looks a lot less like a consumer choice problem and a lot more like a food system problem. Dr. Kevin White sits down with Dr. Campen, a toxicologist and environmental health researcher at the University of New Mexico, to talk through what the science actually shows: where microplastics accumulate in the body, why the brain appears to hold more than any other organ, what his lab found when comparing plastic concentrations in healthy brains versus those with dementia, and why the biggest exposure vector isn't your water bottle. It's processed food, irrigated by groundwater running through plastic-contaminated agricultural fields. They also get into wildfire smoke as a largely overlooked driver of neuroinflammation, and why the recovery window is longer than most people realize. "I worry that the United States may end up being sentinels for the rest of the planet on what the health effects of microplastics are." This isn't a conversation about panic or dismissal. It's an honest look at where the science actually is, what it means for brain health and longevity, and why solving this one is going to take more than switching to a stainless steel bottle. Find Dr. Campen on LinkedIn. Instagram: @kevinwhitemd  YouTube: @kevinwhitemd  primehealthassociates.com Prime Health Associates

  6. Apr 21

    Psychedelics Can Rewrite the DNA of Trauma

    Last Friday, President Trump signed an executive order directing the FDA to fast-track psychedelic medicines for mental health treatment. Joe Rogan texted him about Ibogaine. The president texted back. Fifty million federal dollars followed. You can have a lot of feelings about how that happened. Here is what is not political: a small group of neuroscientists and psychiatrists spent the last decade quietly building the scientific case that certain psychedelic compounds can do something no pill or therapy has ever done. Dr. David Rabin is one of them. He has been training clinicians, treating veterans with PTSD that responded to nothing, and running what has been called the largest controlled study of psychedelic medicines in the world. He published a paper in 2023 showing that MDMA assisted therapy produces measurable changes in the DNA of PTSD patients, at the level of the cortisol receptor, in direct proportion to how much better they got. Washington just showed up to a party that started ten years ago. Dr. Kevin White sits down with Dr. Rabin to talk about what MDMA is actually doing in the brain, why the safety hypothesis changes how you think about stress and chronic illness, what Ibogaine does to opioid receptors that nothing else can, and why most of the ketamine being prescribed right now is being given wrong. "Psychedelic medicines are to mental illness what antibiotics were to infection in the first half of the 20th century." The science was already there. Now find out what it actually says. Find more from Dr. Rabin at drdave.io and apolloneuro.com. Try the Apollo wearable at wearablehugs.com. His first book, A Simple Guide To Being Alive, is available at asimpleguidetobeingalive.com Follow The Daily Apple and leave a review to help more people find the show.  Instagram: @KevinWhiteMD  YouTube: @KevinWhiteMD www.primehealthassociates.com  Prime Health Associates

4.6
out of 5
17 Ratings

About

We dive into all topics regarding the science of longevity along with some other subjects we find of interest with the hopes to provide useful information for everyone. This stems from our personal interest to optimize the human condition to not just live longer, but live better.

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