5 episodes
Basics to Brilliance: Haematology Podcast Basics to Brilliance
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- Education
Welcome to Basics to Brilliance, the Haematology podcast created to supplement & bolster your knowledge for the FRCPath Part 1. Featuring a two way, non-didactic conversational-style Q&A between the SpR and SHO, this podcast will be your pocket companion no matter where you are.We aim to cover: - Malignant and non-malignant topics
- The whole syllabus for FRCPath part 1
- Review UK guidelines
- Go into science/lab detail
- Discuss how guidelines often translate into practice
- Review and appraise hallmark trials
- Discuss future research directions
All readily accessible and completely free of charge!For every budding haematologist out there, we hope this podcast aids you in your endeavours and fills you with interest and excitement for the brilliant world of Haematology. Warmest Regards,Dr. EverdenDr. FaseyDr. JafriNote: Guidelines discussed are the most recent as of late 2023/early 2024
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Polycythemia Rubra Vera
Polycythaemia- red cell #Erythrocytosis – in red cell massAbsolute Erythrocytosis- M: Hct >0.60 or >0.52 + RCM >25% of mean- F: Hct >0.56 or >0.48 + RCM >25% of meanApparent Erythrocytosis- Men: Hct >0.52 + normal RCM- Women: Hct >0.48 + normal RCMRelative erythrocytosis-Normal RCM + Reduced plasma volume (pathological dehydration)M>FMedian >60yo2' PRV: treat underlying cause +/- venesection (higher hct threshold)Classification of Absolute:EPO dependent-&nb...
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Secondary CNS Lymphoma
- Synchronous CNS and systemic lymphoma at initial presentation (treatment-naïve; TN-SCNSL)- CNS relapse without recurrent systemic lymphoma (relapsed isolated CNS lymphoma; RI-SCNSL)- Relapsed concomitant systemic and CNS disease following treatment for systemic lymphoma (RC-SCNSL) Generally hybrid disease Investigations- MRI Head w gadolinium- PET-CT- Testicular US (blood testes barri...
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Primary CNS Lymphoma
CNS Lymphomas1% of all NHL3% of all Brain tumoursMost common subtype (90%) is DLBCL Clinical division:1. 1* CNS lymphoma, 2. 2* CNS lymphoma- TN-SCNSL- RI-SCNSL- RC-SCNSL3. Immune deficiency assoc- HIV; better prog. Presentation: - SOL Sx - Raised ICP: morning headaches w N+V- Neuropsych, Behavioural, Memory, Language- Focal motor + Stroke Sx- Seizures- Visual Sx and uveit...
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Chronic Monomyelocytic Leukemia (CMML)
Chronic MyeloMonocytic Leukemia (not CML)Persistently high monocyte count- 3 months Most frequent MDS/Myeloproliferative neoplasms – a cross between the twoMedian age 72Median survival 20-40 months Transformation to AML (15-30%) WHO definition of CMML:1. Excess monocytes- persistent over 3 months, ≥ 1 - Monocytes 10% of total WC count2. Dysplasia: morphological difference (blood film on BMBx) OR3. Genetic abnorma...
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Chronic Lymphocytic Leukemia (CLL)
Chronic Lymphocytic Leukemia (CLL)- Chronic Relapsing RemittingMost common leukemia in adultsIncurable but treatable*Remember Supportive Care*Median age of 72M > F80% incidentalSLL: lymphocytes in lymph nodes and spleen instead of blood Presentation: 1) Fatigue2) B symptoms3) High WC4) Cytopenias (Marrow infiltrate, AIHA, ITP, Hyposplenism)Rule out: Reactive (viral serology)- Hepatitis, HIVInvestigate: 1) FBC + blood film (mature lymphocytes) w/ trend2) Haemolysis scre...