Trials and Tribulations | Oncology Trials Podcast

Prof Nick James and Dr Hoda Aty
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Prof Nick James and Dr Hoda Aty share inside view of the development, set-up and running of the STAMPEDE2 and other oncology clinical trials! Views expressed in this podcast are our own. Music from #uppbeat. License code: ZKK8UDRESSNYFCC

  1. 07/25/2025

    Episode 17: Prostate Cancer Surgery, Genomics and AI with Dr Ash Tewari

    Tune in to this insightful episode featuring Dr Ash Tewari, leading urologist and prostate cancer expert from Mount Sinai, New York. He discusses the complexities of prostate cancer management, highlighting the role of biology, genomics, and AI in diagnosis and treatment. Dr Tewari stresses the importance of personalised care and tackling health disparities. He also shares his experience in robotic surgery and advocates for a more refined, patient-centred approach to treatment.

    39 min

  2. 05/23/2025

    Episode 16: Prostate Cancer Trials with Dr Alison Tree

    Tune in to this exciting episode with Dr Alison Tree, Consultant Clinical Oncologist at The Royal Marsden and ICR. We explore the successful delivery of the PACE umbrella trial, with a focus on PACE A and B. Dr Tree shares insights on radiotherapy quality assurance and cost-effectiveness. She also discusses the federated trial model through her role as chair of the MR Linac consortium.

    29 min

  3. 05/15/2025

    Episode 15: Stereotactic Radiotherapy in Renal Cell Cancers with Professor Shankar Siva

    Tune in to this must listen episode with Professor Shankar Siva from the Peter MacCallum Cancer Centre. We revisit the role of radiotherapy in renal cell cancers, focusing on stereotactic radiotherapy. We discuss the set up of a phase III clinical trial , the importance of collaboration and patient involvement as well as clinically relevant endpoints, patient reported-outcomes and health economics.

    33 min

  4. 03/17/2025

    Episode 14: Oncolytic Viruses & Clinical Trials: Expert Insights with Professor Kevin Harrington

    Tune in to this must listen episode with Professor Kevin Harrington, Head of Radiotherapy and Imaging at the Institute of Cancer Research and Consultant Clinical Oncologist at The Royal Marsden Hospital. We explore the challenges of conducting clinical trials in cancer research, with a special focus on oncolytic viruses. Professor Harrington delves into the intricacies of trial design, the balance between safety and efficacy, and the patient-centric approach shaping the future of oncology. He also discusses regulatory and funding obstacles and offers valuable insights for early-career researchers navigating this complex landscape.

    38 min

  5. 02/03/2025

    Episode 13: Breast Cancer Radiotherapy Trials featuring Dr Anna Kirby

    Tune in to this must-listen episode with Dr. Anna Kirby, Consultant Clinical Oncologist at the Royal Marsden Hospital and Institute of Cancer Research, London, UK. She shares insights into the challenges and successes of designing and conducting breast cancer radiotherapy trials, including FAST-FORWARD Boost, and highlights the crucial role of patient and public involvement. As a past president of ESTRO, Dr. Kirby also reflects on the impact of international guidelines, discussing both their successful implementation and the challenges faced in ensuring widespread adoption.

    33 min

  6. 01/07/2025

    Episode 12: Involve Your Urologist! Challenges facing surgical trials featuring Professor Declan Murphy

    Join us for an engaging episode with Professor Declan Murphy, Co-host of the GU Cast Podcast, Director of GU Oncology and Robotic Surgery at the Peter MacCallum Cancer Centre, Melbourne, Australia. We explore the challenges of surgeon heterogeneity, the critical role of equipoise, and why involving urologists early is essential for the success of clinical trials. Discover how multidisciplinary collaboration, cutting-edge innovation, and advanced imaging are transforming the landscape of urological surgical trials!

    34 min

  7. 12/10/2024

    Episode 11: Women in Surgery, Navigating the Intersection of Academia and Clinical Practice with Dr Renu Eapen

    Join us for this must-listen episode with Dr. Renu Eapen, co-host of GU Cast podcast! She shares insights on balancing clinical practice and research and navigating PhD challenges. We discuss the importance of good mentorship and women’s representation in the field. We also hear about her exciting work on the Lutectomy trial.

    26 min

  8. 10/25/2024

    Episode 10: Utilising NHS data for trial follow-up and the role of imaging in outcome assessment featuring Mr Ashwin Sachdeva

    In this episode, Mr Ashwin Sachdeva, Consultant Urologist and Academic Clinical Lecturer at the University of Manchester discusses the following: 00:00 Introduction 02:10 Utilising NHS Data for long-term follow-up 04:40 Fracture rates and hormone therapy in prostate cancer 07:05 Challenges in trial follow-up and data collection 11:18 Imaging and its role in prostate cancer 17:58 Prospective imaging collection in the STAMPEDE trial 22:32 Balancing surgery and research 26:31 Future directions in prostate cancer research

    28 min
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Prof Nick James and Dr Hoda Aty share inside view of the development, set-up and running of the STAMPEDE2 and other oncology clinical trials! Views expressed in this podcast are our own. Music from #uppbeat. License code: ZKK8UDRESSNYFCC

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