Medscape InDiscussion: Myelofibrosis

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Listen to Medscape InDiscussion: Myelofibrosis, a podcast series where thought leaders and clinical experts share their diverse insights and practical ideas for optimizing patient care. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999593. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

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  1. EPISODE 1

    What's Next? Clinical Trials in Myelofibrosis

    Drs Tania Jain and Ruben Mesa discuss the clinical trials and the future of myelofibrosis research. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002053. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Myeloproliferative Neoplasms (MPNs) Have a Significant Impact on Patients' Overall Health and Productivity: The MPN Landmark Survey https://pubmed.ncbi.nlm.nih.gov/26922064/ A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/22375971/ The Myelofibrosis Symptom Assessment Form (MFSAF): An Evidence-Based Brief Inventory to Measure Quality of Life and Symptomatic Response to Treatment in Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/19250674/ Practical Measures of Clinical Benefit With Ruxolitinib Therapy: An Exploratory Analysis of COMFORT-I https://pubmed.ncbi.nlm.nih.gov/28606598/ The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 Patients https://pubmed.ncbi.nlm.nih.gov/21536863/ Randomized, Single-Blind, Multicenter Phase II Study of Two Doses of Imetelstat in Relapsed or Refractory Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/34138638/ Phase III MANIFEST-2: Pelabresib + Ruxolitinib vs Placebo + Ruxolitinib in JAK Inhibitor Treatment-Naive Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/35950489/ Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis (TRANSFORM-2) https://clinicaltrials.gov/study/NCT04468984 Allogeneic Stem Cell Transplant for Patients With Myeloproliferative Neoplasms in Blast Phase: Improving Outcomes in the Recent Era https://pubmed.ncbi.nlm.nih.gov/33821472/ Efficacy and Safety of Ruxolitinib After and Versus Interferon Use in the RESPONSE Studies https://pubmed.ncbi.nlm.nih.gov/29396713/

    22 min

  2. EPISODE 2

    Diet, Exercise, and Myelofibrosis: A Holistic Approach

    Join Drs Tania Jain and Krisstina Gowin as they discuss the role integrative medicine plays in the treatment of myelofibrosis. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002054. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Myeloproliferative Neoplasm (MPN) Symptom Assessment Form Total Symptom Score: Prospective International Assessment of an Abbreviated Symptom Burden Scoring System Among Patients With MPNs https://pubmed.ncbi.nlm.nih.gov/23071245/ The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 Patients https://pubmed.ncbi.nlm.nih.gov/21536863/ Comprehensively Understanding Fatigue in Patients With Myeloproliferative Neoplasms https://pubmed.ncbi.nlm.nih.gov/26670597/ The Hallmarks of Cancer https://pubmed.ncbi.nlm.nih.gov/10647931/ Primary Prevention of Cardiovascular Disease With a Mediterranean Diet Supplemented With Extra-Virgin Olive Oil or Nuts https://pubmed.ncbi.nlm.nih.gov/29897866/ The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Feasibility Phase https://pubmed.ncbi.nlm.nih.gov/37214789/ Lifestyle Factors and Cancer: A Narrative Review https://pubmed.ncbi.nlm.nih.gov/38468817/ Online Yoga in Myeloproliferative Neoplasm Patients: Results of a Randomized Pilot Trial to Inform Future Research https://pubmed.ncbi.nlm.nih.gov/31174535/ American Cancer Society Guideline for Diet and Physical Activity for Cancer Prevention https://pubmed.ncbi.nlm.nih.gov/32515498/ Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults With Cancer: Society for Integrative Oncology-ASCO Guideline https://pubmed.ncbi.nlm.nih.gov/37582238

    26 min

  3. EPISODE 3

    Can We Prevent Myelofibrosis? The New Interferon Era

    Join Drs Tania Jain and Brandi Reeves as they discuss primary myelofibrosis and post-ET (essential thrombocythemia) and post-PV (polycythemia vera) myelofibrosis. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002055. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Primary MF https://emedicine.medscape.com/article/197954-overview Pegylated Interferon: The Who, Why, and How https://pubmed.ncbi.nlm.nih.gov/39644027/ Genetic Background of PV https://pubmed.ncbi.nlm.nih.gov/35456443/ Ropeginterferon Alfa-2b vs Standard Therapy for Polycythaemia Vera (PROUD-PV and CONTINUATION-PV): A Randomised, Non-inferiority, Phase 3 Trial and Its Extension Study https://pubmed.ncbi.nlm.nih.gov/32014125/ Insights Into the Potential Mechanisms of JAK2V617F Somatic Mutation Contributing Distinct Phenotypes in Myeloproliferative Neoplasms https://pubmed.ncbi.nlm.nih.gov/35162937/ Nationwide Prospective Survey of Secondary MF in Japan: Superiority of DIPSS-Plus to MYSEC-PM as a Survival Risk Model https://pubmed.ncbi.nlm.nih.gov/37463903/ Prognostication in Myeloproliferative Neoplasms, Including Mutational Abnormalities https://pubmed.ncbi.nlm.nih.gov/36922447/ ASXL1 Mutations Are Prognostically Significant in PMF, but Not MF Following Essential Thrombocythemia or PV https://pubmed.ncbi.nlm.nih.gov/35020812/ Genomic Analysis of Primary and Secondary MF Redefines the Prognostic Impact of ASXL1 Mutations: A FIM Study https://pubmed.ncbi.nlm.nih.gov/33666653/ Thromboembolic Events in PV https://pubmed.ncbi.nlm.nih.gov/30848334/ Optimal Treatment for Patients With Cavernous Transformation of the Portal Vein https://pubmed.ncbi.nlm.nih.gov/35402447/ Cytoreduction for ET and PV: Who, What, When, and How? https://pubmed.ncbi.nlm.nih.gov/38066871/

    23 min

  4. EPISODE 4

    JAK Inhibitors: Too Many Choices or Not Enough?

    Join Drs Tania Jain and Prithviraj Bose as they discuss the available JAK inhibitors and how they use them to treat myelofibrosis. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002056. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Primary Myelofibrosis https://emedicine.medscape.com/article/197954-overview JAK Inhibition for the Treatment of Myelofibrosis: Limitations and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/32903304/ You Really Got a Hold on Me https://ashpublications.org/ashclinicalnews/news/6493/You-Really-Got-a-Hold-on-Me A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/22375971/ Overall Survival in the SIMPLIFY-1 and SIMPLIFY-2 Phase 3 Trials of Momelotinib in Patients With Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/35869266/ Biological Basis for Efficacy of Activin Receptor Ligand Traps in Myelodysplastic Syndromes https://pubmed.ncbi.nlm.nih.gov/31961337/ Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis (ODYSSEY) https://clinicaltrials.gov/study/NCT06517875 Biology and Therapeutic Targeting of Molecular Mechanisms in MPNs https://pubmed.ncbi.nlm.nih.gov/36534936/ Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors (ESSENTIAL) https://clinicaltrials.gov/study/NCT03627403 Selinexor Plus Ruxolitinib in JAK Inhibitor Treatment-Naïve Myelofibrosis: SENTRY Phase 3 Study Design https://pubmed.ncbi.nlm.nih.gov/39911057/ EHA 2023, Abstract 210: An Open-Label, Global, Phase (Ph) 1b/2 Study Adding Navtemadlin (Nvtm) to Ruxolitinib (Rux) in Patients (Pts) With Primary or Secondary Myelofibrosis (Mf) Who Have a Suboptimal Response to Rux https://library.ehaweb.org/eha/2023/eha2023-congress/387910/john.mascarenhas.an.open-label.global.phase.28ph29.1b.2.study.adding.navtemadlin.html Imetelstat in Intermediate-2 or High-Risk Myelofibrosis Refractory to JAK Inhibitor: IMpactMF Phase III Study Design https://pubmed.ncbi.nlm.nih.gov/35510486/ CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms https://pubmed.ncbi.nlm.nih.gov/26175413/ Ropeginterferon Alfa-2b (ROPEG) and Peginterferon Alfa-2a (PEG) at Low Dose With Response-Based Titration (LDRT) Have Comparable Efficacy and Tolerability in Polycythemia Vera (PV) https://ashpublications.org/blood/article/144/Supplement%201/4568/533799/Ropeginterferon-Alfa-2b-ROPEG-and-Peginterferon The Characteristics of CALR Mutations in Myeloproliferative Neoplasms: A Clinical Experience From a Tertiary Care Center in Qatar and a Literature Review https://pubmed.ncbi.nlm.nih.gov/38804886/ Pelabresib Plus Ruxolitinib for JAK Inhibitor-Naive Myelofibrosis: A Randomized Phase 3 Trial https://pubmed.ncbi.nlm.nih.gov/40065169/ TRANSFORM-1 Trial of Navitoclax in Combination With Ruxolitinib for Myelofibrosis Met Primary but Not Secondary Endpoint https://ashpublications.org/ashclinicalnews/news/7630/TRANSFORM-1-Trial-of-Navitoclax-in-Combination Randomized, Single-Blind, Multicenter Phase II Study of Two Doses of Imetelstat in Relapsed or Refractory Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/34138638/ Efficacy and Safety of Fedratinib in Patients With Myelofibrosis Previously Treated With Ruxolitinib (FREEDOM2): Results From a Multicentre, Open-Label, Randomised, Controlled, Phase 3 Trial https://pubmed.ncbi.nlm.nih.gov/39265613/ Fedratinib in Patients With Myelofibrosis Previously Treated With Ruxolitinib: An Updated Analysis of the JAKARTA2 Study Using Stringent Criteria for Ruxolitinib Failure https://pubmed.ncbi.nlm.nih.gov/32129512/ Impact of TP53 on Outcome of Patients With Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation https://pubmed.ncbi.nlm.nih.gov/36940410/ SURPASS-ET: Phase III Study of Ropeginterferon Alfa-2b Versus Anagrelide as Second-Line Therapy in Essential Thrombocythemia https://pubmed.ncbi.nlm.nih.gov/35924546/ EXCEED-ET: A Single-Arm Multicenter Study to Assess the Efficacy, Safety, and Tolerability of Ropeginterferon alfa-2b-njft (P1101) in North American Adults With Essential Thrombocythemia https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.TPS7088 Ropeginterferon alfa-2b Versus Standard Therapy for Polycythaemia Vera (PROUD-PV and CONTINUATION-PV): A Randomised, Non-inferiority, Phase 3 Trial and Its Extension Study https://pubmed.ncbi.nlm.nih.gov/32014125/ Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial https://pubmed.ncbi.nlm.nih.gov/37126762/

    27 min

  5. EPISODE 5

    Posttransplant Monitoring in Myelofibrosis

    Join Drs Tania Jain and Rachel Salit as they explore evolving definitions of remission, relapse monitoring, and patient-centered transplant decisions in myelofibrosis care. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002057. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Primary Myelofibrosis https://emedicine.medscape.com/article/197954-overview Role of Hematopoietic Stem Cell Transplantation in Patients With Myeloproliferative Disease https://pubmed.ncbi.nlm.nih.gov/25459177/ Decreasing Chronic Graft-Versus-Host Disease Rates in All Populations https://pubmed.ncbi.nlm.nih.gov/39167805/ Diagnosis and Evaluation of Prognosis of Myelofibrosis: A British Society for Haematology Guideline https://pubmed.ncbi.nlm.nih.gov/37932932/ Prognostic Value of Blasts in Peripheral Blood in Myelofibrosis in the Ruxolitinib Era https://pubmed.ncbi.nlm.nih.gov/32697338/ Acute Myeloid Leukemia (AML) https://emedicine.medscape.com/article/197802-overview CIBMTR Myelofibrosis Medicare Study https://cibmtr.org/CIBMTR/Studies/Research-Programs/Clinical-Trials-Support/Medicare-Clinical-Trials#CMSMF Proposals for Revised International Working Group-European LeukemiaNet Criteria for Anemia Response in Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/39116296/ Utility of Assessing CD3+ Cell Chimerism Within the First Months After Allogeneic Hematopoietic Stem-Cell Transplantation for Acute Myeloid Leukemia https://pubmed.ncbi.nlm.nih.gov/35064642/ Clearance of Driver Mutations After Transplantation for Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/39778169/ Donor Lymphocyte Infusion and Molecular Monitoring for Relapsed Myelofibrosis After Hematopoietic Cell Transplantation https://pubmed.ncbi.nlm.nih.gov/37404772/

    23 min

  6. EPISODE 6

    A Futuristic Vision for Treating Myelofibrosis

    What will the next decade bring for myelofibrosis care? Drs Jain and Pemmaraju explore futuristic therapies, earlier interventions, and smarter diagnostics. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002058. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Manipulating Hepcidin in Polycythemia Vera https://pubmed.ncbi.nlm.nih.gov/37383006/ Role of ASXL1 and TP53 Mutations in the Molecular Classification and Prognosis of Acute Myeloid Leukemias With Myelodysplasia-Related Changes https://pubmed.ncbi.nlm.nih.gov/25860933/ Cryptic KMT2A::AFDN Fusion Due to AFDN Insertion Into KMT2A in a Patient With Acute Monoblastic Leukemia https://pubmed.ncbi.nlm.nih.gov/40149468/  8p11 Myeloproliferative Syndrome: A Review https://pubmed.ncbi.nlm.nih.gov/20226962/ What's Next? Clinical Trials in Myelofibrosis https://www.medscape.com/viewarticle/1002053 Artificial Intelligence-Based Morphological Fingerprinting of Megakaryocytes: A New Tool for Assessing Disease in MPN Patients https://pubmed.ncbi.nlm.nih.gov/32706893/ Phase 1/2 Study of the Pan-PIM Kinase Inhibitor INCB053914 Alone or in Combination With Standard-of-Care Agents in Patients With Advanced Hematologic Malignancies https://pubmed.ncbi.nlm.nih.gov/37290996/ The Telomerase Inhibitor Imetelstat Differentially Targets JAK2V617F Versus CALR Mutant Myeloproliferative Neoplasm Cells and Inhibits JAK-STAT Signaling https://pubmed.ncbi.nlm.nih.gov/37941547/ A Novel Application of XPO1 Inhibition for the Treatment of Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/40454401/ BOREAS: A Global, Phase III Study of the MDM2 Inhibitor Navtemadlin (KRT-232) in Relapsed/Refractory Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/36416118/ Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial https://pubmed.ncbi.nlm.nih.gov/37126762/ Center for International Blood & Marrow Transplant Research (CIBMTR) https://cibmtr.org/ Donor Types and Outcomes of Transplantation in Myelofibrosis: A CIBMTR Study https://pubmed.ncbi.nlm.nih.gov/38916866/  Clearance of Driver Mutations After Transplantation for Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/39778169/  Development of a First-in-Class CAR-T Therapy Against Calreticulin-Mutant Neoplasms and Evaluation in the Relevant Human Tissue Environment https://ashpublications.org/blood/article/144/Supplement%201/871/531067/Development-of-a-First-in-Class-CAR-T-Therapy

    30 min
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Listen to Medscape InDiscussion: Myelofibrosis, a podcast series where thought leaders and clinical experts share their diverse insights and practical ideas for optimizing patient care. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999593. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

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