Modern Thyroid and Wellness

McCall McPherson, PA-C

Unlock the latest insights into thyroid health and wellness with McCall McPherson, PA-C. Through expert interviews, personal stories, and actionable advice, this podcast dives deep into thyroid disorders, exploring how they impact everything from energy levels to mental clarity. Whether you're navigating your own thyroid journey or seeking cutting-edge solutions for optimal health, you'll find practical tips and holistic strategies to support your well-being. Join McCall as she empowers listeners to take control of their thyroid health and live a more vibrant life.

  1. 5d ago

    101: From PCOS & Hypothyroidism to Long COVID: Personalized Healing, Peptides & Regenerative Medicine with Nicole Peterson Doran

    What happens when you’re doing everything “right” for your health but still don’t feel like yourself? In this episode of Modern Thyroid & Wellness, McCall McPherson sits down with Nicole Peterson Doran, co-founder of PUR-FORM, Humanaut Health franchisee, and host of The Healthspan Collective Podcast, to talk about her decades-long journey through PCOS, hypothyroidism, inflammation, fertility concerns, long COVID, mast cell activation symptoms, and ultimately finding a more personalized approach to health. Nicole’s story began at just 16 years old when she rapidly gained weight, developed facial hair, experienced irregular periods, severe fatigue, and intense brain fog. She was diagnosed with PCOS and later hypothyroidism, but traditional treatment did little to resolve how she actually felt. That experience eventually led her into integrative medicine, whole-food nutrition, mindfulness, and the concept of bio-individuality—the idea that what works for one person may not work for another. In This Episode: Nicole’s experience with PCOS and hypothyroidism beginning in her teensWhy whole foods and lifestyle changes became a turning pointThe importance of bio-individuality in thyroid and hormone healthWhy there is no single “best” diet, medication, or wellness plan for everyoneHow Nicole prepared her body for pregnancy after years of PCOSThe supplements and lifestyle changes she personally used while preparing for fertilityHer long-COVID journey and mast cell activation symptomsHer personal experience with microdosed tirzepatideThymosin alpha-1 and larazotideWhy gut health became an important piece of her recoveryWhat EBO2 is and how PUR-FORM uses regenerative therapiesThe evolution from struggling patient to health entrepreneur Fertility After PCOS Nicole shares how being told as a teenager that getting pregnant could be difficult stayed with her for years. When she decided she wanted to conceive, she worked intentionally with her practitioners, focused on reducing inflammation, prioritized rest, limited travel, reduced alcohol and sugar, and used supplements including CoQ10 and fish oil. She became pregnant after approximately three months, while emphasizing that fertility is deeply individual and there is still an element of uncertainty that cannot always be controlled. Long COVID, MCAS & Finding New Tools After COVID, Nicole experienced months of intense histamine-type symptoms, inflammation, brain fog, irritability, and weight changes. She describes working with practitioners and personally using several tools during her recovery, including microdosed tirzepatide, thymosin alpha-1, larazotide, nutritional support, and regenerative therapies. These are shared as Nicole’s personal experience and are not recommendations for every listener. About Nicole Peterson Doran Nicole Peterson Doran is a co-founder of PUR-FORM, a comprehensive health optimization clinic in Boca Raton, Florida. She is also involved with Humanaut Health and hosts The Healthspan Collective Podcast. Her work focuses on personalized health, metabolic and hormonal wellness, regenerative medicine, and helping people find answers when conventional approaches have not been enough. Connect with Nicole Instagram: https://www.instagram.com/nicolejdoran/ LinkedIn: https://www.linkedin.com/in/nicolejpeterson/ PUR-FORM: https://purformhealth.com/ Humanaut Health: https://humanauthealth.com/ This episode is for educational purposes only and does not replace individualized medical advice. 📖 Pre-Order Take Back Your Thyroid + Get a Free Bonus Pre-order McCall McPherson’s new book, Take Back Your Thyroid, and choose one free bonus: 🎓 Thyroid Empowered Course, a $399 value OR 🩺 $150 off a new patient visit at Modern Thyroid Clinic Pre-Order & Claim Your Free Bonus 📲 Follow McCall McPherson & Modern Thyroid and Wellness 💻 Website: modernthyroidclinic.com 🐦 X / Twitter: @thyroidexpert 🌐 Host Website: mccallmcpherson.com 📺 YouTube: McCall McPherson Channel 📘 Facebook: McCall McPherson PAC 📸 Instagram: @mccallmcphersonpa

    101: From PCOS & Hypothyroidism to Long COVID: Personalized Healing, Peptides & Regenerative Medicine with Nicole Peterson Doran
  2. Sep 24

    100: Still Sick on Thyroid Medication? – The Shocking Truth Doctors Aren’t Explaining with Elle Russ

    In this episode of Modern Thyroid and Wellness, McCall McPherson, PA-C sits down with thyroid health expert and bestselling author Elle Russ to discuss why so many people with hypothyroidism and Hashimoto’s continue experiencing symptoms even while taking thyroid medication—and what may be missing from conventional thyroid treatment. They break down the limitations of relying on TSH alone, the difference between “normal” thyroid labs and actually feeling well, and why thyroid treatment may need to consider the bigger picture, including T4, T3, reverse T3, medication type, dosage, timing, symptoms, and the individual patient. If you’ve ever been told your thyroid labs are normal while you still struggle with fatigue, brain fog, stubborn weight gain, mood changes, high cholesterol, fertility concerns, or other hypothyroid symptoms, this conversation will help you better understand the questions to ask about your thyroid care. 📖 PRE-ORDER TAKE BACK YOUR THYROID McCall McPherson’s new book, Take Back Your Thyroid, is the science-based guide for people who are tired of being told everything looks “normal” when they still don’t feel well. Pre-order the hardcover and receive the Thyroid Empowered Course ($399 value) FREE with your pre-order. 👉 Pre-order here: https://book.modernthyroidclinic.com/?utm_source=youtube&utm_medium=organic&utm_campaign=take_back_your_thyroid_preorder&utm_content=episode_62_elle_russ 🔑 IN THIS EPISODE: Why you may still have hypothyroid symptoms while taking thyroid medicationWhy relying only on TSH can leave important information out of the picture“Normal” thyroid lab ranges vs. optimal thyroid functionT4, T3, reverse T3, and thyroid hormone conversionT4-only medication vs. combination thyroid therapyNatural desiccated thyroid vs. synthetic thyroid hormonesHow medication dose and timing can affect thyroid treatmentThe connection between thyroid dysfunction, fatigue, weight, mood, cholesterol, and fertilityCommon misconceptions about thyroid hormone replacementWhy understanding your own thyroid labs mattersHow to become a more informed advocate for your thyroid health 👩‍⚕️ ABOUT ELLE RUSS Elle Russ is a bestselling author, thyroid health educator, and advocate. After experiencing years of hypothyroidism, misdiagnosis, and unsuccessful treatment herself, she became dedicated to helping others better understand thyroid health and advocate for more individualized care. She is the author of The Paleo Thyroid Solution and creator of The Ultimate Thyroid Course. 🔗 ELLE RUSS RESOURCES Website: https://elleruss.com Free Thyroid Guide: https://freethyroidguide.com 🌐 ABOUT MODERN THYROID CLINIC Modern Thyroid Clinic specializes in helping patients understand and address persistent thyroid symptoms through individualized, comprehensive thyroid care. https://www.modernthyroidclinic.com Subscribe for weekly conversations about thyroid health, Hashimoto’s, hypothyroidism, hormones, metabolism, functional medicine, women’s health, and longevity. This podcast is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease or replace individualized medical advice from your healthcare provider. #Hypothyroidism #Hashimotos #ThyroidHealth #ThyroidMedication #WomensHealth

    100: Still Sick on Thyroid Medication? – The Shocking Truth Doctors Aren’t Explaining with Elle Russ
  3. Sep 17

    99: Thyroid Cancer Awareness Month: Early Detection, Surgery & What You Need to Know with Dr. Rashmi Roy

    Could a simple neck self-check help you notice a thyroid concern earlier? September is Thyroid Cancer Awareness Month, and in this episode of Modern Thyroid & Wellness, McCall McPherson sits down with Dr. Rashmi Roy, a fellowship-trained, board-certified endocrine surgeon specializing in thyroid and parathyroid disorders. Dr. Roy practices at the Hospital for Endocrine Surgery in Tampa and has performed thousands of thyroid and parathyroid procedures. Together, McCall and Dr. Roy have an important conversation about thyroid cancer risk, early detection, diagnosis, thyroid nodules, surgery, Hashimoto’s, and how patients can make more informed decisions about their thyroid health. They discuss how to perform a neck self-check, potential signs and risk factors to be aware of, and when thyroid ultrasound or additional evaluation may be appropriate. Dr. Roy also explains what patients should know before thyroid surgery, including common misconceptions, potential complications, and why the experience of your thyroid surgeon can matter when evaluating surgical options. The conversation also explores Hashimoto’s thyroiditis, its relationship to overall thyroid health and thyroid cancer risk, evolving approaches to treatment and post-surgical management, and why learning to ask better questions can help you become a stronger advocate for your own care. Whether you are navigating a thyroid nodule, Hashimoto’s, a possible thyroid cancer diagnosis, or an upcoming thyroid surgery, this episode offers practical information to help you approach the next step with greater clarity. 🔑 In This Episode: How to perform a neck self-checkSigns, symptoms, and risk factors associated with thyroid cancerWhen thyroid ultrasound or additional screening may be consideredWhat patients should know about thyroid nodulesWhy surgeon experience matters when choosing a thyroid surgeonCommon myths about thyroid surgeryPotential risks and complications of thyroid surgeryHashimoto’s and its relationship to thyroid health and thyroid cancer riskNew and emerging approaches to treatment and post-surgical managementHow to advocate for yourself and ask better questions about your care 👩‍⚕️ About Dr. Rashmi Roy Dr. Rashmi Roy is a fellowship-trained, board-certified endocrine surgeon specializing in thyroid and parathyroid disorders. She practices at the Hospital for Endocrine Surgery in Tampa and has performed thousands of thyroid and parathyroid procedures. Her extensive surgical experience gives her a valuable perspective on thyroid cancer diagnosis, surgical decision-making, potential complications, and what patients should consider when selecting a thyroid surgeon. If you know someone navigating thyroid nodules, thyroid cancer, Hashimoto’s, or an upcoming thyroid surgery, share this episode with them during Thyroid Cancer Awareness Month. 📘 Pre-Order Take Back Your Thyroid McCall McPherson’s new book, Take Back Your Thyroid, is available for pre-order now. Pre-order and receive FREE access to the Thyroid Empowered Course — a $399 value. 👉 Pre-order here: https://book.modernthyroidclinic.com/ 📲 Connect with McCall & Modern Thyroid Clinic McCall McPherson, PA-C Instagram: @mccallmcphersonpa https://www.instagram.com/mccallmcphersonpa/ Modern Thyroid Clinic Instagram: @modernthyroid https://www.instagram.com/modernthyroid/ Learn more about Modern Thyroid Clinic: https://www.modernthyroidclinic.com/ This content is for educational purposes only and is not intended to diagnose, treat, or replace individualized medical care. #ThyroidCancerAwarenessMonth #ThyroidCancer #ThyroidHealth #ThyroidCancerAwareness #ThyroidSurgery #ThyroidNodules #Hashimotos #HashimotosDisease #Hypothyroidism #ThyroidDisease #EndocrineHealth #WomensHealth #ModernThyroidClinic #McCallMcPherson #TakeBackYourThyroid

    99: Thyroid Cancer Awareness Month: Early Detection, Surgery & What You Need to Know with Dr. Rashmi Roy
  4. Sep 10

    98: Thyroid Dysfunction, Cellular Stress & Autophagy: A New Way to Think About Chronic Illness with Dr. Bill Rawls

    What if thyroid dysfunction isn’t always an isolated thyroid problem, but a signal that the cells throughout your body are under too much stress? In this episode of Modern Thyroid & Wellness, McCall McPherson sits down with Dr. Bill Rawls, physician, bestselling author, and co-founder of Vital Plan, for a fascinating conversation about cellular health, chronic illness, autophagy, microbes, stress, thyroid function, and the role herbs may play in supporting resilience. Dr. Rawls’ perspective grew out of his own health crisis. After years of intense work and inadequate sleep as an OB-GYN, his health deteriorated dramatically. He experienced fatigue, neurological symptoms, joint problems, cardiac symptoms, and eventually discovered evidence of Lyme disease. After conventional approaches failed to restore his health, his experience with herbal therapy led him into decades of research on chronic illness and cellular wellness. In This Episode, You’ll Learn: Why Dr. Rawls views cellular stress as a common thread in chronic illnessFive major categories that can stress our cellsWhy nutrition, environmental toxins, sleep, movement, and microbes matterWhat autophagy is and why cellular repair is essentialHow fasting, exercise, and stress can influence autophagyThe relationship between thyroid hormone and cellular metabolismWhy Dr. Rawls views thyroid dysfunction as a possible signal of broader cellular stressHis hypothesis about microbes, thyroid cells, and Hashimoto’sHow chronic psychological stress and cortisol affect cellular recoveryWhy whole foods, plant diversity, sleep, movement, and reducing toxic exposures form the foundation of his approachHow adaptogenic herbs may support cellular resilienceAshwagandha, rhodiola, reishi, cordyceps, Japanese knotweed, Chinese skullcap, dandelion, and milk thistleWhy herbs became central to Dr. Rawls’ approach to chronic illness The Five Drivers of Cellular Stress Dr. Rawls encourages listeners to zoom out from individual diagnoses and look at the health of the cells themselves. He organizes common sources of cellular stress into five broad areas: inadequate nutrition, toxic exposures, insufficient recovery and sleep, physical stress or inactivity, and microbes. His goal is not simply to suppress symptoms, but to create an internal environment that gives cells the resources and recovery time they need to function well. Autophagy: Your Cells’ Recycling and Repair System A major part of the conversation focuses on autophagy, the ongoing process cells use to recycle damaged components and maintain themselves. Dr. Rawls explains how fasting, movement, and other mild stressors may stimulate this process, while excessive stress can become counterproductive. He emphasizes balance between stress and recovery, rather than believing that more fasting or harder exercise is always better. What Does This Mean for Thyroid Health? Dr. Rawls describes thyroid hormone as an important metabolic signal that helps cells produce and use energy. His central argument is that when cells are chronically stressed, thyroid function may become part of that larger picture. Rather than viewing fatigue or thyroid dysfunction completely in isolation, he encourages looking at sleep, nutrition, stress, environmental exposures, movement, and overall cellular health. Connect with Dr. Bill Rawls 🌿 Dr. Bill Rawls at RawlsMD 📖 The Cellular Wellness Solution 📖 Unlocking Lyme 🌱 Explore Vital Plan RESTORE180™ Dr. Rawls also shares RESTORE180, Vital Plan’s six-month program for people navigating complex chronic illness. The program progresses through stress regulation, gut and detoxification support, and concentrated botanical formulations. Learn More About RESTORE180 📲 Follow McCall McPherson & Modern Thyroid and Wellness 💻 Website: modernthyroidclinic.com 🐦 X / Twitter: @thyroidexpert 🌐 Host Website: mccallmcpherson.com 📺 YouTube: McCall McPherson Channel 📘 Facebook: McCall McPherson PAC 📸 Instagram: @mccallmcphersonpa

    98: Thyroid Dysfunction, Cellular Stress & Autophagy: A New Way to Think About Chronic Illness with Dr. Bill Rawls
  5. Sep 3

    97: The Thyroid Supplement Guide: What to Take for Energy, Hair Loss, Hashimoto’s & More with Melissa Afflerbach

    With thousands of supplements promising more energy, better hair, improved thyroid function, and healthier aging, how do you know what your body actually needs? In this episode of Modern Thyroid & Wellness, McCall McPherson sits down with Melissa “Mel” Afflerbach, Clinical Director of Weight Loss & Supplement Programs, for a practical conversation about the supplements they use and recommend within their thyroid and metabolic health programs. They break down some of the most common concerns women with hypothyroidism and Hashimoto’s experience—from persistent fatigue and low energy to hair loss—and explain why supplementation should support the bigger picture rather than replace investigating the root cause of a symptom. In This Episode, You’ll Learn: Why correcting thyroid function may not completely resolve fatigueHow adrenal and mitochondrial health relate to energy productionThe difference between stimulant energy and supporting cellular energyWhy thyroid dysfunction can contribute to hair shedding and changes in hair, skin, and nailsWhy ferritin and thyroid labs matter when investigating hair lossHow collagen, micronutrients, and antioxidants may support hair, skin, and nailsWhy myo-inositol and selenium are used in ThyroShield™Why testing and understanding the cause of a symptom still mattersHow McCall and her clinical team choose supplements for MDRN WellnessA sneak peek at what they are developing specifically for the thyroid community McCall also shares the deeply personal story behind the “Sol” found throughout the MDRN Health line. Her late brother, Solomon, had been working on the project before his unexpected passing, and the line now carries part of his legacy forward. Supplements Discussed in This Episode Adrena-Sol — adrenal and energy support Shop Adrena-Sol Mito-Sol — mitochondrial and cellular energy support Shop Mito-Sol Beauty Glow Collagen — collagen support for hair, skin, and nails Shop Beauty Glow Collagen Complete Beauty — micronutrient support for hair, skin, and nails Shop Complete Beauty Astaxanthin Antioxidant — antioxidant and skin support Shop Astaxanthin ThyroShield™ — myo-inositol + selenium thyroid support Shop ThyroShield™ Shop MDRN Wellness The MDRN Wellness store was created to make choosing supplements less overwhelming. Products are selected by McCall and the clinical team with the needs of people navigating thyroid dysfunction, hormone concerns, low energy, and related symptoms in mind. Shop All MDRN Wellness Supplements 📖 Pre-Order Take Back Your Thyroid + Get a Free Bonus Pre-order McCall McPherson’s new book, Take Back Your Thyroid, and choose one free bonus: 🎓 Thyroid Empowered Course, a $399 value OR 🩺 $150 off a new patient visit at Modern Thyroid Clinic Pre-Order & Claim Your Free Bonus 📲 Follow McCall McPherson & Modern Thyroid and Wellness 💻 Website: modernthyroidclinic.com 🐦 X / Twitter: @thyroidexpert 🌐 Host Website: mccallmcpherson.com 📺 YouTube: McCall McPherson Channel 📘 Facebook: McCall McPherson PAC 📸 Instagram: @mccallmcphersonpa

    97: The Thyroid Supplement Guide: What to Take for Energy, Hair Loss, Hashimoto’s & More with Melissa Afflerbach
  6. Aug 27

    96: Your Thyroid Is a Barometer: What Chronic Disease Can Teach Us About Stress, Environment, and Prevention with Kelly McKenna

    What if your thyroid symptoms aren’t an isolated problem, but one signal from a body asking you to pay attention? In this episode of Modern Thyroid & Wellness, McCall McPherson sits down with Kelly McKenna, CEO and Co-Founder of End Chronic Disease, to explore thyroid health, autoimmunity, chronic stress, environmental exposures, nutrition, and what it really means to focus on prevention. Kelly’s health journey began with a celiac disease diagnosis in high school, followed by nearly two decades of autoimmune and chronic health challenges. In her early 30s, thyroid labs disrupted her plans to freeze her eggs and pushed her to ask a different question: instead of accepting hypothyroidism as inevitable, what might actually be driving it? That curiosity eventually changed both her health and career. Key Topics Covered Kelly’s experience with celiac disease, hypothyroidism, and Hashimoto’sHow childhood stress may influence long-term healthWhy sleep, nutrition, movement, relationships, and environment matterEnvironmental exposures and thyroid healthThe conversation around paraquat and chronic diseaseWhy prevention should begin in childhoodIodine, selenium, vitamin D, iron, and thyroid healthWhy Kelly calls her thyroid a “barometer” for her whole bodySimple strategies for fatigue and autoimmune flaresThe importance of boundaries and emotional healthBringing preventive health education into schoolsWhy chronic disease prevention requires both individual and systemic change When Your Thyroid Becomes a Warning System After being re-diagnosed with Hashimoto’s, Kelly began closely observing how changes in sleep, nutrition, nutrient status, stress, and other aspects of daily life corresponded with her symptoms and thyroid labs. She focused on nutrients including iodine, selenium, vitamin D, and iron and experimented with dietary changes. As her thyroid markers improved, she noticed changes in her skin, digestion, fatigue, and overall wellbeing too. Today, Kelly describes her thyroid as a “barometer for my whole body.” When fatigue and familiar symptoms return, she views them as signals that her body may need more support, rest, or recovery. Stress, Environment, and Chronic Disease Kelly also shares how growing up with a brother who experienced significant disabilities and frequent seizures created a chronic sense of uncertainty and stress, even within a loving family. Only later did she recognize how those experiences may have shaped her stress response. The conversation expands into environmental health, including paraquat exposure, ultra-processed foods, school environments, movement, and why the places where we live, work, learn, and eat deserve a larger role in conversations about chronic disease prevention. What If You’re Already Exhausted? When someone is already depleted, complicated wellness routines can feel impossible. Kelly recommends returning to basics. Her personal recovery toolbox has included restorative yoga, putting her legs up the wall, prioritizing sleep, simplifying food, gentle walking, acupuncture, positive experiences with people she loves, and examining emotional stress or boundaries that may be draining energy. The goal is to learn your body’s signals and build a collection of tools you can return to when you need them. About Kelly McKenna Kelly McKenna is the CEO and Co-Founder of End Chronic Disease, an organization focused on chronic disease prevention, education, awareness, and policy change. 🌐 End Chronic Disease 💼 Kelly McKenna on LinkedIn 📸 Kelly on Instagram @earth.to.kelly 📖 Pre-Order Take Back Your Thyroid + Get a Free Bonus Pre-order McCall McPherson’s new book, Take Back Your Thyroid, and choose one free bonus: 🎓 Thyroid Empowered Course, a $399 value OR 🩺 $150 off a new patient visit at Modern Thyroid Clinic Pre-Order & Claim Your Free Bonus 📲 Follow McCall McPherson & Modern Thyroid and Wellness 💻 Website: modernthyroidclinic.com 🐦 X / Twitter: @thyroidexpert 🌐 Host Website: mccallmcpherson.com 📺 YouTube: McCall McPherson Channel 📘 Facebook: McCall McPherson PAC 📸 Instagram: @mccallmcphersonpa

    96: Your Thyroid Is a Barometer: What Chronic Disease Can Teach Us About Stress, Environment, and Prevention with Kelly McKenna
  7. Aug 20

    95: Your DNA Is Not Your Destiny: How Genetics Can Personalize Thyroid Health, Hormones, Metabolism, and Longevity with Kashif Khan

    What if the foods, supplements, workouts, and hormone therapies that work beautifully for someone else are completely wrong for your biology? In this episode of Modern Thyroid & Wellness, McCall McPherson sits down with Kashif Khan, bestselling author of The DNA Way, celebrity longevity coach, and two-time TEDx speaker, for a deep dive into functional genomics and personalized health. Kashif explains how DNA acts as an instruction manual for the body and why understanding those instructions may help explain why people respond so differently to the same foods, environmental exposures, exercise programs, supplements, and hormone therapies. Drawing from his own experience with chronic illness and years of genetic research, Kashif explores the relationship between genetics and lifestyle, including thyroid health, Hashimoto’s, women’s hormones, detoxification, metabolism, gut health, sleep, cognitive function, inflammation, and longevity. The conversation offers a different way to think about personalized medicine: instead of simply asking what disease you may be genetically predisposed to, ask how your biology works and what choices may better support it. Key Topics Covered What DNA actually tells us about everyday healthWhy genetics are not necessarily destinyGenetics versus epigeneticsHow lifestyle, environment, and nutrition interact with genetic predispositionsKashif’s personal journey from chronic illness to genetic researchWhy two people can make the same health choices and experience very different outcomesGenetic differences in detoxificationWhy DNA testing is different from repeatedly testing hormones, cholesterol, or the microbiomeHow genetics may influence sleep and circadian preferencesPersonalizing nutrition and carbohydrate intakeGenetics, metabolism, and gut healthEnvironmental exposures and individual detoxification capacityWomen’s hormone health and estrogen metabolismGenetics, Hashimoto’s, autoimmunity, and thyroid healthWhy functional genomics goes beyond disease-risk scoresPersonalizing exercise according to individual biologyWhy nervous system regulation and gut health may need to come before advanced biohackingThe future of personalized medicine and longevityWhy understanding the biology underneath symptoms matters DNA as Your Body’s Instruction Manual Kashif describes DNA in practical terms as an instruction manual contained within the cells of the body. Genes provide instructions for countless biological processes, including producing hormones, metabolizing food, detoxifying compounds, and supporting cognitive function. The important difference is that everyone's instruction manual is slightly different. That helps explain why two people can follow the same diet, take the same hormone prescription, or perform the same exercise routine and experience dramatically different outcomes. Genetics Load the Gun, Environment Pulls the Trigger One of the central ideas in the episode is the interaction between genetics and epigenetics. Your DNA does not change every time you change your diet or lifestyle, but the choices you make interact with the biological instructions you inherited. Kashif groups those choices into three broad areas: EnvironmentNutritionLifestyle Environment includes what you are exposed to. Nutrition includes food, supplements, and other nutritional interventions. Lifestyle encompasses factors such as exercise, work, and sleep. Understanding genetics, therefore, is not simply about predicting disease. Kashif sees it as a way to understand how your individual body processes the choices you make every day. Kashif’s Personal Health Journey Kashif did not enter genomics through a traditional medical or scientific career path. Around age 38, after previously considering himself healthy, he developed multiple chronic health problems, including severe eczema, psoriasis, gut issues, migraines, reflux, and inflammation. He received diagnoses and prescriptions but remained focused on a different question: Why did this happen? His search took him through traditional Chinese medicine, homeopathy, naturopathy, functional medicine, hormone health, the microbiome, and eventually genetics. Understanding genetic differences helped him begin connecting his individual biology with environmental and lifestyle exposures. His recovery ultimately inspired him to leave his previous technology consulting business and build a genetic research company. Why Your Detoxification Genetics Matter Kashif uses his own GSTM1 genetics as an example of how individual differences can influence detoxification. He explains that glutathione plays an important role in neutralizing and removing unwanted compounds and that genetic differences can affect how those processes function in different areas of the body. In Kashif’s case, he discovered a copy number variation involving GSTM1, which became one piece of understanding why exposures that did not seem to affect someone living an otherwise similar lifestyle could affect him differently. This illustrates the broader problem with one-size-fits-all wellness advice: what is tolerated well by most people may not necessarily be optimal for every individual. Why DNA Testing Is Different Hormones change. The gut microbiome changes. Toxic burden changes. Cholesterol changes. DNA does not. Kashif explains that this permanence is part of what makes genomic information valuable. Rather than repeatedly testing DNA, the goal is to understand what your genetic information means and then use that knowledge alongside changing health data throughout your life. His current mission centers heavily on education and helping people better understand their own genetic information. Start With the Foundation Before Biohacking One of Kashif’s cautions is that people often enter the longevity and biohacking world by copying people who have already spent years optimizing their health. That can quickly become overwhelming. His suggested framework begins with identifying where you currently are. If there is an acute health problem, address that first. Then consider foundational areas such as: Nervous system regulationGut healthToxic burdenHealth optimizationLongevity and advanced biohacking Trying to fix decades of accumulated problems in two weeks is unlikely to create the sustainable outcome people are looking for. The goal is to work in the right order rather than doing everything at once. Five Areas Functional Genomics Can Help Personalize Kashif identifies several major areas where he believes functional genomics can provide useful insights. Cognitive Function Genetic differences may influence neurochemical pathways involved in behavior, reward, focus, and how people perceive and respond to their environment. Sleep Difficulty falling asleep, staying asleep, feeling restored, or naturally functioning better earlier or later in the day may involve different biological pathways. Metabolism People do not necessarily respond identically to the same macronutrient balance. Kashif shares an example involving female athletes who were struggling on a low-carbohydrate approach but performed better after carbohydrates were reintroduced based on their individual biology. Gut and Environmental Health Genetics may help provide context for how an individual responds to environmental exposures and how effectively certain detoxification processes function. Hormones This is one of the areas Kashif believes has enormous potential, particularly for women. Understanding how someone produces, binds, metabolizes, and clears hormones may provide a more personalized framework for women's health. Genetics, Thyroid Health, and Hashimoto’s McCall and Kashif take the conversation directly into thyroid health. Kashif explains that people may arrive with symptoms such as fatigue without realizing that thyroid physiology could be part of the picture. They discuss potential connections among detoxification pathways, environmental exposures, gut-brain signaling, autoimmunity, estrogen metabolism, and thyroid health. The bigger takeaway is that there may not be one universal reason someone develops Hashimoto’s or another thyroid problem. Kashif’s approach is to ask what biological pathways may be contributing in that particular individual so interventions can become more precise rather than simply adding more generalized recommendations. Why Women’s Hormones Need More Personalization Kashif describes women’s hormone health as one of the areas where his research revealed significant gaps in conventional approaches. The conversation explores estrogen metabolism and why understanding what happens after estrogen is produced may matter. Kashif discusses different estrogen metabolites and how genetics may influence their production and processing. For McCall, this aligns with what she sees clinically: thyroid hormones and reproductive hormones cannot always be treated as isolated systems. Understanding how an individual...

    95: Your DNA Is Not Your Destiny: How Genetics Can Personalize Thyroid Health, Hormones, Metabolism, and Longevity with Kashif Khan
  8. Aug 13

    94: Menopause Is Not the End: How to Prepare Your Body to Thrive in Midlife with Lisa Jedan

    What if menopause wasn’t something to fear or simply endure, but a transition you could actively prepare for? In this episode of Modern Thyroid and Wellness, McCall McPherson sits down with Lisa Jedan, creator and host of MenoPositive, to challenge the long-standing narrative that menopause automatically means decline. After a successful career in PR and marketing, where she helped build brands and shape stories, Lisa turned those same skills toward changing the conversation around women’s health and aging. Lisa shares what she has learned from interviewing experts across conventional medicine, Chinese medicine, longevity, breathwork, nutrition, and women’s health. The message she hears repeatedly is clear: hormones do not operate in isolation, and the earlier women invest in their health, the more options they may have as they age. Together, McCall and Lisa explore strength training, nutrition, metabolism, thyroid health, Hashimoto’s, mindset, digestion, protein, fiber, sustainable lifestyle changes, and why midlife may become one of the healthiest and most fulfilling chapters of a woman’s life. Key Topics Covered Why Lisa created MenoPositiveChanging the narrative around menopause and agingWhy menopause preparation should begin before symptoms become overwhelmingHow thyroid health and reproductive hormones overlapLisa’s personal experience with Hashimoto’sWhy women often put themselves lastMoving from perfection toward small, sustainable health changesWhy strength training becomes increasingly important during midlifeBuilding and preserving muscle for healthy agingProtein, fiber, metabolism, and digestive healthWhy regular bowel movements matterSimple ways Lisa adds flaxseed and sprouts to her dietHow mindset may influence the menopause experienceBuilding trust with yourself through consistent habitsMoving beyond biohacking toward “bioharmony”Why wellness optimization can become exhaustingThe importance of sleep, movement, and nutrition before advanced optimizationWhy your best years do not have to be behind you Changing the Menopause Narrative Lisa began her career as a dancer and performer before moving into PR and marketing, where she built a career around storytelling and changing narratives. When she entered perimenopause and menopause herself, she noticed that the cultural story surrounding this stage of life did not match her experience. So much of the messaging centered on loss, decline, and everything women should expect to go wrong. Lisa wanted a different conversation. That desire became MenoPositive, a platform and philosophy built around educating women about hormone changes while showing them what they can actively do to support their health. After interviewing experts from a wide range of disciplines, Lisa says one message consistently emerges: menopause does not have to equal decline. Why We Should Prepare for Menopause Lisa makes a compelling comparison: we prepare for pregnancy, retirement, and marathons, so why do so many women arrive at one of the biggest biological transitions of their lives without preparation? Historically, women have often been taught to wait until symptoms appear and then figure out how to manage them. Lisa wants to reverse that approach. Instead of asking, “How can I manage these symptoms?” she encourages women to ask how they can prepare their bodies for a more positive menopause experience. For Lisa, this is not about perfection. It is about preparation and beginning wherever you are. Thyroid Health and Menopause Symptoms Can Overlap Lisa also lives with Hashimoto’s, giving her firsthand experience with how difficult it can be to distinguish thyroid symptoms from hormonal changes during midlife. Mood changes, libido concerns, fatigue, brain fog, and changes in how the body feels can appear across both thyroid dysfunction and perimenopause. One of the biggest lessons Hashimoto’s taught Lisa was to become curious about what her body was communicating rather than automatically accepting symptoms as her new normal. McCall emphasizes that thyroid hormones and reproductive hormones do not exist in isolation. Understanding both can be especially important as women move through their 30s, 40s, and beyond. Why Women Need to Put Themselves Back on the List Whether a woman is the CEO of a company or the CEO of her household, Lisa observes that women often place themselves third, fourth, or fifth on their own priority lists. Midlife can offer an opportunity to change that. Lisa encourages women to believe they deserve to be healthy and to recognize that investing in themselves does not require changing everything overnight. Cooking one additional vegetable, adding a little movement, or making one sustainable change can begin shifting the trajectory. McCall connects this idea to the power of small habits. Tiny actions may seem insignificant in isolation, but when repeated consistently, they compound. Strength Training as a Midlife “Secret Weapon” For Lisa, two changes significantly influenced her menopause experience: strength training and nutrition. She had always been active because of her background as a dancer, but midlife encouraged her to change the way she exercised. Strength training became a priority. Lisa noticed changes not only in her body, but also in her mood, sleep, confidence, and mindset. McCall emphasizes that building muscle becomes increasingly challenging as women move through perimenopause and menopause, making it valuable to establish that foundation earlier. Lisa compares strength training to putting money in the bank. Building strength now creates reserves that may become increasingly valuable later in life. Keep the Schedule, Change the Scope One of Lisa’s favorite ideas comes from Atomic Habits by James Clear: “Keep the schedule, change the scope.” If you planned to exercise but suddenly only have ten minutes, doing those ten minutes still allows you to keep the promise you made to yourself. Lisa and McCall discuss how this consistency builds something even bigger than fitness: self-trust. Every time you follow through, especially when you do not feel like it, you reinforce the belief that you can rely on yourself. That mindset can make sustainable health changes much more achievable than an all-or-nothing approach. From Biohacking to Bioharmony Women today are surrounded by wellness advice. Eat more protein. Take supplements. Strength train. Optimize your hormones. Track your sleep. Improve your metabolism. Eventually, optimization itself can become exhausting. Lisa believes the conversation is beginning to shift away from constant “biohacking” toward what she calls bioharmony, a more sustainable approach to working with the body rather than endlessly trying to optimize every variable. The foundation remains surprisingly simple: Eat well. Move your body. Sleep. These habits are not always easy, but Lisa believes establishing them first creates a stronger foundation before adding more advanced interventions. Protein, Fiber, and Digestion in Midlife Nutrition is another major part of the conversation. Across Lisa’s interviews with experts, protein repeatedly emerges as an important topic, particularly alongside strength training and maintaining muscle. But protein is not the whole story. Lisa also emphasizes fiber and digestive regularity. She shares that many women assume having a bowel movement every two or three days is normal. Her own experience taught her how stress and rushed mornings could affect digestion. Two simple foods she regularly incorporates are flaxseed and sprouts. She prepares flaxseed ahead of time and adds it to yogurt, while sprouts can easily be added to eggs, salads, or meals. These small, affordable habits reflect Lisa’s larger philosophy: health does not always require expensive or complicated interventions. You Have More Influence Than You Think When McCall asks Lisa what mindset shift she wishes every woman could make, her answer is simple: You have a choice. Lisa believes women have more influence over how they approach and experience menopause than many have been led to believe. That does not mean every symptom can be prevented or that every woman will have the same experience. It means women can become informed, seek appropriate care, strengthen their health foundations, and make choices that support the decades ahead. Your Best Years Are Not Behind You Perhaps the biggest myth Lisa wants to challenge is the idea that a woman’s best years are over once she reaches midlife. She sees the opposite. Women in their 40s, 50s, and 60s are starting businesses, stepping into leadership, pursuing new goals, and redefining what aging looks like. Instead of treating menopause as an ending, Lisa sees it as an opportunity to enter the second half of life with greater wisdom, perspective, confidence, and purpose. For her, menopause can be a powerful new beginning. Final Takeaway Preparing for menopause does not mean pursuing perfection. It means starting where you...

    94: Menopause Is Not the End: How to Prepare Your Body to Thrive in Midlife with Lisa Jedan
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About

Unlock the latest insights into thyroid health and wellness with McCall McPherson, PA-C. Through expert interviews, personal stories, and actionable advice, this podcast dives deep into thyroid disorders, exploring how they impact everything from energy levels to mental clarity. Whether you're navigating your own thyroid journey or seeking cutting-edge solutions for optimal health, you'll find practical tips and holistic strategies to support your well-being. Join McCall as she empowers listeners to take control of their thyroid health and live a more vibrant life.

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