Blindspot Capital

by FemmeHealth Alliance

Exploring the big ideas, trends and investment potential in the future of women's health www.billiondollarblindspot.com

  1. Why It Takes Years to Build in Women’s Health

    FEB 26

    Why It Takes Years to Build in Women’s Health

    Most innovation stories are told as clean upward lines. A founder has an idea. Investors come in. The product launches. Growth follows. Eventually there is an acquisition or an IPO, and the story looks inevitable in hindsight. But in women’s health, progress rarely looks like that. More often, there is a long stretch where the science works and yet nothing seems to move. Inside that stretch, entrepreneurs are judged, investors grow impatient, and real progress is often mistaken for failure. In a recent episode of Blindspot Capital, I sat down with Skip Baldino, former CEO of Gynesonics, to talk about what it actually takes to move a women’s health medical technology through a system that was never designed to adopt change quickly. Much of what looks like an “exit” from the outside is, in reality, the end of a very long middle. Gynesonics, which developed a minimally invasive treatment for uterine fibroids as an alternative to hysterectomy, was acquired by Hologic for $350 million last year. Headlines called it a success story. But the journey was not a straight line. It included multiple leadership transitions, product iterations, clinical trials, reimbursement battles, investor fatigue, and even the collapse of Silicon Valley Bank during one of the most fragile moments in the company’s history. At several points, the company could easily have disappeared. Instead, a small group of investors stayed in when others could not or would not. Importantly, the employees stayed in and the company continued building toward a future that was still invisible to the outside world. We talk about: * The hysterectomy default: why 600,000 procedures still happen annually and what it takes to shift the standard * The real work of medtech commercialization: clinical outcomes, economic proof, reimbursement, and payer dynamics * The do-or-die year at Gynesonics and why key opinion leaders matter * The Blackstone signal: what major capital moving into women’s health could mean for founders and exits This conversation offers a grounded view of how innovation actually moves through healthcare and why patience, conviction, and sustained capital matter more than headlines suggest. If you care about women’s health innovation, this episode offers a rare look inside the part of the journey most people never see. 🎧 Watch the full episode on YouTube 📄 Learn more about the Learn more about uterine-sparing fibroid treatment and minimally invasive options. 🔎 Explore Channel Medsystems and innovation in heavy menstrual bleeding And share this episode with founders, operators, and investors building in women’s health — because commercialization blind spots don’t fix themselves. Join 19,000+ readers of The Billion Dollar Blindspot newsletter on Substack. 📌 Watch the full episode on YouTube Get full access to The Billion Dollar Blindspot at www.billiondollarblindspot.com/subscribe

    35 min
  2. Why Women’s Heart Disease Is Still Misdiagnosed

    JAN 29

    Why Women’s Heart Disease Is Still Misdiagnosed

    In this episode of Blindspot Capital, Maryann sits down with Professor Angela Maas (cardiologist and pioneer of sex- and gender-specific cardiology) to unpack why women’s heart disease is still misunderstood and what medicine, policy, and innovation must change to close the gap. Angela has built her career at the frontier of women’s cardiovascular science and clinical practice. Her work helped shift the field from “atypical symptoms” and one-size-fits-all assumptions toward a life-course view of women’s heart health spanning pregnancy, midlife, menopause, and the long tail of cancer treatment. This conversation exposes how medical blind spots persist, how cultural resistance slows change, and where cross-disciplinary innovation can unlock better outcomes. This episode is a must-listen for anyone navigating midlife health, clinicians working to close the gender gap in outcomes, and investors seeking the next frontier in precision medicine. We Cover: The moment a female patient confronted Angela and why it became a 35-year wake-up call for her career Why women’s ischemic heart disease often isn’t “obstructive” and how spasm and microvascular dysfunction show up differently (especially ages 40–70) The overlooked risk signals hiding in plain sight: migraines, hypertensive pregnancy, miscarriages, early menopause, and severe menopausal symptoms Menopause and “myocardial stiffness” explained in plain language and why prevention must start at the beginning of the transition The hidden cardio-oncology gap: how breast cancer treatment can drive heart damage years later, and why early detection matters What sex-specific medical education should include and why policy starts with who holds leadership and decision power Links Learn more in Angela’s book, A Woman’s Heart: Why Female Heart Health Really Matters — a definitive guide to understanding women’s cardiovascular risk across the life course. Follow Professor Angela Maas on LinkedIn And share this episode with a woman navigating midlife health, clinicians and investors because this blind spot doesn’t fix itself. Join 10,000+ readers of The Billion Dollar Blindspot newsletter on Substack. 📌 Watch the full episode on YouTube Get full access to The Billion Dollar Blindspot at www.billiondollarblindspot.com/subscribe

    35 min
  3. How Hormones Change Women’s Hearts and Why Cardiology Wasn’t Built to See It

    JAN 15

    How Hormones Change Women’s Hearts and Why Cardiology Wasn’t Built to See It

    In this episode of Blindspot Capital, Maryann Selfe speaks with Professor Carolin Lerchenmüller, cardiologist, clinician-scientist, and Switzerland’s first Chair of Gender Medicine, about why heart disease presents differently in women and how hormones across pregnancy, perimenopause, and menopause fundamentally reshape cardiovascular risk. Drawing on decades of research spanning molecular cardiology and clinical care, Carolin explains why modern cardiology guidelines failed to account for female biology and what gender-informed, hormone-literate cardiology must look like next. We Cover: How pregnancy, perimenopause, and menopause alter cardiovascular symptoms and risk in women Why preeclampsia and gestational hypertension are early predictors of lifetime cardiovascular disease How declining estrogen levels affect blood vessels, cholesterol metabolism, and plaque formation Why cardiovascular disease remains the leading cause of death in women worldwide and why awareness remains dangerously low What a hormone-literate, gender-informed cardiology system would require in research, diagnostics, and care delivery Carolin’s predictions for the future of gender medicine and why she sees a turning point in science and clinical practice Links  Learn more about the Women’s Heart Health Program at University Hospital ZurichFollow Professor Lerchenmüller on LinkedIn And share this episode. With a founder. With a policymaker. With a friend. Because this blind spot doesn’t fix itself. Join 10,000+ readers of the FemmeHealth newsletter on Substack. -------------------------- 📌 Watch full episode on YouTube Get full access to The Billion Dollar Blindspot at www.billiondollarblindspot.com/subscribe

    28 min
  4. Tough Love for Women’s Health Founders

    11/06/2025

    Tough Love for Women’s Health Founders

    In this episode of Blindspot Capital, Maryann sits down with Lisa Suennen - longtime healthcare investor, founder of the Venture Valkyrie blog, and Managing Partner of the Go Red for Women Venture Fund to unpack one of the most misunderstood barriers in women’s health investing: the gap between mission and money. Lisa has been on every side of the table: as a founder, VC, nonprofit leader, and fund manager. Her viral blog post, Tough Love for Women’s Health Entrepreneurs, struck a nerve by naming the hard truth many avoid. This episode is a must-listen for founders preparing to pitch, funders looking to cut through the noise, and anyone serious about changing how capital flows into women’s health. We Cover: 🟣 Why many femtech startups stall at Series A 🟣 The difference between pitching a product vs. pitching your stock 🟣 How market size myths derail women's health business cases 🟣 Why language matters: from “women’s health” to “health of women” 🟣 What Lisa’s seeing across 500+ pitch decks at the AHA Venture Fund 🟣 The missing middle: why we need more later-stage capital Links: 📝 Read Lisa’s blog💼 Learn about the Go Red for Women Venture Fund📣 Follow Lisa on LinkedIn And share this episode. With a founder. With an investor. With a policymaker. Because this blind spot doesn’t fix itself. Join 10,000+ readers of the FemmeHealth newsletter on Substack. -------------------------- 📌 Watch full episode on YouTube Get full access to The Billion Dollar Blindspot at www.billiondollarblindspot.com/subscribe

    27 min
  5. She Coined ‘FemTech’. Now She’s Rewriting the Narrative on Women’s Health

    09/25/2025

    She Coined ‘FemTech’. Now She’s Rewriting the Narrative on Women’s Health

    What if naming something was the first step to making it investable? In this episode of Blindspot Capital, I sit down with Ida Tin, entrepreneur, systems thinker, and the woman who coined the term FemTech. She’s also the co-founder and former CEO of Clue, one of the most widely used women’s health apps in the world, with over 10 million active users in 190+ countries. But this conversation isn’t just about legacy. It’s about language, legitimacy, and the long game of funding women’s health. We cover: 🟣 How FemTech started as a bridge to help male investors care 🟣 What naming a category unlocked and unintentionally limited 🟣 The persistent bias that keeps women’s health boxed in as “niche” 🟣 The mindset shift from founder to systems-change leader 🟣 Why we believe women’s health is infrastructure 🟣 What she’s building next with Femtech Assembly and why she’s doing it differently Join 10,000+ readers of the FemmeHealth newsletter on Substack. -------------------------- FEMTECH Assembly -------------------------- Why You Should Listen: If you’re a founder, investor, or operator navigating digital health, this is the truth-telling conversation you won’t hear on stage. No fluff. Just data, capital dynamics, and the patterns no one’s naming. 📌 Watch full episode on YouTube Get full access to The Billion Dollar Blindspot at www.billiondollarblindspot.com/subscribe

    29 min
  6. Why Most Digital Health Startups Will Fail

    09/11/2025

    Why Most Digital Health Startups Will Fail

    Half the headlines in healthcare are hype. But what if we stopped chasing the next shiny thing and started fixing the fundamentals? In this episode of Blindspot Capital, I sit down with Sergei Polevikov, mathematician, investor, and co-host of the podcast Digital Health Inside Out, to talk about what’s broken in digital health from copycat AI startups to gender bias in funding and where we should be paying attention instead. In This Episode We Cover: 🟣 Why most digital health startups are chasing performance signals that don’t matter🟣 The VC paradox: how underperforming funds still raise while women founders get ignored🟣 The rise of “AI tourists” in healthcare and why most won’t survive🟣 What investors are missing in autoimmune, menopause, and cardiovascular health🟣 How women-led companies often outperform and still get passed over🟣 What needs to change in how capital flows are structured🟣 Why Sergei and Alex launched Digital Health Inside Out and what he's learning from clinicians, not conferences. Join 10,000+ readers of the FemmeHealth newsletter on Substack. ---------------------------------------------------- 🎙️ Sergei and Alex’s podcast: Digital Health Inside Out📬 Sergei’s Substack: AI Health Uncut ---------------------------------------------------- Why You Should Listen: If you’re a founder, investor, or operator navigating digital health, this is the truth-telling conversation you won’t hear on stage. No fluff. Just data, capital dynamics, and the patterns no one’s naming. 📌 Watch full episode on YouTube Get full access to The Billion Dollar Blindspot at www.billiondollarblindspot.com/subscribe

    30 min
  7. What Real Science in Women’s Health Looks Like

    08/21/2025

    What Real Science in Women’s Health Looks Like

    Half the population experiences these conditions. Many are universal, recurring, and clinically significant. Yet in the eyes of too many investors, women’s health therapeutics remain “optional.” In this episode of Blindspot Capital, I sit down with Sabrina Johnson, President & CEO of Daré Bioscience, to unpack the misconceptions holding back investment in women’s health from contraception to menopause to vaginal health and explore how disciplined science can change the game. In This Episode We Cover: 🟣 Why women’s health markets are larger and more recurrent than most investors realize 🟣 The false perception that women’s health conditions are “lifestyle” or “optional” 🟣 The reality of recruiting participants for women’s health trials (and why stigma isn’t a barrier) 🟣 What scientific credibility really looks like in biotech and how to protect it 🟣 The difference between medicine and marketing and why the distinction matters for investors 🟣 Why angel investors have a leadership opportunity in women’s health Join 10,000+ readers of the FemmeHealth newsletter on Substack. ------------------------------ Why You Should Listen If you care about women’s health, biotech, or the intersection of science and capital, this is a clear-eyed look at the market opportunities hiding in plain sight and the leadership it will take to unlock them. About Sabrina Johnson Sabrina Johnson is the President & CEO of Daré Bioscience, a biopharmaceutical company driven by a mission to challenge the status quo, making women's health a priority. Daré believes that innovation does not have to start from scratch. The company’s goal is to bring to market as soon as practicable innovative evidence-based solutions that address decades of unmet needs in women’s health and enhance outcomes and convenience, primarily in the areas of contraception, sexual health, pelvic pain, fertility, infectious disease, vaginal health and menopause. Learn more Here 🎧 Listen now and share with someone who still thinks women’s health is “niche.” 📌 Watch on YouTube Get full access to The Billion Dollar Blindspot at www.billiondollarblindspot.com/subscribe

    25 min

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Exploring the big ideas, trends and investment potential in the future of women's health www.billiondollarblindspot.com