The European Hereditary Tumour Group Podcast

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Join us as we delve into the world of hereditary cancer conditions, featuring conversations with opinion leaders, experts, cutting-edge researchers, and patients. Our episodes explore key issues, groundbreaking research, and personal stories that shape the understanding, prevention, and treatment of hereditary cancer syndromes. Stay informed and inspired with every episode!

Episodes

  1. Population level germline testing for cancer risk

    02/11/2025

    Population level germline testing for cancer risk

    In this episode of The European Tumour Group Podcast, we sit down with Professor Ranjit Manchandra from the University of London to discuss his pioneering work in population-level genetic testing and the landmark PROTECTOR study. Prof. Manchandra shares insights into how broad genetic testing strategies can identify individuals at risk of hereditary cancers, particularly BRCA-related breast and ovarian cancers. He explores the benefits, challenges, and ethical considerations of implementing genetic testing at a population level, moving beyond traditional family history-based approaches. A key focus of the conversation is PROTECTOR, a major clinical study evaluating the impact of risk-reducing surgery in women with BRCA1/2 mutations. Prof. Manchandra explains how the study is helping women make informed choices about preventative surgery while balancing quality of life. Tune in to hear about the future of precision medicine, how genetic testing is reshaping cancer prevention, and what needs to happen for these strategies to become mainstream in clinical practice.

    27 min
  2. The story of aspirin with Prof Sir John Burn

    12/18/2024

    The story of aspirin with Prof Sir John Burn

    In this episode, we delve into the fascinating journey of aspirin and its transformative role in cancer prevention with the renowned Professor Sir John Burn. A pioneer in genetics and cancer research, Sir John recounts the incredible story of how a simple over-the-counter medication became a game-changer for individuals with Lynch syndrome—a condition that significantly increases the risk of several cancers, including bowel and endometrial cancer. Discover the science behind aspirin's preventive powers, the groundbreaking clinical trials that reshaped our understanding of cancer prevention, and the challenges and triumphs along the way. From the earliest hypotheses to the latest breakthroughs, Sir John Burn shares his insights into this extraordinary chapter in modern medicine, blending scientific expertise with a personal passion for improving patient outcomes. This episode is a must-listen for anyone curious about the intersection of genetics, cancer prevention, and one of the most widely used drugs in the world.

    34 min
  • 2 Episodes

About

Join us as we delve into the world of hereditary cancer conditions, featuring conversations with opinion leaders, experts, cutting-edge researchers, and patients. Our episodes explore key issues, groundbreaking research, and personal stories that shape the understanding, prevention, and treatment of hereditary cancer syndromes. Stay informed and inspired with every episode!

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