Two guys talking **it - A Gastroenterology and Hepatology podcast

A/Prof Jon Segal and Dr James Haridy
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“Two Guys Talking $#it” is a podcast where two Gastroenterologists break down complex topics into engaging, educational, and occasionally humorous conversations. From liver health to gut microbiota and everything in between, A/Professor Jonathan Segal and Dr James Haridy deliver insights, share the latest research, and discuss clinical pearls with the odd guest in tow. Comments, suggestions, questions please contact us on twitter @2guystalkingit or leave a comment below..

Episodes

  1. 07/29/2025

    #11: A/Prof Elliot Tapper - Liver legends, lies and lactulose

    Today we had the privilege of talking to a true superstar in the world of Hepatology. Elliot B. Tapper MD is an Associate Professor in the Division of Gastroenterology and Hepatology at the University of Michigan. He is Academic Chief of Hepatology. His primary goal is to empower patients to enjoy a high quality of life. He is an expert in the management of chronic liver disease, performance of clinical trials, and big data for the study of liver disease. He has developed strategies that reduce symptoms and improve quality of life and invented tools that have helped keep patients with cirrhosis at home and away from the hospital. He is the Editor-in-Chief of Hepatology Communications. In this episode, A/Prof Tapper discusses his journey in hepatology, the impact of social media on medical education, and his innovative research on muscle cramps and pickle juice. He debunks common myths surrounding methotrexate and liver disease, explores the complexities of ammonia levels in hepatic encephalopathy, and shares insights on frailty in liver disease management. The conversation also touches on the evolving perspectives on antibiotic prophylaxis in cirrhosis and the critical importance of diagnostic paracentesis. Elliot emphasizes the positive aspects of hepatology and the exciting developments in the field. As always comments, questions and feedback please send to: X: @2guystalkingit Email: 2guystalkingit@gmail.com Chapters 05:08 Introduction to Elliot and His Work 08:14 The Power of Social Media in Medical Education 11:10 The Fascination with Pickle Juice and Muscle Cramps 14:00 Innovative Research During COVID-19 17:01 Exploring Non-Pharmaceutical Interventions 20:04 Debunking Myths Around Methotrexate and Liver Disease 23:10 Addressing Misconceptions About Medications 25:56 The Impact of AI on Medical Literature 28:56 The Ammonia Debate in Clinical Practice 30:17 Understanding Ammonia as a Clinical Biomarker 37:28 Assessing Frailty in Liver Disease Patients 44:20 Reevaluating SBP Prophylaxis in Cirrhosis 49:03 The Importance of Diagnostic Paracentesis 52:34 The Positive Side of Hepatology Keywords Elliot Tapper, hepatology, liver disease, medical education, social media, muscle cramps, methotrexate, ammonia levels, frailty, antibiotic prophylaxis, diagnostic paracentesis

    57 min

  2. 07/09/2025

    #10: A/Prof Gianluca Ianiro and Dr Benjamin Mullish - The gut microbiome in health and disease

    Today we’re talking bugs, bowels, and breakthroughs with A/Prof Gianluca Ianiro and Dr. Ben Mullish, two microbiome maestros who make poo science strangely fascinating. A/Prof Gianluca Ianiro is an Associate Professor of Gastroenterology at the Università Cattolica del Sacro Cuore in Rome and a Consultant at the Gastroenterology Unit of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS. His clinical and research interests center on the gut microbiota, with a particular emphasis on fecal microbiota transplantation (FMT) and its applications in gastrointestinal disorders such as Clostridioides difficile infection and irritable bowel syndrome. Recognized as a leading expert in his field, Professor Ianiro has contributed extensively to international consensus guidelines and has been acknowledged for his work with the United European Gastroenterology Rising Star award. He also leads the Microbiome Clinic at Gemelli, translating cutting-edge microbiome research into clinical practice.  Dr. Benjamin Mullish is a Senior Clinical Research Fellow in the Division of Digestive Diseases at Imperial College London and an Honorary Consultant in Hepatology and Gastroenterology at St Mary’s Hospital, part of the Imperial College Healthcare NHS Trust. He is also an IPPRF Research Fellow within the Department of Metabolism, Digestion and Reproduction at Imperial College. His research focuses on the gut microbiome and faecal microbiota transplantation (FMT), particularly in the context of liver disease and gastrointestinal infections.This conversation delves into the complexities of the microbiome, particularly the gut microbiome, and its significant role in health and disease. We discuss the dynamic nature of the microbiome, the challenges in microbiome research, and the potential for microbiome-based therapeutics. They also explore the roles of prebiotics and probiotics, the future of microbiome diagnostics, and the potential future concept for specialised microbiome clinicians to bridge the gap between research and clinical practice. As always comments, questions and feedback please send to: X: @2guystalkingit Email: 2guystalkingit@gmail.com Chapters 00:20 J + J Introduction 05:11 Introduction to the Microbiome   07:16 Understanding the Gut Microbiome   10:04 The Dynamic Nature of the Microbiome   13:21 Factors Influencing the Gut Microbiome   16:15 Clinical Relevance of Stool Microbiome   19:24 Microbiome and Disease: Cancer and Liver Health   22:12 Microbiome in Inflammatory Bowel Disease (IBD) and Metabolism   25:20 Future Directions in Microbiome Research   35:20 The Uncertainty of Microbial Therapeutics   37:10 The Future of Microbiome Research   42:41 Understanding Prebiotics and Probiotics   56:49 The Need for Microbiome Clinician specialists

    1h 3m

  3. 06/05/2025

    #09: A/Professor Emma Halmos & Dr CK Yao - Food is Medicine.. or is it?

    Today we welcome two world-leading dietitians to talk all things diet in IBD and IBS.... A/Prof Emma Halmos is a senior research dietitian at Monash University and the Alfred Hospital. Her scientific achievements have had a major impact in clinical practice nationally and internationally. The most notable was the pivotal feeding study that demonstrated the low FODMAP diet was efficacious in patients with IBS. A/Prof Halmos has been elected onto the D-ECCO (Dietitians of European Crohn’s and Colitis Organisation) committee and is a leading coordinator for the first ECCO guidelines on nutrition in IBD. Her current role at Monash University is leading research on novel dietary therapy to treat IBD and IBS. Dr CK Yao is a senior research dietitian at Monash University and the Alfred Hospital, and recent NHMRC emerging leader. In 2017, CK completed her PhD investigating dietary manipulation of gut microbial function and the application of gaseous biomarkers in patients with functional and inflammatory bowel disease. Dr Yao currently leads a research programme looking at optimising dietary strategies for patients with ulcerative colitis and those with an ileoanal pouch.We discuss the critical role of diet in managing inflammatory bowel disease (IBD), particularly Crohn's disease and ulcerative colitis. We explore various dietary patterns, the impact of emulsifiers and ultra-processed foods, and the importance of personalized dietary advice. We talk about the significance of dietitians in guiding patients towards healthier choices. This conversation delves into the complexities of dietary recommendations for various gastrointestinal conditions, particularly focusing on the Mediterranean diet, Crohn's disease, and IBS. We discuss cultural influences on diet, the importance of personalized nutrition, and the emerging trends in dietary therapy. Finally we touch on the new ECCO Diet in IBD guideline that is set to be published soon. As always comments, questions and feedback please send to: X: @2guystalkingit Email: 2guystalkingit@gmail.com Chapters 00:00 Introduction with J & J 4:20 On to our guests... Diet and IBD 05:50 Dietary Patterns for Disease Prevention 08:53 Therapeutic Diets and Active IBD 11:58 Controversies in Dietary Recommendations 15:02 The Impact of Emulsifiers and Ultra-Processed Foods 18:07 Practical Dietary Advice for Patients in IBD 21:02 Cultural Considerations in Dietary Recommendations 23:57 Food as Medicine: A Discussion 27:03 Exploring Diverse Dietary Patterns 30:13 Conclusion and Future Directions 32:26 Cultural Influences on Diet and Health 34:40 Dietary Recommendations for active Crohn's Disease 37:22 Understanding Pouch Patients 38:11 Initial Assessment for IBS Patients 44:25 Screening for ARFID 48:03 Emerging Dietary Trends in IBS 51:40 New Guidelines in IBD Nutrition Papers discussed Fitzpatrick JA, Gibson PR, Taylor KM, Anderson EJ, Friedman AB, Ardalan ZS, Smith RL, Halmos EP. Clinical Trial: The Effects of Emulsifiers in the Food Supply on Disease Activity in Crohn's Disease: An Exploratory Double-Blinded Randomised Feeding Trial. Aliment Pharmacol Ther. 2025 Apr;61(8):1276-1289.  https://pubmed.ncbi.nlm.nih.gov/39967287/ Fitzpatrick JA, Gibson PR, Taylor KM, Halmos EP. Development of Novel High and Low Emulsifier Diets Based upon Emulsifier Distribution in the Australian Food Supply for Intervention Studies in Crohn's Disease. Nutrients. 2024 Jun 18;16(12):1922. . https://pubmed.ncbi.nlm.nih.gov/38931276/ Halmos EP, Gibson PR. Controversies and reality of the FODMAP diet for patients with irritable bowel syndrome. J Gastroenterol Hepatol. 2019 Jul;34(7):1134-1142. https://pubmed.ncbi.nlm.nih.gov/30945376/ A FODMAP Gentle approach: https://www.monashfodmap.com/blog/gentle-fodmap-diet/ The SCOFF Questionnaire: https://ceed.org.au/wp-content/uploads/2024/05/SCOFF.pdf

    56 min

  4. 04/28/2025

    #08: Professor Gideon Hirschfield - The Art and Science of PSC and Autoimmune Hepatitis

    Summary Dr Gideon Hirschfield is a leading expert in autoimmune liver diseases, including PSC, PBC, and autoimmune hepatitis. He’s helped shape how these conditions are understood and managed around the world, combining cutting-edge research with a real passion for patient care. Today he discusses his work with autoimmune liver diseases, particularly primary sclerosing cholangitis (PSC) and autoimmune hepatitis. We discuss some key topics in PSC (including use of Ursodeoxycholic acid, cancer surveillance as well as the PSC/IBD phenotype), and Professor Hirschfield gives us a masterclass in the management of autoimmune hepatitis. He also offers advice for new hepatologists, highlighting the significance of clear diagnoses, individualized patient management, and clinical trials to drive us into the future. As always comments, questions and feedback please send to: X: @2guystalkingit Email: 2guystalkingit@gmail.com Chapters 00:30 J & J Introduction 06:15 Introduction to Professor Hirschfield and Autoimmune Liver Diseases 07:41 The Role of Ursodeoxycholic Acid in PSC Management 19:06 Understanding the Pathophysiology of PSC 22:43 Cancer Surveillance in PSC Patients 28:39 The Relationship Between PSC and Inflammatory Bowel Disease 32:30 Vancomycin and PSC 36:28 Management Strategies for PSC and IBD Patients including Pouches 40:00 Management of Autoimmune Hepatitis: An Art and Science 56:30 Proactive Approaches in Primary Biliary Cholangitis (PBC) Management 1:01:05 Advice for Aspiring Hepatologists Keywords Hepatology, Autoimmune Liver Disease, PSC, Ursodeoxycholic Acid, Cancer Surveillance, Inflammatory Bowel Disease, Clinical Trials, Patient Care, Liver Transplantation, PSC Management, pouch studies, autoimmune hepatitis, management, PBC, hepatology, patient choices, liver transplant, treatment options, chronic diseases, clinical trials

    1h 6m

  5. 04/07/2025

    #07: Dr Simon Gabe - Rebuilding the gut: Intestinal rehabilitation

    This is a really special episode with an incredible doctor (Jon says "the best clinician I have ever met"). Today we welcome Dr Simon Gabe, an internationally renowned expert in intestinal rehabilitation. Dr Simon Gabe is a consultant in gastroenterology & intestinal rehabilitation at St Mark’s Hospital and chair of the NHS National Reference Centre for Severe Intestinal Failure at St Mark’s. This is also an Integrated Care centre for intestinal failure and a recognised ESPEN Training Centre.  He has a wide clinical experience in dealing with complex nutritional problems, inflammatory bowel disease, fistula management, intestinal failure requiring enteral or parenteral support, home parenteral nutrition and consideration of intestinal transplantation.  Dr Gabe is a past President of BAPEN. He co-founded the National Adult Small Intestinal Transplant (NASIT) Forum in the UK and has been an active member of a Clinical Reference Group within NHS England responsible for the development of a clinical network in England for all patients with Intestinal Failure (HIFNET). He currently co-chairs the HPN Clinical Advice and Management Group for NHS England. As always comments, questions and feedback please send to: X: @2guystalkingit  Email: 2guystalkingit@gmail.com Chapters 04:15 Introduction to Simon Gabe   06:59 Understanding Intestinal Rehabilitation   09:56 Defining Intestinal Failure   13:29 Trends in Intestinal Failure Causes   16:23 Bowel Length and Nutritional Support   20:26 Managing Short Bowel Syndrome   26:06 Barriers to Recognizing Intestinal Failure   30:37 Patient Evaluation Process for Intestinal Failure   33:07 Empowering Patients in Line Management   36:21 Managing Line Sepsis: Best Practices   43:17 Understanding Ehlers-Danlos Syndrome (EDS) and Nutrition   50:14 Nutritional Support in Cancer Patients   54:18 Enteral Support in Dementia Patients   57:15 Addressing Intestinal Ischemia: A Call to Action   Keywords Intestinal rehabilitation, intestinal failure, nutrition, gastroenterology, patient care, bowel length, short bowel syndrome, nutritional support, clinical practice, healthcare, line management, line sepsis, Ehlers-Danlos Syndrome, nutritional support, cancer patients, dementia, intestinal ischemia, patient empowerment, multidisciplinary team, intravenous nutrition

    1h 3m

  6. 03/23/2025

    #06: ECCO Takeaways with Dr Beatriz Gros

    Jon and James welcome Dr Beatriz Gros, a leading expert in inflammatory bowel disease (IBD). They discuss key findings from the recent European Crohn's and Colitis Conference in 2025. Dr. Beatriz Gros (X: @bealoquebea Instagram: @dr.beatrizgros) is a consultant gastroenterologist based in Córdoba, Spain, specializing in inflammatory bowel disease (IBD). She serves as a Consultant Gastroenterologist at Reina Sofía University Hospital in Córdoba and has also worked as a Senior Clinical Fellow at the Western General Hospital in Edinburgh, UK. Dr. Gros has a particular interest in environmental factors associated with the development of IBD and predictors for disease flares, contributing to studies like the PREdiCCt study. She actively engages in medical education through social media platforms such as Instagram and Twitter, and is the creator of the educational website www.ibd-eii.com, which offers summaries of over 140 clinical trials and relevant IBD studies. Dr. Gros’ dedication to advancing IBD research and education has made her a respected figure in the gastroenterology community. As always comments, questions and feedback please send to: X: @2guystalkingit Email: 2guystalkingit@gmail.com Chapters 03:32 Introduction and Guest Introduction 05:30 Reflections on the ECCO Conference 08:10 Systemic antibody response predicting onset of IBD 13:12 Predicting Disease Onset and Flare Factors 13:45 The PREDICT Study and Its Implications 21:44 Dietary Insights and the Mediterranean Diet 23:30 The ADAPT Study on Emulsifiers and IBD 30:00 General dietary recommendations in IBD 33:48 Fiber consumption and Crohn's Disease development 39:40 The Role of Plant-Based Diets in IBD 43:18 Environmental factors in association with IBD 45:53 Understanding Environmental Factors in IBD 47:25 Linking IBD and Neurodegenerative Diseases and Vedolizumab 54:32 Proactive Monitoring in Ulcerative Colitis Keywords IBD, ECCO Conference, Bea Gros, PREDICT Study, Mediterranean Diet, Emulsifiers, Disease Prediction, Patient Care, Dietary Studies, Holistic Health, Crohn's Disease, Ulcerative Colitis, plant-based, fiber, environmental factors, probiotics, nutrition

    1h 4m

  7. 02/08/2025

    #05: A/Professor Jason Tye-Din - Coeliac Disease unpacked: Diagnosis, treatment and emerging approaches

    We very excited about the episode today! We are joined by A/Professor Jason Tye-Din - a leading expert in coeliac disease and immune-mediated gut disorders. He is Coeliac labratory head at the Walter and Eliza Hall Institute of Medical Research, a Mathison Centenary Fellow at the University of Melbourne, and consultant Gastroenterologist at the Royal Melbourne Hospital. His work focuses on the immunology of coeliac disease, novel diagnostic approaches, and developing non-dietary treatments. He is also one of the smartest (and nicest) clinicians that we have had the privilege  of working with.  Joining Jason on the podcast today is Dr Cynthia Kanagasundaram. Cynthia is a UK trained Consultant Gastroenterologist with a vast experience in all things gastroenterology. She prides herself on innovation and has developed a novel GUT HUT service which slashed waiting times and improved patient care. She is embarking on a new stage of her career exploring novel diagnostics, techniques and treatments in Coeliac disease in the Tye-Din lab at the WEHI with A/Prof Jason Tye-Din as her supervisor. Today we delve into the complexities of coeliac disease. We cover the diagnosis, dietary management, refractory celiac disease, models of care and future of coeliac. The International Celiac Disease Symposium (ICDS 2026) will be held in Melbourne Australia 17-20 November 2026. Details at https://www.icds2026.org Chapters 00:20 Introduction with Jon and James 04:42 Introduction to A/Prof Tye-Din and Dr Kanagasundaram 06:42 Understanding Coeliac Disease: Diagnosis and Patient Education 09:17 Dietary Considerations: Foods to Avoid and Oats Discussion 12:44 Biopsy Guidelines and Diagnostic Approaches 16:44 Revisiting Biopsy Techniques and Clinical Observations 19:40 Mucosal Healing and Follow-Up Practices 22:35 Refractory Coeliac Disease: Definitions and Management 26:48 Treatment Strategies for Refractory Coeliac Disease 31:14 Understanding Treatment Targets in Coeliac Disease 32:16 Maintenance Treatment for Refractory Coeliac Disease 33:13 Exploring Alternative Treatment Options 34:12 Balancing Treatment Risks and Benefits 34:59 Advancements in Histology and Scoring Systems 37:05 Future Directions in Coeliac Disease Research 39:01 Innovations in Diagnosis and Screening 41:01 The Role of Gluten Challenges in Diagnosis 43:14 Understanding the Causes of Coeliac Disease 45:14 Patient Management and Follow-Up Care 48:12 Vaccination and Hyposplenism 56:13 Opportunities for Research and Collaboration Links to papers mentioned Iron deficiency.(Link) 2020 ESPGHAN Guidelines for diagnosing Coeliac Disease Clinical and Immunologic Features of Ultra-Short Celiac Disease.  (Link) A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease.(Link) Diagnostic outcomes after gluten challenge in adult patients with unconfirmed coeliac disease already on a gluten-free diet: A 20-year retrospective cohort study.(Link) AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review.  (Link) Open-Capsule Budesonide for Refractory Celiac Disease. (Link) Budesonide Induces Favourable Histologic and Symptomatic Recovery in Patients with Non-responsive and Refractory Coeliac Disease When Given in an Open Capsule Format.  (Link) Stool Gluten Peptide Detection Is Superior to Urinary Analysis, Coeliac Serology, Dietary Adherence Scores and Symptoms in the Detection of Intermittent Gluten Exposure in Coeliac Disease: A Randomised, Placebo-Controlled, Low-Dose Gluten Challenge Study.  https://doi.org/10.3390/nu16020279 Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity.  (Link)

    58 min

  8. 01/22/2025

    #04: Professor Alex Ford - Navigating disorders of gut-brain interaction and IBS

    Professor Alex Ford is a renowned researcher in Gastroenterology, specializing in Disorders of Gut-Brain Interaction (DGBIs). Based at the University of Leeds, he has authored numerous high-impact studies on conditions like irritable bowel syndrome (IBS) and functional dyspepsia. With a focus on evidence-based treatments and advancing our understanding of the gut-brain axis, Professor Ford is widely recognized for his contributions to both clinical practice and academic research. Summary In this conversation, we interview Professor Ford about his work and insights into Disorders of Gut-Brain Interaction (DGBI). Alex explains the complexities of IBS, including its diagnosis, the role of the gut-brain axis, and the impact of symptoms on patients' quality of life. He discusses the diagnostic criteria for IBS, the significance of bile acid diarrhea, and various treatment approaches, including the use of gut-brain neuromodulators. The conversation also covers the ATLANTIS trial, which investigated the efficacy of amitriptyline in treating IBS in primary care, and touches on the concept of neuroplasticity in relation to long-term treatment effects. We go on to discuss the complexities of managing Irritable Bowel Syndrome (IBS), emphasizing the importance of psychological therapies, the nuances of treatment sequencing, and common mistakes made in IBS management. Professor Ford highlights the need for evidence-based approaches, the role of probiotics, and reflects on his academic career, stressing the importance of mentorship and the ability to discern valuable opportunities in one's professional journey. Chapters 03:00 Introduction to Alex Ford and His Work 05:04 Understanding Irritable Bowel Syndrome (IBS) 11:22 Diagnostic Criteria for IBS 14:05 The Role of Bile Acid Diarrhoea 18:44 Treatment Approaches for IBS 20:06 The ATLANTIS Trial and Its Findings 30:07 Neuroplasticity and Long-term Effects of Neuromodulating agents 37:47 Neuromodulator titration and Psychological Therapies in IBS41:59 Sequencing Treatments for IBS 48:45 Common Mistakes in IBS Management 55:34 Probiotics: Evidence and Recommendations 59:56 Reflections on an Academic Career Articles discussed: ATLANTIS Trial: https://www.thelancet.com/article/S0140-6736(23)01523-4/fulltext Probiotic meta-analysis: https://www.gastrojournal.org/article/S0016-5085(23)04838-2/fulltext Follow us: Twitter/X: https://x.com/2guystalkingit

    1h 11m

  9. 01/15/2025

    #03: Our best of 2024 in Gastroenterology and Hepatology

    Every podcast is incomplete without a 'best of' episode from the previous year. In this episode Jon and James talk about their big learnings / seminal papers / themes of 2024 in Gastroenterology and Hepatology. We wish we could have included more! As always, please leave questions/comments either below or on our X (@2guystalkingit).

    43 min

  10. 12/23/2024

    #02: Immune checkpoint colitis and hepatitis

    Episode #02: Checkpoint conversations In the first full episode, we tackle the rising challenge of managing colitis and hepatitis triggered by immune checkpoint inhibitors. From recognizing these entities to exploring (non) evidence-based management strategies. Join us for a conversation packed with insights, or if you just want to hear Jon try and pronounce 'nomenclature'. Please leave any questions, comments, or suggestions either on our twitter feed (@2guystalkingit) or below. We will try to answer any listener questions on the next show.

    42 min

  11. SEASON 1, EPISODE 1 TRAILER

    #01: Introduction

    Hello world.. Welcome to Two guys talking **it - a podcast designed for gastroenterologists and hepatologists or anyone interested in the field. Each week, join Jon and James as we bring you expert discussions, the latest research, and practical clinical insights amongst a lot of talking **it.. In this episode we briefly introduce the podcast. Bear with us as we try to work this thing out! Please leave any comments or requests for future episodes, or catch us on twitter (@Jonathansegal85 or @JamesHaridy)

    4 min

Trailer

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out of 5
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About

“Two Guys Talking $#it” is a podcast where two Gastroenterologists break down complex topics into engaging, educational, and occasionally humorous conversations. From liver health to gut microbiota and everything in between, A/Professor Jonathan Segal and Dr James Haridy deliver insights, share the latest research, and discuss clinical pearls with the odd guest in tow. Comments, suggestions, questions please contact us on twitter @2guystalkingit or leave a comment below..

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