The BioDisruptors Podcast

The BioDisruptors
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The BioDisruptors Podcast – Making Biotech Make Sense 🧬 Biotech is evolving fast, but keeping up shouldn’t feel like reading a textbook. We break down dense white papers and complex science into clear, engaging discussions—so you stay informed without the headache. Whether you're a biotech professional or just curious about the latest breakthroughs, we’ve got you covered. No fluff, no unnecessary jargon—just biotech made simple. 🔬 Follow us to stay ahead of the latest biotech innovations! 🎧 Listen now and turn biotech complexity into clarity.

  1. JAN 22

    Ep. 29 Inside the Plant Powered Pharmaceutical Factory

    What if the factory of the future looks more like a greenhouse than a clean room full of steel tanks? In this episode, we explore a surprising shift in biotechnology where scientists use living plants to make vaccines, antibodies, and other critical medicines. You will learn why a humble tobacco relative has become one of the most important tools in modern biotech, how genes can be delivered into leaves in a matter of minutes, and why this approach could dramatically speed up responses to future pandemics and supply chain disruptions. Featured Article: Harnessing Transient Expression Systems with Plant Viral Vectors for the Production of Biopharmaceuticals in Nicotiana benthamiana (https://doi.org/10.3390/ijms26125510)

    15 min

  2. JAN 7

    Ep. 28 Bursting the Bubble: The Hidden Threat to Bioprocessing

    Foam is more than just a nuisance! In large-scale biomanufacturing, it is a multibillion-dollar risk. This episode explores how "foaming out" can jeopardize sterility and kill the cell cultures responsible for life-saving drugs. We examine the high-stakes trade-off between foam control, cell health, and productivity. We also look at the shift toward optical monitoring, a non-invasive technology that is replacing outdated sensors to ensure process stability and maximize yield. Featured Article: Measurement and Control of Foam Generation in a Mammalian Cell Culture (https://doi.org/10.1002/btpr.3450)

    12 min

  3. 12/16/2025

    Ep. 27 Astronaut Food to mRNA: The Radical Evolution of Lyophilization

    This week, we explore the critical yet often overlooked world of lyophilization, better known as freeze drying. While you might associate it with astronaut food, it is actually the backbone of the modern pharmaceutical supply chain, stabilizing everything from mRNA vaccines to life saving biologics. We break down how the industry is ditching inefficient, decades old batch processing for a revolutionary suspended vial continuous system. By suspending vials individually, manufacturers can eliminate the effect of uneven heating, ensuring every single dose experiences identical physics. Featured Article:  Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing (https://doi.org/10.1002/advs.202511693)

    11 min

  4. 12/02/2025

    Ep. 26 DMSO in Cell Therapy: Separating Fact from Fiction

    In this episode, we break down the truth about DMSO in cell therapy, how it works, why it is used, and what the data really says about its safety. Drawing from a comprehensive review of more than 1100 patients, we explore infusion reactions, dose thresholds, and common misconceptions around DMSO toxicity. We also discuss pharmacokinetics, including the half life of DMSO, urinary elimination, and its metabolism into dimethyl sulfide. Whether you are in biotech, manufacturing, or clinical development, this episode offers a clear and evidence based look at one of the most misunderstood ingredients in regenerative medicine. Featured Article:  Dimethyl Sulfoxide in Cryopreserved Mesenchymal Stromal Cell Therapy Products: Is there a Safety Risk to Patients? (https://doi.org/10.1186/s12967-025-06807-6)

    13 min

  5. 11/12/2025

    Ep. 25 The Organoid Revolution: Ending Animal Testing with Better Science

    What if we could test new drugs and study diseases without using animals? In this episode, we dive into the world of organoids, mini organs grown from human cells that are reshaping biomedical research. We unpack how these tiny living systems mimic real human tissue, offering scientists a more accurate and ethical way to study biology and develop new treatments. From breakthroughs in drug testing to the promise of personalized medicine, this episode explores how organoids are driving a revolution in science that is both smarter and more humane. Featured Article:  Replacing Animal Testing with Stem Cell-Organoids : Advantages and Limitations (https://doi.org/10.1007/s12015-024-10723-5)

    15 min

  6. 10/28/2025

    Ep. 24 Rethinking Sterilization: Why X Ray is Gaining Ground

    Can X ray sterilization really replace gamma irradiation for single use biopharma components? In this episode, we explore a recent study that directly compares the two methods across single-use bioprocessing polymers. The findings are surprising. X ray achieved the same sterilization performance as gamma while running at lower peak temperatures and creating no new extractables or measurable radioactivity. We also discuss what this means for supply chain flexibility, material stability, and the future of sterilization in biomanufacturing. The conversation clears up common misconceptions and includes insights from the scientists who led the research. Featured Article:  Impact of X-ray Irradiation as an Equivalent Alternative to Gamma for Sterilization of Single-Use Bioprocessing Polymers (https://doi.org/10.1002/btpr.3339)

    15 min

  7. 10/14/2025

    Ep. 23 From Waste to Watts: What Really Drives Biotech’s Carbon Footprint

    In this episode of The BioDisruptors Podcast, we explore what it really means to make biologics sustainable. We uncover surprising facts about where the biggest environmental impacts actually come from. It is not the plastic waste most people think of, but the electricity that powers clean rooms and HVAC systems, making up most of the footprint. We discuss how shortening process durations, increasing yields, and switching to renewable energy can dramatically lower emissions while also cutting costs. The conversation shows how sustainability and profitability can go hand in hand, creating a future where greener manufacturing also means greater access to life saving medicines. Featured Article:  Streamlined Life Cycle Assessment of Single Use Technologies in Biopharmaceutical Manufacture (https://doi.org/10.1016/j.nbt.2022.01.002)

    15 min

  8. 09/30/2025

    Ep. 22 Antibody–Drug Conjugates: Precision Weapons in Cancer Therapy

    Antibody–drug conjugates, or ADCs, are transforming cancer therapy by combining the precision of monoclonal antibodies with the potency of cytotoxic drugs. In this episode, we explore the science behind ADC design, including the choice of antibody backbones, linker technologies, and payload classes.  We also look at lessons learned from early market withdrawals, the resurgence of re-engineered therapies, and how bystander effects shape clinical outcomes. With more than 15 approvals, ADCs represent one of the fastest-growing classes in oncology. Tune in to learn how scientific innovation and careful design choices are shaping the future of targeted cancer treatment. Featured Article:  Antibody–Drug Conjugates (ADCs): Current and Future Biopharmaceuticals (https://doi.org/10.1186/s13045-025-01704-3)

    11 min
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About

The BioDisruptors Podcast – Making Biotech Make Sense 🧬 Biotech is evolving fast, but keeping up shouldn’t feel like reading a textbook. We break down dense white papers and complex science into clear, engaging discussions—so you stay informed without the headache. Whether you're a biotech professional or just curious about the latest breakthroughs, we’ve got you covered. No fluff, no unnecessary jargon—just biotech made simple. 🔬 Follow us to stay ahead of the latest biotech innovations! 🎧 Listen now and turn biotech complexity into clarity.

Information

  • Creator
    The BioDisruptors
  • Years Active
    2025 - 2026
  • Episodes
    30
  • Rating
    Clean
  • Copyright
    © The BioDisruptors
  • Show Website
    The BioDisruptors Podcast