The College of Glycation with Dr. Paul Reynolds

Paul Reynolds
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The College of Glycation with Dr. Paul Reynolds explores how sugar impacts aging, health, and disease. Join Dr. Reynolds as he unpacks the science of glycation and AGEs through expert interviews, myth-busting insights, and practical takeaways. Whether you're a health professional or simply curious, this podcast brings clarity to the sticky world of sugar metabolism. New episodes weekly.

  1. Keto & Carnivore Diets

    6D AGO

    Keto & Carnivore Diets

    In this episode of the College of Glycation, Dr. Paul Reynolds examines one of the most debated questions in metabolic health: do ketogenic and carnivore diets worsen glycation—or help prevent it? Breaking down the biochemistry, he explains how glycation forms advanced glycation end products (AGEs) that drive inflammation, oxidative stress, and accelerated aging, and why chronically elevated blood glucose is the primary trigger behind this damage. Dr. Reynolds explores how carbohydrate restriction lowers HbA1c and reduces endogenous AGE formation, while addressing concerns about dietary AGEs from cooked meat and methylglyoxal production during ketosis. He also highlights the protective role of beta-hydroxybutyrate (BHB), the body’s glyoxalase detoxification system, and the often-overlooked impact of fructose in accelerating glycation. The result is a clear, evidence-based look at how ketogenic and carnivore diets intersect with metabolic chemistry—and what that means for long-term health. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    24 min
  2. Reproductive System and Glycation

    FEB 25

    Reproductive System and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds explores how glycation impacts one of the most metabolically sensitive systems in the body: the reproductive system. From PCOS and ovarian dysfunction to erectile dysfunction and impaired nitric oxide signaling, this episode connects advanced glycation end products (AGEs) to hormonal imbalance, vascular damage, and chronic inflammation. Dr. Reynolds also examines gestational diabetes, placental dysfunction, and the emerging science of transgenerational metabolic programming—revealing how a mother’s metabolic health may influence not only her child, but potentially future generations. Grounded in peer-reviewed research, this conversation makes a compelling case that fertility and sexual health are not isolated issues—they are reflections of metabolic integrity. If you care about hormones, pregnancy, longevity, or preventing chronic disease, this episode underscores a powerful principle: protecting your metabolism protects everything downstream. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    30 min
  3. Integument System Physiology and Glycation

    FEB 18

    Integument System Physiology and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—dives into the integumentary system and explains why your skin is one of the most revealing indicators of metabolic health. Unlike internal organs you can’t see, the effects of glycation and chronic inflammation show up directly on your face, hands, and body. Dr. Reynolds breaks down how advanced glycation end products (AGEs) form when sugars bind to proteins, and why long-lived structural proteins like collagen and elastin are especially vulnerable to becoming stiff, cross-linked, and dysfunctional over time. This lecture connects the biochemistry of glycation to real-world outcomes like wrinkles, sagging, dull or yellowed skin tone, barrier breakdown, increased infection risk, and delayed wound healing—especially in diabetes. You’ll also learn why skin autofluorescence is emerging as a powerful marker of AGE burden, even in non-diabetics, and how daily lifestyle choices can reduce glycation load and protect skin integrity as you age. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    28 min
  4. Sensory Organ Physiology and Glycation

    FEB 11

    Sensory Organ Physiology and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores how glycation quietly damages two of the body’s most delicate and essential systems: the eyes and the ears. While most people associate diabetes-related damage with the heart or kidneys, this lecture shows how advanced glycation end products (AGEs) progressively harm the retina, lens, and cochlea through microvascular breakdown, oxidative stress, inflammation, and mitochondrial dysfunction—often long before someone is formally diagnosed with diabetes. You’ll learn why sensory organs are uniquely vulnerable due to their extreme metabolic demand, fragile end-artery circulation, and limited regenerative capacity. From pericyte loss and blood-retinal barrier failure in diabetic retinopathy, to crystallin protein cross-linking in cataracts, to the underrecognized connection between rising A1c and hearing loss, this episode connects molecular biochemistry to real-world outcomes—and highlights why reducing glycation through metabolic health is one of the most powerful strategies for protecting vision and hearing over a lifetime. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    22 min
  5. Nervous System Physiology and Glycation

    FEB 4

    Nervous System Physiology and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores how glycation and metabolic dysfunction silently damage the nervous system. From neurons and myelin to the blood-brain barrier, Dr. Reynolds explains how advanced glycation end products (AGEs) disrupt electrical signaling, trigger inflammation through the AGE–RAGE pathway, impair mitochondrial function, and accelerate both peripheral neuropathy and cognitive decline. The nervous system’s high energy demands, limited antioxidant defenses, and irreplaceable neurons make it uniquely vulnerable to sugar-driven damage. Drawing from decades of peer-reviewed research, this episode connects metabolic health to brain aging, nerve degeneration, and even the emerging concept of Alzheimer’s disease as a form of metabolic dysfunction. Importantly, Dr. Reynolds emphasizes that these processes are not limited to people with diabetes—anyone with insulin resistance or high dietary AGE intake may be affected. This conversation offers a clear, science-based framework for understanding how diet, lifestyle, and glycation shape long-term neurological health—and what can be done to protect it. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    30 min
  6. Musculoskeletal Physiology and Glycation

    JAN 28

    Musculoskeletal Physiology and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds, Professor of Cell Biology and Physiology, explores how glycation and chronic inflammation undermine the musculoskeletal system—one of the body’s most critical drivers of movement, strength, and metabolic health. Beginning with normal muscle and bone physiology, Dr. Reynolds explains why skeletal muscle serves as the body’s primary glucose sink and how impaired glucose handling accelerates glycation, insulin resistance, mitochondrial dysfunction, and age-related muscle loss. The episode also examines bone and connective tissues, highlighting how glycation of long-lived collagen degrades tissue quality rather than density, increasing fracture risk, joint degeneration, and tendon injury—especially in diabetes and aging. Drawing from mechanistic and clinical research, Dr. Reynolds reveals how AGE accumulation, oxidative stress, and inflammation create reinforcing cycles that drive sarcopenia, frailty, osteoarthritis, and metabolic decline. The discussion closes by emphasizing why exercise—particularly resistance training—is one of the most powerful tools for countering glycation, preserving musculoskeletal integrity, and maintaining long-term metabolic resilience. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    21 min
  7. Renal Physiology and Glycation

    JAN 21

    Renal Physiology and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—dives into the kidneys, organs that quietly perform some of the most demanding work in the body. He begins by explaining how healthy kidneys filter massive volumes of blood, maintain fluid and electrolyte balance, regulate blood pressure, and preserve essential proteins through the highly specialized structure of the nephron. With nearly a million nephrons per kidney and an intricate filtration barrier built on size and charge selectivity, the kidneys are marvels of biological engineering—but also uniquely vulnerable to metabolic stress.Dr. Reynolds then reveals how glycation and chronic hyperglycemia progressively damage this delicate system. Advanced glycation end products (AGEs) alter long-lived structural proteins in the glomerular basement membrane, injure podocytes with limited regenerative capacity, and trigger inflammation and fibrosis through the AGE–RAGE axis. These processes drive hyperfiltration, albumin leakage, oxidative stress, and the vicious cycles that characterize diabetic kidney disease. The episode highlights why kidney damage is often silent until advanced stages, why early detection is critical, and how understanding these mechanisms provides a framework for preventing chronic kidney failure. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    20 min
  8. Liver Physiology and Glycation

    JAN 14

    Liver Physiology and Glycation

    In this episode of College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the liver’s central role in metabolic health and reveals how glycation and chronic inflammation quietly disrupt its vital functions. As the body’s primary metabolic hub, the liver is uniquely exposed to high concentrations of glucose and fructose, making it especially vulnerable to the formation of advanced glycation end products (AGEs). Dr. Reynolds breaks down how glycation alters liver enzymes, impairs insulin signaling, and initiates inflammatory cascades that ripple throughout the body. You’ll learn why fructose metabolism in the liver accelerates glycation through potent intermediates like methylglyoxal, how AGE–RAGE signaling drives fatty liver disease, fibrosis, and insulin resistance, and why the liver is both a victim and a driver of metabolic dysfunction. Grounded in peer-reviewed science, this episode provides a clear mechanistic framework for understanding fatty liver disease, diabetes, and systemic inflammation—and highlights why restoring liver health is one of the most powerful strategies for reclaiming metabolic resilience and long-term health. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3   Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    20 min
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The College of Glycation with Dr. Paul Reynolds explores how sugar impacts aging, health, and disease. Join Dr. Reynolds as he unpacks the science of glycation and AGEs through expert interviews, myth-busting insights, and practical takeaways. Whether you're a health professional or simply curious, this podcast brings clarity to the sticky world of sugar metabolism. New episodes weekly.

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