Hope & Histamine: The Paediatric Allergy Podcast

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“Helping you understand allergies—one episode at a time” Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children. From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical advice—empowering parents, caregivers, and patients with reliable information and hope. Tune in for expert insights, real stories, and up-to-date recommendations designed to help you breathe a little easier.

  1. 3d ago

    Allergy and Eustachian Tube Dysfunction: Causes, Symptoms, Diagnosis & Treatment

    Why do your ears feel blocked during allergy season? Can hay fever really affect your hearing? What causes that frustrating sensation of ear fullness, popping, crackling or pressure that just won’t go away? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the important relationship between allergic disease and Eustachian Tube Dysfunction (ETD)—a common but often misunderstood condition affecting both children and adults. Join us as we discuss: What the Eustachian tube is and why it is essential for normal ear function.How allergic rhinitis, environmental allergies and nasal inflammation contribute to Eustachian Tube Dysfunction.The common symptoms of ETD, including ear fullness, pressure, popping, crackling, muffled hearing, tinnitus and discomfort during flying or altitude changes.How ETD differs from ear infections, glue ear and other causes of hearing problems.The role of allergy testing and ENT assessment in making an accurate diagnosis.Evidence-based treatments, including allergen avoidance, intranasal corticosteroids, antihistamines, saline nasal irrigation and when specialist ENT interventions may be appropriate.Practical self-care strategies for managing symptoms at home.When persistent ear symptoms require urgent medical assessment.Whether you’re a parent, patient, allergy sufferer, healthcare professional or simply curious about the connection between allergies and ear health, this episode provides clear, evidence-based guidance to help you better understand and manage Eustachian Tube Dysfunction. Source:  Klimek, L. et al. (2025) 'Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An EAACI Position Paper', Allergy. doi: 10.1111/all.16554. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Subscribe to Hope & Histamine for expert discussions on paediatric allergy, immunology and related conditions, featuring the latest research and practical advice from specialists. 🎧 Listen on your favourite podcast platform or visit: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoy the podcast, please subscribe, leave a review and share this episode to help others learn more about allergy-related conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  2. Jul 23

    Orofacial Granulomatosis (OFG): Symptoms, Diagnosis, Causes & Modern Treatment

    Orofacial Granulomatosis (OFG) is a rare but often overlooked inflammatory condition that can present with persistent lip swelling, oral ulcers, gum changes, and facial swelling. Because its symptoms overlap with many other conditions, diagnosis is frequently delayed, leaving patients and families searching for answers. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we take a deep dive into the science and clinical management of Orofacial Granulomatosis. We discuss what OFG is, why it develops, and its important associations with Crohn’s disease, allergy, and other inflammatory disorders. You’ll learn how clinicians approach the diagnosis, the role of biopsies and investigations, and the latest evidence-based treatment options available for both children and adults. Whether you’re a healthcare professional, medical student, patient, or parent, this episode provides a clear, practical, and evidence-based overview of this fascinating condition. In this episode, we cover: What is Orofacial Granulomatosis (OFG)?Common signs and symptoms, including persistent lip swellingCauses and current theories behind OFGThe relationship between OFG and Crohn’s diseaseIs allergy involved?How OFG is diagnosed and the role of biopsyImportant differential diagnoses clinicians should considerMedical and dietary treatment optionsLong-term outlook and follow-upKey take-home messages for patients, families, and healthcare professionalsJoin us as we separate fact from fiction and explore the latest understanding of Orofacial Granulomatosis, helping listeners recognise the condition earlier and understand the best approaches to diagnosis and management. Sources: Courtney, A., Holmes, Z., Sharma, S. and Brand, R., 2023. Orofacial granulomatosis: Challenges in diagnosis and treatment. Journal of Paediatrics and Child Health, 59, pp. 159-161.Galdiero, M.R., Maio, F., Arcoleo, F., Boni, E., Bonzano, L., Brussino, L., Cancian, M., Cremonte, L., Del Giacco, S.R., De Paulis, A., Detoraki, A., Firinu, D., Lamacchia, D., Loffredo, S., Nettis, E., Parente, R., Parronchi, P., Pellacani, G., Petraroli, A., Rolla, G., Senter, R., Triggiani, M., Vitiello, G., Spadaro, G. and Bova, M., 2021. Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature. Allergy, 76(7), pp. 2189-2200.Haaramo, A., Alapulli, H., Aine, L., Saarnisto, U., Tuokkola, J., Ruuska, T., Sipponen, T., Pitkäranta, A. and Kolho, K.L., 2017. Detailed Follow-up Study of Pediatric Orofacial Granulomatosis Patients. Journal of Pediatric Gastroenterology and Nutrition, 65(4), pp. 388-393.Marttala, A., Sihvonen, E., Kantola, S., Ylöstalo, P. and Tervonen, T., 2018. Diagnosis and Treatment of Orofacial Granulomatosis. Journal of Dentistry for Children, 85(2), pp. 83-87.Pathania, Y.S., 2022. Current treatment modalities in granulomatous cheilitis. International Journal of Dermatology, 61, pp. 755-759.Sahni, V.N., Yim, R., Amanullah, A., Sahni, D., Powell, D., deShazo, R., Rhoads, J.L.W., Clarke, J.T., Hansen, C.B., Zone, J.J., Hull, C.M. and Hopkins, Z.H., 2026. An Allergy-Based Approach to Orofacial Granulomatosis: A Narrative Review. Dermatitis, 37(1), pp. 13-19. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations 🎧 Subscribe to Hope & Histamine: The Paediatric Allergy Podcast for expert discussions on paediatric allergy, immunology, and related conditions. New episodes feature practical, evidence-based insights from leading specialists, designed for clinicians, patients, and families alike. 🌐 Podcast website: https://hopeandhistaminepodcasts.buzzsprout.com Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  3. Jul 13

    Idiopathic Anaphylaxis Explained: Causes, Diagnosis & Treatment

    What happens when someone experiences anaphylaxis, but no trigger can be identified? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore idiopathic anaphylaxis—a diagnosis that can be both frightening for patients and challenging for clinicians. Join us as we discuss the latest understanding of idiopathic anaphylaxis, including how it is diagnosed, important conditions that can mimic anaphylaxis, and the investigations needed to exclude identifiable causes such as food allergy, medication allergy, insect venom allergy, mast cell disorders, hereditary alpha-tryptasemia, and alpha-gal syndrome. We also cover: What idiopathic anaphylaxis is and why it occursCommon symptoms and clinical presentationDifferential diagnoses and conditions that mimic anaphylaxisThe role of serum tryptase, allergy testing, and other investigationsMast cell activation syndrome and systemic mastocytosisAcute emergency management of anaphylaxisLong-term treatment strategies and preventionAdrenaline (epinephrine) auto-injectors and personalised emergency action plansPatient education, follow-up, and improving quality of lifeThe latest evidence and future directions in researchWhether you’re a healthcare professional, paediatrician, allergist, trainee, medical student, or someone living with recurrent unexplained allergic reactions, this episode provides practical, evidence-based insights to help you better understand and manage idiopathic anaphylaxis. If you enjoy this episode, please follow, rate, and share the podcast to help us bring high-quality paediatric allergy education to a wider audience. Hope & Histamine: The Paediatric Allergy Podcast—making paediatric allergy evidence practical, accessible, and easy to understand. Sources: Applewhite, T.L. (2025) 'The Lived Experience of Patients With Idiopathic Anaphylaxis', The Journal for Nurse Practitioners, 21(1), p. 105329.Ben-Shoshan, M., Akin, C., Cook, V.E. and Khalaf, R. (2025) 'Idiopathic anaphylaxis', The Journal of Allergy and Clinical Immunology: In Practice, 13(12), pp. 3169-3175.Calvani, M. (2022) 'Update on idiopathic anaphylaxis', Pediatric Allergy and Immunology, 33(Suppl. 27), pp. 52-53. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  4. Jul 4

    Preventing and Treating Peanut Allergy in Children: From Early Introduction to Immunotherapy

    Peanut allergy has become one of the most important and widely discussed topics in paediatric allergy. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the prevention and treatment of peanut allergy in children, from the landmark evidence supporting early peanut introduction to the evolving role of oral immunotherapy. We discuss why peanut allergy develops, which children are at higher risk, and how early dietary exposure may help reduce the chance of allergy in infancy. The episode also covers practical approaches to diagnosis, avoidance, emergency management, and treatment, including oral peanut immunotherapy and its potential benefits and limitations. Designed for parents, healthcare professionals, and anyone interested in childhood allergy, this episode brings together evidence-based guidance and practical clinical insights to help make sense of modern peanut allergy care. Source: Du Toit, G. and Lack, G. (2026) 'Prevention and Treatment of Peanut Allergy', New England Journal of Medicine, 394(24), pp. 2449–2458. Available at: https://doi.org/10.1056/NEJMcp2314424. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  5. Jun 24

    Eosinophilic Oesophagitis (EoE) Explained: Pathophysiology, Diagnosis, and Modern Treatment Strategies

    In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore Eosinophilic Oesophagitis, or EoE— an increasingly recognised allergic inflammatory condition of the oesophagus that can affect feeding, swallowing, growth, and quality of life in children and young people. We break down the pathophysiology of EoE, including the role of food allergens, type 2 inflammation, eosinophils, epithelial barrier dysfunction, and immune signalling pathways. The episode also covers how EoE presents in different age groups, from feeding difficulties and reflux-like symptoms in younger children to dysphagia, food impaction, and avoidance behaviours in older children and adolescents. We discuss the key steps in diagnosing Eosinophilic Oesophagitis, including clinical suspicion, endoscopy, oesophageal biopsies, histological criteria, and the importance of excluding other causes of oesophageal eosinophilia. The episode then moves into practical treatment strategies, including proton pump inhibitors, swallowed topical steroids, dietary elimination approaches, multidisciplinary care, monitoring response, and emerging therapies such as biologics. This episode is ideal for paediatricians, allergy clinicians, gastroenterologists, nurses, dietitians, trainees, and parents who want a clear, practical, and evidence-informed overview of EoE in children. Sources: Dhar, A., Haboubi, H.N., Attwood, S.E. et al. (2022) 'British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults', Gut, 71, pp. 1459–1487.Mahon, M., Muir, A.B. and Lynch, K. (2026) 'Eosinophilic oesophagitis: pathophysiology, diagnosis, and treatment', BMJ Medicine, 5, p. e001459. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  6. Jun 14

    Bee and Wasp Sting Allergy in Children: Diagnosis, Risk Assessment and Management of Hymenoptera Venom Allergy

    In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the diagnosis and management of Hymenoptera venom allergy in children, including allergic reactions to bee, wasp and other insect stings. We discuss how to distinguish between normal local reactions, large local reactions and systemic allergic reactions, and when a child should be referred for specialist allergy assessment. The episode covers key aspects of diagnosis, including clinical history, venom-specific IgE testing, skin testing and risk assessment. We also look at the acute management of sting-related allergic reactions, including the role of adrenaline auto-injectors, emergency action plans and education for families and schools. Finally, we explore long-term management, including venom immunotherapy, who may benefit from it, and how it can reduce the risk of future severe reactions. This episode is designed for parents, healthcare professionals and anyone supporting children with insect sting allergy, offering practical, evidence-informed guidance on recognising risk, improving safety and supporting confident long-term care. Sources: Biló, B.M., Rueff, F., Mosbech, H., Bonifazi, F., Oude-Elberink, J.N.G. and the EAACI Interest Group on Insect Venom Hypersensitivity (2005) 'Diagnosis of Hymenoptera venom allergy', Allergy, 60, pp. 1339–1349.Bonifazi, F., Jutel, M., Biló, B.M., Birnbaum, J., Muller, U. and the EAACI Interest Group on Insect Venom Hypersensitivity (2005) 'Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice', Allergy, 60, pp. 1459–1470.Dhami, S., Zaman, H., Varga, E.M., Sturm, G.J., Muraro, A., Akdis, C.A., Antolín-Amérigo, D., Biló, M.B., Bokanovic, D., Calderon, M.A., Cichocka-Jarosz, E., Oude Elberink, J.N.G., Gawlik, R., Jakob, T., Kosnik, M., Lange, J., Mingomataj, E., Mitsias, D.I., Mosbech, H., Ollert, M., Pfaar, O., Pitsios, C., Pravettoni, V., Roberts, G., Ruëff, F., Sin, B.A., Asaria, M., Netuveli, G. and Sheikh, A. (2017) 'Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis', Allergy, 72, pp. 342–365.Krishna, M.T., Ewan, P.W., Diwakar, L., Durham, S.R., Frew, A.J., Leech, S.C. and Nasser, S.M. (2011) 'Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines', Clinical & Experimental Allergy, 41, pp. 1201–1220.Sturm, G.J., Varga, E.M., Roberts, G., Mosbech, H., Biló, M.B., Akdis, C.A., Antolín-Amérigo, D., Cichocka-Jarosz, E., Gawlik, R., Jakob, T., Kosnik, M., Lange, J., Mingomataj, E., Mitsias, D.I., Ollert, M., Oude Elberink, J.N.G., Pfaar, O., Pitsios, C., Pravettoni, V., Ruëff, F., Sin, B.A., Agache, I., Angier, E., Arasi, S., Calderón, M.A., Fernandez-Rivas, M., Halken, S., Jutel, M., Lau, S., Pajno, G.B., van Ree, R., Ryan, D., Spranger, O., van Wijk, R.G., Dhami, S., Zaman, H., Sheikh, A. and Muraro, A. (2018) 'EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy', Allergy, 73, pp. 744–764. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  7. Jun 6

    Food Allergy Anxiety: The Hidden Impact on Children, Parents and Everyday Life

    Food allergies are often seen as a medical condition centred around avoidance, emergency plans and adrenaline auto-injectors — but the impact goes far beyond the plate. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore how food allergies affect children’s emotional wellbeing, family life, school experiences, social confidence and overall quality of life. We discuss the anxiety, fear and daily uncertainty that many children and parents live with, from checking food labels and managing birthday parties to navigating school meals, travel, eating out and the risk of accidental reactions. This episode also looks at the emotional burden on parents and carers, including hypervigilance, guilt, sleep disruption, family stress and the challenge of helping children feel safe without feeling restricted. Whether you are a parent, clinician, teacher, or someone living with a food allergy, this episode highlights why food allergy care must include psychological support, practical coping strategies, and compassionate conversations about quality of life. Sources: Knibb, R.C. and Semper, 2013. Impact of suspected food allergy on emotional distress and family life. Pediatric Allergy and Immunology, 24, pp. 798–803. Available at: https://doi.org/10.1111/pai.12176. (Note: The initial for the co-author Semper is not listed in the provided text).Knibb, R.C., Jones, C.J., Herbert, L.J. and Screti, C., 2024. Psychological support needs for children with food allergy and their families: A systematic review. Pediatric Allergy and Immunology, 35, p. e14108. Available at: https://doi.org/10.1111/pai.14108.Knibb, R.C., Howell, C., Whitehouse, A. and Peterson, C.C., 2025. The role of food allergy‐related worry and self‐efficacy in explaining quality of life in caregivers of children. Pediatric Allergy and Immunology, 36, p. e70248. Available at: https://doi.org/10.1111/pai.70248. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  8. May 29

    Ibuprofen Allergy or NSAID Hypersensitivity in Children? Diagnosis and Management Guide

    NSAID hypersensitivity in children can be challenging to recognise, diagnose, and manage safely. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore paediatric NSAID hypersensitivity, including reactions to commonly used medicines such as ibuprofen and other non-steroidal anti-inflammatory drugs. We discuss the different types of NSAID reactions, how to distinguish true hypersensitivity from other adverse effects, and the importance of a careful clinical history. The episode also covers diagnostic approaches, the role of drug provocation testing, cross-reactive versus selective NSAID reactions, and practical management strategies for children who need safe pain relief or fever treatment. This episode is aimed at clinicians, trainees, healthcare professionals, and interested parents who want a clearer understanding of NSAID allergy and hypersensitivity in children. Listen to learn about: How NSAID hypersensitivity presents in childrenThe difference between NSAID allergy, intolerance, and adverse drug reactionsIbuprofen-related reactions and when to suspect hypersensitivityCross-reactive and selective NSAID hypersensitivityDiagnostic pathways and the role of supervised drug challengesSafe alternatives and practical management adviceA practical, evidence-informed discussion to help improve confidence in recognising and managing NSAID hypersensitivity in paediatric practice. Sources:  Cousin, M., Chiriac, A., Molinari, N., Demoly, P. and Caimmi, D. (2016) 'Phenotypical characterization of children with hypersensitivity reactions to NSAIDs', Pediatric Allergy and Immunology, 27, pp. 743-748.Guvenir, H., Misirlioglu, E.D., Capanoglu, M., Buyuktiryaki, B., Onay, Z.R., Ginis, T., Toyran, M., Civelek, E. and Kocabas, C.N. (2018) 'The Frequency of Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Children with Asthma', International Archives of Allergy and Immunology, 176(1), pp. 26-32.Kidon, M., Blanca-Lopez, N., Gomes, E., Terreehorst, I., Tanno, L., Ponvert, C., Chin, C.W., Caubet, J.C., Soyer, O., Mori, F., Blanca, M. and Atanaskovic-Markovic, M. (2018) 'EAACI/ENDA Position Paper: Diagnosis and management of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) in children and adolescents', Pediatric Allergy and Immunology, 29, pp. 469-480.Mori, F., Atanaskovic-Markovic, M., Blanca-Lopez, N., Gomes, E., Gaeta, F., Sarti, L., Bergmann, M.M., Tmusic, V., Valluzzi, R.L. and Caubet, J.C. (2020) 'A Multicenter Retrospective Study on Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Children: A Report from the European Network on Drug Allergy (ENDA) Group', The Journal of Allergy and Clinical Immunology: In Practice, 8(3), pp. 1022-1031. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

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“Helping you understand allergies—one episode at a time” Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children. From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical advice—empowering parents, caregivers, and patients with reliable information and hope. Tune in for expert insights, real stories, and up-to-date recommendations designed to help you breathe a little easier.

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