Hope & Histamine: The Paediatric Allergy Podcast

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“Helping you understand allergies—one episode at a time” Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children. From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical advice—empowering parents, caregivers, and patients with reliable information and hope. Tune in for expert insights, real stories, and up-to-date recommendations designed to help you breathe a little easier.

  1. 5d ago

    Rethinking the Blue Inhaler: Budesonide–Formoterol vs Salbutamol in Children with Mild Asthma | The CARE Trial

    Is it time to rethink the traditional blue reliever inhaler for children with mild asthma? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we examine the landmark 2025 CARE trial published in The Lancet. This 52-week randomised controlled trial compared budesonide–formoterol with salbutamol as reliever therapy in children with mild asthma. We explore whether an anti-inflammatory reliever inhaler can provide better protection than salbutamol alone, examining the trial’s findings on asthma attacks, symptom control, safety and treatment burden. We also consider what the results could mean for paediatric asthma guidelines, clinical practice and conversations with children and their families. Whether you are a paediatrician, GP, nurse, pharmacist, trainee or parent, this episode offers a clear and clinically relevant discussion of a study that could reshape how mild childhood asthma is managed. Listen now to discover whether budesonide–formoterol could represent the future of reliever therapy for children with mild asthma. Source: Hatter, L., Holliday, M., Oldfield, K., Kearns, C., Barry, T., Black, M., Bruce, P., Colman, A., Dickinson, E., Eathorne, A., Harwood, M., Hills, T., Lamb, R., Kerse, K., Krishnamoorthy, S., Martindale, J., Semprini, A., Shortt, N., McNamara, D., Byrnes, C.A., Dalziel, S.R., Bush, A., Weatherall, M. and Beasley, R., 2025.Budesonide–formoterol versus salbutamol as reliever therapy in children with mild asthma (CARE): a 52-week, open-label, multicentre, superiority, randomised controlled trial. The Lancet, 406, pp. 1473–1483. Available at: https://doi.org/10.1016/S0140-6736(25)00861-X. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Hope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice. 🎧 Listen and subscribe: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  2. Aug 28

    The Peanut Patch Revolution: Is Epicutaneous Immunotherapy the Future of Peanut Allergy Treatment in Children?

    Could a simple skin patch transform the treatment of peanut allergy in young children? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence on epicutaneous immunotherapy (EPIT)—also known as the peanut patch—for toddlers and children with peanut allergy. Drawing on findings from the EPITOPE and EPOPEX studies, we examine how peanut patch therapy works, its long-term effectiveness and safety, and whether it can increase the amount of peanut a child can tolerate. We also discuss its potential to reduce the risk of allergic reactions from accidental exposure to packaged foods and consider how well EPIT works in children who also have atopic conditions such as eczema, asthma and allergic rhinitis. Can epicutaneous immunotherapy offer families meaningful protection while avoiding some of the challenges associated with oral immunotherapy? Could the peanut patch become part of routine childhood peanut allergy treatment? Join us as we translate the emerging research into clear, practical information for parents, clinicians and everyone interested in the future of paediatric food allergy care. Sources: Burks, A., Sindher, S., Wang, J., O'Sullivan, M., Du Toit, G., Kim, E., Bois, T. and Greenhawt, M., 2022. EPITOPE study results: Phase 3, randomized, double-blind, placebo-controlled study of epicutaneous immunotherapy in peanut-allergic toddlers [Abstract]. Annals of Allergy, Asthma & Immunology, 129(5 Supplement), p. S12.Greenhawt, M., Wang, J., DuToit, G., O’Sullivan, M., Brown-Whitehorn, T., Bois, T., Bee, K., Green, T., Sampson, H. and Burks, A., 2025. Long-term efficacy and safety of epicutaneous immunotherapy in peanut-allergic toddlers: EPOPEX end of study results [Abstract]. Annals of Allergy, Asthma & Immunology, 135(5 Supplement), p. S10. Remington, B.C., Krone, T., Kim, E.H., Bird, J.A., Green, T.D., Lack, G., Fleischer, D.M. and Koppelman, S.J., 2019. Estimated risk reduction to packaged food reactions by epicutaneous immunotherapy (EPIT) for peanut allergy. Annals of Allergy, Asthma & Immunology, 123(5), pp. 488-493. Scurlock, A.M., Fleischer, D.M., Du Toit, G., Arends, N.J.T., Pongracic, J.A., Trujillo, J., Turner, P., Vogelberg, C., Bee, K.J., Green, T.D., Meney, J., Bois, T., Campbell, D.E., Sampson, H.A. and Burks, A.W., 2025. Efficacy and safety of epicutaneous immunotherapy in children with peanut allergy with atopic comorbidities. Annals of Allergy, Asthma & Immunology, 135(2), pp. 203-210. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  3. Aug 19

    Dupilumab in Children: A Game-Changer for Eczema, Asthma and Atopic Disease

    Dupilumab has transformed the treatment of several type 2 inflammatory conditions—but how does it work, which children may benefit, and what should clinicians and families know before starting treatment? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the expanding role of dupilumab in paediatrics, including its use in atopic dermatitis (eczema), severe asthma and eosinophilic oesophagitis. We discuss how blocking interleukin-4 and interleukin-13 signalling helps control allergic inflammation, along with patient selection, administration, monitoring, potential adverse effects, and the practical considerations of biologic treatment. Whether you are a paediatrician, allergy specialist, healthcare professional, or parent, this episode provides a clear, clinically relevant introduction to how dupilumab is reshaping the management of childhood atopic disease. Sources: Foti Randazzese, S., Calamita, A., D’Angelo, D., Marseglia, A., Mesa Lombardero, E., Pedersoli, S., Tedeschi, M., De Amici, M., Manti, S., Brazzelli, V., Licari, A. and Marseglia, G.L. (2026) 'Emerging Paediatric Uses of Dupilumab Beyond Approvals', Clinical & Experimental Allergy. Available at: https://doi.org/10.1111/cea.70381.Gutsche, A., Grabowska, W., Altrichter, S., Grekowitz, E., Roll, S., Heine, G., Staubach, P., Pfützner, W., Brehler, R., Bauer, A., Wagner, N., Wurpts, G., Salameh, P., Salehzadeh-Yazdi, A., Jahandideh, S.S. and Metz, M. (2026) 'Dupilumab in Cholinergic Urticaria: An Exploratory Phase 2 Investigator-Initiated Study', Allergy. Available at: https://doi.org/10.1111/all.70454.Lasek, A., Bellon, N., Mallet, S., Aubert, H., Vera, C., Achour, L., Thénié, C., Prescilla, R., Abasq-Thomas, C. and Barbarot, S. (2026) 'Dupilumab treatment in children aged 6 months to 5 years with severe atopic dermatitis', Journal of the European Academy of Dermatology and Venereology, 40, pp. 1208–1217. Available at: https://doi.org/10.1111/jdv.70268.Wechsler, M.E., Wenzel, S.E., Groshong, S.D., Castro, M., Pavord, I.D., Rabe, K.F., Laws, E., Jagerschmidt, A., Gayvert, K., Harel, S., Hamilton, J.D., Amin, N., Zhang, L., Xing, H., Elfakir, A., Coulibaly, B., Naimi, S., Hamon, S., Rowe, P.J., Nestle, F., Cunoosamy, D.M., de Rinaldis, E. and Mannent, L.P. (2026) 'Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma', Allergy. Available at: https://doi.org/10.1111/all.70391. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  4. Aug 8

    Pediatric Hereditary Angioedema: Diagnosis, Treatment & Long-Term Management

    Hereditary angioedema (HAE) is a rare but potentially life-threatening genetic disorder that often presents during childhood, yet diagnosis is frequently delayed for many years. Early recognition and timely treatment can dramatically improve quality of life and reduce the risk of serious complications, including airway obstruction. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence and practical approaches to diagnosing and managing paediatric hereditary angioedema (HAE). Whether you’re a paediatrician, allergy specialist, emergency clinician, trainee, nurse, or allied healthcare professional, this episode provides a comprehensive overview of this important condition. In this episode, we discuss: Understanding the genetics and pathophysiology of hereditary angioedemaClinical features that distinguish HAE from allergic angioedemaCommon triggers and patterns of attacks in childrenDiagnostic investigations, including complement testing and genetic confirmationRecognising red flags for life-threatening laryngeal oedemaAcute management of HAE attacksShort-term and long-term prophylactic treatment optionsThe role of C1 esterase inhibitor replacement therapy, bradykinin-targeted treatments and emerging therapiesFamily screening, genetic counselling and transition to adult servicesPractical tips for emergency action plans and improving patient outcomesJoin us as we review current guidelines, discuss real-world clinical challenges, and share practical insights to help clinicians recognise hereditary angioedema earlier and deliver evidence-based care for children and young people living with HAE. Source: Farkas, H. et al. (2026) 'International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema', Allergy. Available at: https://onlinelibrary.wiley.com/doi/10.1111/all.70207. DOI: 10.1111/all.70207. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Hope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice. 🎧 Listen and subscribe: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  5. Aug 1

    Allergy and Eustachian Tube Dysfunction: Causes, Symptoms, Diagnosis & Treatment

    Why do your ears feel blocked during allergy season? Can hay fever really affect your hearing? What causes that frustrating sensation of ear fullness, popping, crackling or pressure that just won’t go away? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the important relationship between allergic disease and Eustachian Tube Dysfunction (ETD)—a common but often misunderstood condition affecting both children and adults. Join us as we discuss: What the Eustachian tube is and why it is essential for normal ear function.How allergic rhinitis, environmental allergies and nasal inflammation contribute to Eustachian Tube Dysfunction.The common symptoms of ETD, including ear fullness, pressure, popping, crackling, muffled hearing, tinnitus and discomfort during flying or altitude changes.How ETD differs from ear infections, glue ear and other causes of hearing problems.The role of allergy testing and ENT assessment in making an accurate diagnosis.Evidence-based treatments, including allergen avoidance, intranasal corticosteroids, antihistamines, saline nasal irrigation and when specialist ENT interventions may be appropriate.Practical self-care strategies for managing symptoms at home.When persistent ear symptoms require urgent medical assessment.Whether you’re a parent, patient, allergy sufferer, healthcare professional or simply curious about the connection between allergies and ear health, this episode provides clear, evidence-based guidance to help you better understand and manage Eustachian Tube Dysfunction. Source:  Klimek, L. et al. (2025) 'Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An EAACI Position Paper', Allergy. doi: 10.1111/all.16554. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Subscribe to Hope & Histamine for expert discussions on paediatric allergy, immunology and related conditions, featuring the latest research and practical advice from specialists. 🎧 Listen on your favourite podcast platform or visit: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoy the podcast, please subscribe, leave a review and share this episode to help others learn more about allergy-related conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  6. Jul 23

    Orofacial Granulomatosis (OFG): Symptoms, Diagnosis, Causes & Modern Treatment

    Orofacial Granulomatosis (OFG) is a rare but often overlooked inflammatory condition that can present with persistent lip swelling, oral ulcers, gum changes, and facial swelling. Because its symptoms overlap with many other conditions, diagnosis is frequently delayed, leaving patients and families searching for answers. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we take a deep dive into the science and clinical management of Orofacial Granulomatosis. We discuss what OFG is, why it develops, and its important associations with Crohn’s disease, allergy, and other inflammatory disorders. You’ll learn how clinicians approach the diagnosis, the role of biopsies and investigations, and the latest evidence-based treatment options available for both children and adults. Whether you’re a healthcare professional, medical student, patient, or parent, this episode provides a clear, practical, and evidence-based overview of this fascinating condition. In this episode, we cover: What is Orofacial Granulomatosis (OFG)?Common signs and symptoms, including persistent lip swellingCauses and current theories behind OFGThe relationship between OFG and Crohn’s diseaseIs allergy involved?How OFG is diagnosed and the role of biopsyImportant differential diagnoses clinicians should considerMedical and dietary treatment optionsLong-term outlook and follow-upKey take-home messages for patients, families, and healthcare professionalsJoin us as we separate fact from fiction and explore the latest understanding of Orofacial Granulomatosis, helping listeners recognise the condition earlier and understand the best approaches to diagnosis and management. Sources: Courtney, A., Holmes, Z., Sharma, S. and Brand, R., 2023. Orofacial granulomatosis: Challenges in diagnosis and treatment. Journal of Paediatrics and Child Health, 59, pp. 159-161.Galdiero, M.R., Maio, F., Arcoleo, F., Boni, E., Bonzano, L., Brussino, L., Cancian, M., Cremonte, L., Del Giacco, S.R., De Paulis, A., Detoraki, A., Firinu, D., Lamacchia, D., Loffredo, S., Nettis, E., Parente, R., Parronchi, P., Pellacani, G., Petraroli, A., Rolla, G., Senter, R., Triggiani, M., Vitiello, G., Spadaro, G. and Bova, M., 2021. Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature. Allergy, 76(7), pp. 2189-2200.Haaramo, A., Alapulli, H., Aine, L., Saarnisto, U., Tuokkola, J., Ruuska, T., Sipponen, T., Pitkäranta, A. and Kolho, K.L., 2017. Detailed Follow-up Study of Pediatric Orofacial Granulomatosis Patients. Journal of Pediatric Gastroenterology and Nutrition, 65(4), pp. 388-393.Marttala, A., Sihvonen, E., Kantola, S., Ylöstalo, P. and Tervonen, T., 2018. Diagnosis and Treatment of Orofacial Granulomatosis. Journal of Dentistry for Children, 85(2), pp. 83-87.Pathania, Y.S., 2022. Current treatment modalities in granulomatous cheilitis. International Journal of Dermatology, 61, pp. 755-759.Sahni, V.N., Yim, R., Amanullah, A., Sahni, D., Powell, D., deShazo, R., Rhoads, J.L.W., Clarke, J.T., Hansen, C.B., Zone, J.J., Hull, C.M. and Hopkins, Z.H., 2026. An Allergy-Based Approach to Orofacial Granulomatosis: A Narrative Review. Dermatitis, 37(1), pp. 13-19. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations 🎧 Subscribe to Hope & Histamine: The Paediatric Allergy Podcast for expert discussions on paediatric allergy, immunology, and related conditions. New episodes feature practical, evidence-based insights from leading specialists, designed for clinicians, patients, and families alike. 🌐 Podcast website: https://hopeandhistaminepodcasts.buzzsprout.com Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  7. Jul 13

    Idiopathic Anaphylaxis Explained: Causes, Diagnosis & Treatment

    What happens when someone experiences anaphylaxis, but no trigger can be identified? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore idiopathic anaphylaxis—a diagnosis that can be both frightening for patients and challenging for clinicians. Join us as we discuss the latest understanding of idiopathic anaphylaxis, including how it is diagnosed, important conditions that can mimic anaphylaxis, and the investigations needed to exclude identifiable causes such as food allergy, medication allergy, insect venom allergy, mast cell disorders, hereditary alpha-tryptasemia, and alpha-gal syndrome. We also cover: What idiopathic anaphylaxis is and why it occursCommon symptoms and clinical presentationDifferential diagnoses and conditions that mimic anaphylaxisThe role of serum tryptase, allergy testing, and other investigationsMast cell activation syndrome and systemic mastocytosisAcute emergency management of anaphylaxisLong-term treatment strategies and preventionAdrenaline (epinephrine) auto-injectors and personalised emergency action plansPatient education, follow-up, and improving quality of lifeThe latest evidence and future directions in researchWhether you’re a healthcare professional, paediatrician, allergist, trainee, medical student, or someone living with recurrent unexplained allergic reactions, this episode provides practical, evidence-based insights to help you better understand and manage idiopathic anaphylaxis. If you enjoy this episode, please follow, rate, and share the podcast to help us bring high-quality paediatric allergy education to a wider audience. Hope & Histamine: The Paediatric Allergy Podcast—making paediatric allergy evidence practical, accessible, and easy to understand. Sources: Applewhite, T.L. (2025) 'The Lived Experience of Patients With Idiopathic Anaphylaxis', The Journal for Nurse Practitioners, 21(1), p. 105329.Ben-Shoshan, M., Akin, C., Cook, V.E. and Khalaf, R. (2025) 'Idiopathic anaphylaxis', The Journal of Allergy and Clinical Immunology: In Practice, 13(12), pp. 3169-3175.Calvani, M. (2022) 'Update on idiopathic anaphylaxis', Pediatric Allergy and Immunology, 33(Suppl. 27), pp. 52-53. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  8. Jul 4

    Preventing and Treating Peanut Allergy in Children: From Early Introduction to Immunotherapy

    Peanut allergy has become one of the most important and widely discussed topics in paediatric allergy. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the prevention and treatment of peanut allergy in children, from the landmark evidence supporting early peanut introduction to the evolving role of oral immunotherapy. We discuss why peanut allergy develops, which children are at higher risk, and how early dietary exposure may help reduce the chance of allergy in infancy. The episode also covers practical approaches to diagnosis, avoidance, emergency management, and treatment, including oral peanut immunotherapy and its potential benefits and limitations. Designed for parents, healthcare professionals, and anyone interested in childhood allergy, this episode brings together evidence-based guidance and practical clinical insights to help make sense of modern peanut allergy care. Source: Du Toit, G. and Lack, G. (2026) 'Prevention and Treatment of Peanut Allergy', New England Journal of Medicine, 394(24), pp. 2449–2458. Available at: https://doi.org/10.1056/NEJMcp2314424. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

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“Helping you understand allergies—one episode at a time” Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children. From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical advice—empowering parents, caregivers, and patients with reliable information and hope. Tune in for expert insights, real stories, and up-to-date recommendations designed to help you breathe a little easier.

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