Hope & Histamine: The Paediatric Allergy Podcast

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“Helping you understand allergies—one episode at a time” Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children. From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical advice—empowering parents, caregivers, and patients with reliable information and hope. Tune in for expert insights, real stories, and up-to-date recommendations designed to help you breathe a little easier.

  1. 23h ago

    Omalizumab vs Oral Immunotherapy for Multiple Food Allergies: OUtMATCH Trial Explained

    How does omalizumab compare with oral immunotherapy for treating multiple food allergies? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore OUtMATCH Stage 2, comparing omalizumab (Xolair) with omalizumab-facilitated multi-allergen oral immunotherapy (OIT). We unpack the findings on treatment success, allergic reactions, side effects and treatment discontinuation—and explain why tolerability matters when interpreting the results. What do these findings mean for children with peanut allergy and other food allergies, their families, and the clinicians supporting them? Join us for an accessible, evidence-based discussion of anti-IgE therapy, food allergy desensitisation and personalised treatment decisions. Whether you’re a paediatrician, allergist, trainee or parent, discover what the OUtMATCH trial adds to the evolving conversation about multifood allergy treatment. Sources: Wood, R.A. et al. (2024) 'Omalizumab for the Treatment of Multiple Food Allergies', New England Journal of Medicine, 390(10), pp. 889–899. doi: 10.1056/NEJMoa2312382.Wood, R.A. et al. (2026) 'Treatment of Multifood Allergy With Omalizumab or Multiallergen Oral Immunotherapy: A Randomized Clinical Trial', JAMA Pediatrics, Advance online publication. doi: 10.1001/jamapediatrics.2026.2910. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Hope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice. 🎧 Listen and subscribe: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help advance the care of children with rare allergic and immunological conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  2. Sep 22

    Eggs and Peanuts in Pregnancy: Why More Didn’t Reduce Infant Allergy Risk

    Can eating more eggs and peanuts during pregnancy and breastfeeding reduce a baby’s risk of developing food allergy? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we examine the PrEggNut trial, a large randomised study involving more than 2,100 pregnant women whose babies had a strong family history of allergic disease. Researchers compared a maternal diet rich in eggs and peanuts with a standard-intake diet from pregnancy until four months after birth. Despite greater maternal exposure, the high-intake diet did not significantly reduce egg or peanut allergy in infants at one year of age. We explore the study’s findings, its strengths and limitations, and what the results mean for maternal diet, breastfeeding and current approaches to preventing food allergy in children. A concise, evidence-based discussion for parents, paediatricians, allergy professionals and anyone interested in pregnancy nutrition and infant allergy prevention. Source: Palmer, D.J., Sullivan, T.R., Campbell, D.E., Netting, M.J., McWilliam, V., Perrett, K.P., Makrides, M., et al. (2026)'Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy', New England Journal of Medicine, 395(11), pp. 1090–1099. doi: 10.1056/NEJMoa2605659. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Hope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice. 🎧 Listen and subscribe: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help advance the care of children with rare allergic and immunological conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  3. Sep 13

    Kounis Syndrome Explained: When a Severe Allergic Reaction Triggers Acute Coronary Syndrome

    What happens when a severe allergic reaction affects not only the skin and airways but also the coronary arteries? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore Kounis syndrome—an acute coronary syndrome triggered by an allergic or hypersensitivity reaction. We discuss how mast-cell activation and inflammatory mediators can cause coronary artery spasm, plaque disruption or stent thrombosis, resulting in symptoms that may resemble a heart attack alongside features of anaphylaxis. Discover the common triggers, different clinical types, warning signs, diagnostic challenges and key management considerations. This episode also examines the delicate balance involved in treating anaphylaxis and cardiac ischaemia simultaneously. An essential listen for paediatricians, allergists, emergency clinicians, cardiologists, trainees and anyone interested in the important connection between allergy and the heart. Sources: Anastasopoulou, M., Karanasos, A., Grafanaki, K., Almpanis, G., Koutsogiannis, N., Mplani, V., Papadionysiou, C., Kounis, N.G., Georgiou, S. and Davlouros, P. (2026) 'Incidence of Elevated Cardiac Biomarkers in Patients Presenting to the Emergency Department With Allergic Symptoms: Implications for the Diagnosis of Kounis Syndrome', The American Journal of Cardiology, 258, pp. 1–8. doi: 10.1016/j.amjcard.2025.08.036.Ceasovschih, A., Kounis, N.G., Markos, S., Ejubovic, M., Cherska, M., Barkas, F., Ristovski, V., Corlateanu, A., Sivapalan, P., Kotlyarov, S., Sorodoc, V. and Sorodoc, L. (2026) 'Kounis Syndrome Features in Special Populations', Medical Sciences, MDPI, pp. 1–20.Foti Randazzese, S., Caminiti, L., Crisafulli, G., Giovannini, M., Kounis, N.G. and Manti, S. (2024) 'Kounis syndrome in an adolescent with lipid transfer protein allergy', Pediatric Allergy and Immunology, 35, p. e14239. doi: 10.1111/pai.14239.Kalambay, J.D., Tashli, M., Zaman, M., Elwidaa, A., Shet, V. and Phillip, M. (2026) 'Kounis Syndrome: A Systematic Review and Meta-analysis', The American Journal of Cardiology, 268, pp. 25–31. doi: 10.1016/j.amjcard.2026.03.019. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Hope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice. 🎧 Listen and subscribe: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  4. Sep 7

    Rethinking the Blue Inhaler: Budesonide–Formoterol vs Salbutamol in Children with Mild Asthma | The CARE Trial

    Is it time to rethink the traditional blue reliever inhaler for children with mild asthma? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we examine the landmark 2025 CARE trial published in The Lancet. This 52-week randomised controlled trial compared budesonide–formoterol with salbutamol as reliever therapy in children with mild asthma. We explore whether an anti-inflammatory reliever inhaler can provide better protection than salbutamol alone, examining the trial’s findings on asthma attacks, symptom control, safety and treatment burden. We also consider what the results could mean for paediatric asthma guidelines, clinical practice and conversations with children and their families. Whether you are a paediatrician, GP, nurse, pharmacist, trainee or parent, this episode offers a clear and clinically relevant discussion of a study that could reshape how mild childhood asthma is managed. Listen now to discover whether budesonide–formoterol could represent the future of reliever therapy for children with mild asthma. Source: Hatter, L., Holliday, M., Oldfield, K., Kearns, C., Barry, T., Black, M., Bruce, P., Colman, A., Dickinson, E., Eathorne, A., Harwood, M., Hills, T., Lamb, R., Kerse, K., Krishnamoorthy, S., Martindale, J., Semprini, A., Shortt, N., McNamara, D., Byrnes, C.A., Dalziel, S.R., Bush, A., Weatherall, M. and Beasley, R., 2025.Budesonide–formoterol versus salbutamol as reliever therapy in children with mild asthma (CARE): a 52-week, open-label, multicentre, superiority, randomised controlled trial. The Lancet, 406, pp. 1473–1483. Available at: https://doi.org/10.1016/S0140-6736(25)00861-X. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Hope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice. 🎧 Listen and subscribe: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  5. Aug 28

    The Peanut Patch Revolution: Is Epicutaneous Immunotherapy the Future of Peanut Allergy Treatment in Children?

    Could a simple skin patch transform the treatment of peanut allergy in young children? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence on epicutaneous immunotherapy (EPIT)—also known as the peanut patch—for toddlers and children with peanut allergy. Drawing on findings from the EPITOPE and EPOPEX studies, we examine how peanut patch therapy works, its long-term effectiveness and safety, and whether it can increase the amount of peanut a child can tolerate. We also discuss its potential to reduce the risk of allergic reactions from accidental exposure to packaged foods and consider how well EPIT works in children who also have atopic conditions such as eczema, asthma and allergic rhinitis. Can epicutaneous immunotherapy offer families meaningful protection while avoiding some of the challenges associated with oral immunotherapy? Could the peanut patch become part of routine childhood peanut allergy treatment? Join us as we translate the emerging research into clear, practical information for parents, clinicians and everyone interested in the future of paediatric food allergy care. Sources: Burks, A., Sindher, S., Wang, J., O'Sullivan, M., Du Toit, G., Kim, E., Bois, T. and Greenhawt, M., 2022. EPITOPE study results: Phase 3, randomized, double-blind, placebo-controlled study of epicutaneous immunotherapy in peanut-allergic toddlers [Abstract]. Annals of Allergy, Asthma & Immunology, 129(5 Supplement), p. S12.Greenhawt, M., Wang, J., DuToit, G., O’Sullivan, M., Brown-Whitehorn, T., Bois, T., Bee, K., Green, T., Sampson, H. and Burks, A., 2025. Long-term efficacy and safety of epicutaneous immunotherapy in peanut-allergic toddlers: EPOPEX end of study results [Abstract]. Annals of Allergy, Asthma & Immunology, 135(5 Supplement), p. S10. Remington, B.C., Krone, T., Kim, E.H., Bird, J.A., Green, T.D., Lack, G., Fleischer, D.M. and Koppelman, S.J., 2019. Estimated risk reduction to packaged food reactions by epicutaneous immunotherapy (EPIT) for peanut allergy. Annals of Allergy, Asthma & Immunology, 123(5), pp. 488-493. Scurlock, A.M., Fleischer, D.M., Du Toit, G., Arends, N.J.T., Pongracic, J.A., Trujillo, J., Turner, P., Vogelberg, C., Bee, K.J., Green, T.D., Meney, J., Bois, T., Campbell, D.E., Sampson, H.A. and Burks, A.W., 2025. Efficacy and safety of epicutaneous immunotherapy in children with peanut allergy with atopic comorbidities. Annals of Allergy, Asthma & Immunology, 135(2), pp. 203-210. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  6. Aug 19

    Dupilumab in Children: A Game-Changer for Eczema, Asthma and Atopic Disease

    Dupilumab has transformed the treatment of several type 2 inflammatory conditions—but how does it work, which children may benefit, and what should clinicians and families know before starting treatment? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the expanding role of dupilumab in paediatrics, including its use in atopic dermatitis (eczema), severe asthma and eosinophilic oesophagitis. We discuss how blocking interleukin-4 and interleukin-13 signalling helps control allergic inflammation, along with patient selection, administration, monitoring, potential adverse effects, and the practical considerations of biologic treatment. Whether you are a paediatrician, allergy specialist, healthcare professional, or parent, this episode provides a clear, clinically relevant introduction to how dupilumab is reshaping the management of childhood atopic disease. Sources: Foti Randazzese, S., Calamita, A., D’Angelo, D., Marseglia, A., Mesa Lombardero, E., Pedersoli, S., Tedeschi, M., De Amici, M., Manti, S., Brazzelli, V., Licari, A. and Marseglia, G.L. (2026) 'Emerging Paediatric Uses of Dupilumab Beyond Approvals', Clinical & Experimental Allergy. Available at: https://doi.org/10.1111/cea.70381.Gutsche, A., Grabowska, W., Altrichter, S., Grekowitz, E., Roll, S., Heine, G., Staubach, P., Pfützner, W., Brehler, R., Bauer, A., Wagner, N., Wurpts, G., Salameh, P., Salehzadeh-Yazdi, A., Jahandideh, S.S. and Metz, M. (2026) 'Dupilumab in Cholinergic Urticaria: An Exploratory Phase 2 Investigator-Initiated Study', Allergy. Available at: https://doi.org/10.1111/all.70454.Lasek, A., Bellon, N., Mallet, S., Aubert, H., Vera, C., Achour, L., Thénié, C., Prescilla, R., Abasq-Thomas, C. and Barbarot, S. (2026) 'Dupilumab treatment in children aged 6 months to 5 years with severe atopic dermatitis', Journal of the European Academy of Dermatology and Venereology, 40, pp. 1208–1217. Available at: https://doi.org/10.1111/jdv.70268.Wechsler, M.E., Wenzel, S.E., Groshong, S.D., Castro, M., Pavord, I.D., Rabe, K.F., Laws, E., Jagerschmidt, A., Gayvert, K., Harel, S., Hamilton, J.D., Amin, N., Zhang, L., Xing, H., Elfakir, A., Coulibaly, B., Naimi, S., Hamon, S., Rowe, P.J., Nestle, F., Cunoosamy, D.M., de Rinaldis, E. and Mannent, L.P. (2026) 'Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma', Allergy. Available at: https://doi.org/10.1111/all.70391. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  7. Aug 8

    Pediatric Hereditary Angioedema: Diagnosis, Treatment & Long-Term Management

    Hereditary angioedema (HAE) is a rare but potentially life-threatening genetic disorder that often presents during childhood, yet diagnosis is frequently delayed for many years. Early recognition and timely treatment can dramatically improve quality of life and reduce the risk of serious complications, including airway obstruction. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence and practical approaches to diagnosing and managing paediatric hereditary angioedema (HAE). Whether you’re a paediatrician, allergy specialist, emergency clinician, trainee, nurse, or allied healthcare professional, this episode provides a comprehensive overview of this important condition. In this episode, we discuss: Understanding the genetics and pathophysiology of hereditary angioedemaClinical features that distinguish HAE from allergic angioedemaCommon triggers and patterns of attacks in childrenDiagnostic investigations, including complement testing and genetic confirmationRecognising red flags for life-threatening laryngeal oedemaAcute management of HAE attacksShort-term and long-term prophylactic treatment optionsThe role of C1 esterase inhibitor replacement therapy, bradykinin-targeted treatments and emerging therapiesFamily screening, genetic counselling and transition to adult servicesPractical tips for emergency action plans and improving patient outcomesJoin us as we review current guidelines, discuss real-world clinical challenges, and share practical insights to help clinicians recognise hereditary angioedema earlier and deliver evidence-based care for children and young people living with HAE. Source: Farkas, H. et al. (2026) 'International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema', Allergy. Available at: https://onlinelibrary.wiley.com/doi/10.1111/all.70207. DOI: 10.1111/all.70207. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Hope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice. 🎧 Listen and subscribe: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

  8. Aug 1

    Allergy and Eustachian Tube Dysfunction: Causes, Symptoms, Diagnosis & Treatment

    Why do your ears feel blocked during allergy season? Can hay fever really affect your hearing? What causes that frustrating sensation of ear fullness, popping, crackling or pressure that just won’t go away? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the important relationship between allergic disease and Eustachian Tube Dysfunction (ETD)—a common but often misunderstood condition affecting both children and adults. Join us as we discuss: What the Eustachian tube is and why it is essential for normal ear function.How allergic rhinitis, environmental allergies and nasal inflammation contribute to Eustachian Tube Dysfunction.The common symptoms of ETD, including ear fullness, pressure, popping, crackling, muffled hearing, tinnitus and discomfort during flying or altitude changes.How ETD differs from ear infections, glue ear and other causes of hearing problems.The role of allergy testing and ENT assessment in making an accurate diagnosis.Evidence-based treatments, including allergen avoidance, intranasal corticosteroids, antihistamines, saline nasal irrigation and when specialist ENT interventions may be appropriate.Practical self-care strategies for managing symptoms at home.When persistent ear symptoms require urgent medical assessment.Whether you’re a parent, patient, allergy sufferer, healthcare professional or simply curious about the connection between allergies and ear health, this episode provides clear, evidence-based guidance to help you better understand and manage Eustachian Tube Dysfunction. Source:  Klimek, L. et al. (2025) 'Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An EAACI Position Paper', Allergy. doi: 10.1111/all.16554. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTube Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website. Buy me a coffee: https://coff.ee/goodlifecreations Subscribe to Hope & Histamine for expert discussions on paediatric allergy, immunology and related conditions, featuring the latest research and practical advice from specialists. 🎧 Listen on your favourite podcast platform or visit: https://hopeandhistaminepodcasts.buzzsprout.com If you enjoy the podcast, please subscribe, leave a review and share this episode to help others learn more about allergy-related conditions. Send us Fan Mail Support the show Brought to you by - Goodlife Creations (2026).  Music by - Denys Kyshchuk from Pixabay.

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“Helping you understand allergies—one episode at a time” Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children. From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical advice—empowering parents, caregivers, and patients with reliable information and hope. Tune in for expert insights, real stories, and up-to-date recommendations designed to help you breathe a little easier.

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