Psychedelics are everywhere right now - and most physicians still feel uneasy even saying the words out loud. In this episode of Out of Network, Dr. Ryon Parker and Dr. Rishi Seth have a no-hype conversation about psychedelics in medicine: ketamine, psilocybin, MDMA, and what these therapies could mean for patients with refractory depression, anxiety, and PTSD who feel like they’ve run out of options. You’ll hear: A real clinical case where a patient had tried “everything,” including multiple meds and therapy, and still wasn’t okayWhy Dr. Seth is skeptical (FDA approval, data quality, who these therapies are NOT for)Dr. Parker’s decision to refer to a guided retreat option after clinical trials weren’t availableA personal story from Dr. Parker that adds a completely different layer to the conversationKetamine’s role today (anesthesia, pediatrics, refractory pain) and why “ketamine clinics” raise real questionsTimestamps 00:00 – Why psychedelics in medicine makes doctors uncomfortable 01:26 – Clinical scenario: “nothing is working” for severe depression/anxiety 03:44 – The lineup: ketamine, MDMA, LSD, psilocybin 04:07 – Skepticism: “not FDA approved,” limited robust data 05:23 – A Colorado retreat enters the conversation 09:20 – The hard part: tapering off meds safely, risks, close follow-up 10:10 – Outcome: “first time I feel better” after the retreat 13:16 – Who psychedelics are NOT for (bipolar/psychotic disorders risk) 14:07 – What the research hints at (and what we still don’t know) 16:20 – Dr. Parker shares his personal experience and why this topic matters 28:40 – Ketamine: what it’s used for, what’s legit, what’s questionable 34:21 – Takeaways: hope, ambiguity, and why this deserves a real conversation Connect with Out of Network: 🌐 Website: https://www.outofnetworkpod.com/ 📱 Instagram: https://www.instagram.com/outofnetworkpodcast/ ▶️ YouTube: https://www.youtube.com/@OutofNetworkPodcast 🎵 TikTok: https://www.tiktok.com/@outofnetworkpodcast Connect with the Hosts: Dr. Ryon Parker → https://www.instagram.com/dr.ryonparker/ Parker Medical: https://parkermedical.org/ Dr. Rishi Seth → https://www.instagram.com/drrishiseth/ Seth Premiere Medical: https://sethmedical.com/ Enjoyed the Episode? If this conversation resonated with you, please like, comment, and subscribe. Share it with someone who cares about the future of healthcare. 🎙 About Out of Network Out of Network is a bold, physician-led podcast hosted by Dr. Ryon Parker and Dr. Rishi Seth. Each week, they challenge the broken healthcare system and explore how medicine can be reimagined—through patient-first care, prevention, and real human stories. Enjoyed the Episode? If you liked this conversation, please subscribe, leave us a review, and share this podcast with a friend—it helps more people discover a new vision for healthcare.
