The Singing Stethoscope

The Singing Stethoscope

The Singing Stethoscope is a podcast that uses music to make medicine more memorable. Starting with pharmacology and other high-yield topics, the songs feature tips, tricks, and mnemonics to help boost retention of key medical concepts. This podcast is dedicated to decreasing your stress level and increasing your confidence, whether you’re studying for USMLE Step 1, PANCE, or NP certification exams. Now you can keep studying even when you're driving, hitting the gym, whipping up dinner, or doing the dishes. For the best experience, get the lyrics delivered straight to your inbox. Just go to thesingingstethoscope.substack.com and join the email list for free. thesingingstethoscope.substack.com

Episodes

  1. Antifungals

    08/16/2025

    Antifungals

    It’s time to have fun, fun, fun Fun with antifungals With polyene antifungals, let’s begin These are amphotericin B and nystatin Swish and swallow nystatin liquid form For esophageal candidiasis it's the norm Fungal cells’ plasma membrane is made up of ergosterol And basically, these drugs tear holes in that wall They destroy the cell membrane’s structural integrity So just remember that “tear” is in ampho-TEAR-icin B You should also know these are heavy duty medications And heavy duty side effects are the expectation Amphotericin B can cause fever, chills, and other things Am-PH-PH-PH-tericin B, pretend you’re shivering, am-PH-PH-PH-tericin B There’s also the risk of electrolyte abnormalities Decreased potassium and magnesium are potential realities So remember ampho B as in am-FLOW-tericin B To remind you it might lead to nephrotoxicity We’re having fun, fun, fun Fun with antifungals Now the next class of antifungals, we’re on a roll Are the real a-holes also known as the azoles Like clotrimazole, ketoconazole, and fluconazole They simply inhibit the synthesis of ergosterol Also inhibiting ergosterol synthesis are the allylamines A couple of examples are terbinafine and butenafine Then there’s griseofulvin, which works like this It prevents fungal cells’ proliferation by inhibiting mitosis The last class of antifungal drugs are the echinocandins Like caspofungin, anidulafungin, and micafungin They inhibit the synthesis of cell wall beta-glucan So echinocandins, as in, e-kinda-can’t-do that man Hope you had fun, fun, fun Fun with antifungals This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com

    3 min
  2. Cephalosporins

    08/09/2025

    Cephalosporins

    There are five generations of cephalosporins And I’ve got some clever ways You can remember them For the first generation we have Cefazolin and Cephalexin Now Cef-hAZ-olin sounds kind of like “has” And Cephalexin contains the word “ale” So the first question you want to ask is, Do you has any ale? That’s the first thing you might ask When you go to a friend’s house Do you has any ale? For Cef-hAZ-olin and Ceph-ALE-xin That’s the first generation Now we’re going to skip altogether The cephalosporins in the second generation There’s no easy way to remember this group So you’ll have to use the process of elimination But fortunately the third generation is easy All you gotta do is remember the number three You can fix things in three days with Ce-FIX-ime And “tri” means three in Cef-TRI-axone Cefo-TAX-ime reminds you people do their taxes Usually in the third month of the year And for Cef-TAZ-idime, just close your eyes And picture three TAZ-manian devils That’s the third generation Along the same lines, for the fourth generation We’ll focus on the number four Cefepime covers Pseudomonas, And that has four syllables: Pseu-do-mon-as So it goes with Ce-FOUR-pime That’s the fourth generation And last but not least, Ceftaroline Ceftaroline is in the fifth generation Think of a star with five points And say Cef-STAR-oline That’s the fifth generation There are five generations of cephalosporins And now you know some clever ways to remember them This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com

    4 min
  3. CYP-450 Drug Interactions

    08/02/2025

    CYP-450 Drug Interactions

    Cytochrome P450 isoenzymes play a big role In the metabolism of certain medications They’re found in the liver and throughout the body And they’re the star of this song today, so congratulations Drug interactions are what you have to watch out for ‘Cause these enzymes’ activity can be affected By certain drugs and compounds, inducers or inhibitors And the effect of this on other meds is connected This mnemonic is all you need to remember The inducers of Cytochrome P450 “This CRAP GPS induces my rage” “This CRAP GPS induces my rage” — pretty nifty Now let’s break it down: C for Carbamazepine R for Rifampin A for Alcohol, chronic use P for Phenytoin G for Griseofulvin P for Phenobarbital S for Sulfonylureas These inducers increase the production and activity of the Cytochrome P450 isoenzymes This increases drug metabolism Which can cause a sub-therapeutic effect oftentimes This mnemonic is all you need to remember The inducers of Cytochrome P450 “This CRAP GPS induces my rage” “This CRAP GPS induces my rage” — pretty nifty Now let’s break it down: C for Carbamazepine R for Rifampin A for Alcohol, chronic use P for Phenytoin G for Griseofulvin P for Phenobarbital S for Sulfonylureas And on a test if a drug or compound isn’t an inducer Then it's likely an inhibitor by process of elimination Inhibitors decrease Cytochrome P450 activity Which can lead to toxic drug levels and higher concentration But just memorize the inducers And then you’ll be good to go “This CRAP GPS induces my rage” Now you're a pharmacology pro This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com

    4 min
  4. The 10 Rights of Prescription Writing

    07/26/2025

    The 10 Rights of Prescription Writing

    When you write a prescription There’s a lot you need to know So sing along to avoid the most common mistakes And get it right from the get-go These are the ten rights of prescription writing 1. Right patient 2. Right date 3. Right drug 4. Right dose 5. Right frequency 6. Right route 7. Right number of refills 8. Right duration of treatment 9. The Right to informed consent 10. The Right to refuse treatment These are the ten rights of prescription writing If you want to be a hero Check your decimal points and zeros They always lead and never trail Always lead and never trail Point one milligrams (.1 mg) can look like one milligram (1 mg) So add a leading zero and write zero point one (0.1 mg) And one point zero milligrams (1.0 mg) might look like ten milligrams (10 mg) So drop the trailing zero and just write one milligram (1 mg) Here are the ten rights of prescription writing 1. Right patient 2. Right date 3. Right drug 4. Right dose 5. Right frequency 6. Right route 7. Right number of refills 8. Right duration of treatment 9. The Right to informed consent 10. The Right to refuse treatment These are the ten rights of prescription writing When you write a prescription Take your time and double check your work Always keep an eye out for patients’ allergies And be clear to avoid any guesswork This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com

    2 min
  5. When Drugs Get Withdrawn

    07/19/2025

    When Drugs Get Withdrawn

    Pharmacology is ever evolving So keep in mind that what you learn today Might be slightly out of date By the time you graduate When safety signals start to show Sometimes medications have to go Darvocet, an opioid was widely prescribed for years But fatal heart issues led to lots of tears Post-marketing surveillance is key We keep watching drugs even after they're released Phase IV never really ends Cause we're always tracking adverse events Cylert was a stimulant for treating ADHD But it was withdrawn because of severe hepatotoxicity Vioxx nearly doubled the risk of heart attack or stroke So it was pulled too cause that’s no joke But not every risky drug goes away completely Especially if it provides benefits uniquely Sometimes a strong warning is given instead So everyone’s informed about the risks ahead A black box warning was added for Celebrex Cause this COX-2 inhibitor increases the risk of GI events As well as the risk of heart attacks and strokes So the FDA decided they should warn folks Post-marketing surveillance is key We keep watching drugs even after they're released Phase IV never really ends Cause we're always tracking adverse events New data and updates can easily accrue So staying current is what you gotta do Post-marketing surveillance is key We keep watching drugs even after they're released Phase IV never really ends Cause we're always tracking adverse events This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com

    3 min
  6. Controlled Substances

    07/05/2025

    Controlled Substances

    Some drugs have the potential for dependence and abuse These controlled substances are consequential And Schedules I through V are used to help prevent misuse Schedule I is the most restrictive Cause these drugs like LSD and heroin Are highly, highly addictive So there’s no situation you’d prescribe them in Now something that might surprise you Is that at the level of the federal government Marijuana is considered Schedule I it’s true So “no accepted medical use” is what’s meant Controlled substances are a delicate dance Weighing risks and benefits in every circumstance From Schedule I to V, they're all clearly defined To help protect patients in both body and mind Schedule II includes drugs like oxycodone and Vicodin The potential for abuse is still pretty high Cocaine, Dilaudid, fentanyl, Adderall, and Ritalin Drugs like these aren’t always people’s ally With Schedule III like ketamine and testosterone The risk of dependence is moderate That’s what the research has shown So you still need to be smart about it Controlled substances are a delicate dance Weighing risks and benefits in every circumstance From Schedule I to V, they're all clearly defined To help protect patients in both body and mind Schedule IV drugs are ones like Xanax And its potential for abuse is relatively low So this doesn’t need to get too complex Then there’s Ambien and Valium too you know Schedule V is the least restrictive Because meds like Lyrica and Robitussin A.C. Are much less likely to be addictive So their potential for abuse is the lowest you see Controlled substances are a delicate dance Weighing risks and benefits in every circumstance From Schedule I to V, they're all clearly defined To help protect patients in both body and mind This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com

    4 min
  7. A Brief History of Pharmacology

    06/28/2025

    A Brief History of Pharmacology

    Pharmacology as we know it today Was shaped by a lot of people along the way Around the fifteen hundreds this guy named Paracelsus Was a Swiss physician and alchemist He spoke with knowledge not yet widespread, “The dose makes the poison," he famously said This laid the groundwork for modern toxicology And he shifted things from plants toward chemistry In 1906 the Pure Food and Drug Act was passed It required ingredients to be accurately labeled at last Misbranded foods and drugs could no longer be sold Between states in the U.S. that’s how this story unfolds In 1912 Congress added the Shirley Amendment An early attempt to regulate drug labels’ content Fraudulent claims about cures were made illegal But it was still hard to prove the fraudulent intent of people Pharmacology as we know it today Was shaped by a lot of policies along the way The Federal Food, Drug, and Cosmetic Act was passed in 1938 Leading to the drug approval process we still use today Manufacturers are now required to prove drug safety Before they market products that could cause a tragedy This was a response to what happened with sulfanilamide An antibiotic that killed over a hundred far and wide A liquid version was released with children in mind But the medication and a toxic chemical were combined A couple decades later there was another tragedy Thalidomide affected over ten thousand babies When pregnant women were nauseous they took the medication But it caused severe birth defects and major deformations This triggered the Kefauver-Harris Amendment of 1962 And Good Manufacturing Practices were established too Proving drugs were safe and effective became the priority And the FDA was given a lot more authority Pharmacology as we know it today Was shaped by a lot of policies along the way In 1970 a new system for controlled substances was created Classified into five schedules so they could be better regulated Its name is kind of a mouthful, now that’s a fact The Comprehensive Drug Abuse Prevention and Control Act By 1997, some more updates were needed And the call for reform was finally heeded When the FDA Modernization Act passed It created a fast-track approval process at last The goal was to bring beneficial drugs to market more quickly Of course without compromising patient safety Companies could also share off-label use information Which changed drug advertising across the nation Pharmacology as we know it today Was shaped by a lot of policies along the way This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com

    4 min

About

The Singing Stethoscope is a podcast that uses music to make medicine more memorable. Starting with pharmacology and other high-yield topics, the songs feature tips, tricks, and mnemonics to help boost retention of key medical concepts. This podcast is dedicated to decreasing your stress level and increasing your confidence, whether you’re studying for USMLE Step 1, PANCE, or NP certification exams. Now you can keep studying even when you're driving, hitting the gym, whipping up dinner, or doing the dishes. For the best experience, get the lyrics delivered straight to your inbox. Just go to thesingingstethoscope.substack.com and join the email list for free. thesingingstethoscope.substack.com

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