Cardiology Today

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Stay current with cardiovascular medicine without the time commitment. Every morning, we deliver concise audio summaries of the latest original research from top cardiology journals. Top 5 breakthrough studies briefed in under 5 minutes (perfect for your commute or between patients). PubMed links included for full articles. Perfect for cardiologists, cardiothoracic surgeons, cardiac nurses, researchers, and healthcare workers who need to stay informed but lack time to scan multiple journals daily. For educational and reference purposes only. Not intended as medical advice.

  1. 15H AGO

    Cell-free DNA Reveals Heart Transplant Recipient Injury 02/17/26

    Welcome to Cardiology Today – Recorded February 17, 2026. This episode summarizes 5 key cardiology studies on topics like Endothelial function and Venous thromboembolism. Key takeaway: Cell-free DNA Reveals Heart Transplant Recipient Injury. Article Links: Article 1: Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. (Journal of the American College of Cardiology) Article 2: Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women. (Circulation) Article 3: Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. (Circulation) Article 4: Allograft and Recipient Tissue Injury during Cardiac Allograft Rejection: Evidence from Cell-free DNA. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/cell-free-dna-reveals-heart-transplant-recipient-injury-02-17-26/ Featured Articles Article 1: Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41697183 Summary: The Evolut Low Risk trial provided 6-year clinical outcomes comparing transcatheter aortic valve replacement and surgical aortic valve replacement in patients with severe aortic stenosis at low surgical risk. Researchers observed an increase in reintervention rates at 6 years, prompting additional analyses using available 7-year data to further characterize these trends. This long-term follow-up is crucial for understanding the durability and reintervention needs of both treatment modalities in this patient population, especially concerning long-term structural valve deterioration. Article 2: Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41697979 Summary: Hypertensive disorders of pregnancy were identified as early indicators of cardiovascular risk in a diverse cohort of young United States women. The study specifically found a quantifiable association between these disorders and incident cardiovascular disease in a real-world population. These findings, replicated across multiple health systems, underscore that hypertensive disorders of pregnancy independently increase the risk for premature cardiovascular disease, rather than solely reflecting pre-pregnancy health. Article 3: Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41693575 Summary: This study identified new circulating protein biomarkers and biological pathways for incident venous thromboembolism. Researchers employed large-scale, high-throughput aptamer-based proteomics across four longitudinal cohorts, including the Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, the Multi-Ethnic Study of Atherosclerosis, and the Trøndelag Health study. These findings advance the understanding of venous thromboembolism etiology and hold implications for improved risk prediction and potential therapeutic strategies. Article 4: Allograft and Recipient Tissue Injury during Cardiac Allograft Rejection: Evidence from Cell-free DNA. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41698554 Summary: This study provided evidence that cardiac allograft rejection is linked to recipient tissue injury, challenging the conventional view of rejection solely as an allograft disease. Researchers measured recipient tissue injury through plasma cell-free DNA, a recognized biomarker of tissue damage, confirming its occurrence during allograft rejection. The analysis identified genetic and epigenetic signatures associated with this process, clarifying a previously poorly defined risk factor for poor survival in cardiac transplant recipients. Article 5: Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41698896 Summary: This randomized, two-arm parallel feeding study investigated the effects of increased total fruit intake, specifically incorporating avocado and mango, on endothelial function and cardiometabolic risk factors. Eighty-two adults with prediabetes followed an eight-week diet daily including one avocado and one cup of mango, compared to an energy-matched low-fat control diet. The study provided a structured intervention to assess how these specific fruits impact vascular and metabolic health in a population at risk for cardiometabolic diseases, addressing a global risk factor of low fruit intake. Transcript Today’s date is February 17, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. The Evolut Low Risk trial provided 6-year clinical outcomes comparing transcatheter aortic valve replacement and surgical aortic valve replacement in patients with severe aortic stenosis at low surgical risk. Researchers observed an increase in reintervention rates at 6 years, prompting additional analyses using available 7-year data to further characterize these trends. This long-term follow-up is crucial for understanding the durability and reintervention needs of both treatment modalities in this patient population, especially concerning long-term structural valve deterioration. Article number two. Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women. Hypertensive disorders of pregnancy were identified as early indicators of cardiovascular risk in a diverse cohort of young United States women. The study specifically found a quantifiable association between these disorders and incident cardiovascular disease in a real-world population. These findings, replicated across multiple health systems, underscore that hypertensive disorders of pregnancy independently increase the risk for premature cardiovascular disease, rather than solely reflecting pre-pregnancy health. Article number three. Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. This study identified new circulating protein biomarkers and biological pathways for incident venous thromboembolism. Researchers employed large-scale, high-throughput aptamer-based proteomics across four longitudinal cohorts, including the Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, the Multi-Ethnic Study of Atherosclerosis, and the Trøndelag Health study. These findings advance the understanding of venous thromboembolism etiology and hold implications for improved risk prediction and potential therapeutic strategies. Article number four. Allograft and Recipient Tissue Injury during Cardiac Allograft Rejection: Evidence from Cell-free DNA. This study provided evidence that cardiac allograft rejection is linked to recipient tissue injury, challenging the conventional view of rejection solely as an allograft disease. Researchers measured recipient tissue injury through plasma cell-free DNA, a recognized biomarker of tissue damage, confirming its occurrence during allograft rejection. The analysis identified genetic and epigenetic signatures associated with this process, clarifying a previously poorly defined risk factor for poor survival in cardiac transplant recipients. Article number five. Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes. This randomized, two-arm parallel feeding study investigated the effects of increased total fruit intake, specifically incorporating avocado and mango, on endothelial function and cardiometabolic risk factors. Eighty-two adults with prediabetes followed an eight-week diet daily including one avocado and one cup of mango, compared to an energy-matched low-fat control diet. The study provided a structured intervention to assess how these specific fruits impact vascular and metabolic health in a population at risk for cardiometabolic diseases, addressing a global risk factor of low fruit intake. Thank you for listening. Don’t forget to subscribe. Keywords Endothelial function, Venous thromboembolism, Cardiac allograft rejection, Prediabetes, Transplant immunology, Women’s health, Plasma biomarkers, Avocado, Hypertensive disorders of pregnancy, Transcatheter aortic valve replacement, Mango, Cell-free DNA, Surgical aortic valve replacement, Cardiovascular disease, Proteomics, Premature cardiovascular disease, Recipient tissue injury, Cardiovascular risk, Aortic stenosis, Biological pathways, Cardiometabolic risk factors, Low surgical risk, Cardiac transplantation, Etiology, Reintervention rates, Fruit intake. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Cell-free DNA Reveals Heart Transplant Recipient Injury 02/17/26 first appeared on Cardiology Today.

  2. 1D AGO

    Percutaneous Coronary Intervention Mortality Breakdown. 02/16/26

    Welcome to Cardiology Today – Recorded February 16, 2026. This episode summarizes 5 key cardiology studies on topics like heart transplant rejection and Percutaneous coronary intervention. Key takeaway: Percutaneous Coronary Intervention Mortality Breakdown.. Article Links: Article 1: ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). (The American journal of cardiology) Article 3: Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. (The American journal of cardiology) Article 4: Revascularization in Patients Over 75 With Acute Coronary Syndrome. (The American journal of cardiology) Article 5: Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/percutaneous-coronary-intervention-mortality-breakdown-02-16-26/ Featured Articles Article 1: ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41692363 Summary: This study found that Z-DNA induced PANoptosis in human microvascular endothelial cells through ZBP1. Researchers observed that ADAR1 and R. I. P. K. one collaboratively regulated the activation of the ZBP1-R. I. P. K. three complex, controlling PANoptosis in a time-dependent manner. The interaction of ADAR1 with ZBP1 specifically protected against Z-DNA-induced cell death. These findings reveal crucial molecular mechanisms driving PANoptosis and its potential relevance in heart transplant rejection. Article 2: Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41478442 Summary: This study established global longitudinal strain reference values for the Hispanic/Latino population using data from the Echocardiographic Study of Latinos. Researchers defined the 95th-percentile lower limit of normal global longitudinal strain values from a healthy reference sample. These established values provide essential clinical benchmarks for detecting early cardiac dysfunction in this specific demographic. The findings offer crucial guidance for assessing heart failure risk factors and interpreting echocardiographic results in Hispanic/Latino patients. Article 3: Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41421515 Summary: This multicenter analysis compared clinical outcomes of optical coherence tomography versus intravascular ultrasound guidance for primary percutaneous coronary intervention in patients with S. T.-elevation myocardial infarction. The study utilized data from 2777 S. T.-elevation myocardial infarction patients who underwent primary percutaneous coronary intervention at 12 Japanese hospitals. Researchers found comparative data on the use of both imaging modalities, which are recommended by current guidelines for percutaneous coronary intervention guidance. These findings contribute to understanding the relative performance and clinical utility of optical coherence tomography and intravascular ultrasound in this critical patient population. Article 4: Revascularization in Patients Over 75 With Acute Coronary Syndrome. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41391816 Summary: This retrospective analysis investigated revascularization strategies in patients over 75 years old presenting with acute coronary syndromes. Observational data previously showed that coronary artery bypass graft was associated with improved one-year outcomes, including lower rates of death and rehospitalization, compared to percutaneous coronary intervention and medical management in general acute coronary syndrome patients with multivessel coronary artery disease. This study provided specific data addressing these outcomes in the elderly population. The findings contribute to clinical decision-making for optimal revascularization strategies in acute coronary syndrome patients aged over 75. Article 5: Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41692131 Summary: This study analyzed mortality following percutaneous coronary intervention using data from the P. R. O. G. R. E. S. S. minus C. O. M. P. L. I. C. A. T. I. O. N. S. registry. Among 22503 patients undergoing percutaneous coronary intervention, 115 patients, representing 0.5 percent, died before hospital discharge. Researchers found that 15 patients, 13.0 percent of the mortalities, died during the procedure, while 10 patients, 8.7 percent, died within the first 24 hours post-procedure, and 90 patients, 78.3 percent, died more than 24 hours after the intervention. The study also revealed that patients who died exhibited a high burden of comorbidities. Transcript Today’s date is February 16, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. This study found that Z-DNA induced PANoptosis in human microvascular endothelial cells through ZBP1. Researchers observed that ADAR1 and R. I. P. K. one collaboratively regulated the activation of the ZBP1-R. I. P. K. three complex, controlling PANoptosis in a time-dependent manner. The interaction of ADAR1 with ZBP1 specifically protected against Z-DNA-induced cell death. These findings reveal crucial molecular mechanisms driving PANoptosis and its potential relevance in heart transplant rejection. Article number two. Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). This study established global longitudinal strain reference values for the Hispanic/Latino population using data from the Echocardiographic Study of Latinos. Researchers defined the 95th-percentile lower limit of normal global longitudinal strain values from a healthy reference sample. These established values provide essential clinical benchmarks for detecting early cardiac dysfunction in this specific demographic. The findings offer crucial guidance for assessing heart failure risk factors and interpreting echocardiographic results in Hispanic/Latino patients. Article number three. Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. This multicenter analysis compared clinical outcomes of optical coherence tomography versus intravascular ultrasound guidance for primary percutaneous coronary intervention in patients with S. T.-elevation myocardial infarction. The study utilized data from 2777 S. T.-elevation myocardial infarction patients who underwent primary percutaneous coronary intervention at 12 Japanese hospitals. Researchers found comparative data on the use of both imaging modalities, which are recommended by current guidelines for percutaneous coronary intervention guidance. These findings contribute to understanding the relative performance and clinical utility of optical coherence tomography and intravascular ultrasound in this critical patient population. Article number four. Revascularization in Patients Over 75 With Acute Coronary Syndrome. This retrospective analysis investigated revascularization strategies in patients over 75 years old presenting with acute coronary syndromes. Observational data previously showed that coronary artery bypass graft was associated with improved one-year outcomes, including lower rates of death and rehospitalization, compared to percutaneous coronary intervention and medical management in general acute coronary syndrome patients with multivessel coronary artery disease. This study provided specific data addressing these outcomes in the elderly population. The findings contribute to clinical decision-making for optimal revascularization strategies in acute coronary syndrome patients aged over 75. Article number five. Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. This study analyzed mortality following percutaneous coronary intervention using data from the P. R. O. G. R. E. S. S. minus C. O. M. P. L. I. C. A. T. I. O. N. S. registry. Among 22503 patients undergoing percutaneous coronary intervention, 115 patients, representing 0.5 percent, died before hospital discharge. Researchers found that 15 patients, 13.0 percent of the mortalities, died during the procedure, while 10 patients, 8.7 percent, died within the first 24 hours post-procedure, and 90 patients, 78.3 percent, died more than 24 hours after the intervention. The study also revealed that patients who died exhibited a high burden of comorbidities. Thank you for listening. Don’t forget to subscribe. Keywords heart transplant rejection, Percutaneous coronary intervention, P. C. I. mortality, comorbidities, O

  3. 2D AGO

    E. C. G. Boosts Microvascular Disease Detection 02/15/26

    Welcome to Cardiology Today – Recorded February 15, 2026. This episode summarizes 5 key cardiology studies on topics like sex differences and heart failure with preserved ejection fraction. Key takeaway: E. C. G. Boosts Microvascular Disease Detection. Article Links: Article 1: Prognostic importance of exercise electrocardiography in patients with suspected microvascular disease. (Heart (British Cardiac Society)) Article 2: Prosthetic annulus size mismatch and recurrent mitral regurgitation after repair in advanced degenerative disease. (Heart (British Cardiac Society)) Article 3: Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure. (Heart (British Cardiac Society)) Article 4: Timing of anticoagulation restart after serious bleeding in atrial fibrillation. (Heart (British Cardiac Society)) Article 5: Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/e-c-g-boosts-microvascular-disease-detection-02-15-26/ Featured Articles Article 1: Prognostic importance of exercise electrocardiography in patients with suspected microvascular disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41690708 Summary: Exercise electrocardiography showing ST-segment depression demonstrates a very high positive predictive value for coronary microvascular dysfunction in specific patient groups. The present study focused on chest pain patients, using myocardial perfusion single photon emission computed tomography to rule out ischemia from epicardial coronary stenosis. This approach precisely identifies patients with suspected coronary microvascular dysfunction. Such precise identification is crucial for managing this condition, which is associated with a poor prognosis. Article 2: Prosthetic annulus size mismatch and recurrent mitral regurgitation after repair in advanced degenerative disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41320292 Summary: Recurrent mitral regurgitation remains a major limitation of mitral valve repair in patients with advanced degenerative mitral regurgitation and left ventricular enlargement. This retrospective study included 445 patients with advanced degenerative mitral regurgitation, classified as stages C two to D, who underwent mitral valve repair with restrictive annuloplasty. The investigation focused on whether a disproportion between left ventricular size and prosthetic annulus dimension predicts long-term mitral regurgitation recurrence. This research addresses a critical aspect of durable mitral valve repair outcomes and adverse left ventricular remodeling. Article 3: Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40707240 Summary: Tricuspid regurgitation is a common finding in heart failure and associates with adverse patient outcomes. This study precisely assessed sex differences in tricuspid regurgitation prevalence, etiology, and prognosis among patients with heart failure and its subgroups. Patients were enrolled with recent transthoracic echocardiography and categorized by left ventricular ejection fraction into groups with reduced and preserved ejection fraction, using a 50 percent cutoff. This research contributes to understanding sex-specific manifestations and prognostic implications of tricuspid regurgitation in heart failure patients. Article 4: Timing of anticoagulation restart after serious bleeding in atrial fibrillation. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40670148 Summary: Restarting direct oral anticoagulants after a serious bleeding event in patients with atrial fibrillation presents a significant clinical dilemma, balancing stroke prevention and recurrent bleeding risk. This study leveraged nationwide Danish registries from 2012 to 2021 to identify atrial fibrillation patients who experienced serious bleeding events. The cohort included individuals with a Congestive heart failure, Hypertension, Age seventy-five (doubled), Diabetes, Stroke (doubled), Vascular disease, Age sixty-five to seventy-four, Sex category (female) (C. H. A. two D. S. two V. A. S. c) score of two or higher. This research provides crucial data to inform the optimal timing of anticoagulation restart in these high-risk patients. Article 5: Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40645760 Summary: Myeloperoxidase, a neutrophil-derived enzyme, associates with oxidative stress and inflammation, contributing to the pathophysiology of heart failure with preserved ejection fraction. Bioactive myeloperoxidase also causes vascular dysfunction and accumulation of serum uric acid. This cross-sectional analysis of 1677 participants from the STANISLAS cohort investigated the association of plasma myeloperoxidase and serum uric acid with echocardiographic variables of impaired diastolic function in a populational setting. This research helps elucidate mechanisms and identify early biomarkers for heart failure with preserved ejection fraction development. Transcript Today’s date is February 15, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Prognostic importance of exercise electrocardiography in patients with suspected microvascular disease. Exercise electrocardiography showing ST-segment depression demonstrates a very high positive predictive value for coronary microvascular dysfunction in specific patient groups. The present study focused on chest pain patients, using myocardial perfusion single photon emission computed tomography to rule out ischemia from epicardial coronary stenosis. This approach precisely identifies patients with suspected coronary microvascular dysfunction. Such precise identification is crucial for managing this condition, which is associated with a poor prognosis. Article number two. Prosthetic annulus size mismatch and recurrent mitral regurgitation after repair in advanced degenerative disease. Recurrent mitral regurgitation remains a major limitation of mitral valve repair in patients with advanced degenerative mitral regurgitation and left ventricular enlargement. This retrospective study included 445 patients with advanced degenerative mitral regurgitation, classified as stages C two to D, who underwent mitral valve repair with restrictive annuloplasty. The investigation focused on whether a disproportion between left ventricular size and prosthetic annulus dimension predicts long-term mitral regurgitation recurrence. This research addresses a critical aspect of durable mitral valve repair outcomes and adverse left ventricular remodeling. Article number three. Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure. Tricuspid regurgitation is a common finding in heart failure and associates with adverse patient outcomes. This study precisely assessed sex differences in tricuspid regurgitation prevalence, etiology, and prognosis among patients with heart failure and its subgroups. Patients were enrolled with recent transthoracic echocardiography and categorized by left ventricular ejection fraction into groups with reduced and preserved ejection fraction, using a 50 percent cutoff. This research contributes to understanding sex-specific manifestations and prognostic implications of tricuspid regurgitation in heart failure patients. Article number four. Timing of anticoagulation restart after serious bleeding in atrial fibrillation. Restarting direct oral anticoagulants after a serious bleeding event in patients with atrial fibrillation presents a significant clinical dilemma, balancing stroke prevention and recurrent bleeding risk. This study leveraged nationwide Danish registries from 2012 to 2021 to identify atrial fibrillation patients who experienced serious bleeding events. The cohort included individuals with a Congestive heart failure, Hypertension, Age seventy-five (doubled), Diabetes, Stroke (doubled), Vascular disease, Age sixty-five to seventy-four, Sex category (female) (C. H. A. two D. S. two V. A. S. c) score of two or higher. This research provides crucial data to inform the optimal timing of anticoagulation restart in these high-risk patients. Article number five. Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals. Myeloperoxidase, a neutrophil-derived enzyme, associates with oxidative stress and inflammation, contributing to the pathophysiology of heart failure with preserved ejection fraction. Bioactive myeloperoxidase also causes vascular dysfunction and accumulation of serum uric acid. This cross-sectional analysis of 1677 participants from the STANISLAS cohort investigated the association of plasma myeloperoxidase and serum uric acid with echocardiographic variables of impaired diastolic function in a populational setting. This research helps elucidate mechanisms and identify early biomarkers for heart failure with preserved ejection fraction development. Thank you for listening. Don’t forget to subscribe. Keywords sex differences, heart failure with preserved ejection fraction, coronary microvascular dysfunction, stroke prevention, direct oral anticoagulants, mitral regurgitation, atrial fibrillation, ST-segment depression, left ventricular ejection fraction, diagnosis, anticoagulation restart, myeloperoxidase, myocardial perfusion imaging, annuloplasty, bleeding events, prosthetic annulus, diastolic dysfunction, echocardiography, m

  4. 2D AGO

    Remote Heart Failure Management Sustains Benefits 02/15/26

    Welcome to Cardiology Today – Recorded February 15, 2026. This episode summarizes 5 key cardiology studies on topics like N. L. R. P. three and lipid management. Key takeaway: Remote Heart Failure Management Sustains Benefits. Article Links: Article 1: Lipoprotein(a)-lowering therapies: a promising future. (European heart journal) Article 2: Macrophage SBK2 suppresses inflammation and atherosclerosis by NLRP3 phosphorylation. (European heart journal) Article 3: Seated Pulmonary Artery Pressure Management in Patients With Heart Failure: 12-Month Outcomes of the PROACTIVE-HF Trial. (JACC. Heart failure) Article 4: Early childhood hospital utilization and diagnoses for children born to mothers with kidney transplants: An Australian cohort study. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Airway molecular signatures in antibody mediated lung transplant rejection. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Full episode page: https://podcast.explainheart.com/podcast/remote-heart-failure-management-sustains-benefits-02-15-26/ Featured Articles Article 1: Lipoprotein(a)-lowering therapies: a promising future. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684258 Summary: This article identifies lipoprotein(a), or L. P. A., as a significant, genetically determined contributor to atherosclerotic cardiovascular disease. Elevated L. P. A. levels drive increased atherogenicity, contributing substantially to residual cardiovascular risk despite successful low-density lipoprotein cholesterol management. Affecting a large proportion of the population, L. P. A. represents a high-impact therapeutic target. Future L. P. A.-lowering therapies therefore hold considerable promise for reducing cardiovascular morbidity and mortality. Article 2: Macrophage SBK2 suppresses inflammation and atherosclerosis by NLRP3 phosphorylation. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684124 Summary: B. K. two suppresses inflammation and atherosclerosis by N. L. R. P. three phosphorylation. This study found that macrophage S. H. three domain-binding kinase two, known as S. B. K. two, actively suppresses inflammation and atherosclerosis. S. B. K. two achieves this by phosphorylating nucleotide-binding oligomerization domain-like receptor family pyrin domain containing three, or N. L. R. P. three. This specific molecular mechanism highlights S. B. K. two’s pivotal role in modulating macrophage-mediated inflammatory responses. These findings identify S. B. K. two as a significant therapeutic target for managing the progression of atherosclerosis. Article 3: Seated Pulmonary Artery Pressure Management in Patients With Heart Failure: 12-Month Outcomes of the PROACTIVE-HF Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41686133 Summary: The PROACTIVE-H. F. trial demonstrated that remote heart failure management, using seated mean pulmonary artery pressure and vital signs via the Cordella system, was safe and effective. This approach resulted in a low rate of heart failure hospitalizations and mortality, which was initially observed through 6 months. The 12-month evaluation confirmed the sustained efficacy and continued benefits of this management approach for patients with New York Heart Association class three heart failure. This method offers a valuable strategy for reducing adverse events in this high-risk patient population. Article 4: Early childhood hospital utilization and diagnoses for children born to mothers with kidney transplants: An Australian cohort study. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41690842 Summary: This Australian cohort study found that children born to mothers with kidney transplants experienced increased hospital utilization during early childhood. From 2067661 babies, 137 children of transplanted mothers were identified, experiencing 137 birth admissions and 444 subsequent admissions. The data demonstrated that these children had a higher burden of adverse health outcomes, requiring more frequent hospitalizations compared to children of mothers not exposed to kidney replacement therapy. This provides critical definition to previously undefined childhood health outcomes for this specific population. Article 5: Airway molecular signatures in antibody mediated lung transplant rejection. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41690369 Summary: This study found that specific airway inflammation gene signatures effectively distinguished antibody mediated rejection, or A. M. R., cases from controls in lung transplant recipients. The analysis of small airway brush R. N. A. sequencing from 16 A. M. R. cases and 39 controls revealed distinct gene signatures for complement activation, mechanistic target of rapamycin signaling, and natural killer cell-mediated responses. These identified molecular signatures provide novel and precise biomarkers needed for more accurate diagnosis of severe A. M. R. This advancement offers potential for improved diagnostic precision for a condition associated with chronic lung allograft dysfunction and death. Transcript Today’s date is February 15, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Lipoprotein(a)-lowering therapies: a promising future. This article identifies lipoprotein(a), or L. P. A., as a significant, genetically determined contributor to atherosclerotic cardiovascular disease. Elevated L. P. A. levels drive increased atherogenicity, contributing substantially to residual cardiovascular risk despite successful low-density lipoprotein cholesterol management. Affecting a large proportion of the population, L. P. A. represents a high-impact therapeutic target. Future L. P. A.-lowering therapies therefore hold considerable promise for reducing cardiovascular morbidity and mortality. Article number two. Macrophage S. B. K. two suppresses inflammation and atherosclerosis by N. L. R. P. three phosphorylation. This study found that macrophage S. H. three domain-binding kinase two, known as S. B. K. two, actively suppresses inflammation and atherosclerosis. S. B. K. two achieves this by phosphorylating nucleotide-binding oligomerization domain-like receptor family pyrin domain containing three, or N. L. R. P. three. This specific molecular mechanism highlights S. B. K. two’s pivotal role in modulating macrophage-mediated inflammatory responses. These findings identify S. B. K. two as a significant therapeutic target for managing the progression of atherosclerosis. Article number three. Seated Pulmonary Artery Pressure Management in Patients With Heart Failure: 12-Month Outcomes of the PROACTIVE-HF Trial. The PROACTIVE-H. F. trial demonstrated that remote heart failure management, using seated mean pulmonary artery pressure and vital signs via the Cordella system, was safe and effective. This approach resulted in a low rate of heart failure hospitalizations and mortality, which was initially observed through 6 months. The 12-month evaluation confirmed the sustained efficacy and continued benefits of this management approach for patients with New York Heart Association class three heart failure. This method offers a valuable strategy for reducing adverse events in this high-risk patient population. Article number four. Early childhood hospital utilization and diagnoses for children born to mothers with kidney transplants: An Australian cohort study. This Australian cohort study found that children born to mothers with kidney transplants experienced increased hospital utilization during early childhood. From 2067661 babies, 137 children of transplanted mothers were identified, experiencing 137 birth admissions and 444 subsequent admissions. The data demonstrated that these children had a higher burden of adverse health outcomes, requiring more frequent hospitalizations compared to children of mothers not exposed to kidney replacement therapy. This provides critical definition to previously undefined childhood health outcomes for this specific population. Article number five. Airway molecular signatures in antibody mediated lung transplant rejection. This study found that specific airway inflammation gene signatures effectively distinguished antibody mediated rejection, or A. M. R., cases from controls in lung transplant recipients. The analysis of small airway brush R. N. A. sequencing from 16 A. M. R. cases and 39 controls revealed distinct gene signatures for complement activation, mechanistic target of rapamycin signaling, and natural killer cell-mediated responses. These identified molecular signatures provide novel and precise biomarkers needed for more accurate diagnosis of severe A. M. R. This advancement offers potential for improved diagnostic precision for a condition associated with chronic lung allograft dysfunction and death. Thank you for listening. Don’t forget to subscribe. Keywords N. L. R. P. three, lipid management, lung transplant, pulmonary artery pressure, therapeutic targets, remote monitoring, Macrophage, Heart failure, atherosclerosis, biomarkers, birth outcomes, S. B. K. two, airway inflammation, inflammation, Australian cohort, PROACTIVE-H. F. trial, Kidney transplant, cardiovascular risk, Antibody mediated rejection, SH3 domain-binding kinase two, gene signatures, Lipoprotein(a), hospitalization, hospital utilization, childhood health, athe

  5. 3D AGO

    Soluble S. T. 2 Drives Fulminant Myocarditis 02/14/26

    Welcome to Cardiology Today – Recorded February 14, 2026. This episode summarizes 5 key cardiology studies on topics like C. C. R. 8 and Left Heart Dysfunction. Key takeaway: Soluble S. T. 2 Drives Fulminant Myocarditis. Article Links: Article 1: Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension. (Circulation) Article 2: CCR8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. (Circulation) Article 3: Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability. (European heart journal) Article 4: Soluble ST2 drives fulminant myocarditis progression via the IGF2R-YY1 mitochondrial axis. (European heart journal) Article 5: Air pollution before and during the COVID-19 pandemic: changes in risk of acute myocardial infarction. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/soluble-s-t-2-drives-fulminant-myocarditis-02-14-26/ Featured Articles Article 1: Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41685452 Summary: The study identified a distinct subgroup of patients within adjudicated Group 1 Pulmonary Hypertension who demonstrated an elevated pulmonary artery wedge pressure, exceeding 15 mmHg. It characterized this patient population by comparing their profiles to those with normal pulmonary artery wedge pressure and to patients with combined pre- and postcapillary pulmonary hypertension. This work establishes that not all Group 1 Pulmonary Hypertension patients present with the expected normal pulmonary artery wedge pressure, highlighting diagnostic complexities. Article 2: CCR8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41685444 Summary: C. R. 8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. This study revealed that C. C. R. 8 expression on regulatory T cells dictates their tissue adaptation trajectories within the heart following myocardial infarction. It found that these C. C. R. 8-positive regulatory T cells provide protection against myocardial infarction-induced tissue damage. The data delineated specific differentiation pathways of heart regulatory T cells in a murine model, establishing a molecular mechanism for regulatory T cell-mediated cardiac protection. Article 3: Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41685669 Summary: This study, using spatial and single-cell transcriptomics on 13 human carotid plaques, revealed a key role for fibroblast-like vascular smooth muscle cells in atherosclerotic cell crosstalk and plaque stability. It precisely mapped intercellular communication patterns within the human plaque microenvironments. The data demonstrated that these specific fibroblast-like vascular smooth muscle cells are critical mediators, identifying specific cellular interactions as potential novel targets for preventing atherosclerotic events. Article 4: Soluble ST2 drives fulminant myocarditis progression via the IGF2R-YY1 mitochondrial axis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684269 Summary: T. 2 drives fulminant myocarditis progression via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. This study demonstrated that soluble S. T. 2 drives the progression of fulminant myocarditis via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. It defined the cellular source and function of soluble S. T. 2 in a Coxsackievirus B3-induced fulminant myocarditis mouse model. The research found that markedly elevated soluble S. T. 2 directly contributes to disease pathogenesis, establishing a critical mechanistic pathway that could be targeted for treating this high-mortality inflammatory cardiomyopathy. Article 5: Air pollution before and during the COVID-19 pandemic: changes in risk of acute myocardial infarction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684267 Summary: O. V. I. D. minus 19 pandemic: changes in risk of acute myocardial infarction. This study established ambient P. M. 2.5 exposure as a known risk factor for acute myocardial infarction, distinguishing myocardial infarction with non-obstructive coronary arteries as a distinct subtype from myocardial infarction with obstructive coronary disease. It capitalized on the C. O. V. I. D. minus 19 pandemic public health measures, which altered exposure patterns, as a natural experiment. The research characterized the association between short-term P. M. 2.5 exposure and these acute myocardial infarction subtypes during this unique period, providing crucial insights into how environmental shifts can influence risk profiles. Transcript Today’s date is February 14, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension. The study identified a distinct subgroup of patients within adjudicated Group 1 Pulmonary Hypertension who demonstrated an elevated pulmonary artery wedge pressure, exceeding 15 mmHg. It characterized this patient population by comparing their profiles to those with normal pulmonary artery wedge pressure and to patients with combined pre- and postcapillary pulmonary hypertension. This work establishes that not all Group 1 Pulmonary Hypertension patients present with the expected normal pulmonary artery wedge pressure, highlighting diagnostic complexities. Article number two. C. C. R. 8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. This study revealed that C. C. R. 8 expression on regulatory T cells dictates their tissue adaptation trajectories within the heart following myocardial infarction. It found that these C. C. R. 8-positive regulatory T cells provide protection against myocardial infarction-induced tissue damage. The data delineated specific differentiation pathways of heart regulatory T cells in a murine model, establishing a molecular mechanism for regulatory T cell-mediated cardiac protection. Article number three. Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability. This study, using spatial and single-cell transcriptomics on 13 human carotid plaques, revealed a key role for fibroblast-like vascular smooth muscle cells in atherosclerotic cell crosstalk and plaque stability. It precisely mapped intercellular communication patterns within the human plaque microenvironments. The data demonstrated that these specific fibroblast-like vascular smooth muscle cells are critical mediators, identifying specific cellular interactions as potential novel targets for preventing atherosclerotic events. Article number four. Soluble S. T. 2 drives fulminant myocarditis progression via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. This study demonstrated that soluble S. T. 2 drives the progression of fulminant myocarditis via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. It defined the cellular source and function of soluble S. T. 2 in a Coxsackievirus B3-induced fulminant myocarditis mouse model. The research found that markedly elevated soluble S. T. 2 directly contributes to disease pathogenesis, establishing a critical mechanistic pathway that could be targeted for treating this high-mortality inflammatory cardiomyopathy. Article number five. Air pollution before and during the C. O. V. I. D. minus 19 pandemic: changes in risk of acute myocardial infarction. This study established ambient P. M. 2.5 exposure as a known risk factor for acute myocardial infarction, distinguishing myocardial infarction with non-obstructive coronary arteries as a distinct subtype from myocardial infarction with obstructive coronary disease. It capitalized on the C. O. V. I. D. minus 19 pandemic public health measures, which altered exposure patterns, as a natural experiment. The research characterized the association between short-term P. M. 2.5 exposure and these acute myocardial infarction subtypes during this unique period, providing crucial insights into how environmental shifts can influence risk profiles. Thank you for listening. Don’t forget to subscribe. Keywords C. C. R. 8, Left Heart Dysfunction, P. M. 2.5, C. O. V. I. D. minus 19, Coxsackievirus B3, Spatial Transcriptomics, I. G. F. 2. R. minus Y. Y. 1 Axis, Air Pollution, Cell Crosstalk, Atherosclerotic Plaques, Myocardial Infarction, Cardiac Protection, Fibroblast-like Vascular Smooth Muscle Cells, Pulmonary Artery Wedge Pressure, Fulminant Myocarditis, Acute Myocardial Infarction, Tissue Damage, Plaque Stability, Pulmonary Hypertension, Group 1 Pulmonary Hypertension, Regulatory T Cells, Inflammatory Cardiomyopathy, Precapillary Hypertension, Soluble S. T. 2, Myocardial Infarction with Non-obstructive Coronary Arteries. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Soluble S. T. 2 Drives Fulminant Myocarditis 02/14/26 first appeared on Cardiology Today.

  6. 4D AGO

    AF: The 25% Diabetes Complication You Miss 02/13/26

    Welcome to Cardiology Today – Recorded February 13, 2026. This episode summarizes 5 key cardiology studies on topics like obesity and body mass index. Key takeaway: AF: The 25% Diabetes Complication You Miss. Article Links: Article 1: Second- and Third-Generation BCR-ABL Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. (Circulation) Article 2: Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. (Circulation) Article 3: Atrial fibrillation: an underappreciated complication of diabetes. (European heart journal) Article 4: Left Atrial Volumetric Enlargement in Heart Failure With Reduced Ejection Fraction: Obligatory Consequence or Independent Predictor of Outcome? (JACC. Heart failure) Article 5: Progression From Exercise-Induced to Resting Left Atrial Hypertension in HFpEF: Impact of Reduced Atriopulmonary Compliance. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/af-the-25-diabetes-complication-you-miss-02-13-26/ Featured Articles Article 1: Second- and Third-Generation BCR-ABL Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41674449 Summary: C. R. A. B. L. Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. An increasing link between B. C. R. A. B. L. tyrosine kinase inhibitors and pulmonary arterial hypertension has been recognized since 2009. This study precisely evaluated the risk of pulmonary arterial hypertension associated with second- and third-generation inhibitors compared to imatinib in adults. Utilizing the French national health care database, researchers established a robust prevalent new-user design which identified patient cohorts initiating these treatments between 2008 and 2024. The investigation offered a critical framework to quantify this potential adverse event for clinical practice. Article 2: Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41674444 Summary: Obesity is a confirmed risk factor for cardiovascular disease, with specific relationships across the full spectrum of body mass index, including severe obesity, requiring further characterization. The Cross-Cohort Collaboration definitively described the prospective associations of obesity and its severity with nine specific cardiovascular outcomes. This comprehensive analysis included 289875 participants, comprising 79 point 2 percent women, from 21 distinct cohorts enrolled between 1948 and 2017. The study provides an extensive dataset essential for understanding long-term cardiovascular disease risks across various obesity classes. Article 3: Atrial fibrillation: an underappreciated complication of diabetes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41668366 Summary: Atrial fibrillation is identified as a significant complication of diabetes, demonstrating a prevalence of up to 25 percent in individuals with the condition. The incidence rates of atrial fibrillation are increasing among patients with diabetes. This development of atrial fibrillation in diabetic individuals occurs independently of other risk factors such as hypertension, atherosclerotic cardiovascular disease, or heart failure. The pathogenesis involves multifactorial atrial structural, electrical, and autonomic remodeling directly linked to diabetes. Article 4: Left Atrial Volumetric Enlargement in Heart Failure With Reduced Ejection Fraction: Obligatory Consequence or Independent Predictor of Outcome? Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41677478 Summary: This study definitively investigated the independent association between left atrial volume index and long-term mortality in patients with heart failure. The research specifically considered its interaction with the severity of functional mitral regurgitation, establishing a crucial assessment framework for this relationship. The investigation provided a comprehensive approach to understanding the prognostic implications of left atrial volume index in this patient population. Article 5: Progression From Exercise-Induced to Resting Left Atrial Hypertension in HFpEF: Impact of Reduced Atriopulmonary Compliance. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41677477 Summary: F. pEF: Impact of Reduced Atriopulmonary Compliance. Approximately one-third of patients with heart failure with preserved ejection fraction demonstrate normal resting pulmonary capillary wedge pressure, yet experience left atrial hypertension exclusively during exercise. This study thoroughly investigated the clinical course of these patients presenting with exercise-induced left atrial hypertension. The research explored whether this condition represents a distinct heart failure with preserved ejection fraction phenotype or an earlier stage that progresses to resting left atrial hypertension over time. This investigation provided critical insights into the natural history and progression of left atrial hypertension in heart failure with preserved ejection fraction. Transcript Today’s date is February 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Second- and Third-Generation B. C. R. A. B. L. Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. An increasing link between B. C. R. A. B. L. tyrosine kinase inhibitors and pulmonary arterial hypertension has been recognized since 2009. This study precisely evaluated the risk of pulmonary arterial hypertension associated with second- and third-generation inhibitors compared to imatinib in adults. Utilizing the French national health care database, researchers established a robust prevalent new-user design which identified patient cohorts initiating these treatments between 2008 and 2024. The investigation offered a critical framework to quantify this potential adverse event for clinical practice. Article number two. Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. Obesity is a confirmed risk factor for cardiovascular disease, with specific relationships across the full spectrum of body mass index, including severe obesity, requiring further characterization. The Cross-Cohort Collaboration definitively described the prospective associations of obesity and its severity with nine specific cardiovascular outcomes. This comprehensive analysis included 289875 participants, comprising 79 point 2 percent women, from 21 distinct cohorts enrolled between 1948 and 2017. The study provides an extensive dataset essential for understanding long-term cardiovascular disease risks across various obesity classes. Article number three. Atrial fibrillation: an underappreciated complication of diabetes. Atrial fibrillation is identified as a significant complication of diabetes, demonstrating a prevalence of up to 25 percent in individuals with the condition. The incidence rates of atrial fibrillation are increasing among patients with diabetes. This development of atrial fibrillation in diabetic individuals occurs independently of other risk factors such as hypertension, atherosclerotic cardiovascular disease, or heart failure. The pathogenesis involves multifactorial atrial structural, electrical, and autonomic remodeling directly linked to diabetes. Article number four. Left Atrial Volumetric Enlargement in Heart Failure With Reduced Ejection Fraction: Obligatory Consequence or Independent Predictor of Outcome? Left atrial remodeling, specifically progressive enlargement, is a common observation in heart failure with reduced ejection fraction and reflects left ventricular dysfunction and functional mitral regurgitation. This study definitively investigated the independent association between left atrial volume index and long-term mortality in patients with heart failure. The research specifically considered its interaction with the severity of functional mitral regurgitation, establishing a crucial assessment framework for this relationship. The investigation provided a comprehensive approach to understanding the prognostic implications of left atrial volume index in this patient population. Article number five. Progression From Exercise-Induced to Resting Left Atrial Hypertension in H. F. pEF: Impact of Reduced Atriopulmonary Compliance. Approximately one-third of patients with heart failure with preserved ejection fraction demonstrate normal resting pulmonary capillary wedge pressure, yet experience left atrial hypertension exclusively during exercise. This study thoroughly investigated the clinical course of these patients presenting with exercise-induced left atrial hypertension. The research explored whether this condition represents a distinct heart failure with preserved ejection fraction phenotype or an earlier stage that progresses to resting left atrial hypertension over time. This investigation provided critical insights into the natural history and progression of left atrial hypertension in heart failure with preserved ejection fraction. Thank you for listening. Don’t forget to subscribe. Keywords obesity, body mass index, cardiovascular disease, imatinib, functional mitral regurgitation, pathogenesis, resting left atrial hypertension, long-term mortality, heart failure with reduced ejection fraction, atriopulmonary compliance, severe obesity, prognostic significance, exercise-induced left atrial hypertension, pulmonary capillary wedge pressure, prevalence, incidence, diabetes, drug adverse events, atrial fibrillation, d

  7. 5D AGO

    Acoramidis Reduces ATTR-CM Mortality & Hospitalization. 02/12/26

    Welcome to Cardiology Today – Recorded February 12, 2026. This episode summarizes 5 key cardiology studies on topics like transthyretin silencers and macrophage PRMT9. Key takeaway: Acoramidis Reduces ATTR-CM Mortality & Hospitalization.. Article Links: Article 1: Sirolimus-Eluting Iron Bioresorbable Scaffolds vs Everolimus-Eluting Stents for Percutaneous Coronary Intervention: A Randomized Trial (IRONMAN II). (Journal of the American College of Cardiology) Article 2: Myocardial Amyloid Burden in Transthyretin Amyloidosis. (Journal of the American College of Cardiology) Article 3: Timing of Mortality Benefit in Outcomes Trials in Transthyretin Amyloidosis. (Journal of the American College of Cardiology) Article 4: Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis From ATTRibute-CM. (Journal of the American College of Cardiology) Article 5: Macrophage PRMT9 Ameliorates Acute Myocardial Infarction by Promoting Symmetric Dimethylation and Degradation of STAT1. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/acoramidis-reduces-attr-cm-mortality-hospitalization-02-12-26/ Featured Articles Article 1: Sirolimus-Eluting Iron Bioresorbable Scaffolds vs Everolimus-Eluting Stents for Percutaneous Coronary Intervention: A Randomized Trial (IRONMAN II). Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41670556 Summary: The novel thin-strut sirolimus-eluting iron bioresorbable scaffold demonstrated safety and efficacy in a prior nonrandomized first-in-human study. The IRONMAN-II trial, a prospective multicenter randomized study, directly compared this bioresorbable scaffold with contemporary metallic cobalt chromium everolimus-eluting stents. This head-to-head comparison addressed the clinical need for advanced percutaneous coronary intervention devices in patients with coronary artery disease. Article 2: Myocardial Amyloid Burden in Transthyretin Amyloidosis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41369616 Summary: Cardiovascular magnetic resonance extracellular volume reflects myocardial amyloid, establishing its role as a quantitative measure. This characteristic means it provides a framework for disease staging and therapeutic planning in transthyretin amyloidosis. The study confirmed the utility of defining calibrated thresholds and evaluating the diagnostic and prognostic value of this noninvasive measure. Article 3: Timing of Mortality Benefit in Outcomes Trials in Transthyretin Amyloidosis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41225306 Summary: Therapies for transthyretin amyloidosis with cardiomyopathy, including transthyretin stabilizers and silencers, demonstrated a clear mortality benefit in three previous randomized trials. The current study rigorously evaluated the time course of this mortality benefit, which had often appeared delayed. Understanding this precise time course provides critical information for optimizing clinical use and guiding future trial design. Article 4: Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis From ATTRibute-CM. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41143759 Summary: Acoramidis, an approved oral therapy for transthyretin amyloid cardiomyopathy, achieves early and near-complete (90 percent) transthyretin stabilization. In the phase three ATTRibute-CM study, acoramidis significantly reduced the composite endpoint of all-cause mortality or first cardiovascular-related hospitalization. This finding demonstrates acoramidis’s effectiveness in improving recurrent and cumulative outcomes for patients with transthyretin amyloid cardiomyopathy. Article 5: Macrophage PRMT9 Ameliorates Acute Myocardial Infarction by Promoting Symmetric Dimethylation and Degradation of STAT1. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41669821 Summary: Macrophage PRMT9 ameliorates acute myocardial infarction by promoting symmetric dimethylation and degradation of STAT1 protein. This mechanism directly modulates M1-like macrophages, which are known to exacerbate myocardial injury through excessive secretion of inflammatory cytokines during myocardial infarction. The finding establishes PRMT9 as a novel and specific therapeutic target for acute myocardial infarction. Transcript Today’s date is February 12, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Sirolimus-Eluting Iron Bioresorbable Scaffolds vs Everolimus-Eluting Stents for Percutaneous Coronary Intervention: A Randomized Trial (IRONMAN II). The novel thin-strut sirolimus-eluting iron bioresorbable scaffold demonstrated safety and efficacy in a prior nonrandomized first-in-human study. The IRONMAN-II trial, a prospective multicenter randomized study, directly compared this bioresorbable scaffold with contemporary metallic cobalt chromium everolimus-eluting stents. This head-to-head comparison addressed the clinical need for advanced percutaneous coronary intervention devices in patients with coronary artery disease. Article number two. Myocardial Amyloid Burden in Transthyretin Amyloidosis. Cardiovascular magnetic resonance extracellular volume reflects myocardial amyloid, establishing its role as a quantitative measure. This characteristic means it provides a framework for disease staging and therapeutic planning in transthyretin amyloidosis. The study confirmed the utility of defining calibrated thresholds and evaluating the diagnostic and prognostic value of this noninvasive measure. Article number three. Timing of Mortality Benefit in Outcomes Trials in Transthyretin Amyloidosis. Therapies for transthyretin amyloidosis with cardiomyopathy, including transthyretin stabilizers and silencers, demonstrated a clear mortality benefit in three previous randomized trials. The current study rigorously evaluated the time course of this mortality benefit, which had often appeared delayed. Understanding this precise time course provides critical information for optimizing clinical use and guiding future trial design. Article number four. Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis From ATTRibute-CM. Acoramidis, an approved oral therapy for transthyretin amyloid cardiomyopathy, achieves early and near-complete (90 percent) transthyretin stabilization. In the phase three ATTRibute-CM study, acoramidis significantly reduced the composite endpoint of all-cause mortality or first cardiovascular-related hospitalization. This finding demonstrates acoramidis’s effectiveness in improving recurrent and cumulative outcomes for patients with transthyretin amyloid cardiomyopathy. Article number five. Macrophage PRMT9 Ameliorates Acute Myocardial Infarction by Promoting Symmetric Dimethylation and Degradation of STAT1. Macrophage PRMT9 ameliorates acute myocardial infarction by promoting symmetric dimethylation and degradation of STAT1 protein. This mechanism directly modulates M1-like macrophages, which are known to exacerbate myocardial injury through excessive secretion of inflammatory cytokines during myocardial infarction. The finding establishes PRMT9 as a novel and specific therapeutic target for acute myocardial infarction. Thank you for listening. Don’t forget to subscribe. Keywords transthyretin silencers, macrophage PRMT9, percutaneous coronary intervention, cardiovascular outcomes, M1-like macrophages, transthyretin amyloidosis, time-varying treatment effects, myocardial amyloid burden, transthyretin amyloidosis with cardiomyopathy, transthyretin stabilizers, coronary artery disease, everolimus-eluting stent, IRONMAN two trial, sirolimus-eluting iron bioresorbable scaffold, diagnostic value, symmetric dimethylation, all-cause mortality, transthyretin amyloid cardiomyopathy, cardiovascular magnetic resonance, TTR stabilization, extracellular volume, STAT1 degradation, acoramidis, acute myocardial infarction, mortality benefit. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Acoramidis Reduces ATTR-CM Mortality & Hospitalization. 02/12/26 first appeared on Cardiology Today.

  8. 6D AGO

    AF Rate Control: Evidence Gap Identified 02/11/26

    Welcome to Cardiology Today – Recorded February 11, 2026. This episode summarizes 5 key cardiology studies on topics like qualitative research and heart failure. Key takeaway: AF Rate Control: Evidence Gap Identified. Article Links: Article 1: Changes in Haemodynamics, Cardiac Energetics, and Cell Signalling Pathways Induced by VA-ECMO with or without Left Ventricular Active Unloading. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Heart rate in early rhythm control therapy in patients with atrial fibrillation. (Heart (British Cardiac Society)) Article 3: From Representation to Reform: A Qualitative Study of Gender Equity in Interventional Cardiology. (The American journal of cardiology) Article 4: Comprehensive Assessment of Left Ventricular Function and Exercise Endurance in Patients with Hypertrophic Cardiomyopathy: The Combined Application of Left Ventricular Pressure-Strain Loop and Cardiopulmonary Exercise Testing. (Cardiology) Article 5: Peripheral Perfusion Index as a Marker of Hypoperfusion in Heart Failure. (Cardiology) Full episode page: https://podcast.explainheart.com/podcast/af-rate-control-evidence-gap-identified-02-11-26/ Featured Articles Article 1: Changes in Haemodynamics, Cardiac Energetics, and Cell Signalling Pathways Induced by VA-ECMO with or without Left Ventricular Active Unloading. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41667045 Summary: A.-E. C. M. O. with or without Left Ventricular Active Unloading. Veno-arterial extracorporeal membrane oxygenation (V. A.-E. C. M. O.), commonly used in refractory cardiogenic shock, is known to exacerbate left ventricular loading conditions and impair cardiac energetics. Adjunctive left ventricular unloading strategies are frequently combined with V. A.-E. C. M. O. to counteract these negative effects. These strategies, including intra-aortic balloon pump (I. A. B. P.) or Impella, aim to enhance myocardial recovery through activation of cardioprotective pathways. This approach directly addresses the recognized myocardial strain induced by V. A.-E. C. M. O. Article 2: Heart rate in early rhythm control therapy in patients with atrial fibrillation. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41663267 Summary: Current clinical recommendations advise preventing high heart rates in atrial fibrillation (A. F.) to reduce A. F.-related symptoms and morbidity. However, robust evidence demonstrating a strong relationship between lower heart rate during A. F. and a reduction in symptoms or cardiovascular complications is notably lacking. This analysis specifically compared patient symptoms, treatment strategies, and a composite endpoint of cardiovascular death, stroke, or hospitalization with worsening heart failure. It highlighted an ongoing clinical gap regarding optimal heart rate targets in early rhythm control therapy. Article 3: From Representation to Reform: A Qualitative Study of Gender Equity in Interventional Cardiology. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41666966 Summary: Women represent fewer than five percent of practicing interventional cardiologists in the United States. The W. E. C. A. R. E. study, through semi-structured interviews with 18 women interventional cardiology attendings and fellows, identified five major themes. These themes comprehensively characterize the unique career experiences, challenges, and support systems for women within the interventional cardiology subspecialty. This qualitative research provides specific insights into gender equity dynamics and potential areas for reform in the field. Article 4: Comprehensive Assessment of Left Ventricular Function and Exercise Endurance in Patients with Hypertrophic Cardiomyopathy: The Combined Application of Left Ventricular Pressure-Strain Loop and Cardiopulmonary Exercise Testing. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41662326 Summary: The study utilized a comprehensive approach to assess left ventricular function and exercise endurance in 55 patients with non-obstructive hypertrophic cardiomyopathy. This assessment combined left ventricular pressure-strain loop and cardiopulmonary exercise testing. Researchers explored correlations between maximum left ventricular wall thickness and various clinical, echocardiographic, and cardiopulmonary exercise testing parameters. This methodological integration provides a thorough evaluation framework for hypertrophic cardiomyopathy patients. Article 5: Peripheral Perfusion Index as a Marker of Hypoperfusion in Heart Failure. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41662304 Summary: Current heart failure guidelines advocate for hemodynamic assessment based on four clinical profiles: dry-warm, wet-warm, dry-cold, and wet-cold. However, evaluation of perfusion status often receives less attention due to a recognized absence of simple and reliable physical indicators. This study focused on the perfusion index, a noninvasive parameter derived from the ratio of pulsatile to non-pulsatile blood flow, as a potential marker for detecting hypoperfusion in heart failure patients. It addressed a crucial diagnostic gap in routine clinical assessment. Transcript Today’s date is February 11, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Changes in Haemodynamics, Cardiac Energetics, and Cell Signalling Pathways Induced by V. A.-E. C. M. O. with or without Left Ventricular Active Unloading. Veno-arterial extracorporeal membrane oxygenation (V. A.-E. C. M. O.), commonly used in refractory cardiogenic shock, is known to exacerbate left ventricular loading conditions and impair cardiac energetics. Adjunctive left ventricular unloading strategies are frequently combined with V. A.-E. C. M. O. to counteract these negative effects. These strategies, including intra-aortic balloon pump (I. A. B. P.) or Impella, aim to enhance myocardial recovery through activation of cardioprotective pathways. This approach directly addresses the recognized myocardial strain induced by V. A.-E. C. M. O. Article number two. Heart rate in early rhythm control therapy in patients with atrial fibrillation. Current clinical recommendations advise preventing high heart rates in atrial fibrillation (A. F.) to reduce A. F.-related symptoms and morbidity. However, robust evidence demonstrating a strong relationship between lower heart rate during A. F. and a reduction in symptoms or cardiovascular complications is notably lacking. This analysis specifically compared patient symptoms, treatment strategies, and a composite endpoint of cardiovascular death, stroke, or hospitalization with worsening heart failure. It highlighted an ongoing clinical gap regarding optimal heart rate targets in early rhythm control therapy. Article number three. From Representation to Reform: A Qualitative Study of Gender Equity in Interventional Cardiology. Women represent fewer than five percent of practicing interventional cardiologists in the United States. The W. E. C. A. R. E. study, through semi-structured interviews with 18 women interventional cardiology attendings and fellows, identified five major themes. These themes comprehensively characterize the unique career experiences, challenges, and support systems for women within the interventional cardiology subspecialty. This qualitative research provides specific insights into gender equity dynamics and potential areas for reform in the field. Article number four. Comprehensive Assessment of Left Ventricular Function and Exercise Endurance in Patients with Hypertrophic Cardiomyopathy: The Combined Application of Left Ventricular Pressure-Strain Loop and Cardiopulmonary Exercise Testing. The study utilized a comprehensive approach to assess left ventricular function and exercise endurance in 55 patients with non-obstructive hypertrophic cardiomyopathy. This assessment combined left ventricular pressure-strain loop and cardiopulmonary exercise testing. Researchers explored correlations between maximum left ventricular wall thickness and various clinical, echocardiographic, and cardiopulmonary exercise testing parameters. This methodological integration provides a thorough evaluation framework for hypertrophic cardiomyopathy patients. Article number five. Peripheral Perfusion Index as a Marker of Hypoperfusion in Heart Failure. Current heart failure guidelines advocate for hemodynamic assessment based on four clinical profiles: dry-warm, wet-warm, dry-cold, and wet-cold. However, evaluation of perfusion status often receives less attention due to a recognized absence of simple and reliable physical indicators. This study focused on the perfusion index, a noninvasive parameter derived from the ratio of pulsatile to non-pulsatile blood flow, as a potential marker for detecting hypoperfusion in heart failure patients. It addressed a crucial diagnostic gap in routine clinical assessment. Thank you for listening. Don’t forget to subscribe. Keywords qualitative research, heart failure, hypoperfusion, left ventricular unloading, veno-arterial extracorporeal membrane oxygenation, heart rate control, hemodynamic assessment, left ventricular function, perfusion index, gender equity, women in medicine, intra-aortic balloon pump, exercise endurance, cardiogenic shock, rhythm control, stroke prevention, pressure-strain loop, career challenges, Impella, diagnostic markers, atrial fibrillation, hypertrophic cardiomyopathy, interventional cardiology, cardiopulmonary exercise testing, cardiovascular complications. About Concise summaries of cardiovascular research for professionals. Subscribe • S

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Stay current with cardiovascular medicine without the time commitment. Every morning, we deliver concise audio summaries of the latest original research from top cardiology journals. Top 5 breakthrough studies briefed in under 5 minutes (perfect for your commute or between patients). PubMed links included for full articles. Perfect for cardiologists, cardiothoracic surgeons, cardiac nurses, researchers, and healthcare workers who need to stay informed but lack time to scan multiple journals daily. For educational and reference purposes only. Not intended as medical advice.

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    Deconstructed Cardiology
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    2025 - 2026
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    © 2025 Deconstructed Cardiology LLC
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