The Silicon Fox Podcast

Mitchell Leshchiner

The Silicon Fox Podcast covers a range of topics related to biomarkers and health optimization, as well as interviews with entrepreneurs and scientists working on cutting edge technology in health tech and beyond. The host Mitchell Leshchiner is an entrepreneur, ex-pro athlete, and longevity enthusiast. He is a 2x founder currently working on an electrolyte tracking startup, Electrokare. Mitchell played soccer in the French 4th division and continues to follow his passion for science-based approaches to maximize performance and holistic health.

  1. May 31

    Breathing: The New Biomarker. The hidden link between environment, inflammation, and longevity.

    Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → https://www.livemomentous.com/ In this episode of The Silicon Fox Podcast, we sit down with the team at Climatic to ask why lungs, the only internal organ directly exposed to the outside world, have been left out of the wellness conversation entirely. We discuss what's actually happening inside the airways with every breath, why mucociliary clearance is the most important defense system nobody's heard of. We get into why VO2 max keeps showing up as one of the strongest predictors of lifespan, how compromised oxygenation drives cascades through the cardiovascular and immune systems, and why "go see a pulmonologist" remains the only lung health intervention most people can name. We also dig into what a proactive lung health routine could actually look like, and whether respiratory wellness is positioned to become the next gut health, a daily consumer category rather than a reactive medical one. A rigorous, evidence-first conversation about the organ system the wellness industry forgot.

  2. May 31

    Killing Cancer At The Source w/ Dr. Jeff Liu

    Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs In this episode of The Silicon Fox Podcast, we sit down with Jeff of FinalDose to ask whether sixty years of drug discovery has been working at the wrong layer entirely, chasing proteins when disease actually begins in the DNA. We get into the undruggable 85%: the vast majority of disease drivers that have no targetable protein, and why that left most of medicine off-limits. We dig into whether protein-first was ever a scientific conviction or just an artifact of the tools and incentives that happened to exist. We unpack the "terminus layer", what a clean way to kill a diseased cell actually looks like versus the messy mechanisms therapies rely on today, and the harder problem of a molecule that reads DNA inside a living cell and decides, on the spot, whether that cell is diseased. If one platform really does unlock most of the currently undruggable targets, what happens to the $2.6B-per-drug, ten-year model, and does the category of "cancer" eventually dissolve into something else entirely? A rigorous, first-principles conversation about whether we've been treating disease one layer too late.

  3. May 31

    You Shouldn't Optimize Alone with/ Justin Hibbert

    Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs In this episode of The Silicon Fox Podcast, we sit down with Justin, founder of Everhaus, who spent his 20s as the lead host at Hakkasan selling people the best night of their life, and then walked away to build a longevity club. We get into the personal 180: what people were actually buying in nightlife, the moment that whole world stopped working for him, and whether nightlife and longevity are really opposites or two expressions of the same underlying skill. We dig into the "indulgence operating system", what a decade reading rooms taught him about human behavior that the wellness world doesn't grasp, why people chase the indulgent version even when they know better, and whether the shift toward performance and longevity is a real cultural movement or a rich-person trend with good PR. We get into his case that discipline is a skill rather than a personality trait, the habits he got completely wrong at first, the most overrated rituals in wellness, and where the industry straight-up lies to people. And we push on the thesis underneath Everhaus: that you can't out-discipline your environment, that removing friction beats willpower, and whether a private club is a genuine cultural shift or just nightlife's social pull wearing a healthy coat of paint. Then the bet itself: why build this in Las Vegas rather than Miami or Austin where the market's already proven, whether cultural change comes from the resorts or the residents, and what a Vegas native wants his city to become for the kids growing up there now. A candid conversation about indulgence, discipline, and whether you can re-engineer a city built to break your willpower.

  4. Apr 26

    AI Biology Revolution: AI drug discovery, de novo proteins, and the future of therapeutics

    Sponsors: Go to https://amp.ai/go for the most convenient, sleek, and high-quality at home gym experience Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → https://www.livemomentous.com/ In this episode of The Silicon Fox Podcast, we sit down with Dr. Ori Zelichov, physician, synthetic biologist, co-founder of a CRISPR cancer therapy company as a med student, and now Co-Founder, President, and CMO of ZipBio. Drug development still takes 10–15 years and $2B+ per molecule. Ori breaks down what's broken in that pipeline, what most AI drug discovery companies get wrong, and why compressing proteins rather than designing them from scratch changes the math. We go deep on spatial biology, what AI sees in cancer tissue that human pathologists can't, and trace the full arc from Ori's original CRISPR insight as a student to watching that work reach real patients in pivotal trials a decade later. A conversation about what happens when software logic meets drug design and what the pipeline looks like if this technology actually matures.

  5. Apr 26

    Next Generation Medicine: Personalized care, AI, and the end of algorithmic medicine w/ Dr. Anant

    Sponsors: Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → https://www.livemomentous.com/ In this episode of The Silicon Fox Podcast, we sit down with Dr. Anant Vinjamoori, Stanford-trained biologist, Harvard MD/MBA, former product lead at Virta Health ($3B), and Chief Longevity Officer at Superpower, to ask why modern medicine still isn't designed to keep people well. We discuss what longevity medicine actually is beyond the hype, why primary care is structurally broken, what the next generation of biomarkers makes possible, and what it takes to build real clinical products in a system resistant to change. A sharp, no-hype conversation about rebuilding medicine from the cell up.

  6. Apr 26

    Qore Performance: How managing body temp impacts endurance, cognition, and output w/Justin Li

    Sponsors: Check out the Qore Performance × Electrokare partnership and get your bundle now → https://www.electrokare.com Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → https://www.livemomentous.com/ In this episode of The Silicon Fox Podcast, we sit down with Justin Li, CEO of Qore Performance, to ask why thermoregulation, the single biggest limiter of human performance, is still an afterthought for most athletes and operators. We discuss why core body temperature dictates everything from endurance to decision-making, what dehydration is actually doing to your blood volume and cognitive output, and how Qore is building cooling and hydration systems trusted by special operations forces and elite endurance athletes. We also get into why managing heat is the most overlooked variable in the wearable and performance optimization space. A direct, gear-tested conversation about the physiology most people ignore until it shuts them down.

  7. Apr 26

    The Drivers of Aging: Cellular damage, chronic inflammation, and why modern life is accelerating it

    Sponsors: Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → https://www.livemomentous.com/ In this episode of The Silicon Fox Podcast, we sit down with Matthew Craine of Semaine Health to ask why aging, the single biggest driver of chronic disease, is still treated as an inevitability instead of a measurable, modifiable process. We discuss what's actually happening inside a cell as it ages, why chromatin deterioration and DNA damage may be more cause than symptom, and how chronic inflammation turns cellular wear into systemic disease. We get into why two people born the same year can be biologically decades apart, and which lifestyle interventions actually hold up at the cellular level versus which ones are wishful thinking. A rigorous, evidence-first conversation about the organ system medicine has been content to let decay.

  8. Apr 26

    The Toilet As a Health Device: The next wave of health is continuous and preventative

    Sponsors: Use code "siliconfox20" for 20% off your first SiPhox Health test → https://siphoxhealth.com/programs Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → https://www.livemomentous.com/ In this episode of The Silicon Fox Podcast, we sit down with Scott Hickle to ask why gut health, the system linked to everything from immunity to cancer to mental health, is still almost completely unmonitored. We discuss why 70 million Americans have digestive diseases and nobody treats it like a crisis, what ultra-processed food is actually doing to the microbiome and why colon cancer is now the leading cause of cancer death in men under 50. We also get into why gut health is the biggest gap in the wearable and continuous monitoring revolution. A direct, evidence-first conversation about the organ system medicine forgot to measure.

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5
out of 5
6 Ratings

About

The Silicon Fox Podcast covers a range of topics related to biomarkers and health optimization, as well as interviews with entrepreneurs and scientists working on cutting edge technology in health tech and beyond. The host Mitchell Leshchiner is an entrepreneur, ex-pro athlete, and longevity enthusiast. He is a 2x founder currently working on an electrolyte tracking startup, Electrokare. Mitchell played soccer in the French 4th division and continues to follow his passion for science-based approaches to maximize performance and holistic health.

Information

  • Creator
    Mitchell Leshchiner
  • Years Active
    2025 - 2026
  • Episodes
    47