Signal and Symptoms Podcast

Harvey Castro MD, Junaid Kalia MD, & Edward Marx
  • 5.0 (2)
  • BUSINESS NEWS

Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions affect patient care, getting it right isn't optional.

  1. 3D AGO

    Why Healthcare AI Startups Fail—Microsoft Global Health Leader Reveals the Fix

    Why do brilliant healthcare products fail before they ever reach patients? Sally Ann Frank, who leads Microsoft's worldwide strategy for health startups, exposes the fatal mistake and her proven protocol to avoid it. In this episode, Sally Ann Frank, Global Lead for Health & Life Sciences at Microsoft for startups, breaks down her proven Startup Protocol framework to achieve healthcare AI startup success in an agentic AI era. Drawing from her work with hundreds of early-stage companies, Sally emphasizes the critical mistake first-time founders make: investing all their energy in building a great product without doing customer discovery to prove anyone will actually pay for it. As AI agents transform healthcare delivery, she argues the conversation must shift from talking about AI capabilities to obsessively documenting the tangible value it creates—whether that's saving clinician time, improving patient outcomes, or streamlining administrative workflows. This episode provides Sally's tactical playbook for documenting value so convincingly that doing nothing becomes your customer's riskiest choice. From ideation to scale, her framework delivers the strategic clarity founders need to transform breakthrough ideas into fundable, sustainable businesses. What You Will Discover: - Sally Ann Frank: Her Mission In Action - Why Startups Fail Before Launch - How to Document End-User Value in Agentic AI era - Who Validates Value Before Scaling - The Unicorn Protocol - The No Free Pilots Rule - The Founder Mindset that Wins - Your Biggest Competitor: Customers Doing Nothing - A No Is Never Final Referenced in the show: 🖇️ "The Start Up Protocol: A Guide for Digital Health Startups to Bypass Pitfalls and Adopt Strategies That Work" by Sally Ann Frank – https://www.amazon.com/Startup-Protocol-Startups-Pitfalls-Strategies/dp/103263944X/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1699382769&sr=8-8 🖇️ “The Unicorn Protocol: Digital Health Unicorns, How They Got There and What You Can Learn From Them” – https://www.amazon.com/Unicorn-Protocol-Digital-Health-Unicorns/dp/1032711019/?_encoding=UTF8&pd_rd_w=G2PgE&content-id=amzn1.sym.0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_p=0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_r=135-3915937-9293427&pd_rd_wg=HIDM6&pd_rd_r=dfd48b8a-14cb-42ef-98fc-b91d305d282c&ref_=aufs_ap_sc_dsk Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - a...

    20 min

  2. FEB 10

    Why Only Doctors Can Fix What's Broken

    Healthcare is at a critical crossroads where clinicians are increasingly sidelined by administrative weight and third-party interests. The path forward isn't just surviving a broken system—it’s reclaiming our roles as primary stakeholders and system architects through a unified, "Doctor-to-Doctor" movement. Joining us to lead this conversation is Dr. Kianor Shah, a Southern California-based oral surgeon with 20 years of clinical experience and founder of the Global Summit Institute. Dr. Shah argues that the integration of medicine and dentistry is the next frontier of patient care, with AI serving as the "divine tool" to bridge these historical silos. By leveraging predictive analysis and peer-to-peer collaboration, we can move beyond the administrative burdens that cause burnout and return our focus to clinical excellence. This mission culminates in the 2026 Global Medical Dental AI Summit in London, a landmark effort to set rigorous, doctor-led standards for AI implementation. Together, we explore how transitioning from a service-provider mindset to a stakeholder mindset allows us to get around industry challenges and restore the oral-systemic health connection. What You Will Discover: - On Building the Doctor-to-Doctor movement - The Entrepreneurial Mindset - Bridging the Medical-Dental Gap - 2026 Global Medical Dental AI Summit - The Strategic Formula (0.5%) for Healthcare Transformation - Does a 3-5 Year Timeline Matter for Physician Leadership? - AI as the Unifying Catalyst, Not the End Goal About the Conference: 2026 Global Medical Dental AI Summit 📍 Leonardo Royale Hotel, London Tower Bridge 📅 May 14-16, 2026 🎤 100+ speakers | 3 tracks (Medical, Dental, Business) | 700 attendees Exclusive offer for Signals & Symptoms listeners: Use the discount code VIP20 for a special offer 🔗 https://top100doc.com/london/ Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest: Kianor Shah DMD, MBS, Founder, Global Summits Institute 💼LinkedIn - a href="https://www.linkedin.com/in/kianorshah/" rel="noopener noreferrer"...

    18 min

  3. FEB 3

    What FDA's Step Back Means in Building Credibility

    The FDA stepped back. Now, organizational governance is the only thing standing between innovation and liability. At CES 2026, the FDA officially announced it won't regulate wellness devices or Clinical Decision Support tools—removing approval bottlenecks and accelerating innovation. But this regulatory shift transfers responsibility to healthcare organizations themselves. Who builds the frameworks for data management when there's no FDA requirement? How do health systems justify physician time reviewing continuous patient streams without reimbursement pathways? And where does liability fall in this new landscape? In this episode, Dr. Junaid and Ed tackle the AI governance vacuum, exploring how healthcare AI agents can scale care, from filtering patient data to managing population health. They share J.P. Morgan Healthcare Conference updates on why organizational trust, rather than just regulatory stamps, is the key to successful AI in healthcare. What You Will Discover: - What changed in the regulatory landscape? - How the shift affects clinician workflows - Who should pay for clinical data platforms? - JPM Conference Insights - The importance of governance and trust - Biologics, biosimilars, and China competition - Practical strategies for continuous learning Referenced in the show: 🖇️ "Supercharging a New FDA: Marty Makary on Science, Power & Patients" – https://www.youtube.com/watch?v=DBlOJpT9Y1Y 🖇️A Field Guide to Deploying AI Agents in Clinical Practice – https://mitsloan.mit.edu/shared/ods/documents?PublicationDocumentID=10789 Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd 📑Substack - https://substack.com/@junaidkaliamd2025? Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en 📑Substack - https://harveycastromd.substack.com/ Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Visit our website: a href="https://signalandsymptoms.com/" rel="noopener noreferrer"...

    19 min

  4. JAN 28

    From Individual Patients to System-Level Impact: A Neurologist's Journey

    AI transformation in healthcare isn't something happening to physicians—it's an evolution physicians can actively shape and lead. In this episode, we introduce our host, Dr. Junaid Kalia, a practicing neurologist who experienced healthcare's systemic failures firsthand and decided to build the solution himself. As founder of SaveLife.AI, his journey embodies physician-led innovation: combining clinical expertise with entrepreneurial action to create real transformation. Joining the conversation are his sister, Dr. Saira Kalia (academic program director), and close friend, Dr. Danish Bhatti (angel investor/advisor), as they discuss the evolution from clinician to innovator—and why "action bias" matters more than perfect planning. Join our panel of a private sector entrepreneur, an academic program director, and an angel investor/advisor for a peer-to-peer reality check on the barriers, breakthroughs, and lessons learned. What You Will Discover: - Meet the Panel: Neurologist, Psychiatrist, and Their Unconventional Journeys - Why They Stepped Outside the Traditional Clinical Pathway - The Reality of Physician-Entrepreneurship - Reason Behind Execution Failure - The Resistance & Barriers They Didn’t Expect Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest: Saira Kalia, MD, Associate Professor, Arizona & Pediatric & Perinatal Psychiatry 💼LinkedIn - https://www.linkedin.com/in/saira-kalia-md-60685a132/overlay/about-this-profile/ Danish Bhatti, MD, Serial Entrepreneur and Angel Investor in Healthcare Startups 💼LinkedIn - https://www.linkedin.com/in/danish-bhatti/ Visit our website: https://signalandsymptoms.com/ Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/

    22 min

  5. JAN 20

    Why Are Junior Researchers Outperforming Gene Editing Experts?

    Drug development today forces patients to fit standard medications—but what if we could reverse that paradigm and design treatments tailored to each patient's unique biology? This episode explores how specialized AI cloud infrastructure is transforming drug discovery and healthcare research–not as a distant future possibility, but as tools available to researchers today. Joining the conversation is Dr. Ilya Burkov, who shares how the right computational foundation and HPC tools accelerate scientific breakthroughs at AI speed. The conversation reveals a significant shift in accessibility: junior researchers without specialized training now achieve 80-90% success rates in complex CRISPR experiments using agentic AI systems. These results once required years of expertise. Small research teams and startups can now access the same cutting-edge infrastructure as major pharmaceutical companies. This democratization directly impacts clinical practice: drug development timelines are compressing from decades to months, which means personalized treatments tailored to individual biology could become available within your career timeline. It's not just about raw infrastructure efficiency. It's about the combination of technology, accessibility, domain expertise, and white-glove support that together transform what's possible in healthcare innovation. What You Will Discover: - Dr. Burkov: Bridging Biology and AI Infrastructure - Nebius: AI Cloud for Drug Discovery, Genomics, Health Tech - Scaling Personalized Patient Medicine - Expert Support vs. Generic Clouds - AI Success for Junior Researchers - AI in Drug Discovery - Nebius On Democratizing Latest GPU Access - Future: Predicting Individual Patient Outcomes Referenced in the show: 🖇️ "CRISPR-GPT for agentic automation of gene-editing experiments" – https://pubmed.ncbi.nlm.nih.gov/40738974/ Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest: Dr. Ilya Burkov, Global Head of Healthcare & Lifesciences at Nebius 💼LinkedIn - a href="https://www.linkedin.com/in/ilyaburkov/" rel="noopener noreferrer"...

    19 min

  6. JAN 14

    Is Healthcare Sustainable Without AI?

    The most dangerous assumption in healthcare AI today is that we have time to "wait and see" how tools develop. With the state-of-the-art for AI models now shifting every 7 days, the traditional 3-year implementation cycle isn't just slow—it’s stagnating clinical transformation. In this episode, Dr. Khan Siddiqui (Radiologist and Founder of Hoppr AI) joins the panel to reveal why the future of medicine isn’t about choosing the "perfect" tool. Instead, it’s about building a sustainable system that can keep pace with technology improving at 1,600 times the speed of human practice. This conversation moves beyond theory to address a raw, systemic crisis facing modern medicine: where radiologists must read 145 cardiac CT scans in a single shift—roughly 5.5 images per second. This unsustainable pace leaves physicians exhausted and their families suffering the collateral damage of clinical burnout. Dr. Siddiqui breaks down how the collision of massive workforce shortages and declining reimbursements has moved AI from a "luxury" to a baseline requirement for survival. To meet this challenge, the episode explores the critical shift in a clinician-led innovation, frictionless workflow, and dynamic regulation. What You Will Discover: - From Clinician to AI Visionary - The Microsoft Origin of Hoppr - The True Cost of Clinical Burnout - The Systemic Collapse: Workforce Gaps - Why Augmentation is Survival - Ending Static AI Governance - Dr. Siddiqui’s Vision for the Future of Medicine - AI Without the Tech Tax - Why the FDA Model is Failing Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest: Khan Siddiqui, MD, Radiologist, Founder of HOPPR 💼LinkedIn - https://www.linkedin.com/in/khansiddiqui/ 🏥Hoppr AI - ​​https://www.hoppr.ai/ Visit our website: https://signalandsymptoms.com/ Get advisory insights about Healthcare AI — at zero cost: a...

    20 min

  7. 12/30/2025

    15 Healthcare Leaders Predict 2026: AI Will Transform Care (Or Collapse Under Bureaucracy)

    This Holiday Special brings together 15 healthcare leaders, technologists, and innovators to tackle the biggest questions facing medicine in 2026. AI tools are proliferating across hospitals, but can healthcare systems integrate them effectively? Healthcare stands at a crossroads in 2026. AI is everywhere—from radiology to clinical decision support—but critical questions remain. Will it lower costs for patients? Can hospitals keep pace with innovation? And most importantly: who's steering this transformation? Our diverse panel of physicians, educators, consultants, and entrepreneurs shares their frontline perspectives on what's working, what's failing, and what must change. Tune in to discover practical steps for upskilling, embedding AI into workflows, and ensuring the next generation enters the workforce ready to leverage these technologies for better patient outcomes. What You Will Discover: - What's Coming in Healthcare AI 2026 - Breakthrough Technologies & AI in Practice - What's Holding Healthcare Back - What You Can Do Now Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest: Avinash Jayaswal, MD, MS, MSc, 💼LinkedIn - https://www.linkedin.com/in/avinash-jayaswal-md-ms-msc-464a5a2/ Jim Pollock 💼LinkedIn - https://www.linkedin.com/in/jimdpollock/ Dipu Patel, DMSc, MPAS, ABAIM, PA-C 💼LinkedIn - https://www.linkedin.com/in/dipu-patel-dmsc-pa-c-695000b/ Arlen Meyers, MD, MBA 💼LinkedIn - https://www.linkedin.com/in/ameyers/ Kianor Shah DMD, MBA 💼LinkedIn - a...

    24 min

  8. 12/23/2025

    What If Better Patient Care Actually Cost Less? The AI Reality

    The future of AI-enabled care is massive and available, but the question remains: will we be the ones leading it? In this episode, Dr. Robert Pearl – Former CEO of Permanente Medical Group (Kaiser Permanente), Author of "ChatGPT, MD", Forbes Contributor – joins the panel to challenge the core of how we practice medicine today. Medical students are entering training with AI capabilities that their professors don't possess. But beneath this technological evolution lies a clinical crisis: 400,000 deaths annually from misdiagnosis, intermittent care for chronic diseases, and a system that could eliminate up to $2 trillion in wasteful spending. The conversation addresses why AI integration advances rapidly in other countries, yet the US lags, not from lack of technology, but from cultural resistance and misaligned financial incentives. Dr. Pearl reveals the solution he's witnessed work at scale that allows a delivery system to have smarter chronic disease management and better doctor-patient interaction. This discussion connects directly to what matters most in clinical practice: better diagnostic accuracy, continuous disease monitoring that actually works, and care delivery that doesn't burn out physicians while delivering superior results. The paradigm can shift from the traditional trade-off between quality, access, and cost to a model where increasing quality and access genuinely lowers cost. What You Will Discover: - The Era of Smarter Students: AI Skills Professors Don't Have - The Clinical Crisis: 400,000 Deaths From Misdiagnosis - How 24/7 AI Monitoring Reduces Heart Attacks & Strokes by 30-50% - Why Singapore & Dubai Lead While the US Lags - Why Current Incentives Block AI Adoption - The Fee-for-Service Problem: Rewarding Volume Over Outcomes - How AI will Impact Pharmaceutical innovations - Flipping the Paradigm: Lower Cost Through Higher Quality & Access Referenced in the show: 🖇️ "ChatGPT, MD: How-AI Empowered Patients & Doctors Can Take Back Control of American Medicine" – https://www.amazon.com/dp/B0CWCV9DVZ 🖇️ “Mistreated: Why We Think We’re Getting Good Health Care – And Why We’re Usually Wrong” – https://www.amazon.com/Mistreated-Think-Getting-Health-Usually/dp/1610397657/ Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - a...

    19 min
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out of 5
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About

Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions affect patient care, getting it right isn't optional.

Information

  • Creator
    Harvey Castro MD, Junaid Kalia MD, & Edward Marx
  • Years Active
    2025 - 2026
  • Episodes
    29
  • Rating
    Explicit
  • Copyright
    © Copyright 2026 Harvey Castro MD, Junaid Kalia MD, & Edward Marx
  • Show Website
    Signal and Symptoms Podcast