The Best AI Show on Pharma

Ayush Mishra

In a world where healthcare decisions are getting faster, smarter, and more complex, one force is quietly reshaping the entire pharma landscape: intelligence. Not the kind you read in reports, but the kind that emerges when data, science, and experience collide. The Best AI Show on Pharma steps right into that intersection. Hosted by Ayush Mishra, this podcast brings you candid, future-facing conversations with leaders who are redefining how medicines are discovered, developed, and delivered. Each episode goes beyond buzzwords, beyond hype, and beyond surface-level talk. These are the real stories, the challenges no one admits, the breakthroughs no one sees coming, and the visions shaping the next decade of medicine. Whether you are a pharma professional, a healthcare innovator, or someone who believes that smarter technology can lead to better outcomes, this is where the future becomes understandable, practical, and actionable.

Episodes

  1. Ep #7 I The Biggest Lie Pharma Industry Tells Itself About AI | Dr. Neha Gupta

    MAR 24

    Ep #7 I The Biggest Lie Pharma Industry Tells Itself About AI | Dr. Neha Gupta

    Every pharma company today says they're doing AI. But how much of it is actually real? In this episode of The Best AI Show on Pharma with Ayush Mishra our guest is Dr. Neha Gupta who is a clinician, digital health product leader, and Ironman athlete and the one who has spent years building real digital products that have had to survive regulators, compliance frameworks, audits, and actual patients across multiple markets. She is one of the rare people who has seen healthcare from inside the clinic, inside the product team, and inside the pharma system. You will hear insights on: Where AI is genuinely creating value inside pharma organizations today and where it quietly collapsesWhy AI confidence without calibration is one of the most dangerous problems in healthcareWhy model accuracy and clinical trust are not the same numberHow real world evidence is being used to change what's possible in clinical trials and drug labelingWhy 85% of AI pilots in pharma never move beyond the pilot stageWhat AI transformation in pharma actually demands from organizations beyond just technologyThe one space startup founders building for life sciences should be focused on right nowWhich global markets are leading healthcare AI innovation and why Brazil made this listThe biggest lie the pharma industry tells itself about AI adoptionIf you work in pharma, digital health, clinical operations, or life sciences technology, this conversation offers one of the most honest assessments of where AI in pharma actually stands today. Dr. Neha Gupta's LinkedIn: https://www.linkedin.com/in/drnehagupta/  Ayush Mishra's LinkedIn: https://www.linkedin.com/in/ayushmishra/   Watch this episode now on YouTube: https://youtu.be/kDG4VpM8kfo  Watch Now on YouTube

    1h 5m
  2. Ep #6 | From Google to Drug Discovery with AI: Why "Science Advances One Funeral at a Time" | Javier Tordable

    FEB 24

    Ep #6 | From Google to Drug Discovery with AI: Why "Science Advances One Funeral at a Time" | Javier Tordable

    Early-stage drug discovery can take years and requires deep expertise in computational chemistry that most biologists don't have. This creates a massive bottleneck in getting new therapies from concept to testing. In this episode, Ayush Mishra sits down with Javier Tordable, Founder & CEO of Pauling.AI, to explore how AI is automating the most time-intensive parts of drug discovery and why adoption remains the industry's biggest challenge. You will hear insights on: Why he left 16 years at Google to focus entirely on pharmaceutical AIHow rational drug design works and where the traditional process breaks downWhat Pauling.AI does differently, an AI agent that handles target identification, molecular design, and binding predictions like ChatGPT handles textThe real resistance AI faces from veteran scientists and the uncomfortable truth about generational change in pharmaWhen we can expect to see the first fully AI-designed drugs receive FDA approvalWhere emerging market founders can find datasets when premium pharmaceutical data is locked behind paywallsWhat human scientists will always do better than AI, and why that mattersHis brutally honest take on the "science advances one funeral at a time" phenomenonPractical advice for biotech entrepreneurs building AI healthcare companies in Asia and AfricaIf you work in pharma R&D, drug discovery, biotech innovation, computational chemistry, or clinical development strategy, this conversation offers an unfiltered view of where AI is actually taking pharmaceutical research. Javier Tordable's LinkedIn: https://www.linkedin.com/in/jtordable/  Ayush Mishra's LinkedIn: https://www.linkedin.com/in/ayushmishra/  Watch Now on YouTube

    59 min
  3. Ep #5 | Surgeon to Biotech CEO: Regenerating Human Skin, AI in Wound Care & Healthcare's Broken System | Dr. Ned Swanson

    FEB 11

    Ep #5 | Surgeon to Biotech CEO: Regenerating Human Skin, AI in Wound Care & Healthcare's Broken System | Dr. Ned Swanson

    Dr. Ned Swanson walked away from surgery residency to commercialize technology that regenerates human tissue. What started with mouse studies is now helping real patients heal wounds that traditional medicine couldn't solve. But here's the twist: the science wasn't the hardest part. In this episode, Dr. Ned Swanson (President & CMO at Polarity Bio) sits down with Ayush Mishra to reveal the brutal truths about building biotech, navigating healthcare's broken reimbursement systems, and separating AI signal from noise in wound care. IN THIS EPISODE:  The Career Gamble Why he left surgery residency mid-trainingThe moment he realized biotech could help patients faster than academiaGrant money vs VC funding: which path offers more creative freedomTaking a company public while still thinking like a resident Building Biotech: The Brutal Reality The #1 challenge that blindsided him (it's not what you think)Moving technology from mouse studies to human patientsNavigating FDA approval processesWhy hiring the right people is harder than everything elsePatient stories that made the risk worth itHealthcare's Uncomfortable Truths How cost and reimbursement drive medical decisions more than evidenceThe "pure medicine" illusion every resident experiencesWhy the same products are priced $100 vs $5,000 per square centimeterWhat breaks when you step outside the hospital wallsAI in Healthcare: Reality Check Where AI genuinely helps in wound care: imaging, monitoring, real-world evidenceSmart boots tracking diabetic ulcers and patient complianceHow platforms like Open Evidence are changing clinical decisionsWhy AI won't replace RCTs but will expand their impactThe future of wound care in 5-10 yearsRegenerative Medicine Explained How SkinTE technology actually worksWhy 95% of traditional skin grafts failFrom lab bench to patient bedside: the real timelineExpanded access programs and their impactIf you work in pharma, clinical operations, wound care, or research strategy, this conversation offers a clear view of where the future of healthcare is heading. Dr. Ned Swanson LinkedIn: https://www.linkedin.com/in/ned-swanson-md-9612b120/  Ayush Mishra's LinkedIn: https://www.linkedin.com/in/ayushmishra/   Watch Now on YouTube

    1h 9m
  4. Ep #4 | Accelerating Clinical Trials with Real-World Data, Know What Actually Works with Ayush Mishra and Chandi Kodthiwada

    JAN 19

    Ep #4 | Accelerating Clinical Trials with Real-World Data, Know What Actually Works with Ayush Mishra and Chandi Kodthiwada

    The pharmaceutical industry doesn’t struggle with scientific innovation, it struggles with execution. Feasibility, enrollment, evidence generation, and regulatory confidence remain the biggest constraints on getting medicines to patients faster. In this episode of The Best AI Show on Pharma, Ayush Mishra speaks with Chandi Kodthiwada, Vice President, Product Management, Komodo Health, whose work sits at the intersection of real-world data, clinical development, and AI strategy across the life sciences ecosystem. While for more than a decade building data products for biopharma, Chandi explains why most AI initiatives stall, why clinical trial operations remain deeply inefficient, and why real-world evidence is becoming a strategic lever rather than a research afterthought. From feasibility to enrollment to post-market monitoring, we explore how data is reshaping drug development and where the industry is actually seeing ROI. This is not a futurist conversation, it’s a grounded look at what’s working today, what still breaks, and what needs to change for AI to truly matter in biopharma. Also get ready to know some deets on the recent partnership that happened between Komodo Health and Anervea. What You’ll Learn in This Episode: • Why AI pilots struggle inside pharma organizations  • Why 30% of clinical trial sites never enroll a patient  • Recent partnership that happened between Komodo Health and Anervea  • Why RWE is gaining regulatory traction beyond publications  • Why consulting isn’t going away, but the slide work is  • Why trial bottlenecks are now operational, not scientific  • Why structured context beats model complexity in real use cases  • Why execution is the new competitive edge in drug development  • Why startups need ecosystem fluency, not just technology If you’re involved in clinical development, RWE, regulatory, digital, medical, or commercial strategy, this episode offers a clear lens into where the industry is headed, and what’s required to get there. Connect with Ayush Mishra https://www.linkedin.com/in/ayushmishra/  Connect with Chandi Kotriwada https://www.linkedin.com/in/chandikodthiwada/ Watch on YouTube https://youtu.be/XIHNrAbE5N4  Watch Now on YouTube

    40 min
  5. Ep #3 | Beyond the AI Hype: Real Solutions for Clinical Trial Efficiency with Ayush Mishra and Suzanne Vyvoda

    JAN 14

    Ep #3 | Beyond the AI Hype: Real Solutions for Clinical Trial Efficiency with Ayush Mishra and Suzanne Vyvoda

    Clinical trials don’t fail because of bad science, they fail because the operations behind them are broken. In this high-signal episode, Ayush Mishra sits down with Suzanne Vyvoda, a 20-year clinical operations veteran who has built teams across 40+ countries, scaled billion-dollar trials, advised CROs, biotech founders, and helped companies cut trial costs by up to 25% without compromising quality. From the chaos inside clinical sites and the “Excel tracker economy” that still runs global trials to the quiet operational failures that delay drugs, inflate budgets, and frustrate stakeholders, Suzanne breaks down what really drives clinical trial inefficiency, and why AI alone won’t fix it. But this isn’t a pessimistic take. We unpack where AI is actually working, which use cases offer real ROI today, why RWE is becoming operationally strategic, and why the future of drug development won’t be about replacing people, but augmenting them. In This Episode, You’ll Learn: Why clinical trials are still powered by spreadsheets and PDFsWhy sites, CROs, and biotechs are all frustrated, and all correctWhy tech adoption fails when it adds work instead of removing itWhy RWE + site intelligence is the next frontier of feasibilityHow good contract design alone can cut trial costs dramaticallyWhy “ecosystem fluency” is the missing skill for AI foundersWhy CROs fear tech, and why that incentive structure needs to changeWhy the right MVP solves one problem, not 27Why the next wave of tools must feel native to real operatorsIf you want a real look at how trials actually run, from budget to operations to site burden to CRO incentives, and clarity on where AI fits (and doesn’t), this episode is unmissable. Watch till the end. Your understanding of clinical operations will change. Connect with Ayush Mishra https://www.linkedin.com/in/ayushmishra/  Connect with Suzanne Vyvoda https://www.linkedin.com/in/suzanne-vyvoda/ Watch on YouTube https://youtu.be/dalypa2iYi0  Watch Now on YouTube

    1h 8m
  6. Ep #2 | What’s Broken in American Healthcare and What the Future Holds with Ayush Mishra Ft. Dr. Marschall S. Runge

    12/16/2025

    Ep #2 | What’s Broken in American Healthcare and What the Future Holds with Ayush Mishra Ft. Dr. Marschall S. Runge

    America spends more on healthcare than any country on Earth, so why are they ranked 60th in healthy life expectancy? In this eye-opening episode, Ayush Mishra sits down with Dr. Marschall Runge, cardiologist, researcher, long-time CEO of Michigan Medicine, and author of The Great Healthcare Disruption, to unpack one of the biggest paradoxes in modern medicine. From the rise of chronic disease and the collapse of preventive care to the shocking inefficiencies buried inside the U.S. healthcare system, Dr. Runge breaks down what’s really driving America's poor outcomes and why critical care is world-class while the rest of healthcare continues to fall behind. But this conversation isn’t doom and gloom.  We dig into where AI is already transforming care, how predictive analytics will rewrite diagnosis and treatment, why smartwatches are saving more lives than ever, and why Big Tech (Amazon, Google) and pharma giants (like Eli Lilly) are redefining the future of medicine. You’ll also hear: Why academic medical centers must evolve or risk irrelevanceHow AI assistants will revolutionize chronic disease managementWhy preventive care is the REAL magic button to fix healthcareThe danger zones of AI and what must never be automatedWhether AI will reduce or widen the affordability gap If you want clarity on where American healthcare is headed and why the next decade will reshape medicine more than the last 100 years this episode is unmissable. Watch till the end. Your understanding of healthcare will change. Connect with Ayush Mishra: https://www.linkedin.com/in/ayushmishra/ Connect with Dr. Marschall S. Runge: https://www.linkedin.com/in/marschallsrunge/ Watch Now on YouTube

    1h 1m
  7. Ep #1 | 80% of Trials Fail. Here's How AI Is Saving Billions for Pharma with Ayush Mishra ft. Dr. Scott Treiber

    11/11/2025

    Ep #1 | 80% of Trials Fail. Here's How AI Is Saving Billions for Pharma with Ayush Mishra ft. Dr. Scott Treiber

    80% of clinical trials fail to recruit patients on time. This leads to massive financial losses and delays in getting life changing treatments to patients. In this episode, Ayush Mishra sits down with Scott Treiber, COO of Cedar Health Research, to explore how modern technology and smarter workflows are transforming clinical research from the ground up. You will hear insights on: Why clinical trials still move slowly and face major operational challengesHow tools like Forge help clinics identify the right patients fasterReal examples of improvements in recruitment and site productivityWhich technologies in areas like AE monitoring, risk prediction and retention can impact patient outcomes the fastestHow doctors, nurses and patients respond when new digital tools are introduced in everyday practiceThe biggest misconceptions and risks that still hold the industry backWhat the next five years of clinical research could look like with the right adoptionIf you work in pharma, clinical operations, site networks, or research strategy, this conversation offers a clear view of where the future of trials is headed. Scott Treiber's LinkedIn: https://www.linkedin.com/in/streiber/ Ayush Mishra's LinkedIn: https://www.linkedin.com/in/ayushmishra/ Watch Now on YouTube

    39 min

  8. SEASON 1, EPISODE 1 TRAILER

    The Best AI Show on Pharma - Trailer

    What if the next big shift in medicine doesn’t start in a lab but in a conversation? A conversation where data meets discovery, where intelligence challenges tradition, and where the future of pharma begins to take shape. This trailer is your first look into The Best AI Show on Pharma hosted by Ayush Mishra, bringing together the voices redefining how healthcare thinks, decides, and innovates. From drug discovery to patient impact, from clinical trials to commercial strategy, these are the stories shaping the next decade of medicine. The trailer is just a glimpse. The real conversations are coming. Searching for the most insightful life sciences podcast that reveals how AI is reshaping pharma strategy, research, and commercialization?  Discover The Best AI Show on Pharma, hosted by Ayush Mishra, featuring the leaders who are building the next era of intelligent healthcare. Episode 1 drops soon. Watch Now on YouTube

    2 min

Trailer

About

In a world where healthcare decisions are getting faster, smarter, and more complex, one force is quietly reshaping the entire pharma landscape: intelligence. Not the kind you read in reports, but the kind that emerges when data, science, and experience collide. The Best AI Show on Pharma steps right into that intersection. Hosted by Ayush Mishra, this podcast brings you candid, future-facing conversations with leaders who are redefining how medicines are discovered, developed, and delivered. Each episode goes beyond buzzwords, beyond hype, and beyond surface-level talk. These are the real stories, the challenges no one admits, the breakthroughs no one sees coming, and the visions shaping the next decade of medicine. Whether you are a pharma professional, a healthcare innovator, or someone who believes that smarter technology can lead to better outcomes, this is where the future becomes understandable, practical, and actionable.

Information

  • Creator
    Ayush Mishra
  • Years Active
    2025 - 2026
  • Episodes
    8
  • Rating
    Clean
  • Copyright
    © 2026 The Best AI Show on Pharma
  • Show Website
    The Best AI Show on Pharma