ImmunoChat

Pia Madeleine Leipe

The German Association for Immunology (DGfI) appreciates its young members.  The Young Immunologists (YI) group was founded to support early-career scientists within the DGfI with their scientific career development.This Podcast is for young immunologists from young immunologists. Check out our website and become a young immunologist: https://dgfi.org/young-immunologists/Find the Young Immunologists on Twitter: https://twitter.com/YI_dgfiContact the host, Pia via: PiaMadeleine.Leipe@ukmuenster.de // https://www.linkedin.com/in/pia-madeleine-l-75b749207?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=ios_app

  1. Jul 4

    Immunity Unleashed: Turning Influenza into a Cancer Warrior 🦠🦸

    Send us Fan Mail Keywords Oncolytic viruses, Influenza A viruses, Cancer therapy, Lung cancer, Immune activation    Summary In this episode, Pia Madeleine Leipe talks with Dr. Ramona Meissner about an exciting frontier in cancer research: oncolytic viruses. Together, they explore how Influenza A viruses can be used to selectively target and destroy tumor cells, why these viruses are particularly promising againstlung cancer , and how the immune system plays a key role in this approach. Ramona shares insights from her research, explaining how engineered viruses can both kill cancer cells and stimulate anti-tumor immune responses. The conversation also touches on current challenges, safety considerations, and the future potential of this innovative therapeutic strategy.   Takeaways Viruses can selectively target and destroy tumor cells.Influenza A shows promise as an oncolytic virus for lung cancer treatment.Combines direct tumor killing with immune activation.Research results reveal high potential of influenza A as OV.   Resources & Links Review: Oncolytic viruses: advanced strategies in cancer therapy (Nature 2026)Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer (Molecular Therapy Oncolytics 2023) Connect with Dr. Ramona Meissner Postdoc in Claudia Rössig´s Group (Cellular Immunotherapy) at Princess Máxima Centerfor Pediatric Oncology in UtrechtLinkedInSupport the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

  2. Apr 28

    The gut microbiome and autoimmunity: How our gut bacteria influence the immune system 🔬

    Send us Fan Mail Keywords: Gut Microbiome, Autoimmunity, Lupus, Microbiome Research, Enterococcus gallinarum, Immunological Tolerance, Microbiome Therapies Summary:  In this episode of the Young Immunologist Podcast ImmunoChat, Pia Madeleine Leipe talks with Carina Brune about the role of the gut microbiome in the immune system and its connection to autoimmune diseases. They discuss the importance of gut microbes, the challenges in researching autoimmune diseases, and the potential therapeutic approaches emerging from microbiome research. Takeaways: The gut microbiome plays a crucial role in regulating the immune system.Dysbiosis in the microbiome can lead to autoimmune diseases.Enterococcus gallinarum is a bacterium linked to the development of lupus.Future therapies may target microbiome modulation, including vaccines and phage therapy.Please find here links to publications referred to in this Episode:   General Info:  Family size, infection and atopy: the first decade of the 'hygiene hypothesis' | ThoraxHost–microbiota interactions in immune-mediated diseases | Nature Reviews MicrobiologySLE and microbiome: Translocation of a gut pathobiont drives autoimmunity in mice and humans | ScienceWithin-host evolution of a gut pathobiont facilitates liver translocation | NatureTranslocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human | Science Translational MedicineLupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders | Annals of the Rheumatic Diseases Phage therapy Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation: CellYouTube Video Hinter den Kulissen des Tierlaboratoriums der Medizinischen Hochschule Hannover Contact details Carina Brune – University of Münster | LinkedIn Immune-Microbiota Interactions Lab (@agkriegel.bsky.social) — Bluesky Die Abteilung Translationale Rheumatologie und Immunologie   Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

  3. Feb 23

    🦠 Hunting HIV: How Cytotoxic CD4+ T Cells Could Crack the Viral Hideout 🦠

    Send us Fan Mail Keywords HIV, immunology, virology, immunological niches, Cytotoxic CD4 T cells, , CD137, HIV reservoirs   Summary In this episode of the Young Immunologist Podcast ImmunoChat, Pia Leipe engages with Dr. Anna Malyshkina to explore the complexities of HIV, its interaction with the immune system, and the innovative research being conducted to combat this virus. They discuss the roles of various immune cells, the challenges of antiretroviral therapy, and the significance of immunological niches where HIV can hide. Dr. Malyshkina shares insights into her research on cytotoxic CD4 T follicular helper cells and the potential of CD137 as a target for immunotherapy.    Takeaways HIV primarily targets CD4 T cells, disrupting the immune system's coordination.Antiretroviral therapy suppresses HIV but does not eliminate it.Immunological niches provide safe harbors for HIV, complicating treatment.CD4 T follicular helper cells can be armed to target HIV.CD137 is a promising target for enhancing T cell responses.  Please find here links to publications referred to in this Episode:   https://pubmed.ncbi.nlm.nih.gov/37965314/  https://pubmed.ncbi.nlm.nih.gov/37883584/ https://pubmed.ncbi.nlm.nih.gov/30635687/ https://pubmed.ncbi.nlm.nih.gov/30782653/  https://pubmed.ncbi.nlm.nih.gov/28798348/  https://pubmed.ncbi.nlm.nih.gov/26608920/ https://pubmed.ncbi.nlm.nih.gov/37910505/    Contact details ·      Dr. Anna Malyshkina  ·      LinkedIn: https://www.linkedin.com/in/anna-malyshkina-776324178/ ·      Institute of Physiology Essen: https://www.uni-due.de/physiologie/ ·      Institute for Virology Essen: https://www.uni-due.de/virologie/ ·    ELAN Proposal UDE: https://www.unidue.de/med/promotionskolleg/evaluierte_projekte.php  Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

  4. 11/19/2025

    🫁 Breathing Life Into Research: Lung Explants, Organoids & Nasal ALIs 🫁

    Send us Fan Mail Keywords Lung research, Respiratory tract, Human lung explants, Organoids, Air-liquid interface cultures, Infections, Drug testing, Disease mechanisms, Virology Summary In this episode of the Young Immunologist Podcast ImmunoChat, host Pia Leipe interviews Dr. Saskia Hinse, a postdoc at the University clinic Münster at the Institute of molecular Virology, to discuss models of the respiratory tract. They explore the use of human lung explants, organoids, and air-liquid interface cultures in lung research, focusing on their applications in studying infections, drug testing, and understanding disease mechanisms. The conversation highlights the advantages and challenges of these models, emphasizing their role in complementing traditional in vitro and in vivo experiments. Takeaways Lung explants are small pieces of human lung tissue used for research.Organoids are grown from type II pneumocytes and can be maintained for months.Air-liquid interface cultures mimic the upper respiratory tract.These models help study infections and drug testing.Lung explants and organoids complement in vitro and in vivo experiments.Challenges include tissue availability and heterogeneity.Human tissue models are key for understanding disease mechanisms.Please find here links to publications using the models discussed today - Lung explants, Organoids and ALIs:  https://pubmed.ncbi.nlm.nih.gov/39248230/ https://pubmed.ncbi.nlm.nih.gov/36423831/ Contact details  Dr. Saskia Sophie Hinse LinkedIn: https://www.linkedin.com/in/saskia-sophie-hinse-0a273a398/Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

  5. 03/07/2025

    🧪⚖️Inventing Knowledge: Intellectual Property in Academic Research 🧠🔏

    Send us Fan Mail keywords academic integrity, plagiarism, intellectual property, research ethics, PhD students, collaborations, scientific publications, open access, patents, copyrights summary In this podcast episode, Nora Balzer (Dr rer Nat) discusses the complexities of intellectual property in academia, particularly in the context of a case involving a PhD student accused of plagiarism. The conversation explores the balance between sharing research for public good and protecting intellectual achievements, the challenges of collaborations, and practical advice for PhD students navigating these issues. takeaways Sophie’s case highlights the complexities of academic integrity - reference: https://www.spiegel.de/lebenundlernen/uni/professor-contra-doktorandin-wer-klaut-hier-bei-wem-a-776909.html - accessed on 27-02-2025.Intellectual property in academia is often misunderstood.The need to protect research can conflict with sharing knowledge.Patents and copyrights are crucial but challenging to navigate.Open access aims to make research freely available but has costs.Collaborations can complicate ownership of research outcomes.PhD students should choose their supervisors wisely.Reading contracts is essential for understanding rights.Building a support network is vital for early career scientists.Emotional responses to credit disputes should be managed rationally.Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

  6. 06/21/2023

    Episode 4.: The power of a community - Young European Federation of Immunological Societies (yEFIS)

    Send us Fan Mail Listen to our special episode with our European partner society, the yEFIS. https://www.yefis.org/ Here, we discuss the power of a community on the national and European level to support young immunologists on their path. My guests are Rami Bechara (@ramibechara), Santiago Costas, and Anne Hahn (@kuriosera) the power-engine behind yEFIS and the collaboration with EJI, the European Journal of Immunology. Listen to our podcast and take advantage of an international community of young immunologists. Contact them via: yEFIS email: yefis@efis.org  yEFIS website registration: https://www.yefis.org/join-now/register/yefis-network-register-and-login.html  yEFIS twitter: y_efis  yEFIS LinkedIn: y-efis  Twitter handle: @EurJImmunol Apply to the DGFI travel award:  https://dgfi.org/reisekostenbeihilfen/ The Podcast is hosted by Nóra Balzer - https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de https://twitter.com/norabalzer1 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/ Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

  7. 06/07/2023

    Episode 3.: Parenting in science; work-life romance master course

    Send us Fan Mail In this episode, 3 immunologists discuss about the beauty and the challenges of parenting in science. Katarzyna Placek became mother as a junior group leader at the LIMES Institute https://www.limes-institut-bonn.de/forschung/arbeitsgruppen/unit-2/abteilung-netea/mitarbeiter/  Listen her podcast about Women in Science: https://www.limes-institut-bonn.de/ueber-uns/gleichstellung/wis-podcast/ Sabrina B. Bennstein, spokesperson of the DGfI - YI Board shares her thoughts on becoming a parent as a postdoctoral researcher. https://dgfi.org/young-immunologists/board/?sfw=pass1685907944 The Podcast is hosted by Nóra Balzer, who became a mother way before becoming a scientist. https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de https://twitter.com/norabalzer1 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/ Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

  8. 04/29/2023

    Episode 2.: Research animals in immunology

    Send us Fan Mail Listen our special episode on animal research on the word week of lab animals and day of immunology. We compare the general ethic and regulations in animal research between two European countries. We will compare the German and the Swiss system. It is a pleasure to exchange with Dr. Roman Stilling from the initiative “Tierversuce verstehen” - understand animal research who will give us great insight into the principles and animal experiment ethics in Germany. The Swiss side is represented by Dr. Lena Siewert from the University of Basel. https://www.tierversuche-verstehen.de/ The Podcast is hosted by Nóra Balzer - https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de https://twitter.com/norabalzer1 The podcast is supported by the German association of immunology (GDfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

    Episode 2.: Research animals in immunology
  9. 04/15/2023

    Episode 1.: Aimed Analytics, a start up to shape future medicine

    Send us Fan Mail Aimed Analytics (https://www.aimed-analytics.com/) was founded by Dr. Patrick Günther - https://www.linkedin.com/in/patrick-guenther/  https://twitter.com/patguenther1 Dr. Kevin Baßler - https://www.linkedin.com/in/kevin-ba%C3%9Fler-3a230592/ https://twitter.com/kevin_bassler Jan Rudolph - https://www.linkedin.com/in/jan-rudolph/ https://twitter.com/janews They have been supported by the Exist Start-Up Grant - https://www.exist.de/EXIST/Navigation/EN/Start-upFunding/EXIST-Business-Start-up-Grant/exist-business-start-up-grant.html and by ENACOM transfer center - https://www.uni-bonn.de/de/forschung-lehre/transfercenter-enacom The Podcast is hosted by Nóra Balzer - https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de https://twitter.com/norabalzer1 The podcast is supported by the German association of immunology (GDfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US Support the show The Podcast is hosted by Pia Madeleine Leipe - www.linkedin.com/in/pia-madeleine-l-75b749207 The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI) https://dgfi.org/ https://dgfi.org/young-immunologists/ https://www.linkedin.com/company/dgfi-yi/ https://twitter.com/YI_dgfi Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US https://www.yefis.org/

About

The German Association for Immunology (DGfI) appreciates its young members.  The Young Immunologists (YI) group was founded to support early-career scientists within the DGfI with their scientific career development.This Podcast is for young immunologists from young immunologists. Check out our website and become a young immunologist: https://dgfi.org/young-immunologists/Find the Young Immunologists on Twitter: https://twitter.com/YI_dgfiContact the host, Pia via: PiaMadeleine.Leipe@ukmuenster.de // https://www.linkedin.com/in/pia-madeleine-l-75b749207?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=ios_app