Base by Base - Music

Gustavo Barcelos Barra
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Base by Base Music is the musical extension of Base by Base — a space for the original soundscapes, themes, and atmospheres that accompany science, reflection, and discovery. Here, music takes the lead: cinematic, thoughtful, and immersive compositions created to inspire focus, wonder, and intellectual curiosity.

  1. Jul 23

    Lactate Lights the Switch

    This release contains only the music track from Base by Base Episode 433. Song title: Lactate Lights the Switch Original Base by Base episode: 433: Lactate, HSP90α and the Mitochondrial Switch Article metadata: Article title: HSP90α lactylation orchestrates PGC1α and LRPGC1 nuclear translocation driving mitochondrial biogenesis Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2528979123 Reference: Wu G., Li H., He T., et al. HSP90α lactylation orchestrates PGC1α and LRPGC1 nuclear translocation driving mitochondrial biogenesis. PNAS. 2026;123(30):e2528979123. doi:10.1073/pnas.2528979123 Lyrics: Verse 1 Late-night numbers on a glowing screen A quiet signal turns the gears unseen Lactate in the air like a spark in the room Telling small engines how to make more room Pre-Chorus A chaperone hears the chemical call Two tiny marks and the dominos fall Locks and latches, line by line Open the door to a power-up sign Chorus Lactate lights the switch, let the whole cell sing HSP90 holds the fire like a wedding ring PGC1 on the move to the nucleus tonight Building more mitochondria, raising up the light Verse 2 K58 pulls ULK1 into place S39 written like a starter’s pace K616 shuts CDK5 outside So S596 can’t slow the ride Bridge NRF1, NRF2—blueprints in the dark New membranes rising from a single spark More fuel, more breath when the morning begins A brighter charge under the skin Final Chorus Lactate lights the switch, let the whole cell sing HSP90 turns the signal into everything PGC1 and LRPGC1 cross that open door More mitochondria waking, asking for more

  2. Jul 23

    Pocket Factor Fallout

    This release contains only the music track from Base by Base Episode 432. Song title: Pocket Factor Fallout Original Base by Base episode: 432: Echovirus 18: Capsid opening releases the genome Article metadata: Article title: Particles of echovirus 18 open to release their genomes in vivo Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2601182123 Reference: Mukhamedova L., Buchta D., Hrebík D., et al. Particles of echovirus 18 open to release their genomes in vivo. PNAS. 2026;123(30):e2601182123. https://doi.org/10.1073/pnas.2601182123 Lyrics: Verse 1 Late in the cell where the cold light glows A quiet shell keeps a secret close One touch at the surface, the lock comes loose A loaded little world looking for a route Pre-Chorus A receptor hand on a viral frame Kicks out the oil from a hidden lane No time for statues, no frozen pose Just one sharp signal and the pressure grows Chorus Open up, let it go—capsid cracks in the afterglow One to three walls fall away, and the message starts to flow No steady in-betweens, just a break in the dome When the pocket factor’s gone, the genome finds its way home Verse 2 In endosome shadows, it turns on fast Primed by binding, not built to last You won’t catch the middle—it's gone too soon A blink of geometry, a missing moon Bridge If you can stop that first small shove Or block the hinge where the panels love to move You can freeze the spill before it starts Keep the code from crossing into hearts Final Chorus Open up, let it go—capsid cracks in the afterglow One to three walls fall away, and the message starts to flow No steady in-betweens, just a break in the dome Cut the trigger, hold the line—don’t let the genome roam

  3. Jul 23

    Plaque of Light

    This release contains only the music track from Base by Base Episode 431. Song title: Plaque of Light Original Base by Base episode: 431: KIAP4 and the ARND family: essential proteins for Leishmania–sand fly adhesion Article metadata: Article title: Identification of a conserved gene family with an essential role in Leishmania parasite–insect vector adhesion Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2603653123 Reference: Owino BO, Yanase R, Pruzinovac K, Farr H, Lopez Y, Marron AO, Vaughan S, Volf P, Sunter JD. Identification of a conserved gene family with an essential role in Leishmania parasite–insect vector adhesion. Proc Natl Acad Sci U S A. 2026;123(30):e2603653123. doi:10.1073/pnas.2603653123 Lyrics: Verse 1 Under cold blue screens, the night stays wide awake A tiny traveler learns the hold it has to take On a narrow threshold where the currents twist and roll It builds a quiet landing gear for its whole soul Pre-Chorus Threads align where the flagellum meets the wall A hidden scaffold answers to the call Not fire, not fuel—just shape and fit A lock made of contact, molecule by bit Chorus Hold on, hold fast, at the edge of the flow A plaque of light where the pathways go If we break that grip, the story can bend Stop the ride before it starts again Verse 2 A conserved code repeats in cousins far apart Same silent engine with a missing start No Walker to walk, no spark to burn Still it pulls the pieces where they need to turn Bridge Name it KIAP4—watch it rise with the change As haptomonads form, the pattern rearranges Cut the gene and the anchor comes undone No valve to colonize, no race to be run Final Chorus Hold on, hold fast, at the edge of the flow A plaque of light where the pathways go Find that scaffold, cut the chain, defend Stop transmission—let the cycle end

  4. Jul 23

    Steady Light, Deep Time

    This release contains only the music track from Base by Base Episode 430. Song title: Steady Light, Deep Time Original Base by Base episode: 430: Proterozoic Rise: Steady Diversification of Crown Eukaryotes Article metadata: Article title: Environmental phylogenetics supports a steady diversification of crown eukaryotes starting from the mid-Proterozoic Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2600283123 Reference: Sandin MM, Burki F, Cohen PA, Morlond H (2026) Environmental phylogenetics supports a steady diversification of crown eukaryotes starting from the mid-Proterozoic. PNAS 123(29):e2600283123. doi:10.1073/pnas.2600283123 Lyrics: Verse 1 Midnight in the lab, bright screens like tides Long-read letters drift where the old world hides In dust-thin echoes, a living outline grows Not one sudden spark—just how the river flows Pre-Chorus We trace the branches back through shadowed years Past broken fossils, past the quiet fears A clock that hums where memory is thin Says life kept learning how to begin Chorus Steady light, deep time, let it rise, let it rise From the mid-Proterozoic to our open eyes Not a single thunderbolt, just a widening choir Crown eukaryotes climbing, line by line, higher Steady light, deep time—watch the whole world bloom Verse 2 A first green engine, borrowed from within Plastids in the dark, turning dawn to skin Archaeplastida holding early ground While predators and partners pull the web around Bridge We don’t catch it all—some names still slip away Half to three-quarters of the hidden array Roots can shift, and calibers can bend Still the curve keeps singing: it never had to end Final Chorus Steady light, deep time, let it rise, let it rise Through the long blue silence to our open eyes Most great lineages in a tight two-hundred million years But the beat stayed constant through the unknown gears Steady light, deep time—now we hear it in the bloom

  5. Jul 23

    Seventeen Little Lights

    This release contains only the music track from Base by Base Episode 429. Song title: Seventeen Little Lights Original Base by Base episode: 429: Validating the EAGL genetic literacy measure Article metadata: Article title: Psychometric validation of the education and assessment of genetic literacy or the EAGL measure Journal: Human Genetics and Genomics Advances DOI: 10.1016/j.xhgg.2026.100651 Reference: Barna LS, Liao Y, Wierzbicki MR, Ramírez-Renta GM, Kaphingst KA, Gunter C. Psychometric validation of the education and assessment of genetic literacy or the EAGL measure. Human Genetics and Genomics Advances. 2026;7:100651. doi:10.1016/j.xhgg.2026.100651. Lyrics: Verse 1 In the glow of late-night screens, we try to make it plain Big words, tiny letters, turning worry into name Some folks say they “get it”, some just guess and hope it lands So we draw the map of knowing with a few well-placed questions Pre-Chorus Is it confidence or clarity when you say you understand? Can you read the simple picture, can you follow what it means? Three threads in one signal, softly braided, hand in hand And the numbers keep the beat when the mind begins to lean Chorus Seventeen little lights, lining up the way we learn What we feel, what we can do, what we truly know for sure Cut the noise, keep it tight, let the meaning take its turn So we talk genetics human—clearer words for every world Verse 2 A quick check for attention, trim the items that are too easy Keep the ones that show the difference when the truth gets kind of breezy Not a test to shame a heart, just a measure to communicate Meet you where you’re standing now, then raise the signal’s weight Bridge Because literacy is motion, not a label you can wear It’s the skill to hold a story without getting lost in air If we measure it with care, we can teach with kinder aim And the right explanation makes the data feel like name Final Chorus Seventeen little lights, lining up the way we learn What we feel, what we can do, what we truly know for sure Make it real, keep it bright, let the meaning take its turn So we talk genetics human—clearer words for every world

  6. Jul 23

    Colocalized Light

    This release contains only the music track from Base by Base Episode 428. Song title: Colocalized Light Original Base by Base episode: 428: Genetic regulation of plasma metabolites in people with HIV Article metadata: Article title: Genome-wide association study of untargeted plasma metabolomic profiles identifies host genetic regulation in people with HIV Journal: Human Genetics and Genomics Advances DOI: 10.1016/j.xhgg.2026.100635 Reference: Ait Oumelloul M, van der Graaf A, Tang S, Thorball CW, Labarile M, Saadat A, Timonina V, Schöpf IC, Wandeler G, Nemeth J, Cavassini M, Calmy A, Schmid P, Stöckle M, Elzi L, Zamboni N, Kouyos RD, Tarr PE, Fellay J; Swiss HIV Cohort Study. Genome-wide association study of untargeted plasma metabolomic profiles identifies host genetic regulation in people with HIV. Human Genetics and Genomics Advances. 2026;7:100635. https://doi.org/10.1016/j.xhgg.2026.100635 Lyrics: Verse 1 Midnight plasma under neon glow, We cast a wide net, let the signals show. From quiet blood to a skyline of peaks, The genome hums in the language it speaks. Pre-Chorus Threads line up where the pathways meet, A hidden switch under every beat. Not one note alone—it's a mapped design, A borrowed spark where the data align. Chorus We found the link in the overlap light, Genes to molecules, holding on tight. Not fate, not guesswork—just cause in view, A new kind of compass to guide us through. Verse 2 Some names are shadows, formulas unconfirmed, But patterns persist where the evidence turned. One metabolite softens creatinine down, Another lifts lipids when it comes around. Bridge Still, we test what the numbers imply, Validate the shapes, ask “when” and “why.” From NAT8 lines to FUT2 doors, We trace small changes to bigger shores. Final Chorus We found the link in the overlap light, Genes to molecules, holding on tight. Step by step, we’re learning what heals, Turning mapped-out echoes into something real.

  7. Jul 23

    Genes on the Menu

    This release contains only the music track from Base by Base Episode 427. Song title: Genes on the Menu Original Base by Base episode: 427: When Genes Talk to Gut: Microbiome as Mediator of Metabolic Risk Article metadata: Article title: The gut microbiome as an effector of metabolic disease gene variants Journal: Trends in Genetics DOI: 10.1016/j.tig.2026.03.011 Reference: Simpson RC, Cutler HB, James DE, Masson SWC. The gut microbiome as an effector of metabolic disease gene variants. Trends in Genetics. 2026;42(7):585-588. https://doi.org/10.1016/j.tig.2026.03.011 Lyrics: Verse 1 I traced a risk through a family line, But the answer lived where the dark stays warm. A hidden crowd in a quiet spine, Turning every bite into signal and storm. Pre-Chorus Immune gates whisper, sugars rearrange, Bile runs gold like a coded tide. What you inherit can still be changed, By the world inside. Chorus Genes on the menu, microbes in the groove, Little makers shifting what the body will do. From fiber to fire, watch the pathways move, A thousand small voices singing you through. Genes on the menu, night after night, We read the pattern in the gut’s soft light. Verse 2 Some variants feed them a different fuel, Some raise defenses like a morning wall. Bifido dancing—breaking an old rule, Akkermansia answering the call. Bridge But the story’s two-way, it circles back, Diet and chance blur cause and clue. So build one map from the scattered tracks, Link genes, bugs, and metabolites too. Final Chorus Genes on the menu, microbes in the groove, Short-chain blessings, bile-acid blues. If we connect the dots, we can choose how we move, Find what fits you, not just what’s true. Genes on the menu, clear and bright, A new prediction in the gut’s soft light.

  8. Jul 23

    Prototypes in the Cloudlight

    This release contains only the music track from Base by Base Episode 426. Song title: Prototypes in the Cloudlight Original Base by Base episode: 426: ProtoCloud — Prototypical self-explaining model for single-cell analysis Article metadata: Article title: ProtoCloud: A prototypical self-explaining model for single-cell analysis Journal: Cell Genomics DOI: 10.1016/j.xgen.2026.101217 Reference: Guo K. & Ding J. ProtoCloud: A prototypical self-explaining model for single-cell analysis. Cell Genomics 6, 101217 (2026). doi:10.1016/j.xgen.2026.101217 Lyrics: Verse 1 Midnight on a bright-screen sea, Millions of whispers in a single-cell key, I used to guess what the clusters meant, Now the map shows why I’m confident. Pre-Chorus Split the signal from the noise in me, Two hidden rooms in one big dream, Walk me closer, don’t just label loud— Let me see the shape inside the cloud. Chorus Hold me to a prototype, don’t let me drift, Show me the genes that make the meaning lift, If I’m unsure, let the warning shine, Name the rare ones, one-by-one, in time. Verse 2 More than one anchor for every kind, A constellation the model can find, Similarity sings in a simple refrain, And misread stories get rewritten again. Bridge I don’t need a black-box prayer tonight, I need a reason with a traceable light, From latent echoes back to what’s expressed, A clear thread through the crowded mess. Final Chorus Hold me to a prototype, don’t let me drift, Show me the genes that make the meaning lift, When the labels shake, let uncertainty speak, We learn the atlas—stronger, calmer, sleek.

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About

Base by Base Music is the musical extension of Base by Base — a space for the original soundscapes, themes, and atmospheres that accompany science, reflection, and discovery. Here, music takes the lead: cinematic, thoughtful, and immersive compositions created to inspire focus, wonder, and intellectual curiosity.

Information

  • Creator
    Gustavo Barcelos Barra
  • Years Active
    2026
  • Episodes
    100
  • Rating
    Clean
  • Copyright
    © 2026
  • Show Website
    Base by Base - Music