Base by Base - Music

Gustavo Barcelos Barra
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Base by Base Music is the musical extension of Base by Base — a space for the original soundscapes, themes, and atmospheres that accompany science, reflection, and discovery. Here, music takes the lead: cinematic, thoughtful, and immersive compositions created to inspire focus, wonder, and intellectual curiosity.

  1. 13h ago

    Fusion Switch (Tau Let Go)

    This release contains only the music track from Base by Base Episode 408. Song title: Fusion Switch (Tau Let Go) Original Base by Base episode: 408: Tau, mitochondria, and the fusion switch Article metadata: Article title: Tau protein as a regulator of mitochondrial function and dynamics Journal: Proceedings of the National Academy of Sciences (PNAS) DOI: 10.1073/pnas.2521642123 Reference: Tsakiria E., Campos-Marques C., Ferreira I.L., Trougakos I.P., Dioli C., Gianniou D.D., Silva J.M., Skourti K., Roussos A., Samiotaki M., Sotiropoulos I., Palikaras K., et al. Tau protein as a regulator of mitochondrial function and dynamics. Proc Natl Acad Sci U S A. 2026; doi:10.1073/pnas.2521642123. Lyrics: Verse 1 Under bright screens in the midnight lab I watch the power in the quiet cradles Tiny engines learning how to grab A steadier rhythm, tighter cables Pre-Chorus There’s a hand on the throttle we never named A silent brake in the cell’s back room Let it loosen and the map gets rearranged Like sunrise pushing through the gloom Chorus When Tau lets go, the lights burn clean Mitochondria fuse like a living stream Breathing higher, voltage on the rise But sparks of ROS in the corners of my eyes Verse 2 No more snap-cuts, fewer splits at the seams Drp1 fades to the background motion Mitofusin pulls the threads of these dreams Stitching fragments into one wide ocean Bridge And the cleanup crews start moving in time Mitophagy humming, taking out the worst Stronger in stress, still paying the dime More fire inside means more to quench first Final Chorus When Tau lets go, the lights burn clean Mitochondria fuse like a living stream Breathing higher, voltage on the rise But sparks of ROS in the corners of my eyes So we ride that trade-off, bold and true More power to live—more heat to see through

    2 min

  2. 1d ago

    Lock the Metals Away

    This release contains only the music track from Base by Base Episode 407. Song title: Lock the Metals Away Original Base by Base episode: 407: SLC11A2 withholds metals from Salmonella in the gut epithelium Article metadata: Article title: SLC11A2 withholds divalent metals from Salmonella in the gut epithelium Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2532675123 Reference: Norberg ES, Knodler LA, et al. SLC11A2 withholds divalent metals from Salmonella in the gut epithelium. PNAS. 2026;123:e2532675123. doi:10.1073/pnas.2532675123 Lyrics: Verse 1 In the gut where the neon microscopes glow, A shadow slips in where the warm cells grow. It thinks it can settle, it thinks it can stay, But the pantry is closing—no feast today. Pre-Chorus You can hide in a bubble, build walls in the dark, But we hear your hunger like a tiny spark. We cut the supply lines, quiet and sure, Starve out the storm with a natural cure. Chorus Lock the metals away, let the invader wait, Iron and manganese—seal that gate. In the vacuole night, watch the numbers fall, No fuel for the fire when we withhold it all. Lock the metals away, no easy win, You can’t grow in a house you can’t eat within. Verse 2 Some cells see the signal—low down to the bone, Less than a whisper of iron to own. A transporter pulls up like a guard on call, Turns the lights down low inside the wall. Bridge Try to steal it back with a desperate plan, MntH on the run, siderophores in hand. But every bright grab meets a colder defense, We tighten the silence with patient suspense. Final Chorus Lock the metals away, let the invader wait, Iron and manganese—seal that gate. In the vacuole night, watch the numbers fall, No fuel for the fire when we withhold it all. Lock the metals away, feel the pressure shift, A hidden kind of power, a cellular gift.

    3 min

  3. 5d ago

    Cold Side of the Gut

    This release contains only the music track from Base by Base Episode 406. Song title: Cold Side of the Gut Original Base by Base episode: 406: Temperature & Age Shape Gut Susceptibility to HCoV-229E Article metadata: Article title: Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E Journal: Proceedings of the National Academy of Sciences (PNAS) DOI: 10.1073/pnas.2600632123 Reference: Synowiec A., Lie L.K., Szczepański A., et al. Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E. Proc. Natl. Acad. Sci. U.S.A. 2026;123(26):e2600632123. https://doi.org/10.1073/pnas.2600632123 Lyrics: Verse 1 Neon in the lab, midnight on the clock, We set that warm line, then we let it drop. Same cells, same gate, but the world rewinds— At thirty-two the virus finds time. Pre-Chorus Quiet alarms in the innate reply, Less of the warning, more room to climb. Screens light up with the rising load— A colder state and an open road. Chorus Temperature tells it when to run, Cold makes a cradle, heat stops the fun. In the enterocytes, it stakes its claim, But at thirty-seven it can’t play the same. Turn the dial, watch the story cut— Cold side of the gut, cold side of the gut. Verse 2 Fetal and young still catch that wave, Adults switch gears and won’t behave. Translation slows, metabolism bends, Stress-path signals draw the ends. Bridge One receptor, one lock: ANPEP on the door, Protease like a razor, it wants a little more. But camostat cuts the spark mid-flight, Shut down entry, fade out the bite. Final Chorus Temperature tells it when to run, Cold makes a cradle, heat stops the fun. In the enterocytes, it stakes its claim, But grown-up heat won’t feed the flame. Turn the dial, let the data erupt— Cold side of the gut, cold side of the gut.

    2 min

  4. 5d ago

    Symmetry in the Sparks

    This release contains only the music track from Base by Base Episode 405. Song title: Symmetry in the Sparks Original Base by Base episode: 405: PRDM9 and the Hotspot Trade-off Article metadata: Article title: On the origin of PRDM9-guided recombination hotspots Journal: Proceedings of the National Academy of Sciences (PNAS) DOI: 10.1073/pnas.2535682123 Reference: Úbeda F, Bürger R, Fyon F. On the origin of PRDM9-guided recombination hotspots. Proc Natl Acad Sci U S A. 2026;123(26):e2535682123. doi:10.1073/pnas.2535682123 Lyrics: Verse 1 In the quiet split of a cell-made night, Two threads drift close to trade their light. Some marks are scattered, some are drawn, A hidden map we’re walking on. Pre-Chorus If you bind too often, you pay the cost, Connections blur and chances get lost. But when the meeting’s mirrored, side by side, That’s where the crossover can decide. Chorus Let it meet in symmetry, let it lock in time, Two matching hands on the same thin line. Even if the net runs lower, it can still ignite— When mirrored sparks turn into new life. Verse 2 One path aims anywhere, wide and free, One path writes names on the genome’s sea. And sometimes both can share the stage, Swinging in cycles from age to age. Bridge On bigger strands, the pressure’s real— Miss one exchange and the whole thing can peel. So the system learns what it can’t ignore: Make the surest crossover worth fighting for. Final Chorus Let it meet in symmetry, let it lock in time, Two matching hands on the same thin line. Trade a little binding for a clearer sign— And watch the hotspots hold the line.

    2 min

  5. 6d ago

    DNA on the Outside

    This release contains only the music track from Base by Base Episode 404. Song title: DNA on the Outside Original Base by Base episode: 404: RUNA Reveals Surface DNA on Exosomes Article metadata: Article title: A nucleic acid labeling chemistry reveals surface DNA on exosomes Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2532281123 Reference: Bošković F, Dutta Gupta P, Zhang J, Szostak JW, Krishnan Y. A nucleic acid labeling chemistry reveals surface DNA on exosomes. Proc Natl Acad Sci U S A. 2026;123(27):e2532281123. doi:10.1073/pnas.2532281123 Lyrics: Verse 1 In the clean-room glow, in a late-night hush Tiny parcels drift where the signals rush We thought the message stayed sealed inside But something bright was riding the outside Pre-Chorus A small switch flips with a careful heat Mark the letters where the membranes meet Draw the line—what’s in, what’s out Turn the mystery into a map, no doubt Chorus DNA on the outside, lit like a flare Not buried in the dark—it's hanging in the air Tag it, trace it, watch it come alive A hidden surface truth where the answers survive Verse 2 Under stress, the repair lines fray and stall And more bare strands show up on the wall Scavenger hands reach, pull the vesicles near And the quiet cells change gears when they hear Bridge From easy-going to a fighting stance A colder calm becomes a hotter chance Not every thread is fully understood But the tool cuts clean where questions stood Final Chorus DNA on the outside, lit like a flare A reversible mark says, “Look right there” From damaged repair to immune rewrite We turn a thin line into guiding light

    3 min

  6. 6d ago

    Scars That Tell the Truth

    This release contains only the music track from Base by Base Episode 404. Song title: Scars That Tell the Truth Original Base by Base episode: 404: HRD-GIS refines BRCA1/2 variant classification in ovarian cancer Article metadata: Article title: Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity Journal: The American Journal of Human Genetics DOI: 10.1016/j.ajhg.2026.05.015 Reference: Schnaiter S., Santer F.R., Csanaky K.A., et al. Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity. The American Journal of Human Genetics. 113, 1–8 (2026). https://doi.org/10.1016/j.ajhg.2026.05.015 Lyrics: Verse 1 On bright screens in the midnight lab, we chase a pattern we can’t quite grab. Shattered ladders, missing rungs, a quiet code on silver tongues. In the wreckage, numbers glow. Pre-Chorus If repair goes dark, the story shows, in loss of pieces, how it grows. A fingerprint you can’t erase, drawn in the genome’s broken place. Let the signal cut through doubt. Chorus These scars don’t lie, they light the way, turn the maybe into “name it” today. When the fix is gone, the fracture’s loud, HRD speaking through the crowd. Hold the line—let evidence stay: scars that tell the truth today. Verse 2 Four cohorts singing, one refrain, thousands of tumors in the chain. When GIS rises past the line, BRCA shadows intertwine. When it’s low, the fear steps back. Bridge Not every variant wears a crown, some live in grey, some won’t come down. So we weigh the odds, we map the chance, likelihood turning into stance. A measured spark in clinic halls— a clearer call when darkness falls. Final Chorus These scars don’t lie, they light the way, turn the maybe into “name it” today. High score, strong pull—support the claim, low score can quiet a warning name. From broken repair, a brighter view: scars that tell the truth—break through.

    3 min

  7. Jun 26

    Scars That Tell the Truth

    This release contains only the music track from Base by Base Episode 403. Song title: Scars That Tell the Truth Original Base by Base episode: 403: HRD-GIS Evidence for BRCA1/2 Variant Classification Article metadata: Article title: Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity Journal: The American Journal of Human Genetics DOI: https://doi.org/10.1016/j.ajhg.2026.05.015 Reference: Schnaiter et al., 2026, The American Journal of Human Genetics 113, 1–8. https://doi.org/10.1016/j.ajhg.2026.05.015 Lyrics: Verse 1 Under bright screens in the quiet of the night, We read the damage where the cells lost the fight. Not every letter screams, not every change is loud, So we follow the footprints in the broken crowd. Pre-Chorus Three little signals, lining up in time, Loss, shift, and stretch—like a rhythm in a crime. When the shield goes missing, the pattern starts to show, A hidden kind of yes, a measured kind of no. Chorus These scars don’t lie, they light the way, A map in the wreckage where the truth can stay. If the score runs high, it’s a warning sign, If the score stays low, let the doubt unwind. We’re not guessing anymore—we’re calling it by design. Verse 2 Some tumors carry silence where a safeguard should be, And some look steady, closer to stability. We weigh what’s likely, we hold it to the scale, So care can be clearer when the family stories fail. Bridge Not perfect, not final, but stronger than before, A likelihood like footsteps across a lab-room floor. From haze into evidence, from maybe into proof, We turn the genome’s weather into shelter, into roof. Final Chorus These scars don’t lie, they light the way, A map in the wreckage where the truth can stay. If the score runs high, it’s a warning sign, If the score stays low, let the doubt unwind. We’re not guessing anymore—we’re calling it by design.

    2 min

  8. Jun 25

    Outliers in the Light

    This release contains only the music track from Base by Base Episode 402. Song title: Outliers in the Light Original Base by Base episode: 402: When Polygenic Scores Miss: Rare Variants in Misaligned Individuals Article metadata: Article title: Individuals who deviate from polygenic expectation are enriched for damaging variants in genes linked to rare disease Journal: The American Journal of Human Genetics 113, 1–19 (2026) DOI: 10.1016/j.ajhg.2026.05.013 Reference: Baya N.A., Lassen F.H., Hill B., Venkatesh S.S., Currant H., Lindgren C.M., Palmer D.S., Individuals who deviate from polygenic expectation are enriched for damaging variants in genes linked to rare disease, The American Journal of Human Genetics 113, 1–19 (2026). doi:10.1016/j.ajhg.2026.05.013 Lyrics: Verse 1 I drew my line in midnight ink, A score that said I shouldn’t sink, But life showed up with different math, A hidden turn, a sideways path. Pre-Chorus Some numbers hum, some numbers shout, But there’s a ghost they leave out, A single letter out of place, That changes speed, that shifts the race. Chorus I’m an outlier in the light, Common winds, rare sparks ignite, When the forecast doesn’t fit the sky, Look closer—there’s a reason why. Verse 2 Too short, too tall, bone turning thin, A quiet break beneath the skin, A switch that dims, a switch that drives, Two kinds of code inside our lives. Bridge So when the curve won’t hold me tight, Don’t call it noise, don’t call it slight, Screen the shadows, name the flame, Find the gene that bends the game. Final Chorus I’m an outlier in the light, Common winds, rare sparks ignite, And if the forecast misses true, The rare can move the common too, Look closer—there’s a reason why.

    2 min
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About

Base by Base Music is the musical extension of Base by Base — a space for the original soundscapes, themes, and atmospheres that accompany science, reflection, and discovery. Here, music takes the lead: cinematic, thoughtful, and immersive compositions created to inspire focus, wonder, and intellectual curiosity.

Information

  • Creator
    Gustavo Barcelos Barra
  • Years Active
    2K
  • Episodes
    100
  • Rating
    Clean
  • Copyright
    © 2026
  • Show Website
    Base by Base - Music