Dr.Jeff & Friends

Jeffrey Piccirillo
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Welcome to Dr. Jeff & Friends… The podcast for people who know something in healthcare isn't adding up. We've been told: 👉 Eat less 👉 Move more 👉 Take another prescription And yet… Chronic disease is rising. Energy is falling. And people are more frustrated than ever. Dr. Jeff, an orthopedic surgeon turned regenerative medicine expert, pulls back the curtain on what's really going on—and what you can actually do about it. This show is about: • Fixing root causes, not chasing symptoms • Understanding your biology, not fighting it • Exploring what's next in medicine—not what's outdated From oxidative stress to metabolism, hormones to longevity, and cutting-edge therapies shaping the future… This isn't anti-medicine. 👉 This is medicine… evolved.

Episodes

  1. 2d ago

    Dr. Jeff & Friends, Season 1, Episode 11: OXIDATIVE STRESS: THE MASTER CLASS WITH DR. DONDEE NETTLES - PART 2 | Mitochondria, Obesity, Cancer & What You Can Do?

    🧬 MASTERCLASS: OXIDATIVE STRESS -  PART 2 In Part 2 of our Oxidative Stress Masterclass, Dr. Donnie Nettles and I take the conversation deeper, looking at what oxidative stress can do at the cellular level and why it may play such an important role in our long-term health. We start with the mitochondria - the structures inside our cells responsible for producing much of the energy our bodies need. What happens when oxidative stress begins damaging mitochondrial function? ATP production can decline. Cellular energy can suffer. And mitochondrial dysfunction has been associated with fatigue, metabolic dysfunction, cardiovascular disease, aging, and many chronic diseases. From there, we explore the connection between oxidative stress, obesity, and our modern food supply including how what we eat can influence inflammation, metabolism, and cellular health. We also discuss a more serious consequence of oxidative damage: DNA damage and genetic mutations, and how accumulated cellular damage can contribute to the processes involved in cancer development. But we didn't want to end the Masterclass by simply talking about what's going wrong. We wanted to talk about what you can actually do about it. So Dr. Nettles and I finish the episode by each sharing 5 things you can start doing TODAY to help reduce oxidative stress and support better overall health. This isn't about chasing one supplement or one treatment. It's about understanding the biology -and then making choices that help your body work the way it was designed to work. ▶️ Watch Masterclass: Oxidative Stress - Part 2 and let us know in the comments which change you're going to start with. Jeff Piccirillo, DO The Dr. Jeff Effect

  2. Sep 22 ·  Video

    Dr. Jeff & Friends, Season 1, Episode 10: OXIDATIVE STRESS: THE MASTER CLASS WITH DR. DONDEE NETTLES - PART 1 | What Changed Our Health?

    🧬 WHAT HAPPENED TO OUR HEALTH? Something changed dramatically over the last 50 years. Obesity increased. Type 2 diabetes increased. Metabolic disease became increasingly common. And today, many people are living longer—but not necessarily living healthier. So what changed? In Part 1 of our Oxidative Stress Master Class, my good friend Dr. Dondee Nettles joins me on Dr. Jeff & Friends to start connecting the dots. We go back to the 1970s and look at the transformation of the American food environment, the growth of ultra-processed foods, and how our changing lifestyles may be affecting our biology. But then we go deeper. 🧬 What exactly is oxidative stress? ⚡ What happens when oxidative stress begins affecting our mitochondria? 🔥 How are oxidative stress and chronic inflammation connected? ⚖️ What is happening metabolically as obesity and insulin resistance develop? 🩸 How can chronically elevated blood sugar damage cells and blood vessels? 🧠 And could some of the diseases we treat as completely separate problems actually share some of the same underlying biological pathways? This is where the conversation gets fascinating. Because maybe we need to spend less time asking only: "What disease do you have?" And start asking: "What is happening to the biology underneath it?" 🎙️ Dr. Jeff & Friends 🧬 OXIDATIVE STRESS: THE MASTER CLASS — PART 1 Featuring Dr. Dondee Nettles Watch the full episode and then share it with someone who needs to hear this conversation. And we're not finished. 👉 PART 2 is coming in two weeks.

  3. Aug 31 ·  Video

    Dr. Jeff & Friends, Season 1, Episode 9: The Savage Factors: How Stress Can Make Us Stronger with Charles Runels, MD

    What if the right kind of stress could actually make us stronger? On this episode of Dr. Jeff & Friends, Dr. Jeff sits down with his friend Dr. Charles Runels, author of Savage Factors and inventor of the O-Shot®, P-Shot® and Vampire Facelift®, for a wide-ranging conversation about the biology of resilience, regeneration and healthy aging. They discuss Charles' personal routine, fasting, why he stays away from his phone until noon, growth hormone and aging, and the concept that carefully applied physiological stress may trigger adaptive responses within the body. The conversation then moves into growth hormone secretagogues, oxidative stress and the importance of creating the right biological environment for repair and regeneration. Finally, Charles tells the stories behind the development of the O-Shot® and P-Shot®, and Dr. Jeff asks him to leave listeners with something practical: What should we all be doing daily, weekly and monthly to improve our health and longevity? Real Conversations. Real Science. Real Impact.

  4. Aug 14 ·  Video

    Dr. Jeff & Friends, Season 1, Episode 8: Gut Health: It's Not Just About Digestion with Dr. Jessica Buhler

    When most people hear "gut health," they think about digestion, bloating, constipation, or stomach problems. But the gut is connected to so much more. In this episode of Dr. Jeff & Friends, Dr. Jeff sits down with special guest Dr. Jessica Buhler to explore why the gut may be one of the most important biological ecosystems in the body. We discuss the connection between gut health and: • The gut microbiome • Inflammation • Immune function • Metabolism • Hormones • Brain health and mood • The gut-brain connection • Diet and ultra-processed foods • Overall health and wellness We also look at what can happen when the microbiome becomes disrupted and why improving gut health may be an important place to start when trying to improve overall health. Your gut isn't simply a tube that processes food. It communicates with your immune system, your metabolism, and even your brain. The bigger question isn't just, "How is your digestion?" It's "How healthy is the ecosystem living inside you?" 🎙️ Dr. Jeff & Friends Conversations about health, wellness, longevity, and the biology behind how our bodies work.

  5. Jul 30 ·  Video

    Dr. Jeff & Friends, Season 1, Episode 7: Should Every Chiropractor Be Using LifeVantage? | The Chiropractic Roundtable

    The Chiropractic Roundtable brings together five experienced chiropractors with more than 160 years of combined clinical practice to discuss the future of wellness-centered chiropractic care. Dr. Jeff is joined by Dr. Kat Kadin, Dr. Jess Buhler, Dr. Maria Cutler, Dr. Carmen Garcia, and Dr. Dondee Nettles for a lively conversation about integrating nutrition, activation science, and lifestyle support into daily practice. The panel discusses: Helping patients maintain their adjustments Liquid Collagen and joint health Gut health with P84 and Probio Protandim NRF2 and oxidative stress NAD support and healthy aging Why chiropractors often lead the way in whole-person wellness This episode offers valuable clinical perspectives from doctors who have collectively cared for patients for more than 160 years.

  6. Jul 10

    Dr. Jeff & Friends, Season 1, Episode 6: Protecting Your Brain: The Power of Product Synergy, Stress & Healthy Aging

    In this episode of Dr. Jeff & Friends, Dr. Jeff welcomes Dr. Brett Brimhall for an in-depth discussion on one of today's most important and often overlooked topics: protecting the brain. Although many people think about brain health only after memory problems begin, the truth is that our brains are constantly being shaped by stress, nutrition, inflammation, oxidative stress, sleep, physical activity, and the choices we make every day. Together, Dr. Jeff and Dr. Brimhall discuss: 🧠 How oxidative stress affects the brain throughout life 🧠 The effects of chronic psychological stress and trauma on cognitive function 🧠 Brain health in children, adults, and healthy aging 🧠 Why product combinations—or "stacking" activation protocols—may provide broader support than focusing on a single product 🧠 Strategies to support energy, recovery, resilience, immune function, and long-term metabolic wellness This conversation explores how activation science, lifestyle, and thoughtful wellness strategies can work together to help protect one of our body's most valuable organs — our brain. Whether you're interested in optimizing performance today or supporting healthy aging for the future, this episode provides practical insights into protecting your brain for the long term.

  7. Jun 26

    Dr. Jeff & Friends, Season 1, Episode 5: The Science Behind Smarter Supplementation with Dr. Nancy Bryan

    What goes into creating a nutritional supplement that is truly backed by science? On this episode of Dr. Jeff & Friends, I'm joined by Dr. Nancy Bryan, former LifeVantage formulator, scientist, and educator, for a fascinating behind-the-scenes look at how science-based nutritional products are developed. Rather than simply discussing ingredients, we explore the why behind the formulations and how thoughtful design can influence health, metabolism, and healthy aging. During our conversation we discuss: • Dr. Bryan's role in developing LifeVantage's D+ (Vitamin D+), AM/PM Vitamins, and Prebiotic • Why Vitamin D deficiency remains one of the most common nutritional deficiencies in America—even for people living in sunny climates • The science behind circadian nutrition and why taking specific nutrients in the morning versus the evening may improve how your body utilizes them • The importance of trace minerals such as copper, zinc, iodine, selenium, and molybdenum, and the critical roles they play in metabolism, thyroid health, antioxidant defense, and cellular function • Why balancing nutrients is often more important than simply taking higher doses • The often-overlooked relationship between prebiotics and probiotics, why they work together, and how supporting your microbiome begins by feeding the beneficial bacteria already living in your gut If you've ever wondered why some supplements seem thoughtfully designed while others are simply a collection of ingredients, this conversation provides a rare look inside the science of nutritional formulation. Whether you're interested in healthy aging, metabolism, thyroid health, gut health, or simply making smarter decisions about supplementation, you'll come away with practical insights you can begin applying immediately. Be sure to subscribe to Dr. Jeff & Friends for more conversations with leading physicians, scientists, innovators, and health experts as we explore how to take back control of your health, your wealth, and your destiny. #DrJeffAndFriends #DrNancyBryan #LifeVantage #VitaminD #NutritionScience #SupplementScience #HealthyAging #CircadianRhythm #FunctionalMedicine #GutHealth #Prebiotics #Microbiome #NRF2 #Metabolism #ThyroidHealth #Longevity #HealthOptimization #Wellness #Podcast #ApplePodcasts #SpotifyPodcasts #YouTube

  8. Jun 15 ·  Video

    Dr. Jeff & Friends, Season 1, Episode 4: Pulling Back the Curtain in LifeVantage: From Concept to Clinical Study

    In this episode of Dr. Jeff & Friends, we pull back the curtain on the fascinating process of developing a health and wellness product—from the initial idea to the final clinical study. Joining Dr. Jeff are two leaders in scientific innovation: Lisa Barnes, Vice President of Research & Development Christina Beers, PhD and Senior Research Scientist Together, they take us behind the scenes of product development and reveal what it really takes to bring a new product to market. In this episode, we discuss: ✅ Where new product ideas come from ✅ The research process behind ingredient selection ✅ How formulations are developed and refined ✅ Bench-top testing and pre-clinical evaluation ✅ The role of human clinical studies ✅ Why scientific validation matters ✅ How new products are evaluated alongside existing products for synergy and effectiveness ✅ What separates evidence-based innovation from marketing hype Most consumers only see the finished product. What they don't see are the years of research, testing, validation, and scientific scrutiny that occur before a product ever reaches the marketplace. This conversation provides a rare look inside the world of product development and offers valuable insight into how science, innovation, and curiosity work together to create meaningful advances in health and wellness. Because every breakthrough starts with a question. And every innovation begins with the courage to ask a better one.

  9. May 30

    Dr. Jeff & Friends, Season 1 , Episode 3 "Why Men Are Struggling Younger Than Ever: Testosterone, ED & The Modern Health Crisis"

    In this episode of Dr. Jeff & Friends, Dr. Jeff sits down with orthopedic surgeon and men's health specialist Dr. Jack Rocco to discuss one of the biggest health challenges facing men today. Over the past 50 years, men's health has changed dramatically. Conditions that were once common in men in their 60s and 70s—such as low testosterone, erectile dysfunction, and metabolic dysfunction—are now being seen in men in their 20s, 30s, and 40s. Together, Dr. Jeff and Dr. Rocco explore: ✅ Why testosterone levels are declining in younger men ✅ The rise of erectile dysfunction at younger ages ✅ How modern diets, obesity, and oxidative stress affect hormones ✅ The impact of pornography and instant access technology on the developing brain ✅ How these issues affect marriages, relationships, confidence, and quality of life ✅ The growing gap between lifespan and healthspan ✅ Hormone replacement therapy, metabolic optimization, and regenerative medicine solutions This is an honest and thought-provoking conversation about what is happening to men today, why it matters, and what can be done about it. Because men's health is about much more than testosterone. It's about energy, vitality, confidence, relationships, and living a longer, healthier life. Topics Covered: Testosterone Erectile Dysfunction Men's Health Oxidative Stress Hormones Metabolism Relationships Pornography and the Brain Healthspan vs Lifespan Regenerative Medicine Longevity

  10. May 18

    Dr. Jeff & Friends, Season 1, Episode 2, with special guest Dr. Dondee Nettles

    This week on Dr. Jeff & Friends: Join my good friend and colleague Dr. Dondi Nettles — one of the most respected voices in LifeVantage, with more than 17 years of experience — as we discuss how the world, our environment, and our health have dramatically changed over the last 50 years, and why controlling oxidative stress with Protandim NRF2 may be more important today than ever before.

  11. Apr 24

    Dr. Jeff & Friends, Season 1, Episode 1: 4 Experts. 1 Question: What Actually Works?

    This is NOT another health podcast. In this first episode of Dr. Jeff & Friends, we bring together four experts from the LifeVantage Scientific Advisory Board to answer two simple—but powerful—questions: 👉 What made you say YES? 👉 And what's keeping you here today? What unfolds is something much bigger… A pattern. A shift. A realization that what most people have been told about health, weight loss, and metabolism… isn't working anymore. In this episode, we break down: • Why metabolism slows down (even when you're "doing everything right") • The real reason diets fail • What happens when you stop treating symptoms and start addressing root causes • How activation science is changing the conversation around health Featuring insights from: Dr. Jessica Buhler Dr. Maria Liu Dr. Joe Lui Dr. Nancy Ciccarelli Bryan Dr. Jeff's Truth: You don't have a weight problem. You don't have a hormone problem. 👉 You have a SYSTEM problem. And when you fix the system… 👉 everything changes. Follow along weekly as we challenge the system, question the narrative, and take control of our health.

    Dr. Jeff & Friends, Season 1, Episode 1: 4 Experts. 1 Question: What Actually Works?
  • 11 Episodes

About

Welcome to Dr. Jeff & Friends… The podcast for people who know something in healthcare isn't adding up. We've been told: 👉 Eat less 👉 Move more 👉 Take another prescription And yet… Chronic disease is rising. Energy is falling. And people are more frustrated than ever. Dr. Jeff, an orthopedic surgeon turned regenerative medicine expert, pulls back the curtain on what's really going on—and what you can actually do about it. This show is about: • Fixing root causes, not chasing symptoms • Understanding your biology, not fighting it • Exploring what's next in medicine—not what's outdated From oxidative stress to metabolism, hormones to longevity, and cutting-edge therapies shaping the future… This isn't anti-medicine. 👉 This is medicine… evolved.

Information

  • Creator
    Jeffrey Piccirillo
  • Years Active
    2026
  • Episodes
    11
  • Rating
    Clean
  • Copyright
    © 2026
  • Show Website
    Dr.Jeff & Friends