Dr. John Campbell

Campbellteaching

Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider

  1. 2h ago

    Prevalence remains high

    UK, high prevalence maintainedUploaded 18-02-22https://covid.joinzoe.com/post/covid-not-showing-signs-of-droppingEnd of SeptemberBased on 39,742 recent swab tests, between 11th and 25th September 202158,126 new daily symptomatic casesBased on PCR and LFT test dataIn the fully vaccinated population, 14,352 new daily symptomatic casesOverall UK PrevalenceOn average 1 in 93 people in the UK have symptomatic COVIDIncrease mostly in under 19sUptick in the number of active cases in people aged 20-50Cases remain low and stable in contributors over the age of 50UK R around 1.1England, 1.1Wales, 1.1 (currently increasing)Scotland, 1.0ZOE’s predicted Long COVID incidence rate804 people a day will go on to experience symptoms for longer than 12 weeksProfessor Tim SpectorWe’re seeing infections being passed up the generational ladder, likely from school children to their parents. Most of these new adult infections are in the under 50s, who still have a relatively low risk of being admitted to hospital, especially if they’ve been fully vaccinated.As the winter approaches, it’s important parents of school-aged children and students don’t pass the virus on to more vulnerable grandparents by not recognising simple cold-like symptoms as a possible COVID infection. This is a critical time and a little caution could make all the difference in avoiding a winter crisis for hospitals.Zoe Live feedhttps://covid.joinzoe.com/data#levels-over-timeUK official datahttps://coronavirus.data.gov.ukCanadahttps://health-infobase.canada.ca/covid-19/epidemiological-summary-covid-19-cases.htmlUnited StatesDeaths, 705,326 (JH)https://coronavirus.jhu.edu/map.htmlCases and deathshttps://covid.cdc.gov/covid-data-tracker/#trends_dailycasesHospital patientshttps://covid.cdc.gov/covid-data-tracker/#hospitalizationsVaccination trendshttps://covid.cdc.gov/covid-data-tracker/#vaccination-trends_vacctrends-total-dailyThe White Househttps://www.washingtonpost.com/nation/2021/10/06/covid-delta-variant-live-updates/$1 billion for rapid, at-home coronavirus testsQuadruple such tests by DecemberUp to 200 million per monthVaccines probably prevented, in Medicare beneficiaries in the first five months of this yearhttps://aspe.hhs.gov/sites/default/files/documents/8d15a6223df12fcb59de1f031adb1eec/aspe-covid-medicare-vaccine-analysis.pdf265,000 infections107,000 hospitalizations39,000 deathsThree Moderna founders make Forbes list of America’s richest during pandemic$2.48 billion in R and D and supply funding from the U.S. governmenthttps://www.fiercepharma.com/pharma/after-nearly-1b-research-funding-moderna-takes-1-5b-coronavirus-vaccine-order-from-u-shttps://www.washingtonpost.com/nation/2021/10/06/covid-delta-variant-live-updates/A list of the top 400 richest people in AmericaTop 400, 40% richer than last yearJohnson and Johnson and AstraZeneca, no profits during the pandemicAustraliahttps://www.health.gov.au/news/health-alerts/novel-coronavirus-2019-ncov-health-alert/coronavirus-covid-19-case-numbers-and-statisticsPolandFourth wave is gathering paceCases up 70% in the past weekHealth service stretched to its limits last springWaldemar Kraska, a deputy health ministerToday's data is a very fast flashing red lightRussia soars daily deaths increasinghttps://news.sky.com/story/covid-news-uk-latest-live-experts-discover-why-people-get-covid-toes-as-wales-introduces-vaccine-passports-12425651The Kremlin confirmed, Cases, + 25,133Deaths, + 929 = 208,842 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

  2. 2h ago

    CDC pushes childhood vaccination

    Link for free download of my 2 textbooks in high res PDFUploaded 14-06-22http://159.69.48.3/COVID-19 Vaccine Recommendations for Children and Teenshttps://www.cdc.gov/coronavirus/2019-ncov/vaccines/vaccines-children-teens.htmlWhat You Need to KnowCDC recommends everyone ages 5 years and older get vaccinated against COVID-19.Everyone ages 5 years and older should also get a COVID-19 booster, when eligible.Booster, at least 5 months after primary courseThe Joint Committee on Vaccination and Immunisation (JCVI)advise that all children aged 5 to 11 are offered the coronavirus (COVID-19) vaccine.https://www.nhs.uk/conditions/coronavirus-covid-19/coronavirus-vaccination/coronavirus-covid-19-vaccination-for-children/coronavirus-covid-19-vaccine-for-children-aged-5-to-15/https://www.nhsinform.scot/covid-19-vaccine/the-vaccines/vaccinating-children-aged-5-to-11-yearshttps://www.gov.uk/government/publications/jcvi-update-on-advice-for-covid-19-vaccination-of-children-aged-5-to-11/jcvi-statement-on-vaccination-of-children-aged-5-to-11-years-oldUK, 5 million age 5 to 11Children aged 5 to 11 years will be offered 2 doses of the coronavirus vaccine.JCVI advises a non-urgent offer of two 10 mcg doses of the Pfizer-BioNTech COVID-19 vaccine (Comirnaty®) to children aged 5 to 11 years of age who are not in a clinical risk group.What about natural immunitySeroprevalence of Infection-Induced SARS-CoV-2 Antibodies — United States, September 2021–February 2022https://www.cdc.gov/mmwr/volumes/71/wr/mm7117e3.htm?s_cid=mm7117e3_e&ACSTrackingID=USCDC_921-DM80513&ACSTrackingLabel=MMWR%20Early%20Release%20-%20Vol.%2071%2C%20April%2026%2C%202022&deliveryName=USCDC_921-DM80513anti-N antibodiesAs of February 2022, approximately 75% of children and adolescents had serologic evidence of previous infection with SARS-CoV-2, with approximately one third becoming newly seropositive since December 2021.These findings illustrate a high infection rate for the Omicron variant, especially among childrenhttps://www.pfizer.com/news/press-release/press-release-detail/pfizer-biontech-covid-19-vaccine-demonstrates-strong-immuneUK, percentage of the population estimated to have antibodies was high for children in Great Britainhttps://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19latestinsights/antibodiesAntibodies against SARS-CoV-2 at or above 179 nanograms per millilitre (ng/ml), UK, 29 November 2021 to 15 May 2022Testing negative means that an individual did not have enough antibodies to be detected in the test, not that they do not have any immune protection against the virus.Pfizer booster dose, the evidencehttps://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-data-demonstrating-high-immuneThursday, April 14, 2022Data from a subanalysis of 30 seraclinical trial of children 5 through 11 years36-fold increase in SARS-CoV-2 Omicron neutralizing titers following a booster (third) dosePhase 2/3 clinical trial with 140 childrena booster (third) dose increased neutralizing antibodies by 6-fold against the SARS-CoV-2 wild-type strainCost of Pfizer vaccine for 5 to 11 year oldshttps://www.pharmaceutical-technology.com/analysis/covid-19-vaccine-pricing-varies-country-company/EU, $23.15 per doseUS, $24UK, x 5,000,000 = $115,750,000Per primary course, = $231,500,000With third dose, $347,250,000£289,000,000US, x 24,000,000 = $576,000,000Per primary course, $1,152,000,000With third dose, $1,728,000,000Why America Doesn't Trust the CDChttps://www.newsweek.com/why-america-doesnt-trust-cdc-opinion-1713145MARTY MAKARY , PROFESSOR, JOHNS HOPKINS SCHOOL OF MEDICINE Centers for Disease Control (CDC) vigorously recommended the booster for all 5 - 11Pfizer spokesperson, it did not determin Learn more about your ad choices. Visit megaphone.fm/adchoices

  3. 3h ago

    Activated Vitamin D trial

    Free download John’s textbooks in high res pdf.https://drjohncampbell.co.ukUploaded 18-09-23Order my Physiology Notes in hard copy if you live in the UK,https://www.ebay.co.uk/itm/154973392319?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=K6raxMZrQnm&sssrc=2047675&ssuid=&widget_ver=artemis&media=EMAILThe effect of 1-hydroxy-vitamin D treatment in hospitalized patients with COVID-19: A retrospective studyhttps://www.sciencedirect.com/science/article/pii/S0261561423002790Vitamin D deficiency is associated with elevated risk, severity, and mortalityAsthma, tuberculosis, chronic pulmonary obstructive disease (COPD), and viral respiratory infectionsConsistent paper 1.Vitamin D and its therapeutic relevance in pulmonary diseaseshttps://www.sciencedirect.com/science/article/abs/pii/S0955286320306033?via%3DihubVitamin D essential for several cellular processes, wound healing, immunity inflammationStudies have displayed strong inter-relations with vit D deficiency and progression of lung disordersIts ease of supplementation and development of personalized medicine,could lead us to an effective adjunct and cost-effective method of therapeutic modality for highly fatal pulmonary diseases.Consistent paper 2.Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deathshttps://www.mdpi.com/2072-6643/12/4/988To reduce the risk of infection, it is recommended that people at risk of influenza and/or COVID-19,consider taking 10,000 IU/d of vitamin D3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40–60 ng/mL (100–150 nmol/L). For treatment of people who become infected with COVID-19, higher vitamin D3 doses might be useful. Vitamin D deficiency is relatively commonEspecially among the elderly, the obese, and patients with comorbidities including hypertension, diabetes, COPD, and CKDVitamin D inducesProduction of antiviral peptides (defensins),especially in the respiratory epitheliumVitamin D upregulates anti-inflammatory cytokines such as interleukin-10 (IL-10),and downregulates pro-inflammatory cytokines including IL-1, IL-6, and tumor necrosis factor alfaVitamin D effects angiotensin-converting enzyme axis,which has a protective effect against ARDSEfficacy of activated vitamin D supplementation in coronavirus disease 2019 (COVID-19)1-hydroxy-vitamin D was prescribed on day 1 or 2 (median duration 8 days)To evaluate the effect of 1-hydroxy-vitamin D,on the prevention of severe disease and mortality,in patients hospitalized for COVID-19.Retrospective study, April 2021 and October 2021Primarily Delta variantHospitalised 312 patients with COVID-19Between July 2022 and September 2022Primarily Omicron variantSerum 25-hydroxyvitamin D (25(OH)D) levels measured at admission1-hydroxy-vitamin D was prescribedPrimary composite endpointsNeed for additional respiratory supportNeed for high-flow oxygen therapy or invasive mechanical ventilationIn-hospital mortality rate. Experimental group (n = 122)Given 1-hydroxy-vitamin DMedian age, 66Baseline vitamin D deficient, 77%Control group ( n = 190)Median age, 58Age difference (p = 0.06)Baseline vitamin D deficient, 65%Baseline D deficiency (p = 0.07)(defined as serum 25(OH)D level less than 20 ng/mL)Proportion of those requiring more respiratory support and in-hospital mortalityVit D group, 6%Control group,14%(p = 0.01)After propensity score matching(to reduce bias caused by confounding variables)(P = 0.03 log-rank test)Proportion of patients who received high flow oxygenVit D group 4%Control group, 11% (P = 0.04)In-hospital mortalityVit D group, 3%Control group, 5% (P = 0.3). Need for additional respiratory supportVit D group, 6%Co Learn more about your ad choices. Visit megaphone.fm/adchoices

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About

Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider

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