The Biotech Voyager

Jeff Martin

Biotech's Live show. Dedicated to covering the early stage signals that indicate what's next in the industry.

  1. Sep 26

    BigHat Raises $75M, a Parkinson’s Vaccine & Engineered Red Blood Cells

    Welcome to The Biotech Voyager. It's the show that covers what's next in biotech, mapping the early-stage signals before their big news. Hosted by Benjamin McLeod and Jeff Martin, PhD. In this episode, the hosts navigate an exceptionally busy day in biotech, examining multiple groundbreaking signals across diverse therapeutic modalities and emerging technologies. From AI-powered antibody discovery to neutrophil cell therapies, the conversation spans cutting-edge innovation while maintaining critical scientific scrutiny. The episode opens with Big Hat Biosciences' impressive $75 million Series C raise, examining their AI-driven platform for antibody drug conjugate development. The hosts explore how Big Hat's cyclical approach integrates automated wet lab experimentation with AI analysis to iteratively improve therapeutic candidates. The discussion contextualizes AI's role in drug discovery, distinguishing between AI for molecular design versus AI for data analysis and experimental optimization. With backing from major pharmaceutical companies including Amgen, BMS, Eli Lilly, and Merck, and fresh patient dosing in Phase I trials, Big Hat represents a significant validation signal for AI-enabled therapeutic development. The conversation continues with Basecamp Research's massive $140 million Series C, exploring their Eden AI model trained on 9.7 trillion nucleotide tokens from ethically sourced genomic data across 30+ countries. The hosts examine how this comprehensive genetic diversity dataset could enable more effective in vivo CAR-T therapies for solid tumors by identifying candidates with broader patient population applicability. The discussion probes the technical challenges of translating genomic data into functional therapeutics while acknowledging the ambitious nature of in vivo cell therapy approaches. Additional signals include AvenCell's $47 million raise for their universal switchable CAR-T platform, which achieved 71% overall response rates in relapsed/refractory AML using adapter molecules that can target multiple antigens. The hosts examine Scarlet Therapeutics' DARPA-funded program developing smart red blood cells that sense environmental conditions and deliver therapeutics accordingly. Lyft Therapeutics emerges from rebranding with neutrophil cell therapies, though the hosts express significant skepticism about the six to twelve hour lifespan challenge inherent to neutrophil-based therapeutics. AC Immune's active immunotherapy for Parkinson's demonstrates 100% antibody response rates at 100 weeks, prompting debate about terminology distinctions between vaccines and active immunotherapies. The episode features an interview with Ryan from LabThread discussing laboratory software challenges and the future of lab automation, followed by examination of Anthropic's Claude-led discovery of a potential new gene editing mechanism and the A16Z Academy as an alternative to traditional university education for aspiring biotech professionals. Listeners will gain insight into how AI is transforming both therapeutic development and laboratory operations, the critical importance of therapeutic lifespan in cell therapy design, the evolving role of government funding through programs like DARPA and ARPA-H, and why the distinction between prophylactic vaccines and therapeutic active immunotherapies matters for understanding emerging modalities. New episodes every Tuesday and Thursday at 11:00 AM. #biotech #AI #drugdiscovery #CARTtherapy #genetherapy #antibodies #celltherapy #activeimmunotherapy #labautomation

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Biotech's Live show. Dedicated to covering the early stage signals that indicate what's next in the industry.

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