Mosaic Biosciences: Biologics Brief

Mosaic Biosciences
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The science and strategy of making protein therapeutic medicines.The Biologics Brief is a podcast about the science and strategy behind making protein therapeutic medicines. Hosted by the scientists at Mosaic Biosciences, a biologics discovery CRO, each episode unpacks the real decisions behind antibody discovery and biologics development, the same conversations we have with our partners every day. From choosing the right discovery platform to evaluating a CRO, scoping a campaign, and navigating difficult targets, we get practical about what actually moves a program forward. Whether you're building at an early-stage biotech, working in pharma, or just curious about how modern medicines get made, you'll come away with sharper questions to ask and frameworks worth keeping.mosaicbio.com

Episodes

  1. Jun 26

    Spotlight: Single B Cell Discovery Essentials

    The Biologics Brief: Spotlight | Single B Cell Discovery: Platforms, Trade-offs, and How to Actually Choose Single B cell discovery has become one of the most powerful tools in antibody drug discovery, but with so many platforms on the market, how do you know which one is right for your campaign? In this special Spotlight episode of The Biologics Brief, Mosaic Biosciences CSO Tracey Mullen sits down with Director of Antibody Discovery Christina Palmer to break down everything you need to know about single B cell discovery platforms, without the vendor spin. What we cover: What single B cell discovery is and why adoption has surged in recent yearsThe core trade-off between resolution and throughput, and why theoretical throughput numbers can be misleadingHow to compare the major platform categories: high-content optofluidic screening (Beacon), microfluidic droplet systems, sequencing-first workflows, and FACS-based platformsWhy genotype-phenotype linkage matters more than most people realizeHow AI is changing the way antibody candidates are prioritizedA practical 5-question framework for choosing the right single B cell workflow for your programWhether you're a biotech team evaluating platforms for the first time or a seasoned drug discovery scientist looking to pressure-test your current approach, this episode gives you the tools to make a more informed decision. About The Biologics Brief The Biologics Brief is a podcast from Mosaic Biosciences, a biologics CRO specializing in antibody discovery and engineering. Each episode features conversations with scientists and industry experts on the topics that matter most in biologics drug development. 🎧 Listen now and subscribe wherever you get your podcasts. mosaicbio.com

    52 min

  2. May 28

    How to Choose a CRO for Antibody Discovery

    Your antibody program doesn’t fail because you picked the “wrong platform” as often as it fails because you picked the wrong partner. We get specific about how to choose a preclinical CRO for antibody discovery by starting with the one thing that should drive every decision: the target clinical profile. If the CRO can’t translate your clinical goals into a practical, testable preclinical plan, you’re not buying confidence, you’re buying activity. We talk about why outsourcing is so common across biotech and pharma, from capital efficiency to speed, and why a disease-agnostic contract research organization can be an advantage when you need battle-tested execution. Then we dig into what “fully integrated” really means in biologics development: not just finding antibody sequences, but carrying knowledge into functional assays, pharmacology, stability, developability, and the steps that support IND-enabling work. We also cover the biggest traps buyers fall into when comparing CRO quotes. A low price can hide missing deliverables, thin characterization, or a handoff that leaves you hunting for the next vendor. You’ll hear the exact questions we think you should ask before you sign: what you get at the end of the first round, what minimum product is delivered if the campaign underperforms, who runs your program, and whether the CRO can clearly explain the pros and cons of different antibody discovery approaches for your target. If you find this useful, subscribe, share it with a teammate, and leave a review with the one CRO question you wish you had asked sooner. mosaicbio.com 🎧 Listen now and subscribe wherever you get your podcasts. mosaicbio.com

    39 min
  • 2 Episodes

About

The science and strategy of making protein therapeutic medicines.The Biologics Brief is a podcast about the science and strategy behind making protein therapeutic medicines. Hosted by the scientists at Mosaic Biosciences, a biologics discovery CRO, each episode unpacks the real decisions behind antibody discovery and biologics development, the same conversations we have with our partners every day. From choosing the right discovery platform to evaluating a CRO, scoping a campaign, and navigating difficult targets, we get practical about what actually moves a program forward. Whether you're building at an early-stage biotech, working in pharma, or just curious about how modern medicines get made, you'll come away with sharper questions to ask and frameworks worth keeping.mosaicbio.com

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