AudioScholar Pathology Weekly

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Pathology — a weekly podcast briefing of the most significant peer-reviewed pathology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

  1. 1d ago

    This Week in Pathology — Oct 31, 2026

    Editor's Pick: Non-invasive tests in metabolic dysfunction-associated steatotic liver disease: the LITMUS prospective multicentre diagnostic accuracy study (The Lancet, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning liver disease and the limits of non-invasive testing, renal and bladder tumour classification, and the standards that shape how we report and how our reports are j… This week's papers: 1. Non-invasive tests in metabolic dysfunction-associated steatotic liver disease: the LITMUS prospective multicentre diagnostic accuracy study. — The Lancet 2026 2. Lipidic obstruction of sinusoids (LOS): a potentially serious complication of steatotic liver disease. — Histopathology 2026 3. BAP1 loss and TFE3 immunoexpression in high-grade clear cell renal cell carcinoma. — Human Pathology 2026 4. Light Microscopy-Based Techniques to Identify TFEB-Altered Renal Cell Carcinoma: A Comparison Study With TFE3-Rearranged Renal Cell Carcinoma and Common Renal… — The American Journal of Surgical Pathology 2026 5. Non-Conventional Histologic Components in Urothelial Carcinoma: Post-Neoadjuvant Chemotherapy Pathologic Outcomes in a Multi-institutional Radical Cystectomy C… — Human Pathology 2026 6. Histological and molecular characterization of lateral extension in papillary urothelial carcinoma: implications for classification and management. — Histopathology 2026 7. Worldwide variation in pathology reporting of esophageal endoscopic resections: a survey and a literature review. — Virchows Archiv 2026 8. HER2 protein expression patterns in gallbladder adenocarcinoma and extrahepatic cholangiocarcinoma. — Virchows Archiv 2026 9. Bone Marrow Cell Depletion in Myelofibrosis Is Associated With High-Risk Features and Shortened Survival: A Bone Marrow Pathology Group Study. — Modern Pathology 2026 10. Contextual diagnostic framework for evaluating histopathology grey zones: a proposal with medicolegal implications using breast pathology as a model. — Virchows Archiv 2026 Listen at https://audioscholar.cc/episode/vk8bv2kpdv

  2. Oct 24

    This Week in Pathology — Oct 24, 2026

    Editor's Pick: Grading colorectal adenocarcinoma: interobserver agreement between American Joint Committee on Cancer and World Health Organization criteria and revisiting diagnostic challenges (Histopathology, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning reproducibility in grading and digital screening, molecular reclassification of rare tumours and haematologic malignancies, and practical classification updates ac… This week's papers: 1. Grading colorectal adenocarcinoma: interobserver agreement between American Joint Committee on Cancer and World Health Organization criteria and revisiting dia… — Histopathology 2026 2. Interobserver variability in the interpretation of Papanicolaou tests using the Hologic Genius Digital Diagnostics System: detailed analysis of cytology verifi… — American Journal of Clinical Pathology 2026 3. Integrated molecular and histopathological analysis reveals genotype-phenotype correlations and diagnostic challenges in endometrial stromal sarcoma. — The Journal of Pathology 2026 4. Acute Erythroid Leukemia Associated With Myeloid Neoplasms: Clinicopathologic Features and Evidence of Clonal Continuity. — Modern Pathology 2026 5. Characterization of the morphological, immunophenotypical and cytogenetic features of high-grade B-cell lymphoma with 11q aberration. — Histopathology 2026 6. High-Grade Follicular Cell-Derived Non-Anaplastic Thyroid Carcinoma and Anaplastic Thyroid Carcinoma. — Modern Pathology 2026 7. Intrahepatic cholangiocarcinoma: contemporary classification, molecular pathology, and emerging concepts. — Virchows Archiv 2026 8. Non-small cell lung carcinoma and its mimics on cytology and small biopsy samples: a practical approach aligned with the WHO Reporting System. — Cancer Cytopathology 2026 9. Primary and secondary vasculitis of the lung - critical evaluation of the update classification. — Virchows Archiv 2026 10. Pathological assessment of neoadjuvant-treated melanoma specimens: a historical overview, lessons learned along the way and the road ahead. — Histopathology 2026 Listen at https://audioscholar.cc/episode/jxvszcqt2b

  3. Oct 17

    This Week in Pathology — Oct 17, 2026

    Editor's Pick: Nuclear grading of myxoid liposarcoma robustly predicts patient outcome: a study of 280 patients (Virchows Archiv, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning sharper prognostic grading and risk stratification, new diagnostic markers that help define difficult entities, and the pre-analytic and digital foundations our re… This week's papers: 1. Nuclear grading of myxoid liposarcoma robustly predicts patient outcome: a study of 280 patients. — Virchows Archiv 2026 2. Peritumoral Malignant Cellular Foci Performs Better Than Tumor Budding and Poorly Differentiated Cluster in Risk Stratification of Lymph Node Metastasis in pT1… — The American Journal of Surgical Pathology 2026 3. Routine H&E Histology Encodes Postoperative Risk Heterogeneity in Resected Pancreatic Ductal Adenocarcinoma: A Multicohort Evaluation of TIGERS. — Modern Pathology 2026 4. Aberrant HER2 Expression as a Specific and Feasible Diagnostic Marker for Fumarate Hydratase-Deficient Renal Cell Carcinoma. — Human Pathology 2026 5. Whole-Exome and Whole-Genome Sequencing Identifies Driver CTNNB1 Mutations in Ossifying Renal Tumor of Infancy. — The American Journal of Surgical Pathology 2026 6. Adamantinoma-like Ewing Sarcoma: An Underrecognized Mimicker in the Head and Neck With Divergent Clinicopathologic Features from Ewing Sarcoma. — Modern Pathology 2026 7. Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: Clinicopathologic and Genetic Analysis of a Large Chinese Cohort. — The American Journal of Surgical Pathology 2026 8. Evaluating immunocytochemistry performance in lung cancer cytology: An IASLC Cytology Working Group study. — Cancer Cytopathology 2026 9. Validation of diagnostic artificial intelligence models for prostate pathology in a Middle Eastern cohort. — Virchows Archiv 2026 10. Myeloid neoplasms with unusual patterns of disease evolution and progression other than acute leukemia: a European Bone Marrow Working Group workshop report. — Human Pathology 2026 Listen at https://audioscholar.cc/episode/3n4fdb4ja3

  4. Oct 10

    This Week in Pathology — Oct 10, 2026

    Editor's Pick: Preanalytical variables affect predictive immunohistochemical biomarker testing in non-small cell lung carcinoma cytology specimens (Cancer Cytopathology, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning a new soft tissue and bone classification with the ancillary tools that support it, the reliability of predictive biomarker testing across specimen types and platf… This week's papers: 1. The 2026 World Health Organization Classification of Tumors of Soft Tissue and Bone: 6th Edition. — The American Journal of Surgical Pathology 2026 2. Diagnostic Utility of USP6 RNA Chromogenic In Situ Hybridization in the Differential Diagnosis of Nodular Fasciitis and Aneurysmal Bone Cyst. — The American Journal of Surgical Pathology 2026 3. A Complementary Role for Immunohistochemistry and NGS for Detection of MTAP Loss in Patients with Non-Small Cell Lung Cancer. — Modern Pathology 2026 4. Preanalytical variables affect predictive immunohistochemical biomarker testing in non-small cell lung carcinoma cytology specimens. — Cancer Cytopathology 2026 5. Alternative lengthening of telomeres in small well-differentiated pancreatic neuroendocrine tumors: independent validation and cross-platform concordance. — Virchows Archiv 2026 6. Ex vivo fluorescence confocal microscopy for real-time margin assessment of nonmelanoma skin cancer in Mohs surgery: A prospective interventional study. — Modern Pathology 2026 7. Do alternative classification systems improve prognostication in phyllodes tumours of the breast? A comparative clinicopathological study. — Histopathology 2026 8. Mitoses counting in phyllodes tumours: rationale for a standardized hotspot-based approach. — Histopathology 2026 9. Gastric dysplasia: an integrated classification of surface epithelium-derived precursor lesions. — Virchows Archiv 2026 10. Parathyroid Pathology Uncovered: Tiny Glands, Big Questions. — Modern Pathology 2026 Listen at https://audioscholar.cc/episode/fwr7nqqvdb

  5. Oct 3

    This Week in Pathology — Oct 3, 2026

    Editor's Pick: Claudin 18.2 Immunohistochemistry in Gastroesophageal Adenocarcinomas: A Study of Interobserver Variability Among Gastrointestinal Pathologists (Human Pathology, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning predictive biomarker scoring in gastroesophageal cancer, prognostic features that sit outside conventional staging, and the shifting boundaries of tumour classific… This week's papers: 1. Claudin 18.2 Immunohistochemistry in Gastroesophageal Adenocarcinomas: A Study of Interobserver Variability Among Gastrointestinal Pathologists. — Human Pathology 2026 2. Spatial and Interlesional Heterogeneity of FGFR2b Expression in Paired Primary and Metastatic Gastric and Gastroesophageal Junction Adenocarcinomas. — Human Pathology 2026 3. Tumour deposits are associated with increased metastatic risk in colorectal cancer: a population-based analysis of metastatic patterns and burden. — Histopathology 2026 4. Does Positive Margin in Secondary Tumors at Radical Prostatectomy Predict Biochemical Recurrence in Multifocal Prostate Cancer? — The American Journal of Surgical Pathology 2026 5. Histologic Features and Clinical Outcomes of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease. — JAMA 2026 6. Expanding the clinicopathological spectrum of BAP1 mutated ccRCC: a study of 84 cases in multi-center cohort. — Human Pathology 2026 7. Immunohistochemical profile of molecularly verified clear cell renal cell carcinomas. — Histopathology 2026 8. Clinicopathologic, immunohistochemical, and molecular correlates in resected primary adrenocortical carcinoma: a single-institution cohort study. — Virchows Archiv 2026 9. Mixed neuroendocrine-non-neuroendocrine neoplasms, amphicrine-like carcinoma and related lesions: a review of changes in classification and current concepts. — Histopathology 2026 10. Papillary Endothelial Hyperplasia in Late Post-Radiation or Late Post-Operative Breast Hematomas Mimicking Angiosarcoma. — Human Pathology 2026 Listen at https://audioscholar.cc/episode/2qxk9gduft

  6. Sep 26

    This Week in Pathology — Sep 26, 2026

    Editor's Pick: Immunohistochemistry Resolves Indeterminate MTAP Deletion Calls from Exome Sequencing: A Pan-Cancer Concordance Study (Modern Pathology, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning reproducibility and grading in surgical pathology, the shifting role of molecular testing and artificial intelligence in thyroid nodules, and ancillary immunohisto… This week's papers: 1. Inter-rater reliability of frozen donor liver macrovesicular steatosis assessment applying the Banff consensus method: a real-world, multi-specialty validation… — Histopathology 2026 2. A modified CAP-based grading system incorporating non-tubular components for prognostic stratification in pancreatic ductal adenocarcinoma. — Virchows Archiv 2026 3. Immunohistochemical expression of p53 is a helpful surrogate marker in the differential diagnosis of primary ovarian mucinous tumors: a large study of 181 case… — Virchows Archiv 2026 4. Western versus Asian utilization of molecular testing for indeterminate thyroid nodules: A meta-analysis of divergent clinical impact. — Cancer Cytopathology 2026 5. Artificial intelligence-assisted digital thyroid FNA cytology: Improved agreement and sensitivity for higher-risk Bethesda categories with enhanced screening e… — Cancer Cytopathology 2026 6. Immunohistochemistry Resolves Indeterminate MTAP Deletion Calls from Exome Sequencing: A Pan-Cancer Concordance Study. — Modern Pathology 2026 7. Immunoglobulin Light Chain mRNA In Situ Hybridization Refines Classification Across the NLPHL-cHL Spectrum. — Modern Pathology 2026 8. In-frame variants in TP53 gene identified in adult leukemia samples are predominantly deleterious: a study of the TP53 Network of Education and Research Initia… — The Journal of Pathology 2026 9. Heterogeneity of breast and nodal response to neoadjuvant pembrolizumab-based chemoimmunotherapy in early triple-negative breast cancer and its clinical signif… — Histopathology 2026 10. RAS/RAF/MAPK alterations in prostatic adenocarcinoma: A multi-institutional study. — Human Pathology 2026 Listen at https://audioscholar.cc/episode/grnc2bvj94

  7. Sep 19

    This Week in Pathology — Sep 19, 2026

    Editor's Pick: Orcein is a more sensitive stain than EVG for detecting large vessel (venous) invasion in colorectal cancer (Histopathology, 2026) Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning three broad themes: the unglamorous but decisive questions of which stain and which block we choose, transcription-factor and copy-number subtyping of aggressive t… This week's papers: 1. Orcein is a more sensitive stain than EVG for detecting large vessel (venous) invasion in colorectal cancer. — Histopathology 2026 2. Ki67 proliferation indices in advanced jejunoileal well-differentiated neuroendocrine tumours are most prognostic when evaluated in mesenteric tumour deposits. — Histopathology 2026 3. Clinicopathologic Spectrum and Intraprostatic Heterogeneity of Primary Mismatch Repair-Deficient Prostate Cancer. — The American Journal of Surgical Pathology 2026 4. Immunohistochemical stratification of bladder small cell carcinoma reveals two major phenotypes with distinct therapeutic biomarker profiles. — Histopathology 2026 5. Molecular Subtyping of Biliary Tract Neuroendocrine Carcinomas: Clinicopathological Features and Prognostic Implications. — The American Journal of Surgical Pathology 2026 6. Acute Myeloid Leukemia With KMT2A Amplification: A TP53-Alteration-Enriched Subgroup Associated With Chromoanagenesis and Poor Prognosis. — Modern Pathology 2026 7. sWGS Identifies a Copy-Number-High Subset of TP53-mutated Multiple-Classifier Endometrial Carcinomas With Adverse Clinicopathological Features. — Modern Pathology 2026 8. Hepatocellular Carcinoma With JAK1 Mutations Harbors Distinct Histologic Features and Specific Mutational Hotspots in an Asian Cohort. — The American Journal of Surgical Pathology 2026 9. Clinicopathological and Molecular Insights into ERBB2-altered S100/SOX10-positive Uterine Sarcoma: A Report of 6 Cases. — Modern Pathology 2026 10. Germline Cancer Predisposition Gene Mutations and Upgrade Rate to Breast Cancer Among Patients with Pleomorphic and Florid Lobular Carcinoma in Situ. — Human Pathology 2026 Listen at https://audioscholar.cc/episode/5wmf94fykw

  8. Sep 12

    This Week in Pathology — Sep 12, 2026

    Editor's Pick: Sarcomatoid malignancies with strong PD-L1 expression often represent dedifferentiated or undifferentiated melanomas (Human Pathology, 2026) Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning classification and molecular taxonomy, new immunohistochemical markers that solve everyday diagnostic problems, and the recurring challenge of cutaneous and soft t… This week's papers: 1. Gastric carcinoma classification in the WHO 6th edition (2026): Updated framework and emerging entities. — Virchows Archiv 2026 2. Methylation profiling in CNS tumor diagnostics: a single-centre real-world experience from Central Europe. — Virchows Archiv 2026 3. An Agreement Study of Stromal Cellularity, Stromal Cell Atypia, and Tumor Border of Phyllodes Tumors of the Breast. — Modern Pathology 2026 4. Sarcomatoid malignancies with strong PD-L1 expression often represent dedifferentiated or undifferentiated melanomas. — Human Pathology 2026 5. FOG1: A Highly Sensitive and Specific Diagnostic Marker for Gastroesophageal Adenocarcinoma. — The American Journal of Surgical Pathology 2026 6. Cribriform tumors of the skin: CD38 expression distinguishes from histologic mimics in a multi-institutional series. — Virchows Archiv 2026 7. C-Cell Lesions and Medullary Thyroid Carcinoma: A Review. — Modern Pathology 2026 8. Uterine Sarcomas With KDM2B Fusion: Clinicopathological Analysis of Three Cases Supporting a Novel BCOR-Altered Entity. — The American Journal of Surgical Pathology 2026 9. Primary Cutaneous Apocrine Carcinoma: Clinicopathologic, Immunohistochemical, and Molecular Characterization of Twenty-Seven Cases. — Modern Pathology 2026 10. Histopathologic, Genomic, and Clinical Characteristics of Primary Cutaneous Melanocytic Tumors With Concomitant NRAS Q61 and IDH1 R132C Mutations. — Modern Pathology 2026 Listen at https://audioscholar.cc/episode/ubw7m4shx8

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Pathology — a weekly podcast briefing of the most significant peer-reviewed pathology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

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