AudioScholar Pathology Weekly

AudioScholar

Pathology — a weekly podcast briefing of the most significant peer-reviewed pathology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

Episodes

  1. 4d ago

    This Week in Pathology — Jul 19, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning digital and biomarker advancements in breast oncology, novel prognostic and diagnostic markers in gastrointestinal and gynecologic pathology, and key clinical upda… This week's papers: 1. UK recommendations for Ki-67 immunohistochemical staining and interpretation in breast cancer — Histopathology 2026 2. Histological grading of invasive breast carcinoma in the digital era: a practical framework for whole slide imaging — Histopathology 2026 3. Single-section assessment of DNA mismatch repair using PMS2/MSH6 double immunohistochemistry — Human Pathology 2026 4. Uterine Leiomyomas Presenting During Pregnancy and Delivery: Comprehensive Characterization of Features Helpful in the Distinction From Malignant Mimics — The American Journal of Surgical Pathology 2026 5. Direct tumour-adipocyte contact / Stroma AReactive Invasion Front Area (TAC/SARIFA) predicts adverse outcome in colorectal cancer: a focused evidence synthesis… — Histopathology 2026 6. Fluorescence In Situ Hybridization Analysis of Hematologic Neoplasms: A 20-Year Review of Proficiency Testing Results From the College of American Pathologists… — Archives of Pathology & Laboratory Medicine 2026 7. EVALI and Beyond: An Update on the Spectrum of Vaping-Associated Lung Pathology — The American Journal of Surgical Pathology 2026 8. HOXB13 Is a Sensitive and Specific Diagnostic Marker for Myxopapillary Ependymoma — The American Journal of Surgical Pathology 2026 9. Current Perspectives on Thyroid Nodule Evaluation: Integrating Cytomorphology, Ultrasound Risk Stratification, and Molecular Testing — Modern Pathology 2026 10. An Immunohistochemistry-based Decision Flowchart to De-escalate Axillary Surgery for Biopsy-Diagnosed Pure Ductal Carcinoma In Situ (DCIS) of the Breast — Modern Pathology 2026 Listen at https://audioscholar.cc/episode/43zkbamf2c

  2. Jul 11

    This Week in Pathology — Jul 11, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning diagnostic updates in genitourinary and renal neoplasms, emerging classification frameworks in thoracic and breast pathology, and advanced diagnostic strategies in… This week's papers: 1. A novel classification of testicular sex cord-stromal tumours from the Testicular Sex Cord-Stromal Tumour (TESST) group: a collaboration of the Genitourinary P… — Histopathology 2026 2. Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours — The Journal of Pathology 2026 3. Lung carcinoids with sustentacular cells and low keratin expression: A common yet under-recognized phenomenon with diagnostic and biological implications — Modern Pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2026 4. Histiocyte-Rich Renal Epithelial Neoplasm: A Morphology Associated With Folliculin Mutations and Birt-Hogg-Dubé Syndrome — The American Journal of Surgical Pathology 2026 5. Flat epithelial atypia of the breast: a pragmatic, context-integrated diagnostic framework within a biological continuum — Histopathology 2026 6. Myxoid neoplasms with MAP3K kinase fusion: a study of 39 cases — Histopathology 2026 7. The essentials-measurable residual disease in hematopoietic neoplasms: current testing landscape and future directions — American Journal of Clinical Pathology 2026 8. Bronchiolar adenoma-like lesions with atypical features beyond the classic morphological spectrum: integrating histomorphology and molecular profiles — The Journal of Pathology 2026 9. Clinicopathologic characterization of plasma cell neoplasms with IGH::CCND3 — American Journal of Clinical Pathology 2026 10. Does renal haemangioblastoma exist? Evidence for inclusion within the MTOR-associated renal cell carcinoma with fibromyomatous stroma spectrum — Histopathology 2026 Listen at https://audioscholar.cc/episode/pqmpfxsdqu

  3. Jul 4

    This Week in Pathology — Jul 4, 2026

    Welcome to This Week in Pathology. This week we're covering ten notable papers spanning diagnostic quality and immunohistochemical specificity, advancements in thoracic and gastrointestinal oncology, and critical management thresholds in breast and p… This week's papers: 1. Margin Adequacy in Phyllodes Tumours Revisited: Reappraisal of the Evidence Base and Knowledge Gaps — Modern Pathology 2026 2. Clinical Impact of Second Opinion Consultation in Bladder Biopsies and Transurethral Resection of Bladder Tumors — Human Pathology 2026 3. Assessing Human Epidermal Growth Factor Receptor 2 in Urothelial Carcinoma: Insights From Clinical Practice Into Scoring Criteria, Histologic Subtypes, and Gen… — Archives of Pathology & Laboratory Medicine 2026 4. Cross-Reactivity of TPIT Antibody Clone OTI2G1 in Chordoma: Structural Mechanisms and Diagnostic Implications — Archives of Pathology & Laboratory Medicine 2026 5. Role of INSM1 expression in the diagnostic work-up of pancreatic acinar cell carcinoma with special reference to the differential diagnosis with neuroendocrine… — Virchows Archiv 2026 6. Deep Learning for Differentiating Pulmonary Metastasis from Primary Lung Cancer Constructed on Frozen Sections for Intraoperative Diagnosis — Modern Pathology 2026 7. TRPS1 and GATA3 Expression in BRG1/SMARCA4-deficient Malignant Neoplasms — Human Pathology 2026 8. Immunophenotypic, Cytogenetic, and Molecular Characterization of NUP98-Rearranged Pediatric Myeloid Neoplasms — Modern Pathology 2026 9. Clinicopathologic and Molecular Analysis of Traditional Serrated Adenoma and Its Possible Precursor Lesions With Special Reference to RSPO Fusion Status: A Lar… — The American Journal of Surgical Pathology 2026 10. TROP2 immunoreactivity in pulmonary large cell neuroendocrine carcinoma — Histopathology 2026 Listen at https://audioscholar.cc/episode/jqh34yt66n

  4. Jun 23

    This Week in Pathology — Jun 23, 2026

    Welcome to This Week in Pathology. This week we are covering nine notable papers spanning diagnostic reproducibility and staging refinements, novel molecular signatures in solid tumors and hematopathology, and the emerging role of high-throughput dat… This week's papers: 1. High interobserver variability exists in grading appendiceal goblet cell adenocarcinoma using World Health Organization 5th edition criteria. — Histopathology 2026 2. Navigating Human Epidermal Growth Factor Receptor 2 (HER2) Assessment by Organ Systems: A Guidebook to HER2 Testing in Solid Tumors. — Archives of Pathology & Laboratory Medicine 2026 3. Chromoanagenesis in Myelodysplastic Syndromes Is Associated With Highly Complex Karyotype, TP53 Disruption and Dismal Prognosis. — Modern Pathology 2026 4. Co-Existent Endometrial and Fallopian Tube Carcinoma, Molecular and Pathological Features for Risk Stratification. — Modern Pathology 2026 5. Diagnostic impact and reproducibility of p53 immunohistochemistry in Barrett's oesophagus: results of the Dutch Esophageal Pathology Panel (DEPP). — Histopathology 2026 6. RUNX2 Rearrangement as a Recurrent Molecular Event and Diagnostic Marker in Salivary Gland Keratocystoma. — Modern Pathology 2026 7. Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights. — The Journal of Pathology 2026 8. Spatial distribution of the proteome in the human body and in cancers. — Nature 2026 9. Towards autonomous medical artificial intelligence agents. — Nature 2026 Listen at https://audioscholar.cc/episode/s7g77c5m54

  5. Jun 16

    This Week in Pathology — Jun 16, 2026

    Welcome to This Week in Pathology. This week we're covering 9 notable papers spanning innovations in cancer diagnostics, new insights into CNS pathology, and the mechanisms driving disease from inflammatory bowel disease to rare genetic disorders. Le… This week's papers: 1. The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM. — Cell 2026 2. Application of The International System for Serous Fluid Cytopathology to cerebrospinal fluid and adjunct flow cytometry analysis improves diagnostic accuracy. — Cancer cytopathology 2026 3. Clinicopathologic Study of 39 Mismatch Repair-deficient Sarcomas Demonstrates Recurrent Histologic Patterns and Supports Universal Screening of Pleomorphic Rha… — The American journal of surgical pathology 2026 4. Predicting TP53 biomarkers from whole slide images across human solid tumours using weakly supervised learning. — The American journal of pathology 2026 5. SIRT7 regulates dosage compensation and safeguards the female X chromosome. — Nature 2026 6. Single-dose mRNA vaccines against Andes hantavirus. — Lancet (London, England) 2026 7. Subretinal Gene Therapy for X-Linked Retinoschisis. — The New England journal of medicine 2026 8. Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease. — The New England journal of medicine 2026 9. Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+ head and neck cancer treated with surgery. — Science translational medicine 2026 10. A cocktail of human mAbs targeting the henipavirus fusion and receptor binding proteins provides cross-species neutralization. — Science translational medicine 2026 Listen at https://audioscholar.cc/episode/rxbaepvpmb

  6. Jun 9

    This Week in Pathology — Jun 9, 2026

    Welcome to This Week in Pathology. This week we're covering 9 notable papers spanning evolving diagnostic classifications in hematopathology and pulmonary pathology, practical solutions for diagnostic dilemmas from renal cancer to Lyme disease, and n… This week's papers: 1. GPR15-guided CD8T regulatory cells control intestinal inflammation. — Nature 2026 2. Inclusion of young adolescents in policy development for new tuberculosis vaccines. — The Lancet. Global health 2026 3. Fibrotic marrow limiting morphologic classification in MDS/MPN with SF3B1 mutation and thrombocytosis: diagnostic implications under the ICC 2022 framework. — Virchows Archiv : an international journal of pathology 2026 4. Diagnostic challenges in pathologic staging of renal cell carcinoma following systemic immunotherapy. — American journal of clinical pathology 2026 5. Reevaluation of Lyme serologic quantitative test indexes: confirmation that high first-tier test index values predict a positive second-tier result in a modifi… — American journal of clinical pathology 2026 6. The 2025 ATS/ERS update of the international multidisciplinary classification of the interstitial pneumonias: implications for the pathologist. — Histopathology 2026 7. Contemporary approach to diagnosis and classification of acute myeloid leukemia. — Human pathology 2026 8. Xenophagocytosis blockade enhances interspecies chimerism. — Cell 2026 Listen at https://audioscholar.cc/episode/buqe6h6vcd

  7. May 28

    This Week in Pathology — May 28, 2026

    Welcome to This Week in Pathology. This week we're covering nine notable papers spanning oncology, advanced diagnostics and organ injury, and key updates in practice and global health. Let's dive in. [PAUSE] Our first theme this week is oncology, w… This week's papers: 1. Genomic instability drives POSTNmyofibroblasts via STING-WNT axis to promote immunosuppression and PARPi resistance in ovarian cancer. — Science translational medicine 2026 2. Efficacy and safety of durcabtagene autoleucel in a phase 1 trial for patients with relapsed/refractory multiple myeloma. — Science translational medicine 2026 3. AI-Informed Architectural Insights of Three-Dimensional Glandular Networks Identify Prostate Cancer Patients at a Higher Risk of Biochemical Recurrence. — Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2026 4. CCR5 and CD74 are potential therapeutic targets for necroinflammation in preclinical cholesterol crystal embolism. — Science translational medicine 2026 5. Human haematopoietic stem cells remember inflammatory stress. — Nature 2026 6. Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure. — The New England journal of medicine 2026 7. Interpretive Diagnostic Error Reduction: Guideline Update from the College of American Pathologists in Collaboration With the Association of Directors of Anato… — Archives of pathology & laboratory medicine 2026 8. Leishmaniasis. — The New England journal of medicine 2026 Listen at https://audioscholar.cc/episode/eu2ahytxbj

  8. May 14

    This Week in Pathology — May 14, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning advances in cancer pathology, including a new CAR T-cell target for glioblastoma and a critical safety signal in gene therapy. We'll also explore the challenges in… This week's papers: 1. Performance of traumatic encephalopathy syndrome criteria in identifying individuals with chronic traumatic encephalopathy. — Nature medicine 2026 2. Dementia studies come to grips with overlapping diseases. — Science 2026 3. Ecotypes of triple-negative breast cancer in response to chemotherapy. — Nature 2026 4. An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism. — Nature 2026 5. Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects. — Cell 2026 6. D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response. — Cell 2026 7. Inflammatory Myopathies. — The New England journal of medicine 2026 8. Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery. — The New England journal of medicine 2026 9. uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target. — Science translational medicine 2026 10. Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts. — Science translational medicine 2026 Listen at https://audioscholar.cc/episode/6agn3axd8w

About

Pathology — a weekly podcast briefing of the most significant peer-reviewed pathology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.