Following design blogs will only give you so much as far as inspiration goes, but it's also important to involve yourself in the discussions that the design community has. This podcast is a great way to keep aware of what the community is talking about. It's one of the few design and creativity-related podcasts I listen to.
Although, I like the hour-long-ish format of a talk show, it would be great if they had "bite-sized" segments that were more focused on one topic, as well, because I don't always have the time to listen to a whole show. Also, the audio quality could be improved, as I find it tinny and set at a much quieter level than all other podcasts I listen to.
Overall, it's a worthy listen, despite the audio, because the content Matt and Aaron provide is actually quite good.