Behind the Batch | a Tozaro original series

Tozaro
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Where we spotlight the moments that shape the people pioneering cell and gene therapy. Failed batches, first viable runs, tech transfers, and everything in between. Hosted by Alex Shephard, Head of Product at Tozaro.

Episodes

  1. 5d ago

    EP 2 - Giuliana Vallanti (AGC Biologics)

    Giuliana Vallanti shares her experience in cell and gene therapy, covering process development, tech transfer and the innovations behind scalable, reliable manufacturing. Key topics - Scaling viral vector manufacturing from lab to industry - Critical factors for successful tech transfer - Early development work and risk mitigation - Advances in lentiviral vector production and scalability - The role of potency assays in product characterisation Chapters 00:00 Introduction to Giuliana Vallanti and her background 10:00 Giuliana's journey into cell and gene therapy 13:02 Lessons learned from early challenges in gene therapy 17:00 Milestones in lentiviral vector manufacturing 19:55 Tech transfer: success factors and common pitfalls 25:54 The importance of comprehensive process understanding 27:02 Key analytical methods and potency assays 29:47 Innovations in vector production technologies 32:11 Final thoughts on advancing cell and gene therapy manufacturing Resources Tozaro - https://www.tozaro.com AGC Biologics - https://www.agcbio.com/ Asimov - https://www.asimov.com/ Lentiviral vector manufacturing - https://www.agcbio.com/technologies/lentiviral-vector Gene of interest feasibility approach - https://www.agcbio.com/approach/GOI-feasibility

    EP 2 - Giuliana Vallanti (AGC Biologics)

  2. Aug 3

    EP1 - Andre Raposo (OXB)

    content type Interview primary goal Educational summary In this episode, Andre Raposo shares his journey from fundamental HIV research to leading innovation in viral vector manufacturing at OXB. We explore the integration of automation, AI, and data-driven approaches in cell and gene therapy development, along with lessons learned from failures and successes. keywords gene therapy, viral vectors, automation, AI, biotech innovation, process development, GMP, data analytics, CDMO, bioprocessing key topics Andre Raposo's career transition from academia to industry The role of automation and AI in GMP manufacturing Common causes of failure in process development and how to learn from them The importance of team and culture in successful tech transfer Future trends in cell and gene therapy manufacturing guest name Andre Raposo sound bites "Automation amplifies existing processes, good or bad" "AI can help automate boring tasks and expedite analysis" "Never make assumptions, let the data tell the story" Chapters 00:00 Introduction to Andre Raposo and his background 00:52 Andre's transition from HIV research to gene therapy process development 04:24 Innovating at OXB: automation, analytics, and AI 06:31 Debunking myths about automation in CGT manufacturing 11:39 A failed experiment: lessons learned and the importance of biology 14:55 The value of failed experiments in leadership and science 17:43 Building computer-aided biology at OXB 22:18 Successful tech transfer and challenges in GMP implementation 26:11 Capturing tacit knowledge and ensuring smooth handoffs resources Oxford Biomedica (OXB) - https://www.oxb.com/ Design of Experiments (DOE) - https://en.wikipedia.org/wiki/Design_of_experiments Hamilton Liquid Handlers - https://www.hamiltoncompany.com/ Unchained Labs - https://www.unchainedlabs.com/ guest links LinkedIn - https://www.linkedin.com/in/andre-raposo/ Twitter - https://twitter.com/andre_raposo

  • 2 Episodes

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Where we spotlight the moments that shape the people pioneering cell and gene therapy. Failed batches, first viable runs, tech transfers, and everything in between. Hosted by Alex Shephard, Head of Product at Tozaro.

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