Life in Voxels

POSITROPTICS LLC
  • 5.0 (2)
  • Life Sciences
  • Monthly

Life in Voxels explores the science, technology, and people shaping the future of medical imaging. Through conversations with researchers, engineers, clinicians, and innovators, the podcast examines how advances in imaging instrumentation, computational methods, artificial intelligence, quantitative imaging, and molecular imaging move from scientific ideas toward practical applications. You may watch the vidcast version on Life in Voxel's YouTube channel: https://www.youtube.com/@lifeinvoxels

Episodes

  1. 23h ago

    Beyond Anatomy: How Molecular Brain Imaging Is Changing Diagnosis and Treatment

    In the third episode of Life in Voxels, we welcome Jana Ivanidze, MD, PhD, Associate Professor of Radiology and Director of Brain PET at Weill Cornell Medicine, for an in-depth conversation about the evolving role of molecular imaging in neuroradiology, neuro-oncology, and neurodegenerative disease. Together with hosts Nikolaos A. Karakatsanis from Weill Cornell Medicine, Georgios Soultanidis from the Biomedical Engineering and Imaging Institute at the Icahn School of Medicine at Mount Sinai, and Ezzat Elmoujarkach from Weill Cornell Medicine, Dr. Ivanidze discusses how PET, MRI, quantitative imaging, and artificial intelligence are increasingly moving brain imaging beyond anatomy toward direct characterization of disease biology. Topics include: • Jana’s education and path toward becoming a physician-scientist in neuroradiology and molecular imaging• The complementary roles of PET and MRI in brain imaging• Quantitative imaging and AI in Neuro-PET• 68Ga-DOTATATE PET/MRI for intracranial meningioma• Somatostatin receptor biology, tumor delineation, and post-treatment assessment• Dynamic PET, tracer kinetics, Patlak analysis, and parametric imaging• The opportunities and challenges of simultaneous PET/MRI• Multi-tracer PET for studying receptor expression, proliferation, hypoxia, and metabolism• 18F-fluciclovine PET/MRI for distinguishing glioblastoma progression from treatment-related changes• 18F-FMISO and 18F-FLT PET for mapping tumor hypoxia and proliferation• Receptor-targeted brain imaging, including 18F-FES PET in breast cancer brain metastases• The emerging role of theranostics in neuro-oncology• Amyloid and tau PET in Alzheimer disease• Quantitative amyloid PET and AI-assisted longitudinal monitoring• The future integration of Neuro-PET, MRI, quantitative imaging, and AI A recurring question throughout the episode is whether molecular imaging can identify clinically important changes in disease biology before they become apparent on conventional anatomical imaging. We also explore how PET may increasingly influence treatment planning and response assessment, and whether the future of brain imaging will depend less on choosing between PET and MRI and more on combining them into a unified molecular and anatomical view of the patient. Join us for this wide-ranging conversation with Dr. Jana Ivanidze. Life in Voxels 🎙️ is a scientific podcast exploring the people, ideas, technologies, and collaborations shaping the future of medical imaging. Hosted by: Nikolaos A. Karakatsanis, PhDDepartment of Radiology, Weill Cornell Medicine Georgios SoultanidisBiomedical Engineering and Imaging InstituteIcahn School of Medicine at Mount Sinai Ezzat ElmoujarkachDepartment of Radiology, Weill Cornell Medicine Follow Life in Voxels 🎙️ podcast for future conversations on PET, molecular imaging, medical physics, neuroradiology, theranostics, artificial intelligence, quantitative imaging, instrumentation, and image reconstruction.

  2. Oct 1

    From Measurement to Personalized Therapy: Making Nuclear Medicine Dosimetry Clinically Practical

    In Episode 2 of Life in Voxels, we welcome Adam L. Kesner, PhD, Attending Physicist in the Department of Medical Physics at Memorial Sloan Kettering Cancer Center, for an extended conversation on the future of quantitative nuclear medicine and personalized radiopharmaceutical therapy. If we can image and quantify where a therapeutic radiopharmaceutical goes inside an individual patient, why do we still often prescribe treatment primarily according to administered activity rather than patient-specific absorbed dose? Together with hosts Nikolaos A. Karakatsanis, Georgios Soultanidis and Ezzat Elmoujarkach, Adam takes us from the fundamentals of quantitative PET and SPECT to the practical challenges of making clinical dosimetry accurate, reproducible and scalable. We discuss the MIRD framework, patient-specific absorbed-dose estimation, quantitative imaging and partial-volume effects, pharmacokinetic modeling, uncertainty, clinical workflow barriers, and the MIRDsoft family of community dosimetry tools—including MIRDcalc, MIRDfit, MIRDy90 and MIRDpvc. The conversation also explores the role of AI and automation, the need for standardized and interoperable dosimetry data, the design of radiopharmaceutical therapy clinical trials, and the provocative question of whether conservative treatment paradigms may leave some patients undertreated. Adam also reflects on his earlier work in data-driven PET respiratory motion correction and what it taught him about an issue that runs throughout this episode: a technically elegant solution only changes medicine when it can be made practical enough to work in real clinical care. This is a wide-ranging discussion about how nuclear medicine can move from measuring radiopharmaceutical biodistribution to using those measurements to guide therapy for the individual patient. 🎙️ Life in Voxels — conversations with the scientists, engineers, medical physicists and clinicians shaping the future of medical imaging.

  3. Sep 1

    From Conceptualization to Prototyping of Positron Emission Tomography Systems

    How does a PET scanner progress from an initial scientific concept to a functioning imaging system? In the inaugural episode of Life in Voxels, hosts Nicolas A. Karakatsanis, Georgios Soultanidis, and Ezzat Elmoujarkach are joined by instrumentation scientists Fiammetta Pagano of the Institute for Instrumentation in Molecular Imaging (i3M), Valencia, Spain, and David Sánchez of Oncovision SA, Valencia, Spain. Their conversation follows the development of PET instrumentation from scientific need and detector design through system integration, calibration, simulation, and image reconstruction, using the Ultra-High-Performance Brain PET (UHB-PET) prototype as a real-world example. The discussion explores why dedicated brain PET systems remain scientifically important; how semi-monolithic detector architectures work; why depth-of-interaction information matters in compact PET geometries; how machine learning can estimate gamma-ray interaction positions; how multiplexing helps translate laboratory detector concepts into scalable systems; and what changes when hundreds of detector components are integrated into a complete scanner. The conversation also goes behind the scenes of UHB-PET calibration and commissioning at Weill Cornell Medicine, examining energy and timing calibration, detector positioning, normalization, system troubleshooting, experimentally informed Monte Carlo simulation, image reconstruction, and the recovery of complex detector events. Finally, the guests discuss the increasingly close relationship between hardware and software innovation and what the next generation of PET instrumentation may look like. Hosts Nikolaos A. Karakatsanis — Department of Radiology, Weill Cornell Medicine Georgios Soultanidis — Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai Ezzat Elmoujarkach — Department of Radiology, Weill Cornell Medicine Guests Fiammetta Pagano — Institute for Instrumentation in Molecular Imaging (i3M), Valencia, Spain David Sánchez — Oncovision, Valencia, Spain Topics Discussed PET instrumentation • dedicated brain PET • UHB-PET • semi-monolithic detectors • LYSO scintillators • silicon photomultipliers (SiPMs) • depth of interaction (DOI) • time of flight (TOF) • machine learning • detector multiplexing • scanner calibration • system commissioning • GATE Monte Carlo simulation • image reconstruction • inter-crystal scattering • artificial intelligence in detector technology Produced and published by POSITROPTICS LLC. © 2026 POSITROPTICS LLC. All rights reserved. The views expressed by the hosts and guests are their own and do not necessarily represent those of their respective institutions or organizations.

  • 3 Episodes

Ratings & Reviews

5
out of 5
2 Ratings

About

Life in Voxels explores the science, technology, and people shaping the future of medical imaging. Through conversations with researchers, engineers, clinicians, and innovators, the podcast examines how advances in imaging instrumentation, computational methods, artificial intelligence, quantitative imaging, and molecular imaging move from scientific ideas toward practical applications. You may watch the vidcast version on Life in Voxel's YouTube channel: https://www.youtube.com/@lifeinvoxels

Information

  • Creator
    POSITROPTICS LLC
  • Years Active
    2026
  • Episodes
    3
  • Rating
    Clean
  • Copyright
    © POSITROPTICS LLC
  • Show Website
    Life in Voxels