chai files

Dr. Low Chai Ling

Honest answers to the questions every woman has about her skin — without the marketing. Hosted by Dr. Low Chai Ling, Medical Director of SW1 Clinic Singapore. Evidence-based skin and aesthetic medicine for professional women who want to make informed decisions about their skin, their face, and how they age. New episodes every two weeks.

  1. Oct 22

    The Menopause Gold Rush: What Women Need—and What They’re Being Sold

    Menopause was ignored for generations. Now it appears everywhere—on clinic menus, supplement labels, hormone-testing packages and social media feeds. The attention is long overdue. The commercial enthusiasm may require slightly more supervision. In this episode of The Chai Files, I speak with Dr Ginni Mansberg: Sydney GP, television presenter, bestselling author of The M Word and The Women’s Longevity Handbook, and co-founder of Evidence Skincare. We discuss: • The real benefits and risks of HRT• Why HRT is neither poison nor a universal anti-ageing solution• When hormone testing is useful—and when it produces an expensive collection of numbers• Regulated body-identical hormones versus compounded “bioidentical” products• What the evidence actually supports for testosterone• Whether “menopause skincare” is medically meaningful or marketing in a hormonal outfit• Why biohacking may distract women from blood pressure, muscle, bone and metabolic health• What genuinely good menopause care should look like Menopause deserves proper medical attention. It does not require panic, perfection or an overflowing shopping cart. Listen to the full conversation, share it with someone navigating midlife, and follow The Chai Files for candid, evidence-based conversations about health, beauty and ageing well. For more on beauty, medicine and ageing well: Read my Substack: Longer reads on the science behind the claims—and whether they deserve your money or attention.https://drlowchailing.substack.com Follow me on Instagram: Short explainers, new episodes and occasional appearances by my dog, who remains medically unqualified.https://www.instagram.com/drlowchailing/ This conversation is for general education and is not a substitute for individual medical advice.

    The Menopause Gold Rush: What Women Need—and What They’re Being Sold
  2. Aug 11

    Everyone Is Injecting Peptides. Do They Actually Work?

    Peptides have escaped the laboratory—and people are already injecting them for injury recovery, energy, anxiety, weight loss and younger-looking skin. But do BPC-157, TB-500, MOTS-c, GHK-Cu, Semax and Selank genuinely work? Or are consumers buying an expensive biological dream? In this episode, aesthetic doctor Dr Low Chai Ling investigates: • Why peptides became popular among athletes, celebrities and Silicon Valley biohackers• What users say they experienced—benefits, side effects and no effect at all• The human Russian research behind Semax and Selank• Why BPC-157 became known as the “Wolverine peptide”• The difference between topical and injectable GHK-Cu• Why tesamorelin and retatrutide change the peptide debate• Whether unpatentable treatments receive less medical research• What the FDA’s controversial 2026 peptide vote actually meant• What laboratories found inside two black-market peptide vials One patient’s vial contained no detectable active peptide—only apparent filler. Another black-market vial labelled as containing 10 mg of retatrutide reportedly contained approximately 19 mg. The peptide market’s problem may not be that nothing works. It may be that something works very powerfully—and consumers cannot be certain what they are receiving. This is not a prosecution or promotion of peptide therapy. It is an investigation into where the science ends, where the anecdotes begin and why “we don’t know yet” is not the same as “it doesn’t work.” This episode is for education only and does not provide individual medical advice. Do not use an injectable or prescription product without assessment and supervision from an appropriately qualified medical professional. 00:00 The patient who injected “fairy dust”00:52 The black-market vial containing nearly double the dose01:38 Do peptides actually work?02:17 Peptides are already legitimate medicines03:32 Did the peptide movement originate in Silicon Valley?05:18 Can so many peptide users be wrong?07:08 BPC-157: the “Wolverine peptide”10:19 TB-500 and the problem with peptide stacks12:20 MOTS-c: can we improve our cellular batteries?14:45 Semax and Selank: what the Russian studies found19:05 GHK-Cu for skin: topical science versus injections21:10 Tesamorelin: when a peptide becomes an approved medicine22:46 Retatrutide: the peptide that changes the argument25:28 Why some promising peptides may never receive major trials27:45 What the FDA’s 2026 peptide vote actually meant30:04 What Dr Low’s patients have experienced31:48 Could the peptide boom be a mass placebo effect?33:30 Dr Low’s peptide evidence spectrum35:28 Final verdict: future medicine or beautiful dream?

    Everyone Is Injecting Peptides. Do They Actually Work?
  3. Aug 4

    Is your new skincare product making you purge—or simply making your skin worse?

    “Keep going, it’s purging” has become the internet’s favourite explanation for almost every breakout, burning sensation and peeling face. But available clinical evidence does not suggest that a significant initial acne flare is common or inevitable with topical retinoids. In this episode of Skin, Honestly, Dr Low Chai Ling explains how she clinically distinguishes an ordinary acne flare from irritant dermatitis, contact allergy, product-related pore occlusion and manageable early retinoid irritation. You’ll discover: • Why burning and itching point toward different diagnoses• How comedones help distinguish acne from dermatitis• Why “non-comedogenic” does not guarantee a product will suit everyone• What patch testing can—and cannot—tell us• Which retinoid reactions may be manageable• Which warning signs require urgent medical attention Studies discussed include: • Yentzer, McClain and Feldman’s review of retinoid-associated acne flaring• Three Phase 3 trials examining early flaring with tretinoin 0.025% gel• The 2024 American Academy of Dermatology acne guideline• A systematic review of topical-retinoid efficacy and tolerability• The European Society of Contact Dermatitis patch-testing guideline• A small human study examining finished cosmetic formulations and comedogenicity Medical disclaimer: This episode is for general education and does not provide personal diagnosis or treatment. Seek urgent medical attention for breathing or swallowing difficulty, throat or tongue swelling, widespread blistering, mucosal involvement, severe pain, fever or visual symptoms. #SkinHonestly #SkincareScience #SkinPurging #Retinoids #AestheticMedicine

    Is your new skincare product making you purge—or simply making your skin worse?

About

Honest answers to the questions every woman has about her skin — without the marketing. Hosted by Dr. Low Chai Ling, Medical Director of SW1 Clinic Singapore. Evidence-based skin and aesthetic medicine for professional women who want to make informed decisions about their skin, their face, and how they age. New episodes every two weeks.