The Peps Report

MyPeps
  • 4.0 (1)
  • Medicine
  • Weekly

Mark and Amy break down the week's peptide research news in plain English: new trials, FDA and WADA decisions, safety alerts, and what the evidence actually shows, including when it doesn't. Every story is sourced, and every episode links to the full write-up on mypeps.info. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Educational information, not medical advice.

Episodes

  1. 4d ago

    Six peps got a panel yes vote. What that does and doesn't mean

    Six peps (BPC-157, KPV, TB-500, MOTS-c, Epitalon and Semax) reportedly got a yes vote from an FDA advisory panel in July, and some people are treating that as a green light. Mark and Amy walk through why a panel vote is a recommendation and not an approval, then look at the research behind two of the six, BPC-157 and TB-500. Both sit at 2 of 5 on our evidence scale. The panel details are reported, not verified here. What we covered Why an advisory panel vote isn't an FDA approval Why missing approval is normal for peps: it mostly tracks who can fund large trials BPC-157: many rodent studies, and a systematic review of three small human reports (30 participants in total) with very low certainty TB-500: a fragment of thymosin beta-4, where the full-length protein has human trials but the fragment mostly doesn't What people's own experience adds, and what it can't show Cautions from clinicians about unregulated injectables Sources Six peptides got a panel yes vote. Here's what that does and doesn't mean How we rate evidence: methodology Free tools MyPeps calculator This is education, not medical advice. Educational information, not medical advice. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. #healthliteracy #scienceexplained #clinicaltrials #healthpodcast #thepepsreport Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/six-peps-got-a-panel-yes-vote-what-that-does-and-doesn-t-mean

  2. Oct 23

    Cagrilintide: the amylin peps that pairs with semaglutide

    Mark and Amy look at cagrilintide, a long-acting version of the fullness hormone amylin, developed mainly to pair with semaglutide as CagriSema. They go through what the phase 2 and phase 3 trials found, how it differs from GLP-1 drugs, and where it stands with regulators. The site rates the evidence 4 of 5. What we covered What amylin is and why a once-weekly version exists Phase 2 (Lancet 2021): about -10.8% at 26 weeks vs -3.0% on placebo REDEFINE 1: cagrilintide alone about -11.5% at 68 weeks vs -3.0% on placebo CagriSema about -20.4% vs -14.9% for semaglutide alone over 68 weeks Not approved on its own; the combination is under FDA review, decision expected around late 2026 WADA banned: yes Calculator arithmetic only: 10 mg vial plus 4 mL water is 2.5 mg/mL Sources Cagrilintide: the weekly amylin analog behind CagriSema https://www.mypeps.info/peptides/cagrilintide https://www.mypeps.info/calculator https://www.mypeps.info/methodology Free tools Peps calculator: https://www.mypeps.info/calculator This is education, not medical advice. Educational information, not medical advice. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. #peptideresearch #clinicaltrials #sciencepodcast #healthliteracy #thepepsreport Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/cagrilintide-the-amylin-peps-that-pairs-with-semaglutide

  3. Oct 22

    KPV and the Gut: What Cell and Mouse Studies Show So Far

    This week Mark and Amy dig into KPV, a tiny fragment of the hormone α-MSH, and the lab research on its anti-inflammatory effects in gut cells and mice. They also look at two new 2026 lab papers, how to weigh personal reports, and why "not FDA-approved" is not a verdict either way. What we covered What KPV is: the last three amino acids (lysine, proline, valine) of α-MSH The site's evidence level of 2 out of 5: cell and mouse colitis studies, no published human trials How KPV is described as entering gut-lining and immune cells via PepT1 and dampening NF-κB and MAP-kinase pathways Why its gut effect does not appear to run through melanocortin receptors, so it is not a tanning peptide A 2026 Tissue & Cell study in mouse macrophages showing similar pathway effects (abstract only, one cell line, nothing about colitis) A 2026 Tissue & Cell fat-cell paper, with oral KPV in mice on a high-fat diet How to weigh "calmer gut and skin" reports: real, but anecdotal Why FDA status is one signal among several, and a note that KPV is on the WADA banned list Sources https://www.mypeps.info/blog/kpv-gut-inflammation-research https://www.mypeps.info/methodology Lysine-Proline-Valine attenuates oxidized low-density lipoprotein-induced foam cell formation and inflammatory responses in RAW264.7 macrophages, Tissue & Cell, Oct 2026: https://pubmed.ncbi.nlm.nih.gov/42854645/ Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards, International Journal of Pharmaceutical Compounding, Sep 2026: https://pubmed.ncbi.nlm.nih.gov/42752426/ KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling, Tissue & Cell, Aug 2026: https://pubmed.ncbi.nlm.nih.gov/42585803/ Free tools Peptide calculator: https://www.mypeps.info/calculator This is education, not medical advice. Educational information, not medical advice. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/kpv-and-the-gut-what-cell-and-mouse-studies-show-so-far

  4. Oct 22

    GLOW: A Three-Peptide Blend With No Studies of Its Own

    GLOW is a premixed vial of BPC-157, TB-500 and GHK-Cu, 70 mg in total, marketed for skin and recovery together. Mark and Amy look at what is actually known. No study has tested the blend itself, so the case for it is borrowed from each ingredient's separate evidence. What we covered What GLOW is: a premixed vial of three peptides, 70 mg in total. The mechanism as described: BPC-157 supports local repair and blood-vessel growth, TB-500 helps cells move to injured tissue, and GHK-Cu delivers copper and drives collagen signaling. How they act together has not been studied. The evidence rating: 2 out of 5. No studies of the blend. BPC-157 and TB-500 are mostly animal data, and GHK-Cu's human data is topical. Skin firmness and collagen: small human studies of GHK-Cu showed improved skin, but they were topical. Tissue repair: BPC-157 and TB-500 sped healing in animal injury models. Skin glow and recovery: self-reported only. Status: not FDA-approved, and banned by WADA. Half-life: mixed, since each component differs, but all are short-acting signals. Calculator arithmetic: a 70 mg vial with 3.5 mL of water is 20 mg/mL, and 2000 mcg is 10 units on a U-100 syringe. This is arithmetic only, not a recommendation. Sources https://www.mypeps.info/peptides/glow https://www.mypeps.info/methodology Free tools Peptide calculator: https://www.mypeps.info/calculator Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Educational information, not medical advice. Episode page: https://www.mypeps.info/podcast/glow-a-three-peptide-blend-with-no-studies-of-its-own

  5. Oct 21

    Recent discoveries in MOTS-c benefits

    Mark and Amy walk through the latest MOTS-c research: a mitochondria-derived peptide studied for insulin sensitivity, exercise capacity, heart damage from sepsis, egg-cell energy in aging, and tissue transplants. They keep one point front and center: most of it is still animal and lab work, and MyPeps rates the evidence at 2 out of 5. Read the full post: Recent discoveries in MOTS-c benefits Peptides covered MOTS-c MOTS-c: A mitochondria-derived peptide studied for metabolism and exercise capacity. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review — Physiology International, Aug 2026. https://pubmed.ncbi.nlm.nih.gov/42640735/ MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential — European Journal of Pharmacology, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42633878/ The Mitochondrial-Derived Peptide MOTS-c Improves Bioenergetics in Aging-Associated Granulosa Cells and Oocytes — Reproduction & Fertility, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42895211/ Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility — Tissue & Cell, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42880137/ Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming — Bioactive Materials, Aug 2026. https://pubmed.ncbi.nlm.nih.gov/42633281/ MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation — Autophagy, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42153537/ Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/recent-discoveries-in-mots-c-benefits

  6. Oct 21

    How to store peptides: freezer, fridge and shelf life explained

    Mark and Amy break down peptide storage: why freeze-dried powder is the stable form, what oxygen, moisture and light do to a chain of amino acids, and how quickly shelf life drops once water is added. They also cover the 28-day sterility rule, sprays, and why approved drugs like Mounjaro and Egrifta SV follow their own labels. Read the full post: How to store peptides: freezer, fridge and shelf life explained Peptides covered BPC-157 MOTS-c Glutathione VIP NAD+ CJC-1295 (no DAC) + Ipamorelin GHK-Cu Tirzepatide Tesamorelin BPC-157: The most-discussed healing peptide, built on a stomach-protein fragment. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources Peptide Storage and Handling — Biosyn, accessed Oct 2026. https://www.biosyn.com/faq/peptide-storage-and-handling.aspx Peptide Storage & Handling — ChemPep, accessed Oct 2026. https://chempep.com/?p=33545 Peptide Storage and Handling — GenScript, accessed Oct 2026. https://www.genscript.com/peptide_storage_and_handling.html Handling and Storage Guidelines for Peptides — Bachem, accessed Oct 2026. https://www.bachem.com/knowledge-center/handling-and-storage-guidelines-for-peptides/ Handling and Storage Guidelines for Peptides and Proteins — Merck Millipore, accessed Oct 2026. https://www.merckmillipore.com/GN/en/technical-documents/technical-article/research-and-disease-areas/cell-and-developmental-biology-research/handling-and-storage Advisory: Sterile Injectable Dispensing (Including Testosterone) — Massachusetts Board of Registration in Pharmacy, Dec 2023. https://www.mass.gov/doc/sterile-injectable-dispensing-including-testosterone-pdf/download What is the recommended storage for Mounjaro (tirzepatide) single-dose pen? — Eli Lilly Medical Information, accessed Oct 2026. https://medical.lilly.com/us/products/answers/what-is-the-recommended-storage-for-mounjaro-tirzepatide-single-dose-pen-311033 Egrifta SV dosage and administration — Drugs.com, accessed Oct 2026. https://www.drugs.com/dosage/egrifta-sv.html Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/how-to-store-peptides-freezer-fridge-and-shelf-life-explained

  7. Oct 19

    16 new compounds at Amino Club: what each one is and what the research shows

    Mark and Amy dig into the 16 research compounds Amino Club just added, from sermorelin and VIP to the Russian "bioregulator" peptides and designer nasal sprays. They sort which have real human data, which rest on one lab, and what the lab certificates do and don't tell you. Read the full post: 16 new compounds at Amino Club: what each one is and what the research shows In this episode 00:00 Theme, cold open and intro 00:48 Personal moment 01:08 What showed up on the shelf 01:27 The four with real human data 03:02 LL-37 and the topical trial 03:24 Brain peptides with a single-lab problem 04:22 Quick hits: AHK-Cu, designer sprays and the new mists 05:13 What the lab certificates show 05:38 Safety and regulatory fine print 05:46 Bottom line 05:59 Wrap-up and Amino Club code Peptides covered VIP ARA-290 Kisspeptin-10 Sermorelin LL-37 Dihexa Pinealon Cartalax AHK-Cu Adamax Adalank Selank + Semax + Pinealon spray BPC-157, BPC-157 + TB-500, DSIP and Melanotan II (nasal mists) See them all, with each lot's certificate of analysis, on the new compounds page. VIP: A 28-amino-acid neuropeptide that relaxes blood vessels and calms inflammation. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources Aviptadil for COVID-19 respiratory failure (TESICO trial) — Lancet Respiratory Medicine, 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC10278994 Cibinetide improves corneal nerve fiber abundance in patients with sarcoidosis-associated small nerve fiber loss and neuropathic pain — Investigative Ophthalmology & Visual Science, 2017. https://research.manchester.ac.uk/en/publications/cibinetide-improves-corneal-nerve-fiber-abundance-in-patients-wit/ Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men — Journal of Clinical Endocrinology & Metabolism, 2011. https://academic.oup.com/jcem/article/96/8/E1228/2833644 Phase IIb study of topical LL-37 (ropocamptide) in hard-to-heal venous leg ulcers — trial report, accessed Oct 2026. https://www.diva-portal.org/smash/get/diva2:1607791/FULLTEXT01.pdf The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system — Journal of Pharmacology and Experimental Therapeutics, 2014. https://pmc.ncbi.nlm.nih.gov/articles/PMC4201273 Dihexa — Cognitive Vitality report, Alzheimer's Drug Discovery Foundation. https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Dihexa_1.pdf Determination that GEREF (sermorelin acetate) was not withdrawn from sale for reasons of safety or effectiveness — Federal Register, March 4, 2013. https://www.govinfo.gov/content/pkg/FR-2013-03-04/pdf/2013-04827.pdf The effect of tripeptide-copper complex on human hair growth in vitro — Archives of Pharmacal Research, 2007. https://agris.fao.org/search/fr/records/65de423b63b8185d9ca7d5b9 FDA's 2026 peptide compounding changes, explained — MyPeps, October 2026. https://www.mypeps.info/blog/fda-2026-peptide-compounding-changes Peptide lab reports (COAs): purity by lot — MyPeps, October 2026. https://www.mypeps.info/lab-reports Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/new-compounds-amino-club-what-the-research-shows

  8. Oct 16

    What Reddit users report on retatrutide, and what the trials actually show

    Mark and Amy dig into a new JAMA Network Open study that used AI to sort nearly 150,000 Reddit posts about unapproved retatrutide. Users report hunger, fatigue and a racing heart; the TRIUMPH trials found mostly stomach effects. They walk through where the two pictures match, why they differ, how glucagon sets retatrutide apart from tirzepatide, and HHS's new peptide access plan. Read the full post: What Reddit users report on retatrutide, and what the trials actually show In this episode 00:00 Theme, cold open and intro 00:50 Amy's forum night and Mark's Lancet weekend 01:10 What 7,800 Reddit users reported 02:19 What the TRIUMPH-2 trial actually found 03:23 Why the two pictures differ: the limits 04:22 Where glucagon and the GLP-1 drugs overlap and split 05:00 Quick hit: HHS peptide access plan and BPC-157 05:30 Safety fine print and the bottom line 05:55 Wrap-up and Amino Club code Peptides covered Retatrutide Tirzepatide Semaglutide BPC-157 Retatrutide: Eli Lilly's investigational triple-hormone agonist: GIP, GLP-1 and glucagon in one weekly shot. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources Penn engineers use AI, Reddit to identify potential side effects of unapproved new GLP-1 (on the JAMA Network Open study "Self-Reported Adverse Effects Among Social Media Users Taking Nonapproved Retatrutide," published Oct 14, 2026) — University of Pennsylvania via EurekAlert!, Oct 15, 2026. https://www.eurekalert.org/news-releases/1147934 Sehgal NKR, Ungar L, Tronieri JS, Rader B, Guntuku SC. Self-Reported Side Effects Among Reddit Users Taking Nonapproved Retatrutide — medRxiv, Aug 18, 2026 (preprint version of the study above, not peer reviewed; analysis of community discussion). https://www.medrxiv.org/content/10.64898/2026.05.28.26352819v2.full.pdf Bellido V, le Roux CW, Ekinci EI, et al. Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial — The Lancet, Oct 10, 2026 (online Sep 29, 2026). https://pubmed.ncbi.nlm.nih.gov/42810372/ Retatrutide cuts weight up to 18.8% in adults with T2D, obesity — Pharmacy Times, Sep 30, 2026. https://www.pharmacytimes.com/view/retatrutide-cuts-weight-up-to-18-8-in-adults-with-t2d-obesity Was dysesthesia reported as an adverse event in the retatrutide TRIUMPH trials? — Lilly Medical, reviewed Aug 18, 2026. https://medical.lilly.com/us/products/answers/was-dysesthesia-reported-as-an-adverse-event-in-the-retatrutide-triumph-trials-in-patients-with-overweight-or-obesity-387925 Jastreboff AM, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial — New England Journal of Medicine, 2023 (background). https://pubmed.ncbi.nlm.nih.gov/37366315/ Ard JD, Almandoz JP. The Power of Two: Harnessing Dual Glucagon and Incretin Signaling for Treatment of Obesity and MASH — Obesity Reviews, Oct 11, 2026. https://pubmed.ncbi.nlm.nih.gov/42860310/ Perrone M. Trump administration advances plan for peptide drugs favored by RFK Jr. — Associated Press via News4JAX, Oct 15, 2026. https://www.news4jax.com/business/2026/10/15/trump-administration-advances-plan-for-peptide-drugs-favored-by-rfk-jr/ Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/retatrutide-reddit-side-effects-vs-trials

  9. Oct 15

    BPC-157 in 2026: what the evidence actually shows

    Mark and Amy dig into BPC-157, maybe the most talked-about peptide online. There are well over a hundred studies behind it, so why can't you get it at a pharmacy? They walk through the animal research, the five small human reports the FDA found, what's still unknown about safety, the WADA ban, and where the July 2026 FDA advisory committee vote actually leaves things. Read the full post: BPC-157 in 2026: what the evidence actually shows In this episode 00:00 Theme, cold open and intro 00:45 Personal moment 01:11 What BPC-157 is and the animal evidence 02:36 The human evidence: five small reports 03:37 The flip side: why we rate it 2 out of 5 04:11 Safety: mostly unknown 05:14 Banned in sport: WADA status 05:28 The FDA compounding vote 05:51 Not legal yet, and the bottom line 06:18 Wrap-up and Amino Club code Peptides covered BPC-157 TB-500 BPC-157: The most-discussed healing peptide, built on a stomach-protein fragment. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources FDA Briefing Document, Pharmacy Compounding Advisory Committee meeting July 23–24, 2026: BPC-157-related bulk drug substances — U.S. Food and Drug Administration, May 11, 2026. https://www.fda.gov/media/193343/download Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review — HSS Journal, Jul. 31, 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC12313605/ Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain — Alternative Therapies in Health and Medicine, 2021. https://pubmed.ncbi.nlm.nih.gov/34324435/ Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study — Alternative Therapies in Health and Medicine, 2024. https://pubmed.ncbi.nlm.nih.gov/39325560/ Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study — Alternative Therapies in Health and Medicine, 2025. https://pubmed.ncbi.nlm.nih.gov/40131143/ A Peptide, a Secretive Scientist, and a Debate Over Evidence — Undark, May 29, 2026. https://undark.org/2026/05/29/stress-test-bpc-157-history/ Croatian researchers thrust into limelight as their 1990s' peptide discovery goes mainstream in the US — Chemistry World, Jun. 11, 2026. https://www.chemistryworld.com/news/croatian-researchers-thrust-into-limelight-as-their-1990s-peptide-discovery-goes-mainstream-in-the-us/4023660.article Athlete Advisory: Explanation of Key Changes on 2022 WADA Prohibited List — U.S. Anti-Doping Agency, Oct. 13, 2021. https://www.usada.org/spirit-of-sport/key-changes-2022-prohibited-list/ World Anti-Doping Code International Standard: Prohibited List 2026 — World Anti-Doping Agency, accessed Oct. 10, 2026. https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf PCO-02 - Safety and Pharmacokinetics Trial (NCT02637284) — ClinicalTrials.gov, last updated Dec. 22, 2015. https://clinicaltrials.gov/study/NCT02637284 FDA advisory committee votes to add popular peptide BPC-157 to drug compounding list — ABC News, Jul. 23, 2026. https://abcnews.com/Health/fda-advisory-committee-votes-add-popular-peptide-bpc/story?id=134913891 Bulk-list bound? PCAC backs majority of peptides in two-day public meeting — McDermott Will & Schulte, Jul. 27, 2026. https://www.mcdermottlaw.com/insights/bulk-list-bound-pcac-backs-majority-of-peptides-in-two-day-public-meeting/ FDA to Remove 12 Popular Peptides from the Category 2 "Do Not Compound" List — Frier Levitt, Apr. 16, 2026. https://www.frierlevitt.com/articles/fda-peptides-do-not-compound-list-update-2026/ Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/bpc-157-evidence-2026

  10. Oct 13

    Semax and Selank explained: Russia's nasal peptides

    Mark and Amy dig into Semax and Selank, two short peptides developed in Russia and usually given as nasal drops. They're registered medicines there, but not approved in the US, Europe, the UK or Australia. What does the research actually show, in rats and in people? Where does the FDA's July 2026 compounding vote leave Semax? And what's known about the newer ready-made sprays, Adamax and Adalank? (Spoiler: no published studies at all.) Read the full post: Semax and Selank explained: Russia's nasal peptides In this episode 00:00 Theme, cold open and intro 00:51 Personal moment 01:12 What Semax and Selank are 02:18 Semax: animal studies vs. people 03:12 Selank and the anxiety trial 03:55 Adamax and Adalank: no studies 04:44 Banned in sport? WADA status 05:21 The FDA compounding vote 05:51 Not legal yet, and the bottom line 06:24 Wrap-up and Amino Club code Peptides covered Semax Selank Adamax Adalank Semax: Russian-developed nootropic peptide, approved there for stroke recovery. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources Semax (Семакс) nasal drops 0.1%: instructions for use, indications and registration — Vidal drug reference (Russia), accessed Oct. 10, 2026. https://www.vidal.ru/drugs/semax__28676 Selank (Селанк) nasal drops 0.15%: instructions for use, indications and registration — Vidal drug reference (Russia), accessed Oct. 10, 2026. https://www.vidal.ru/drugs/selank__21568 FDA Briefing Document, Pharmacy Compounding Advisory Committee meeting July 23–24, 2026: Semax-related bulk drug substances (Semax (free base) and Semax acetate) — U.S. FDA, May 11, 2026. https://www.fda.gov/media/193348/download FDA Advisory Committee Recommends Adding Six of Seven Peptides to Compounding List — American Med Spa Association, Jul. 24, 2026. https://www.americanmedspa.org/news/fda-advisory-committee-recommends-adding-six-of-seven-peptides-to-compounding-list/ Pharmacy Compounding Advisory Committee (PCAC) Meeting, July 23–24, 2026: Agenda — U.S. FDA, Jul. 23, 2026. https://www.fda.gov/media/193771/download Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission — Front Pharmacol, Feb. 18, 2016. https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/ Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus — Brain Res, 2006. https://pubmed.ncbi.nlm.nih.gov/16996037/ Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents — Neurochem Res, 2005. https://pubmed.ncbi.nlm.nih.gov/16362768/ Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion — Int J Mol Sci, Jun. 8, 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8226508/ Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity — Protein Pept Lett, 2018. https://pubmed.ncbi.nlm.nih.gov/30255741/ The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity — Bull Exp Biol Med, 2001. https://pubmed.ncbi.nlm.nih.gov/11550013/ Immunomodulatory effects of selank in patients with anxiety-asthenic disorders — Zh Nevrol Psikhiatr Im S S Korsakova, 2008. https://pubmed.ncbi.nlm.nih.gov/18577961/ Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia — Zh Nevrol Psikhiatr Im S S Korsakova, 2008. https://pubmed.ncbi.nlm.nih.gov/18454096/ Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks — U.S. FDA, content current as of Apr. 22, 2026. https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks FDA's Pep(tide) Rally! What Compounders and Industry Need to Know (Post 1 of 2) — FDA Law Blog (Hyman, Phelps & McNamara), Apr. 21, 2026. https://thefdalawblog.com/2026/04/fdas-peptide-rally-what-compounders-and-industry-need-to-know-post-1-of-2 World Anti-Doping Code International Standard: Prohibited List 2026 — World Anti-Doping Agency, in force Jan. 1, 2026. https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf Athlete Advisory: What's New on the 2027 WADA Prohibited List? — USADA, 2026. https://www.usada.org/spirit-of-sport/athlete-advisory-2027-prohibited-list/ Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/semax-selank-explained

  11. Oct 13

    Peptides for sex and hormones: what a new urology review says the evidence supports

    Mark and Amy dig into a new review of peptides used in urology and sexual medicine. Out of 76 studies, only two peptides, PT-141 and tesamorelin, have defined dosing and an approved use, and both approvals are narrow. They also look at why raising IGF-1 isn't the same as a proven benefit, where kisspeptin and testosterone therapy overlap and split, a new mouse study on kisspeptin and estrogen, and a large records study of GLP-1 drugs before pregnancy in PCOS. Read the full post: Peptides for sex and hormones: what a new urology review says the evidence supports In this episode 00:00 Theme, cold open and intro 00:54 Grocery-store reading 01:05 The new urology review: only two peptides with approved uses 03:34 The flip side: unregulated markets and the review's limits 04:29 Where kisspeptin and testosterone overlap and split 05:19 Quick hits: kisspeptin in mice, GLP-1 drugs and PCOS 06:09 Fine print and what it means for you 06:23 Bottom line 06:45 Wrap-up and Amino Club code Peptides covered PT-141 (bremelanotide) Tesamorelin Ipamorelin Kisspeptin PT-141: Works through the brain, not blood flow — and it's FDA-approved for women. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review — Sexual Medicine Reviews, Sep. 30, 2026. https://pubmed.ncbi.nlm.nih.gov/42862021/ VYLEESI (bremelanotide injection) prescribing information — U.S. Food and Drug Administration, June 2019. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf EGRIFTA (tesamorelin for injection) prescribing information — U.S. Food and Drug Administration, 2012. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022505s004lbl.pdf Drug scheduling — U.S. Drug Enforcement Administration. https://www.dea.gov/drug-information/drug-scheduling World Anti-Doping Code International Standard: Prohibited List 2026 — World Anti-Doping Agency, Jan. 1, 2026. https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice — Journal of Neuroendocrinology, Oct. 2026. https://pubmed.ncbi.nlm.nih.gov/42833261/ Preconception incretin therapy reduces pregnancy and cardiometabolic outcomes in polycystic ovary syndrome — Journal of Clinical Endocrinology & Metabolism, Oct. 10, 2026. https://pubmed.ncbi.nlm.nih.gov/42857939/ Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/peptides-sexual-medicine-review-hormones

  12. Oct 12

    Gray-market peptides and fentanyl precursors: what the new TRM Labs report found

    Mark and Amy dig into a new TRM Labs report: about three in four Chinese chemical vendors it tracked list both peptides and fentanyl precursors, and US buyers send most of the traceable money. They cover what the report can and can't show, the two peptides it named, and what the FDA says about "research use only" labels. Read the full post: Gray-market peptides and fentanyl precursors: what the new TRM Labs report found In this episode 00:00 Theme, cold open and intro 00:46 Weekend catch-up 00:59 What the TRM Labs report found 02:15 The limits of the data 03:14 Melanotan II 04:01 Semaglutide sold as a research chemical 04:37 Why "research use only" isn't a shield 05:05 The policy debate over compounding 05:32 Bottom line 05:57 Wrap-up and Amino Club code Peptides covered Melanotan II Semaglutide Melanotan II: A powerful but unapproved tanning peptide — with real safety warnings from regulators. Free tools Free reconstitution and dosing calculator: mypeps.info/calculator Sources Americans Are Buying Peptides From the Same Chinese Chemical Vendors Selling Fentanyl Precursors: Sales Up 32% Since 2023 — TRM Labs, October 6, 2026. https://www.trmlabs.com/resources/blog/americans-are-buying-peptides-from-the-same-chinese-chemical-vendors-selling-fentanyl-precursors-sales-up-32-since-2023 Americans paying for cheap online semaglutide may be sending money to vendors that also list fentanyl precursors — Medical Daily, October 8, 2026. https://medicaldaily.com/cheap-semaglutide-research-peptides-fentanyl-precursor-vendors-479725 Warning letter: Peptide Partners LLC (MARCS-CMS 735063) — U.S. Food and Drug Administration, August 24, 2026. https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/peptide-partners-llc-735063-08242026 Chinese fentanyl makers find new U.S. market in peptides — Axios, July 7, 2026. https://www.axios.com/2026/07/07/chinese-fentanyl-makers-pivot-peptides Copycat pharmacies and the peptide market — Independent Institute, October 6, 2026. https://independent.org/article/2026/10/06/copycat-pharmacies-peptide-compounding Where we buy Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission. Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Read the full article on MyPeps Episode page: https://www.mypeps.info/podcast/gray-market-peptides-fentanyl-precursor-vendors

  • 12 Episodes

About

Mark and Amy break down the week's peptide research news in plain English: new trials, FDA and WADA decisions, safety alerts, and what the evidence actually shows, including when it doesn't. Every story is sourced, and every episode links to the full write-up on mypeps.info. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS. Educational information, not medical advice.

Information

  • Creator
    MyPeps
  • Years Active
    2026
  • Episodes
    12
  • Rating
    Clean
  • Copyright
    © 2026 MyPeps
  • Show Website
    The Peps Report