Under Load

Andre Heeg

Under Load is the weekly audio edition of Andre Heeg’s newsletter for senior leaders and business owners carrying heavy responsibility. Each episode examines how demanding work affects your health, energy, judgment, and life outside work. Andre draws on current research through the lens of his medical training and business experience. The result is practical guidance built for the reality of leadership. New episodes every Sunday. Read the full editions and supporting evidence at andreheeg.com.

Episodes

  1. 5d ago

    Seed Oils: I Read Both Sides, Including the Trials Nobody Quotes

    I drank butter for breakfast for two years. Two tablespoons, blended into coffee, standing at the kitchen counter before anyone else was awake. I have a medical degree and a dental one. I did it because someone on a podcast explained the science, and it made sense to me at the time. These things always seem to make sense at first. That is the real problem. After butter came MCT oil, then coconut, then ghee, then olive. Five phases over fifteen years, each with its own expert, its own mechanism, and a fat I was told to avoid. The current villain is seed oils, and lately more executives have asked me about them than about anything else. So I read both sides properly, including the arguments I expected to disagree with. In this edition: Why the critics are right about the biology. Linoleic acid really is stored in your cell membranes and your body fat, and its share of American adipose tissue roughly doubled between 1959 and 2008. That part is not in dispute. Where the chain breaks. The one time anyone tested the DNA claim in living people, and what they actually found. The omega-6 to omega-3 ratio, and why the study everybody cites points somewhere other than where they think it does. The two randomized trials that should trouble anyone who believes this question is settled, including the one where more of the intervention group died. I do not soften it, and I explain why the margarine explanation the internet reaches for was rejected by the trial's own authors. Why the cohort studies and the randomized trials disagree with each other, and what each design can and cannot tell you. This is the part of clinical training that transfers to reading any study. Two of my own phases that turned out badly, including the one where I made things more concentrated while believing I had made them lighter. And a hallway outside a wrestling dormitory, which is where this piece actually starts, and where it ends. If you have ever thrown out a bottle of oil because of something you heard, there is a section on where cooking fat actually sits in your diet that will probably annoy you. --- Read the written edition, with all 16 references: https://www.andreheeg.com Under Load is the Sunday edition of The Upward ARC, written by Andre Heeg, MD, DDS. Evidence-led writing on executive health, longevity and performance under load, for people carrying real responsibility. Subscribe: https://www.andreheeg.com --- Studies and sources discussed in this episode are listed in full in the written edition. Key ones: Guyenet & Carlson (2015), Advances in Nutrition: the rise in adipose linoleic acid across 37 studies de Kok et al. (2003), Food and Chemical Toxicology: the human trial of linoleic acid and oxidative DNA damage Zhang et al. (2024), eLife: omega-6, omega-3 and mortality in 85,425 UK Biobank adults Hooper et al. (2018), Cochrane Database of Systematic Reviews: omega-6 fats and cardiovascular disease Ramsden et al. (2016), BMJ: recovered data from the Minnesota Coronary Experiment Ramsden et al. (2013), BMJ: recovered data from the Sydney Diet Heart Study Zhang et al. (2025), JAMA Internal Medicine: butter, plant oils and mortality Hall et al. (2019), Cell Metabolism: the inpatient ultra-processed food trial --- This episode is me reading the written newsletter, adjusted for the spoken word. Figures are rounded and citations are left out; everything is fully referenced in the written edition. I use AI to research and pressure-test the science. The thinking, the conclusions, and the writing are always mine. Nothing here is medical advice, and it is not a substitute for a conversation with your own doctor.

    Seed Oils: I Read Both Sides, Including the Trials Nobody Quotes
  2. Aug 5

    BPC-157: The Peptide I Almost Injected

    In August 2024 I was at the worst point of eighteen months of back pain. My wife was putting my socks on for me. I was half-listening to a podcast when I heard a Stanford neuroscientist mention a compound called BPC-157. That afternoon I was on a vendor's website with a bank transfer form open. I never bought it, and the reason is embarrassing rather than admirable. This episode is about what happened next, and about why nobody can answer the question I now get asked every week: are peptides safe? In this edition: Why "peptide" is a measurement rather than a category of medicine, and how a line drawn at 40 amino acids decides paperwork instead of safety. Insulin is a peptide. So is Ozempic. So is the compound in that vial. What the FDA advisory panel actually did on July 23, and why the answer is closer to nothing than the headlines suggested. What the human evidence for BPC-157 really consists of, and why almost all of it comes from one laboratory in Zagreb whose founder has never published a key part of his own work. The trials registry problem, where searching for evidence today returns Phase 2 studies marked "recruiting" that state inside their own records that they are fictional. The stacks, the marketing, and what a physician sees when a bundle of untested compounds gets named after a comic book character. And a section I did not plan to write, about the prescriptions I refuse to sign, and what years of operating on cancers of the mouth taught me about the phrase "at your own risk." If you are already taking something, there is one part I would want you to hear before the rest. It is about blood vessels. --- Read the written edition, with all 25 references: https://www.andreheeg.com Under Load is the Sunday edition of The Upward ARC, written by Andre Heeg, MD, DDS. Evidence-led writing on executive health, longevity and performance under load, for people carrying real responsibility. Subscribe: https://www.andreheeg.com --- Studies and sources discussed in this episode are listed in full in the written edition. Key ones: Vasireddi et al. (2025), HSS Journal — systematic review of BPC-157 in orthopaedic sports medicine Józwiak et al. (2025), Pharmaceuticals — literature and patent review, and the published exchange with Sikirić Talpos, S. (2026), Undark Magazine — reporting on the unpublished parent sequence Ashraf et al. (2024), Journal of Medical Internet Research — quality analysis of semaglutide bought from online sellers Huberman Lab (June 2026) — Peptides: The Science, Uses & Safety, with Dr. Abud Bakri --- This episode is me reading the written newsletter, adjusted for the spoken word. Figures are rounded and citations are left out; everything is fully referenced in the written edition. I use AI to research and pressure-test the science. The thinking, the conclusions, and the writing are always mine. Nothing here is medical advice, and it is not a substitute for a conversation with your own doctor.

    BPC-157: The Peptide I Almost Injected

About

Under Load is the weekly audio edition of Andre Heeg’s newsletter for senior leaders and business owners carrying heavy responsibility. Each episode examines how demanding work affects your health, energy, judgment, and life outside work. Andre draws on current research through the lens of his medical training and business experience. The result is practical guidance built for the reality of leadership. New episodes every Sunday. Read the full editions and supporting evidence at andreheeg.com.