Longevity Optimization with Kayla Barnes-Lentz

Kayla Barnes-Lentz

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

  1. -5 DIAS

    Dr. Aimie Apigian, MD: The Biology of Trauma + Nervous System Safety

    Longevity isn’t just workouts, supplements, and recovery tools, it starts with nervous system health.  In this episode, Dr. Aimie Apigian explains what trauma actually is (not a label, but a measurable physiological response), how the body shifts from stress into overwhelm, and why “pushing through” often turns into years of avoidance, numbing, and hidden internal strain. She breaks down the biology behind the trauma response, including the role of adrenaline, cortisol timing, and how mitochondrial capacity influences resilience. You’ll also learn her practical, body-based approach to creating “safe enough” in real time, plus the three phases of healing: safety, support, and expansion, so you don’t stay stuck avoiding triggers forever. In this conversation: Stress vs trauma response (and what changes physiologically)Why adrenaline drives the response and cortisol arrives laterHow the body stores trauma as patterns, not just memoriesThe 3 nervous system states and the thoughts they generateA simple somatic exercise to build safety in the bodyWhy devices/meds can be bridges, not the destinationUsing biomarkers + wearables without fooling yourselfWhy modern media can create vicarious traumaJoin the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ YouTube: www.youtube.com/@KaylaBarnesLentz Spotify:https://open.spotify.com/show/4OLWWn22... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Aimie Apigian, MD: Instagram: https://www.instagram.com/draimie/ YouTube: https://www.youtube.com/c/DrAimieApigian Website: https://www.biologyoftrauma.com/ Order her Book “The Biology of Trauma”: https://www.biologyoftrauma.com/book

    1 h 55 min

  2. 14/02

    I Became the First Woman in the World to Test Her Ovarian Age

    For the first time in history, ovarian biological age can be measured, and I became the first woman in the world to take the test. Until now, women have had no real way to understand how their ovaries are aging beyond rough estimates like AMH. But this new machine-learning algorithm, trained on over 40,000 real women across different life stages, analyzes hormone biomarkers, body composition, and reproductive history to estimate ovarian age relative to chronological age. This is a massive step forward in female longevity science. In this episode, I walk through what the test measures, how the algorithm works, and what becoming the first data point actually means, not just for me, but for women collectively. We also explore what may be driving ovarian aging in the first place. I also share how I’m now testing specific interventions in isolation, including hyperbaric oxygen therapy, to determine whether we can meaningfully influence ovarian aging over time. Ovarian lifespan is significantly shorter than overall lifespan and once we can measure it, we can begin to understand it. This is only the first step in redefining female longevity. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member *Kayla's social + website:* Instagram:  https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com SHOW NOTES: 00:01:03 Timeless Biotech Website:https://timelessbiotech.com/ 00:01:13 Podcast With The Founder of Timeless Biotech:https://www.youtube.com/watch?v=s-_EuNUwjsM&t=57s 00:04:12 Kayla’s Protocols:https://www.protocol.kaylabarnes.com/ 00:09:58 Podcast With Dr. Chris Masterjohn:https://www.youtube.com/watch?v=z3quYW_pCDU 00:10:48 Study About Ovarian Stiffness Increasehttps://pmc.ncbi.nlm.nih.gov/articles/PMC7681059/#acel13259-sec-0002 00:16:22 Study For Increased PFAShttps://pubmed.ncbi.nlm.nih.gov/41620147/ 00:17:56 Red Light Therapy Study: https://www.sciencedirect.com/science/article/abs/pii/S1011134424001842?via=ihub

    19 min

  3. 12/02

    Cynthia Thurlow, NP: Perimenopause, Insulin Resistance and Midlife Metabolism

    Perimenopause is not just about hormones, it’s a metabolic transition that affects insulin sensitivity, gut health, stress tolerance, and long-term disease risk. In this episode, Cynthia Thurlow, board-certified nurse practitioner and functional medicine expert, explains how women’s metabolism changes in midlife and why insulin resistance, poor stress resilience, and gut dysfunction often appear years before menopause. She breaks down how perimenopause can begin earlier than most women expect, why symptoms vary so widely, and how lifestyle factors like fasting, exercise intensity, sleep, alcohol, and chronic stress interact with hormones during this transition. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member This conversation explores: Why insulin resistance often emerges in perimenopause How stress and trauma shape metabolic and hormonal health The role of gut health in PMS, mood, and estrogen balance When fasting helps women and when it makes things worse Why “doing everything right” can still lead to symptoms How to individualize nutrition, training, and recovery in midlife Connect with Kayla: Instagram:https://www.instagram.com/kaylabarnes/ TikTok:https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ YouTube: www.youtube.com/@KaylaBarnesLentz Apple: https://podcasts.apple.com/us/podcast...Website:https://www.protocol.kaylabarnes.com Learn more about Cynthia Thurlow Instagram: https://www.instagram.com/cynthia_thurlow_/ YouTube: https://www.youtube.com/cynthiathurlow Website: https://www.cynthiathurlow.com/ Pre-order her upcoming book: The Menopause Gut (28th of April 2026):https://www.penguinrandomhouse.com/books/777129/the-menopause-gut-by-cynthia-thurlow-np/?mcp… ACE (Adverse Childhood Experiences) questionnaire:https://www.acesaware.org/wp-content/uploads/2022/07/ACE-Questionnaire-for-Adults-Identified-English-rev.7.26.22.pdf

    59 min

  4. 5/02

    Dr. Chris Masterjohn, PhD - Mitochondria, Micronutrients, and How Nutrition Actually Drives Longevity

    When cellular energy production is impaired, no diet, supplement, or health protocol can work as intended. In this episode, Dr. Chris Masterjohn, nutrition scientist and expert in micronutrients and metabolism, explains why mitochondrial function is the limiting factor behind stalled progress, persistent fatigue, and supplements that stop working over time. He breaks down why vitamin D supplementation often creates new problems when it is taken without proper nutrient balance, how high doses can disrupt other systems in the body, and why sunlight has biological effects that vitamin D pills alone cannot replicate. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member This conversation explores: Why mitochondrial bottlenecks explain most energy and health plateaus How micronutrient deficiencies undermine supplements and biohacks When creatine supports cellular energy and why it works differently than most supplements Why vitamin D supplementation can backfire without context and balance Why sunlight affects biology in ways supplements cannot replace How diet, fasting, and exercise interact with mitochondrial capacity Why optimizing one system often breaks another without proper foundations Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr Chris Masterjohn’s work: Website: https://www.chrismasterjohn-phd.com/Instagram: https://www.instagram.com/chrismasterjohn/YouTube: https://www.youtube.com/@chrismasterjohn

    2 h 40 min

  5. 29/01

    Dr. Jessica Shepherd, MD – Menopause, Hormone Therapy and Bone Health

    In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your perimenopausal years can make all the difference for long-term health. Dr. Shepard shares the essential labs she runs on patients including ApoB, HbA1c, and thyroid optimization, plus the longevity metrics women should be tracking.We also get into supplement recommendations including why she recommends 10 grams of creatine daily, the role of inflammation in aging, and how estrogen is naturally anti-inflammatory which is why women see increased cardiovascular risk and metabolic dysfunction after menopause. Kayla's social + website: Instagram:  kaylabarnes TikTok:  femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn2... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Dr. Jessica Shepherd's social + website: Website: https://www.jessicashepherdmd.com/ Instagram: https://www.instagram.com/jessicashepherdmd/ Transform Your Health: https://eudemonia.net/?utm_source=podcast&utm_medium=kayla-podcast&utm_campaign=jessica-shepherd

    49 min

  6. 22/01

    Dr. Khanh Nguyen - The Blood Swap: Why Doctors Are Replacing Your Plasma With THIS

    What if your blood is what’s making you sick and the key to reversing it is removing it? In this episode, I sit down with Dr. Khanh Nguyen, a regenerative and anti-aging physician, to explore therapeutic plasma exchange and the rising use of young plasma. We talk detox, autoimmune disease, aging, peptides, and why your blood might be holding you back. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/... Kayla's social + website: Instagram:  kaylabarnes TikTok:  femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn2... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Khanh's social + website: Instagram: https://www.instagram.com/regenwithdrnguyen/ Website: Austin Regenerative Therapy

    1 h 9 min

  7. 15/01

    Dr. Ann Shippy, MD - The Fertility Alarm: Why 1 in 31 Kids Now Has Autism

    Is your environment silently sabotaging your fertility? Dr. Ann Shippy joins the show to reveal how hidden toxins, mold, and overlooked cellular damage may be accelerating ovarian aging and how to reclaim your fertility before it’s too late. From infertility misdiagnoses to rising autism rates, we dive deep into the tests most doctors never run, and the real impact your body’s toxic load has on future generations.  Kayla's social + website: Instagram:  kaylabarnes TikTok:  femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn2... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Dr. Ann Shippy social + website: Instagram: https://www.instagram.com/annshippymd/Website: https://annshippymd.com/

    1 h 2 min

  8. 8/01

    Ashley Koff, RD - Dietitian Reveals: The Hormone Problem That Makes You Eat Everything

    Ashley Koff is a registered dietitian and author who spent 20 years discovering that weight and health aren't separate issues, they're connected through "weight health hormones." After her own struggles with restrictive eating despite doing everything "right," a functional medicine doctor helped her understand what was actually broken, and that was, her body's natural hormone function. In this episode, Ashley explains why GLP-1 medications like Ozempic work, who actually needs them, and the critical foundational work required to avoid devastating rebounds. She reveals why current dietary guidelines fail women, shares her free weight health hormone assessment, cuts through the seed oil controversy, and offers practical strategies for eating healthy on any budget. If you're confused about nutrition, frustrated that eating healthy isn't working, or curious about GLP-1 medications, this conversation provides the clarity you've been missing. Guest’s socials + website: Instagram: @ashleykoffapproved Website: https://thebetternutritionprogram.com/  Kayla's social + website: Instagram:  https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol:  https://www.protocol.kaylabarnes.com Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

    1 h 16 min
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Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

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