The Human 5.0 Project

Ultimate Biohacker 10x
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The Human 5.0 Project is the podcast where science meets self-optimization. Hosted by Ultimate Biohacker 10X, this show explores the real research, real data, and real dosing behind today’s most effective biohacking tools — from peptides, longevity molecules, and nootropics to recovery devices, lifestyle strategies, sleep optimization, training principles, and cutting-edge performance tech. Each episode breaks down complex biology into practical, actionable protocols you can use to improve energy, metabolism, cognition, and overall healthspan. No hype. No fluff. Just evidence-based insights for people who want to understand their bodies, upgrade their biology, and unlock their highest potential. If you’re ready to optimize your life one pathway at a time, you’re in the right place.

  1. HACE 12 H

    Follistatin 344 Explained: Myostatin Inhibitor for Muscle Growth, Gene Therapy Results & Real Risks (2026 Update)

    Myostatin Inhibitor Follistatin-344: Gene Therapy Breakthroughs, Peptide Hype, Side Effects & If It Actually Works   Tired of hitting your genetic muscle ceiling? In this deep dive, we break down Follistatin-344—the "myostatin brake release" everyone's talking about. From animal/primate studies showing massive hypertrophy to human trials in muscular dystrophy, gene therapy (AAV delivery) vs. gray-market peptides, Bryan Johnson/Minicircle experiments, mechanisms (myostatin + activin blockade), realistic gains, side effects (reproductive risks, immune issues, tendon lag), and why most online vials don't match the science. No hype—just signal on whether this unlocks true muscle growth or stays in the lab.     Intro: The Genetic Ceiling & Myostatin Brake Why Myostatin Matters (Belgian Blue Proof) Follistatin Isoforms: FS-344 vs FS-315/288 Mechanism: How It Traps Myostatin & Activins The Three Paths to Hypertrophy Animal & Primate Research: Real Gains & Plateaus Human Trials: Becker MD, sIBM & Safety Signals Gene Therapy vs Peptide Vials: The Brutal Gap Timeline, Stacking & Practical Reality Side Effects, Risks & Unknowns Sourcing Mess & Bigger Picture (Dystrophy > Vanity) Rapid FAQ: Does It Work? Localized? Safe for Women? Final Honest Assessment If you've experimented with follistatin peptides or gene therapy, drop your experience (gains, sides, source) in the comments—no judgment, just signal.   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   #Follistatin344 #MyostatinInhibitor #MuscleGrowth #GeneTherapy #Biohacking #Follistatin #Myostatin #Longevity #BryanJohnson #PEDs #AntiAging #Human5.0Project #PeptideScience #BodybuildingScience #HealthOptimization#Ultimatebiohacker10x

    15 min

  2. HACE 1 DÍA

    Erythritol Exposed: “Zero Sugar” Might Not Be Zero Risk (BBB + Stroke Signal)

    Zero-Sugar, Real Consequences: Erythritol, Clotting, and Brain Vessel Function   You’re in the aisle making the “smart” swap: zero-sugar energy drinks, keto bars, sugar-free gum. Feels like a win… until the science starts whispering a different story. In this episode, UltimateBiohacker10X breaks down why erythritol (a “natural” sugar alcohol used everywhere in keto/low-carb) is getting serious scrutiny—from cardiovascular event associations to a newer lab study showing direct impacts on brain microvascular endothelial cells (the cells that help form the blood–brain barrier). This is educational only — not medical advice. If you have vascular risks, clotting history, diabetes/metabolic disease, migraines with aura, or take meds/supplements that affect clotting or blood pressure, talk to a qualified clinician before changing anything. What we cover Why erythritol got “safe” status + why that doesn’t equal “risk-free” The 2023 signal: higher blood erythritol levels associated with major adverse cardiac events (heart attack, stroke, death) The 2025 lab data: erythritol exposure linked with Oxidative stress up Nitric oxide down (less vasodilation) Endothelin-1 up (more vasoconstriction) t-PA release blunted (reduced fibrinolysis / “clot-busting” capacity) Who may be highest risk (daily high-dose users / “keto stackers”) Practical action steps: label scanning, dose awareness, and smarter swaps “Vascular shields” lifestyle stack (sleep, zone 2, omega-3s, nitrates from greens/beets) Action steps (no panic, just signal) Scan labels: erythritol hides inside “sugar-free,” “keto,” and blends (monk fruit/stevia mixes). Check your dose: occasional gum ≠ daily drinks + bars + candy. Cumulative exposure matters. Consider alternatives: stevia/monk fruit/allulose have different profiles (and still need more data). Train sweetness down: the simplest win is reducing the craving for constant sweetness. 💬 Comment “666FDA” + your topic of concern and I’ll add it to the next breakdown.   Sources to look up (by title) “The artificial sweetener erythritol and cardiovascular event risk” (Nature Medicine, 2023) “The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function…” (Journal of Applied Physiology, 2025) World Health Organization guideline: “Use of non-sugar sweeteners” (May 15, 2023) Cleveland Clinic summary on thrombosis/platelet reactivity (Aug 2024) 🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications. #Erythritol #ZeroSugar #Keto#BloodBrainBarrier #StrokeRisk #EndothelialHealth #CardiovascularHealth #SugarAlcohol #ArtificialSweeteners #NutritionScience #MetabolicHealth #Inflammation #OxidativeStress #NitricOxide #Thrombosis #HeartHealth #BrainHealth #Biohacking #Longevity #HumanPerformance #TheHuman50Project #UltimateBiohacker10X

    7 min

  3. HACE 1 DÍA

    How to Test Your True Biological Age in 2026 – Epigenetic Clocks, Telomeres & Results Explained

    Biological Age vs Chronological Age: The Real Tests That Tell You How Old You Actually Are   Ever wonder why two people the same age feel completely different? Your driver’s license is just a number—your cells have their own clock. In this episode, we break down chronological, genetic (intrinsic), and biological age, plus the top tests that reveal how fast you’re actually aging: telomere length, epigenetic clocks (Horvath, GrimAge, PhenoAge, DunedinPACE), TruDiagnostic, Elysium, GlycanAge, and more. We cover:   How telomere shortening and DNA methylation drive aging At-home testing: spit, finger prick, blood spot—what to expect What your results mean (and the limitations) Why these tests are game-changers for longevity, healthspan, and motivation     Intro: Your body’s real age The three ages explained Telomeres, methylation & epigenetics The tests: which ones actually work Interpreting results & red flags Why you should care (and what to change) Final thoughts & action plan If you’ve run a biological age test, drop your results in the comments—what did it say, and what did you do about it? Subscribe for more cutting-edge biohacking, longevity science, and optimization protocols. Hit the bell so you never miss an update.   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   #BiologicalAge #EpigeneticClock #AgingScience #ReverseAging #Telomeres #DNAMethylation #Longevity #Biohacking #Human5.0 #TruDiagnostic #GrimAge #DunedinPACE #HealthOptimization #AntiAging #Biohacker

    10 min

  4. HACE 2 DÍAS

    AMPK Activation Explained: Exercise + Fasting + mTOR Balance (2026 Guide)

    Stop Chasing Hacks: AMPK + mTOR + Fasting + Exercise Cold plunges are the headline… but AMPK is the real story. In this episode, UltimateBiohacker10X breaks down AMPK (your cell’s low-energy switch) in plain English, then shows how to activate it without living in an ice bath—using exercise, fasting/low glycogen, and recovery strategy.   We also add the missing piece most people ignore: mTOR—the “build mode” signal. The goal isn’t “AMPK forever” or “mTOR forever.” The goal is cycling stress → recovery → adaptation so you don’t become a metabolic hostage.   No hype. Just mechanisms + measurement, plus a clean 30-day framework so you can run one lane, track outcomes, and stop stacking chaos.   What you’ll learn:   What AMPK actually does (fuel use + efficiency mode)   Why exercise is the king AMPK trigger   How fasting can help (and how people misuse it)   AMPK vs mTOR: efficiency mode vs build mode (why balance = longevity)   Red flags you’re overdrafting recovery   A simple 30-day experiment framework (goal → baseline → measure → stop rule)       Open — Cold isn’t the point Disclaimer + rules (foundations first) AMPK explained like you’re human (low-battery mode) Myth buster — more AMPK isn’t always better Activator #1: Exercise (the cleanest AMPK trigger) Activator #2: Fasting / low glycogen (powerful, easy to misuse) AMPK vs mTOR (growth mode vs efficiency mode) “Beyond basics” — research tools vs real life (don’t stack chaos) Safety + red flags (overdrafting recovery) 30-day “run it clean” framework Close — cycle stress + recovery, measure everything   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications. #AMPK #mTOR #Fasting #IntermittentFasting #ExerciseScience #Zone2 #HIIT #MetabolicHealth #FatOxidation #Mitochondria #Longevity #Autophagy #InsulinSensitivity #Biohacking #HealthOptimization #UltimateBiohacker10X #Recovery #StrengthTraining #MetabolicFlexibility #ColdExposure

    12 min

  5. HACE 3 DÍAS

    Cold Plunge Science 2026: AMPK, Brown Fat, Mitochondria & What Actually Changes

    AMPK Explained Simply: How Cold Exposure Triggers Fat Burning, Glucose Uptake & “Cell Cleanup”   Cold exposure isn’t a masculinity contest — it’s a stimulus. And the real story is what happens inside your cells when energy demand spikes.   In this episode, UltimateBiohacker10X breaks down AMPK (5' AMP-activated protein kinase) in plain English: your body’s internal “low fuel” switch that shifts you from storage/build mode into use/repair mode. We connect AMPK to cold thermogenesis, brown fat (BAT), mitochondrial signaling, and give you safe, repeatable protocols (cold showers → cold walks → cold plunge) without the ego traps.   No hype. Just signal: how to use cold as an amplifier, what outcomes are realistic, and what to track so you don’t confuse vibes with results.   NOT medical advice. If you have heart rhythm issues, Raynaud’s, cold urticaria, fainting history, pregnancy, or uncontrolled BP—talk to a clinician and don’t do cold water exposure alone.   If you want Part 2: “AMPK Activators Beyond Cold (exercise, fasting, sleep)” comment AMPK2.   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   Cold isn’t the point (open) Disclaimer + safety rules (don’t be a hero) AMPK explained like you’re human (fuel gauge / low power mode) What actually flips AMPK on (energy demand triggers) AMPK downstream effects (fuel partitioning + repair/efficiency) Cold thermogenesis: what it is vs. what it isn’t Brown fat (BAT) + why results vary person-to-person Practical protocols (cold shower → cold walk → cold plunge) How to measure results + stop rules (adult framework) Close + next episode teaser   #AMPK #ColdThermogenesis #ColdExposure #IceBath #ColdPlunge #Biohacking #MetabolicHealth #FatLossScience #MetabolicFlexibility #BrownFat #Mitochondria #GlucoseControl #Autophagy #Recovery #PerformanceHealth #UltimateBiohacker10X #NoHype #HealthOptimization #WellnessScience #2026Biohacking#TheHuman5.0Project

    14 min

  6. HACE 3 DÍAS

    Peptides 2026: Evidence Ladder + Quality Red Flags (Don’t Get Played)Part2

    Peptides Masterclass Part 2: Evidence Tiers + Purity Red Flags (No Hype) People love peptide “stacks.” Reality loves baselines, evidence tiers, and stop rules.   Part 1(click here)   In Part 2 of the Peptides Masterclass, UltimateBiohacker10X breaks down the Evidence Ladder (Tier 1 human RCTs → Tier 2 small human/mechanistic → Tier 3 preclinical/early) and the Quality Red Flags that turn “biohacking” into expensive confusion.   We run the 5 peptide buckets people actually search:   Fat loss: GLP-1 context + AOD-9604 reality check Injury/Recovery: BPC-157 + TB-500 (what we know vs what’s assumed) Sleep/Brain: Selank, Semax, DSIP (mechanism ≠ outcome) Longevity/Immune: TA1, MOTS-c, KPV (define longevity with metrics) Skin/Hair: GHK-Cu + topical penetration reality (physics > marketing)   Rule #1 stays undefeated: foundations first. If you aren’t tracking baselines, you aren’t doing an experiment—you’re doing a vibe. Educational only. Not medical advice. No dosing. No sourcing. Consult a qualified clinician for personalized decisions.     🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   Open — Evidence Ladder + “Don’t get played” Evidence Ladder explained (Tier 1 / 2 / 3) Bucket 1 — Fat loss (GLP-1s + AOD-9604 evidence + red flags) Bucket 2 — Injury/Recovery (BPC-157 + TB-500 reality check) Bucket 3 — Sleep/Brain (Selank, Semax, DSIP: what’s real vs wanted) Bucket 4 — Longevity/Immune (TA1, MOTS-c, KPV: evidence ladder) Bucket 5 — Skin/Hair (GHK-Cu + topical penetration reality) Universal Quality Red Flags (purity, stacking, no baseline) Close — pick one lane, measure, stop rules       #Peptides #Biohacking #Longevity #HealthOptimization #NoHype #EvidenceBased #Wellness #Recovery #SleepHacks #FatLoss #GLP1 #BPC157 #TB500 #Semax #Selank #DSIP #MOTSc #ThymosinAlpha1 #GHKCu #SkincareScience #AntiAging #FitnessScience #UltimateBiohacker10X #HumanPerformance #2026#TheHuman5.0Project

    11 min

  7. HACE 4 DÍAS

    Peptides in 2026: 5 Reasons People Use Them + A No-Hype Framework (Fat Loss, Recovery, Sleep, Longevity)

    Peptides Masterclass (2026): The 5 Buckets + How to Run a Clean Experiment Peptides are trending in 2026 for five reasons: fat loss, injury recovery, sleep/brain performance, longevity/inflammation, and skin/hair. In this no-hype masterclass, UltimateBiohacker10X breaks down what each bucket is trying to do, where evidence is stronger vs thinner, and the adult decision framework that keeps you from getting played:   ✅ Foundations first ✅ Goal → baseline → measure → stop rule ✅ One lane at a time (no stacking chaos) ✅ Track outcomes, not vibes   Comment “PEPTIDES2” if you want Part 2: Evidence Ladder + Quality Red Flags.   DOWNLOAD: Peptide Dosing Guide DOWNLOAD: Outline For The Episode/Peptide Masterclass (and how to follow it cohesively)   Open — 5 reasons people search peptides Ground rules + disclaimer Rule #1 — foundations first Bucket 1 — fat loss (context + measurement) Bucket 2 — injury/recovery (reality check + rehab first) Bucket 3 — sleep/brain (hierarchy + tracking) Bucket 4 — longevity/inflammation (scorecard thinking) Bucket 5 — skin/hair (topical reality + SPF) Decision framework (goal → baseline → measure → stop rule) Peptides and when to use them Close 🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.     #Peptides #Biohacking #Longevity #FatLoss #Recovery #SleepOptimization #HRV #BodyComposition #AntiAging #UltimateBiohacker10X #Healthspan #FitnessScience#TheHuman5.0Project

    16 min

  8. HACE 4 DÍAS

    VIP Peptide 2026: What It Really Does for Inflammation, Gut Health & Anti-Aging (No Hype Guide)

    In this 30-minute masterclass, UltimateBiohacker10X breaks down VIP (Vasoactive Intestinal Peptide): endogenous vs. aviptadil, mechanisms (vasodilation, anti-inflammatory), evidence from RCTs (COVID/ARDS trials), benefits (respiratory, neuroprotection, skincare), safety (BP drops, GI effects), and a no-BS decision framework. Plus: quality warnings and better alternatives like sleep/conditioning. No fluff—just signal for biohackers chasing real outcomes.   Open Ground Rules VIP 101 Mechanism VIP vs Aviptadil Plausible Uses Safety Decision Framework Don’t Get Played Alternatives Close Comment: What's your top inflammation hack? #VIPPeptide   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications. #VIPPeptide #Biohacking #AntiInflammatory #GutHealth #AntiAging #Neuroprotection #Peptides #Longevity #InflammationHacks #UltimateBiohacker10X #Health#TheHuman5.0Project

    10 min
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The Human 5.0 Project is the podcast where science meets self-optimization. Hosted by Ultimate Biohacker 10X, this show explores the real research, real data, and real dosing behind today’s most effective biohacking tools — from peptides, longevity molecules, and nootropics to recovery devices, lifestyle strategies, sleep optimization, training principles, and cutting-edge performance tech. Each episode breaks down complex biology into practical, actionable protocols you can use to improve energy, metabolism, cognition, and overall healthspan. No hype. No fluff. Just evidence-based insights for people who want to understand their bodies, upgrade their biology, and unlock their highest potential. If you’re ready to optimize your life one pathway at a time, you’re in the right place.

Información

  • Creador
    Ultimate Biohacker 10x
  • Años de actividad
    2025 - 2026
  • Episodios
    100
  • Clasificación
    Apto
  • Copyright
    © Copyright 2025 All rights reserved.
  • Mostrar sitio web
    The Human 5.0 Project

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