Petri Dish

Petri Dish
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Profane, insane, and 100% primo science, Petri Dish is a no-BS podcast that explores the wildest subjects in modern science with clarity and evil joy. Hosted by Sean Allen, a Nanoparticle/Immunology Researcher, and Nathan Allen, his "screenwriter" brother, Petri Dish fuses hard science with a freewheeling and madcap conversational style. Cannabinoids, Plague, Cats, the dreaded Candiru, and the even more dreaded Covid-19: all these and more are dissected with intellect and irreverence, dropping every week. So reject ignorance. Join the Scientific Revolution. Join Petri Dish.

  1. 21/08/2023

    Ep. 185 How to Make a Drug Pt 2: Libraries and Design

    On this second episode about drug discovery, we discuss small molecule drug libraries and the challenges behind rational design! Don't know what that means? Tune in to find out! References: https://www.frontiersin.org/articles/10.3389/fcell.2019.00107/full https://next.cancer.gov/discoveryresources/resources_ndl.htm https://www.molbiolcell.org/doi/10.1091/mbc.E22-08-0377 https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy https://www.goodrx.com/health-topic/gene-therapy/crispr-therapeutics-vertex-exa-cel https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/crispr-timeline

    59 min

  2. 14/08/2023

    Ep. 184 How to Make a Drug Pt 1: A Target

    Hey everyone! Today's episode is about getting into the nitty gritty of drug discovery. We often benefit from the research and development that goes into the creation of drugs we use to treat illnesses without really understanding what goes into that process. In this first part, we will discuss how you conceptually begin the process. References: https://www.nature.com/articles/nrd2399 https://www.fda.gov/vaccines-blood-biologics/zolgensma https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0806-1 https://www.ncbi.nlm.nih.gov/books/NBK519062/ https://www.sciencedirect.com/science/article/pii/B9780128191828000338 https://www.sciencedirect.com/science/article/pii/0006291X89926788?via%3Dihub https://www.nature.com/articles/362841a0 https://www.sciencedirect.com/science/article/pii/S0305737220300554

    55 min

  3. 07/08/2023

    Ep. 183 Influenza Pt 4: Vaccines and Pandemics

    Sorry for the COVID-related break in episodes everyone! In our return, we complete our series on influenza by discussing past epidemics and pandemics to understand how influenza has repeatedly led to large scale medical events. Then we will finish by discussing the current and future state of influenza vaccines! References: https://www.nejm.org/doi/full/10.1056/nejmp058281 https://www.nature.com/articles/nature08157 https://pubmed.ncbi.nlm.nih.gov/16208372/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578040/ https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-influenza-vaccination https://www.scripps.edu/news-and-events/press-room/2020/20200623-wilson-universalflu.html https://www.cdc.gov/flu/season/faq-flu-season-2022-2023.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159335/ https://www.nature.com/articles/nrmicro.2017.118 https://www.sciencedirect.com/science/article/abs/pii/0042682278901538 https://www.cdc.gov/flu/prevent/flushot.htm https://www.science.org/content/article/innovative-universal-flu-vaccine-shows-promises-it-first-clinical-test https://www.science.org/doi/10.1126/science.aaz5143 https://www.nih.gov/news-events/nih-research-matters/using-mrna-technology-universal-flu-vaccine

    49 min

  4. 29/05/2023

    Ep. 182 Influenza Pt 3: Whaddya Gonna Do About It?

    You've had the flu. You've had a cold. Maybe you've even had allergies! But how can you tell them apart? And if you even figure out that you do have influenza, are there any treatments you can take that can help? References: https://www.health.harvard.edu/staying-healthy/gastroenteritis-in-adults-a-to-z https://academic.oup.com/aje/article/182/4/294/113092 https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12515 https://www.cdc.gov/flu/about/burden/preliminary-in-season-estimates.htm https://newsinhealth.nih.gov/2014/10/cold-flu-or-allergy https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000221 https://www.cdc.gov/mmwr/volumes/71/wr/mm7150a4.htm https://www.mobihealthnews.com/news/lucira-health-files-bankruptcy-it-receives-eua-home-covid-19-flu-test https://www.fda.gov/news-events/press-announcements/fda-authorizes-first-over-counter-home-test-detect-both-influenza-and-covid-19-viruses https://www.nature.com/articles/s41598-019-39683-4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108042/ https://www.cdc.gov/flu/treatment/antiviralresistance.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404498/ https://www.mdpi.com/2076-2607/11/1/183 https://www.jbc.org/article/S0021-9258(21)00260-X/fulltext

    36 min

  5. 22/05/2023

    Ep. 181 Influenza Pt 2: The Piggies

    Last episode we discussed the current H5N1 flu that is hitting birds pretty hard. But is bird flu different from swine flu? Is there just a 'human flu', or do we only catch influenza from other animals? Let's get into the evolutionary history of the flu and primary hosts! References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328453/ https://www.ncbi.nlm.nih.gov/books/NBK8611/ https://journals.asm.org/doi/full/10.1128/JVI.01080-14 https://www.cdc.gov/flu/weekly/index.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268205/ https://www.woah.org/en/disease/avian-influenza/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784916/ https://www.frontiersin.org/articles/10.3389/fevo.2018.00131/full https://www.science.org/doi/10.1126/science.1176225 https://pubmed.ncbi.nlm.nih.gov/32967956/

    44 min

  6. 15/05/2023

    Ep. 180 Influenza Pt 1: Highly Pathogenic Avian Influenza

    Today's episode is the first in a four-part series on influenza! This time we are covering just enough background information to discuss the recent H5N1 pandemic in birds, which was responsible for the egg shortage and has been killing a lot of wild birds. References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074182/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198887/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520700/ https://www.frontiersin.org/articles/10.3389/fmolb.2021.727847/full https://jamanetwork.com/journals/jama/article-abstract/2801499 https://www.who.int/docs/default-source/wpro---documents/emergency/surveillance/avian-influenza/ai_20230331.pdf https://www.cdc.gov/flu/avianflu/reported-human-infections.htmhttps://www.cdc.gov/flu/avianflu/h5n1-animals.htm https://www.aphis.usda.gov/aphis/ourfocus/animalhealth/animal-disease-information/avian/avian-influenza/2022-hpai https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.9.2300134?crawler=true https://journals.asm.org/doi/full/10.1128/spectrum.02867-22 https://www.ecdc.europa.eu/en/news-events/efsa-ecdc-eurl-ongoing-avian-influenza-outbreaks-birds-low-risk-public https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.3.2300001 https://perspectivesinmedicine.cshlp.org/content/11/2/a038679.short https://journals.plos.org/Plospathogens/article?id=10.1371/journal.ppat.1011135

    42 min

  7. 01/05/2023

    Ep. 179 The Silence of the Plants

    Sure, plants can sometimes smell good and they do cool stuff like make carbs for us to eat and oxygen for us to breathe. But they sort of look like they're just passively sitting there, right? Just chilling. If only we could hear just a slightly broader range of frequencies, we would hear a whole new world of plants -- one where they are complaining about being thirsty! Find out about the screaming clicks of dying plants, this week on Petri Dish! References: https://www.nature.com/articles/d41586-023-00890-9 https://www.cell.com/cell/pdf/S0092-8674(23)00262-3.pdf https://agrivita.ub.ac.id/index.php/agrivita/article/view/2613 https://onlinelibrary.wiley.com/doi/full/10.1111/ele.13331 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899487/

    33 min

  8. 24/04/2023

    Ep. 178 A Baby Born of Two Daddies

    Hi everyone! This week's episode is about recent work trying to figure out a way to make a baby mouse that has two genetic dads. We also dive into why mammals don't seem to have virgin births!References: https://www.nature.com/articles/cr201115 https://pubmed.ncbi.nlm.nih.gov/17034046/ https://www.nature.com/articles/nature02402 https://www.nature.com/articles/nature11435 https://www.nature.com/articles/d41586-023-00717-7 https://www.science.org/doi/abs/10.1126/science.abe0237 https://www.nature.com/articles/s41586-020-3027-9

    53 min
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About

Profane, insane, and 100% primo science, Petri Dish is a no-BS podcast that explores the wildest subjects in modern science with clarity and evil joy. Hosted by Sean Allen, a Nanoparticle/Immunology Researcher, and Nathan Allen, his "screenwriter" brother, Petri Dish fuses hard science with a freewheeling and madcap conversational style. Cannabinoids, Plague, Cats, the dreaded Candiru, and the even more dreaded Covid-19: all these and more are dissected with intellect and irreverence, dropping every week. So reject ignorance. Join the Scientific Revolution. Join Petri Dish.

Information

  • Creator
    Petri Dish
  • Years Active
    2019 - 2023
  • Episodes
    197
  • Rating
    Explicit
  • Copyright
    © Petri Dish
  • Show Website
    Petri Dish