RealTalk MS

Jon Strum
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Jon Strum cuts through all the jargon and breaks down the latest multiple sclerosis news. You'll meet the scientists who are creating tomorrow's MS treatments today. You'll hear from the experts discussing how the latest tweaks and changes to our healthcare laws will impact your MS treatment. And we'll be talking to the courageous MS warriors who are out there advocating on behalf of the MS community every day, as well as the men and women who are committed to living their best lives with MS and living their best lives as MS caregivers. If you're dealing with multiple sclerosis in your life -- as a patient, caregiver, family member, or friend -- join us each week for RealTalk MS.

  1. 3 DAYS AGO

    The 2026 ACTRIMS Forum with Dr. Manuel Friese, Dr. Amit Bar-Or, and Dr. Haritha Desu

    Last week, over 1,400 scientists and clinicians gathered in San Diego, California, at the 2026 Americas Committee for Treatment and Research in Multiple Sclerosis annual meeting, better known as the ACTRIMS Forum.  This week, in Part One of our coverage, you'll hear from three of the experts who presented their research at the ACTRIMS Forum.   Dr. Manuel Friese, a clinician-scientist at the Institute of Neuroimmunology and Multiple Sclerosis at the University Medical Center Hamburg-Eppendorf in Hamburg, Germany, where he serves as the Director of the Center for Molecular Neurobiology, and the Director of the Institute of Neuroimmunology and Multiple Sclerosis, is this year's winner of the Barancik Prize for Innovation in Multiple Sclerosis. I had an opportunity to talk with Dr. Friese about some of his truly remarkable research. Dr. Amit Bar-Or, the Director of the Centre for Neuroinflammation and Experimental Therapeutics (CNET) and Chief of the Division of Multiple Sclerosis (MS) and related disorders at the University of Pennsylvania, presented encouraging results from two important clinical trials. Dr. Bar-Or and I discussed what those results might mean for people living with relapsing-remitting and primary progressive MS. Dr. Haritha Desu, a young investigator at the ACTRIMS Forum, presented her cutting-edge research on how immune cells interact with cells already resident in the brain to drive damage or potentially promote repair. I talked with Dr. Desu about how her work could be key to stopping MS progression independent of relapse activity.  We have a lot to talk about! Are you ready for RealTalk MS??! This Week: The 2026 ACTRIMS Forum  :22 Barancik Prize winner Dr. Manuel Friese discusses his pioneering discoveries  1:34 Dr. Amit Bar-Or shares encouraging results from two important clinical trials  16:27 Dr. Haritha Desu discusses her research  25:27 Share this episode  32:23 Next week's episode  32:42 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/441 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Support Jon at WALK MS https://realtalkms.com/walkms Find out about ABLEnow Accounts https://ablenow.com JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 441 Guests: Dr. Manuel Friese, Dr. Amit Bar-Or, and Dr. Haritha Desu Privacy Policy

    33 min
  2. An MS Specialist's Response to the FDA with Dr. William Conte

    2 FEB

    An MS Specialist's Response to the FDA with Dr. William Conte

    This past December, the FDA issued a Complete Response Letter to drug manufacturer Sanofi in response to Sanofi's application seeking approval for Tolebrutinib, the first in a new category of investigational disease-modifying therapies to undergo FDA review.    A Complete Response Letter is an official letter from the FDA to a drug manufacturer stating that the agency can't approve a new medicine in its current form. It's not an outright "no" that kills a project; it's more like a "not yet." However, this Complete Response Letter raised some issues which, at first glance, don't appear to be easily fixable. Sanofi has pointed out that the issues raised in the Complete Response Letter were markedly different from the guidance they received from the FDA over the course of this approval process. Sanofi has also indicated that it would work with the FDA to find a path forward for Tolebrutinib. Dr. William Conte, an MS Specialist and a principal investigator in the Phase 3 clinical trial for Tolebrutinib, has published an article responding to the FDA's Complete Response Letter. This week, Dr. Conte joins me to discuss the FDA's action and his response to that action.  We have a lot to talk about! Are you ready for RealTalk MS??! This Week: We're at the 2026 ACTRIMS Forum  :22 Check out the official ACTRIMS Forum Insider podcast!  :42 The FDA's Complete Response Letter about Tolebrutinib  1:09 Dr. William Conte responds to the FDA's Complete Response Letter  4:09 Share this episode  38:10 Next week's episode  38:30 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/440 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Support Jon at WALK MS https://realtalkms.com/walkms Find out about ABLEnow Accounts https://ablenow.com JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 440 Guests: Dr. William Conte Privacy Policy

    39 min
  3. Preventing MS with Dr. Bruce Bebo

    26 JAN

    Preventing MS with Dr. Bruce Bebo

    The first coordinated global research strategy to prevent MS has been announced. This week, Dr. Bruce Bebo, the National MS Society's Executive Vice President and Chief Research & Medical Affairs Officer, joins me to explain what MS prevention looks like and how experts plan to achieve this remarkable goal. We'll also tell you who won the 2025 Barancik Prize for Innovation in MS Research, and we'll explain how their groundbreaking research impacts MS care. We're sharing the details of a newly announced partnership designed to reduce delays in getting an MS diagnosis and expand access to MS care in Wisconsin. We'll tell you how an international drug discovery network found that a drug already approved for another condition could also protect nerve cells and promote remyelination. And we'll share research that shows that AI can accurately predict whether someone newly diagnosed with MS will experience progression independent of relapse activity (PIRA) in the three years following their diagnosis. We have a lot to talk about! Are you ready for RealTalk MS??! I'm asking for your support:  :22 This Week: Preventing MS  1:47 Dr. Manuel Friese is the winner of the 2025 Barancik Prize for Innovation in MS Research  2:41 National MS Society announces a partnership to improve time to MS diagnosis and access to MS care in Wisconsin  6:26 An international drug discovery network identifies a drug that protects nerve cells and promotes remyelination  8:05 STUDY: AI accurately predicts progression independent of relapse activity in individuals who are newly diagnosed with MS  10:51 Dr. Bruce Bebo explains the strategy behind the global research initiative to prevent MS  14:48 Share this episode  31:31 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/439 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Support Jon at WALK MS https://realtalkms.com/walkms RealTalk MS Episode 424: I'm a Participant in a Clinical Trial for CAR T-Cell Therapy for MS with Jan Janisch-Hanzlik https://realtalkms.com/424 STUDY: In Silico Screening and Preclinical Validation Identify Bavisant as a Therapeutic Candidate for Multiple Sclerosis https://science.org/doi/10.1126/scitranslmed.ads0633 STUDY: Machine Learning Analysis Applied to Prediction of Early Progression Independent of Relapse Activity in Multiple Sclerosis Patients https://onlinelibrary.wiley.com/doi/10.1111/ene.70417 Find out about ABLEnow Accounts https://ablenow.com JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 439 Guests: Dr. Bruce Bebo Privacy Policy

    33 min
  4. The Discovery of 2 MS Subtypes with Dr. Arman Eshaghi

    19 JAN

    The Discovery of 2 MS Subtypes with Dr. Arman Eshaghi

    One of the more confusing aspects of MS is that it can present differently from one person to the next. A research team at University College London may have uncovered a reason for that when they identified two new, and quite different, subtypes of MS.    Joining me to walk us through this discovery and to explain how it may impact MS clinical care is the study's principal investigator, Dr. Arman Eshaghi. We're also sharing study results that may explain how the Epstein-Barr Virus triggers MS in some individuals. We'll tell you about the free online fitness and wellness programs for veterans living with MS offered by the Paralyzed Veterans of America. And we'll explain how the latest entrant in the AI for healthcare revolution can prepare you for your next appointment with your neurologist. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Discovering 2 new subtypes of MS  :22 Study results show how the Epstein-Barr Virus may trigger MS  1:20 The PVA is offering free online fitness and wellness classes for veterans with MS  5:45 Claude for Healthcare joins the AI in healthcare revolution  7:03 Dr. Arman Eshaghi discusses his team's discovery of 2 subtypes of MS  9:59 Share this episode  28:15 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/438 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com EBV Infection and HLA-DR15 Jointly Drive Multiple Sclerosis by Myelin Peptide Presentation https://www.cell.com/cell/fulltext/S0092-8674(25)01495-3 STUDY: Combined Magnetic Resonance Imaging and Serum Analysis Reveals Distinct Multiple Sclerosis Types https://academic.oup.com/brain/article/148/12/4578/8321558 PVA Offers Free Online Fitness & Wellness Classes for Vets with MS https://pva.org/sports-recreation/online-programs Find out about ABLEnow Accounts https://ablenow.com Claude for Healthcare https://claude.com/solutions/healthcare JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 438 Guests: Dr. Arman Eshaghi Privacy Policy

    29 min
  5. Remembering David Mitchell

    12 JAN

    Remembering David Mitchell

    I don't have to remind anyone who listens to this podcast that the cost of MS disease-modifying therapies is obscenely high. And we're not just talking about relatively new medications. Older medications -- some decades old -- continue to increase in price without any rational explanation for why or how.   On January 2nd, we lost a true warrior in the ongoing battle to lower the price of prescription drugs when David Mitchell, the founder of Patients for Affordable Drugs, passed away.   I met David in 2018 at a National MS Society Public Policy Conference, and he was a guest on Episode 31 of RealTalk MS.  This week, I'm re-sharing the conversation we had in 2018. We'll also tell you about an international workshop that represents the initial steps in developing a global research agenda to end MS. We're explaining how AI is about to have a major impact on healthcare. And we'll share the American Medical Association's brief to Congress, making the case for extending access to telehealth. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: We're remembering David Mitchell  :22 The first steps toward a global research agenda to prevent MS were just published  1:02 Doctor AI will see you now  5:45 The American Medical Association asks lawmakers to extend access to telehealth  10:27 David Mitchell in his own words  12:41 Share this episode  27:56 Next week  28:16 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/437 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Patients for Affordable Drugs https://patientsforaffordabledrugs.org PAPER: Toward a Global Research Agenda for Preventing Multiple Sclerosis https://journals.sagepub.com/doi/10.1177/13524585251398381 AMA BRIEF: The Case for Permanent Telehealth Policy and Expanded Access to Virtual Care https://ama-assn.org/system/files/issue-brief-telehealth-policy-expanded-access-to-virtual-care.pdf ChatGPT Health https://openai.com/index/introducing-chatgpt-health JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 437 Guests: David Mitchell Privacy Policy

    29 min
  6. 3 Questions Your Neurologist Should Be Asking Themselves with Dr. Leorah Freeman

    5 JAN

    3 Questions Your Neurologist Should Be Asking Themselves with Dr. Leorah Freeman

    Scientists are expanding our understanding of MS at an unprecedented pace. This week, Dr. Leorah Freeman discusses why, as new discoveries and medications enter clinical practice, neurologists and MS specialists should ask themselves 3 important questions when considering a patient's treatment plan. Dr. Freeman is the Director of the Multiple Sclerosis and Neuroimmunology Center at Dell Medical School at the University of Texas at Austin, where she also leads the MS and Neuroimmunology fellowship program and the MS Imaging and Outcomes Research Laboratory.  We'll also tell you about study results that reveal two distinct biologically-informed MS subtypes. We're explaining some of the confusing background to the FDA's decision not to approve a disease-modifying therapy that achieved positive results in its Phase 3 clinical trial. And did we really need a study to tell us that people living with MS fear experiencing a relapse or disease progression? Well, yes. We'll explain why. We're also reminding you to mail your insurance premium payments and other important documents earlier than you have in the past.  And we're sharing details about the two clinical trials that received $4.1 million in funding as part of the International Progressive MS Alliance Experimental Medicine Trial Awards. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: 3 questions your neurologist should be asking themselves  :22 Public Service Announcement: How the new rule about postmarks could affect your healthcare  1:16 FDA says it's not ready to approve Tolebrutinib  3:16 Study identifies two biologically-informed MS subtypes  6:29 Study results remind us that people with MS fear relapse and progression  10:09 The International Progressive MS Alliance invests $4.1 million in two clinical trials  14:04 Dr. Leorah Freeman discusses why neurologists need to ask themselves 3 important questions when considering a patient's treatment plan  17:18 Share this episode  33:16 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/436 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com The Multiple Sclerosis Insider https://themultiplesclerosisinsider.substack.com STUDY: Combined Magnetic Resonance Imaging and Serum Analysis Reveals Distinct Multiple Sclerosis Types https://academic.oup.com/brain/article/148/12/4578/8321558 STUDY: Fear of Disease Progression and Relapse in Multiple Sclerosis: A Systematic Scoping Review https://frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1680781/full JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 436 Guests: Dr. Leorah Freeman Privacy Policy

    34 min
  7. Revisiting ECTRIMS 2025 with Dr. Bruce Bebo and Kristine Werner Ozug

    29/12/2025

    Revisiting ECTRIMS 2025 with Dr. Bruce Bebo and Kristine Werner Ozug

    We're closing out the year by revisiting the most listened-to episode of RealTalk MS in 2025. And it shouldn't come as a major surprise that this year's most listened-to episode was our review of the largest MS research conference in the world, ECTRIMS.   This episode features the annual conversation that I have with Dr. Bruce Bebo, right outside of the conference center, just minutes after ECTRIMS adjourns. Dr. Bebo is the Executive Vice President of Research at the National MS Society, and each year, he very generously closes out 3 days of nonstop meetings, presentations, and research reviews by sharing his initial thoughts on the announcements and presentations that caught his eye during the conference.   When I produced this episode last September, I also wanted to capture a patient's perspective on what can easily become an overwhelming 3 days of presentations, news, and announcements. Kristine Werner Ozug, a member of the RealTalk MS team who lives with MS, joined me right after the conference to share her perspective on ECTRIMS 2025. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: ECTRIMS 2025   :22 Dr. Bruce Bebo shares his first impressions of the news and research presented at ECTRIMS 2025  1:22 Kristine Werner Ozug weighs in with an MS patient's perspective on the news and research presented at ECTRIMS 2025  10:35 Share this episode  22:45 Next week on RealTalk MS  23:06 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/435 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com RealTalk MS at ECTRIMS 2025 on YouTube https://www.youtube.com/playlist?list=PLATxgj1uHpxNoXakZif9TEkKT6mQSwX_9 Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 435 Guests: Dr. Bruce Bebo and Kristine Werner Ozug Privacy Policy

    24 min
  8. Revisiting Managing Menopause While You're Managing MS with Dr. Riley Bove

    22/12/2025

    Revisiting Managing Menopause While You're Managing MS with Dr. Riley Bove

    The holiday season gives me the opportunity to indulge in what's become a RealTalk MS tradition. I reserve the last two episodes in December to revisit the most popular conversations that I've had over the past year.  Women represent two-thirds of the MS population.  Yet, surprisingly, there isn't nearly enough data related to women's health issues and MS. With an estimated 300,000 women living with MS in the United States who are currently in peri- or post-menopause, researchers have started to focus on how menopause and MS interact, and the best ways to treat symptoms of each.    This brings me to a conversation I had last March about managing menopause while managing MS with Dr. Riley Bove.    Dr. Bove is a neurologist and the founding director of the Sex and Gender-Enriched (SAGE) Neurology Program at the University of California, San Francisco, and she's considered one of the world's foremost experts on women's health issues and MS. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Managing menopause while you're managing MS   :22 Dr. Riley Bove discusses some of the issues facing the estimated 30% of the MS population who are currently in peri- or post-menopause  1:53 Share this episode  20:30 Next week on RealTalk MS  20:51 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/434 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com RealTalk MS at ECTRIMS 2025 on YouTube https://www.youtube.com/playlist?list=PLATxgj1uHpxNoXakZif9TEkKT6mQSwX_9 Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 434 Guests: Dr. Riley Bove Privacy Policy

    22 min
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About

Jon Strum cuts through all the jargon and breaks down the latest multiple sclerosis news. You'll meet the scientists who are creating tomorrow's MS treatments today. You'll hear from the experts discussing how the latest tweaks and changes to our healthcare laws will impact your MS treatment. And we'll be talking to the courageous MS warriors who are out there advocating on behalf of the MS community every day, as well as the men and women who are committed to living their best lives with MS and living their best lives as MS caregivers. If you're dealing with multiple sclerosis in your life -- as a patient, caregiver, family member, or friend -- join us each week for RealTalk MS.

Information

  • Creator
    Jon Strum
  • Years Active
    2017 - 2026
  • Episodes
    495
  • Rating
    Clean
  • Copyright
    © Copyright 2025 All rights reserved.
  • Show Website
    RealTalk MS

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