The Human 5.0 Project

Ultimate Biohacker 10x
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The Human 5.0 Project is the podcast where science meets self-optimization. Hosted by Ultimate Biohacker 10X, this show explores the real research, real data, and real dosing behind today’s most effective biohacking tools — from peptides, longevity molecules, and nootropics to recovery devices, lifestyle strategies, sleep optimization, training principles, and cutting-edge performance tech. Each episode breaks down complex biology into practical, actionable protocols you can use to improve energy, metabolism, cognition, and overall healthspan. No hype. No fluff. Just evidence-based insights for people who want to understand their bodies, upgrade their biology, and unlock their highest potential. If you’re ready to optimize your life one pathway at a time, you’re in the right place.

  1. −9 H

    AOD-9604: The REAL Science on This Fat-Burning Peptide (Trials, GRAS, FDA 2024)

    You wake up at 5:47 a.m., lights on, shirt off… and that lower-belly fat is still mocking you. You’ve optimized sleep, training, macros, GLP-1s, fasted cardio, cold plunges — yet the scale won’t move. Then the peptide groups light up: “AOD-9604. The actual fat-burning fragment of HGH. Melts visceral fat. No IGF-1 spike. No water retention. No b******t.” Is it the real signal… or is the hype hallucinating? In this no-BS breakdown we rip open:   The full 16-amino-acid C-terminal fragment story $50 million pharma R&D, 6 human trials, 925 subjects 2005 Phase 2b result (2.8 kg vs 0.8 kg placebo) and why the larger trial failed Exact mechanism: lipolysis + lipogenesis inhibition 2012 GRAS self-affirmation for oral use December 4, 2024 FDA PCAC meeting — Dr. Edwin Lee’s testimony + unanimous “No” on compounding Research dosing, cycling, and 10X stacking protocols Safety data, sourcing risks, WADA ban   No affiliate links. No bro-science. Just the raw data.   The mirror test (intro) Mandatory disclaimer What AOD-9604 actually is Mechanism – no fluff The human trials – the real story GRAS status – the 2012 twist December 2024 FDA reality check Dosing & cycling – research protocols only 10X stacking strategies Safety – real talk AOD-9604 vs. the competition Final verdict – no cope Your 5-point checklist Outro Strong Disclaimer AOD-9604 is research-grade only. Never FDA-approved for any human use. Sold strictly for laboratory research — “not for human consumption.” Human use is experimental, carries unknown long-term risks, sourcing dangers, and is banned by WADA. This video is for educational and entertainment purposes only. Consult a licensed physician, get bloodwork, and comply with all laws. Citations: • Heffernan et al., Endocrinology 2001 • Wittert et al., Diabetes 2005 • Stier et al., J Endocrinol Metab 2013 • Calzada GRAS announcement, June 2012 • FDA PCAC public minutes, Dec 4 2024 Drop your biggest question about AOD-9604 in the comments — I read every single one.   Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   #AOD9604 #AOD9604Peptide #FatLossPeptide #PeptideTherapy #Biohacking #StubbornFat #VisceralFat #GRAS #FDAUpdate #PeptideStacking #HumanGrowthHormone #WeightLossScience #UltimateBiohacker #Human5.0project #ResearchPeptides

    14 min

  2. −1 D

    HRV Truth Serum: Which Wearables Are Accurate at Night? (Oura vs WHOOP vs Garmin vs Polar)

    Best Wearable for HRV? New Study Validates Oura, WHOOP, Garmin & Polar vs ECG (Sleep Data)   Is your nightly HRV actually real… or just wearable noise?   A new open-access validation study in Physiological Reports (Aug 2025) compared nocturnal resting heart rate (RHR) and heart rate variability (HRV, RMSSD) from five popular consumer wearables against an ECG reference (Polar H10 chest strap) across 536 nights in real-world home sleep conditions (13 healthy adults).   Devices tested:   Oura Ring Gen 3   Oura Ring Gen 4   WHOOP 4.0   Garmin Fenix 6   Polar Grit X Pro   Key takeaways (biohacker translation): RHR was generally solid across devices during sleep (Oura strongest). HRV is where accuracy separates: Oura (Gen 4 & Gen 3) came out closest to ECG, WHOOP was acceptable for trends, while Garmin and Polar showed lower concordance for HRV in this dataset. The real play isn’t obsessing over one night — it’s using trend tracking (7–14 day averages) and making decisions off patterns, not vibes.   Educational only — not medical advice. Wearables aren’t diagnostic tools.   Comment HRV with what device you use and whether your numbers match how you feel.   Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   #Human50Project #HRV #RestingHeartRate #Wearables #Biohacking #Recovery#OuraRing #Whoop #GarminFenix #PolarGritXPro #PolarH10 #SleepTracking#Physiology #SportsScience#Training#HeartRateVariability#SignalVsNoise #UltimateBiohacker10X

    9 min

  3. −1 D

    CGM for Drugs? New Patch Tracks Vancomycin Every 5 Minutes — Could Peptides Be Next?

    What if your skin could show a medication’s concentration curve in real time—updated every 5 minutes?   A pilot clinical trial published in Nature Biotechnology (Feb 2026) tested a wearable microneedle patch that continuously measures vancomycin levels in dermal interstitial fluid using electrochemical aptamer-based sensors. The patch was reported as safe and nearly pain-free, captured high-resolution trends, and revealed pharmacokinetic dynamics that sparse blood draws can miss—though sensor degradation limited the most robust analysis to roughly the first ~12 hours.   In this Human 5.0 Project episode, we break down the tech like grown-ups:   What the patch is and how it works (microneedles + aptamer sensors) Why therapeutic drug monitoring today is still “rear-view mirror medicine” The CGM parallel: why continuous trends beat snapshots The real limitations (small pilot, drift, healthy volunteers) BONUS (Peptide Future Segment): Could this platform ever monitor peptides/bioregulators? We talk what’s plausible, what’s hard, and why “continuous chemistry monitoring” is the next frontier—without overpromising.   Educational only — not medical advice. Do not self-medicate. For meds, hormones, or peptides, consult a qualified clinician.   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.     #Human50Project #Biohacking #PrecisionMedicine #Wearables #Microneedles #Aptamer #TherapeuticDrugMonitoring #Vancomycin #Pharmacokinetics #PrecisionDosing #ContinuousMonitoring #CGM #HealthTech #Peptides #Bioregulators #Longevity #SignalVsNoise #UltimateBiohacker10X

    9 min

  4. −2 D

    The Motherlode: Feeding the Future (The 71% Truth: What’s Really in Your Baby’s Food?)

    Is your baby's food secretly ultra-processed? A brand-new study just dropped a bombshell: 71% of infant and toddler foods on U.S. grocery shelves are ultra-processed. In this episode, we break down exactly what that means for your little one's developing gut, taste buds, and long-term health — and most importantly, what you can actually DO about it.     THE STUDY HIGHLIGHTS:   71% of 651 products analyzed were ultra-processed 105 different additives found across baby foods In 71% of products, the FIRST ingredient was an additive, not fruit or veg Ultra-processed versions had nearly double the sugar Snacks: 94% ultra-processed | Pouches: 73% | Dry cereals: 100%   WHO DID THE RESEARCH:   Researchers from The George Institute (the team behind the FoodSwitch app), published in the journal Nutrients (February 2026).   IN THIS EPISODE, YOU'LL LEARN: The headline stat that changes everything Study breakdown: What they actually found Why additives in baby food matter The science of baby guts and developing taste buds Long-term health risks (without the fear-mongering) Practical takeaways: What you can do TODAY The 5-minute homemade hack New U.S. dietary guidelines for infants Final encouragement: Progress, not perfection   The George Institute (link) Dunford Article(link) People.com(link) Show notes: (link) Baby Food Grocery Cheat Sheet(link)   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.     #BabyFoodStudy #UltraProcessedFoods #InfantNutrition #ParentingAdvice #BabyFoodAdditives #Ultimatebiohacker10x #FeedingBabies #HealthyBabyFood #TheGeorgeInstitute #NutrientsJournal #BabyGutHealth #ToddlerMeals #RealFoodBaby #ParentingScience #TheHuman5.0Project #InfantNutrition #FeedingBabies #TheMotherlode

    9 min

  5. −3 D

    Biohacking Your Diet in 2026: AI + Genomics + Wearables—What Actually Works

    Personalized Nutrition 2026: Biohacking With AI, Wearables & DNA (Signal vs Noise): Unlock the 2026 edge in biohacking and personalized nutrition—without the hype. In this episode, we dive into why one-size-fits-all diets fail, explore metabolic flexibility, gut microbiome, genomics, and brain-body links. Get a no-BS breakdown of tools like CGMs, wearables, AI apps, and peptides, plus controversies around extremes and data overload. End with a free Monday start plan: protocols for stable energy, fat loss, gut health, and more.   Opening: The Edge of Personalized Nutrition Disclaimer & Mission Hook: One-Size-Fits-All is Dead Definitions: Biohacking vs. Personalized Nutrition Science: Why You Respond Differently 2026 Toolkit: Signal vs. Noise Biohacker’s Pantry: Food-First Precision Controversy Corner: Risks & Extremes Monday Start Plan: Minimum Viable System Close: Thesis & CTA   Educational only—not medical advice. Tailored for biohackers in hot spots like Fort Lauderdale? Hydration is key! Subscribe for more signal-over-noise health content. What's your top goal? Comment below!   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   #PersonalizedNutrition #Biohacking #Nutrition #MetabolicHealth #Longevity #Healthspan #AI #Wearables #OuraRing #WHOOP #CGM #Glucose #BloodSugar #ContinuousGlucoseMonitor #Genetics #Nutrigenomics #DNA #Microbiome #GutHealth #Viome #ZOE #Supplements #Peptides #Nootropics #Sleep #HRV #Recovery #Exercise #WholeFoods #HealthPodcast #ScienceBased #EvidenceBased #SignalVsNoise #UltimateBiohacker10X

    16 min

  6. −4 D

    Brewing Up Brain Health-Can Coffee Prevent Alzheimer's?

    Ground Truths: Coffee, Correlation, and the Quest to Prevent Dementia   Dive into the latest JAMA study linking caffeinated coffee and tea to a potential 18% lower dementia risk—but hold the hype! In this 30-minute episode of Ground Truths, we break down the science with a biohacker lens: from the massive 43-year cohort data on over 131,000 people, to the "massive grain of salt" warnings from Dr. Céline Gounder. We explore associations vs. causation, plausible mechanisms like adenosine blocking, and why decaf misses the mark. Plus, actionable takeaways on timing your caffeine, stacking it with proven prevention strategies (exercise, diet, hearing health), and avoiding the sleep paradox. Is your morning brew a brain booster or just a marker of healthy habits? We zoom out to the boring winners that actually move the needle on dementia risk, affecting over 7 million Americans. Open: Permission vs. Prevention The Grain of Salt: Causation Caveats Study Deep Dive: Design & Results Mechanisms & Biohacks Practical Steps & Prevention Stack Outro: Build a Brain-Friendly Life Sources: JAMA (2026 study), CBS News (Dr. Gounder), Alzheimer's Association. Educational content; consult a doctor for personal advice.   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications. #CoffeeAndBrainHealth #DementiaPrevention #CaffeineScience #Biohacking #JAMAStudy #AlzheimersRisk #TeaBenefits #EvidenceBasedHealth #PublicHealth #NoHypeScience#TheHuman5.0Project#Ultimatebiohacker10X

    12 min

  7. −4 D

    Follistatin 344 Explained: Myostatin Inhibitor for Muscle Growth, Gene Therapy Results & Real Risks (2026 Update)

    Myostatin Inhibitor Follistatin-344: Gene Therapy Breakthroughs, Peptide Hype, Side Effects & If It Actually Works   Tired of hitting your genetic muscle ceiling? In this deep dive, we break down Follistatin-344—the "myostatin brake release" everyone's talking about. From animal/primate studies showing massive hypertrophy to human trials in muscular dystrophy, gene therapy (AAV delivery) vs. gray-market peptides, Bryan Johnson/Minicircle experiments, mechanisms (myostatin + activin blockade), realistic gains, side effects (reproductive risks, immune issues, tendon lag), and why most online vials don't match the science. No hype—just signal on whether this unlocks true muscle growth or stays in the lab.     Intro: The Genetic Ceiling & Myostatin Brake Why Myostatin Matters (Belgian Blue Proof) Follistatin Isoforms: FS-344 vs FS-315/288 Mechanism: How It Traps Myostatin & Activins The Three Paths to Hypertrophy Animal & Primate Research: Real Gains & Plateaus Human Trials: Becker MD, sIBM & Safety Signals Gene Therapy vs Peptide Vials: The Brutal Gap Timeline, Stacking & Practical Reality Side Effects, Risks & Unknowns Sourcing Mess & Bigger Picture (Dystrophy > Vanity) Rapid FAQ: Does It Work? Localized? Safe for Women? Final Honest Assessment Link to SLUPP-332 Podcast   If you've experimented with follistatin peptides or gene therapy, drop your experience (gains, sides, source) in the comments—no judgment, just signal.   🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.   #Follistatin344 #MyostatinInhibitor #MuscleGrowth #GeneTherapy #Biohacking #Follistatin #Myostatin #Longevity #BryanJohnson #PEDs #AntiAging #Human5.0Project #PeptideScience #BodybuildingScience #HealthOptimization#Ultimatebiohacker10x

    15 min

  8. −5 D

    Erythritol Exposed: “Zero Sugar” Might Not Be Zero Risk (BBB + Stroke Signal)

    Zero-Sugar, Real Consequences: Erythritol, Clotting, and Brain Vessel Function   You’re in the aisle making the “smart” swap: zero-sugar energy drinks, keto bars, sugar-free gum. Feels like a win… until the science starts whispering a different story. In this episode, UltimateBiohacker10X breaks down why erythritol (a “natural” sugar alcohol used everywhere in keto/low-carb) is getting serious scrutiny—from cardiovascular event associations to a newer lab study showing direct impacts on brain microvascular endothelial cells (the cells that help form the blood–brain barrier). This is educational only — not medical advice. If you have vascular risks, clotting history, diabetes/metabolic disease, migraines with aura, or take meds/supplements that affect clotting or blood pressure, talk to a qualified clinician before changing anything. What we cover Why erythritol got “safe” status + why that doesn’t equal “risk-free” The 2023 signal: higher blood erythritol levels associated with major adverse cardiac events (heart attack, stroke, death) The 2025 lab data: erythritol exposure linked with Oxidative stress up Nitric oxide down (less vasodilation) Endothelin-1 up (more vasoconstriction) t-PA release blunted (reduced fibrinolysis / “clot-busting” capacity) Who may be highest risk (daily high-dose users / “keto stackers”) Practical action steps: label scanning, dose awareness, and smarter swaps “Vascular shields” lifestyle stack (sleep, zone 2, omega-3s, nitrates from greens/beets) Action steps (no panic, just signal) Scan labels: erythritol hides inside “sugar-free,” “keto,” and blends (monk fruit/stevia mixes). Check your dose: occasional gum ≠ daily drinks + bars + candy. Cumulative exposure matters. Consider alternatives: stevia/monk fruit/allulose have different profiles (and still need more data). Train sweetness down: the simplest win is reducing the craving for constant sweetness. 💬 Comment “666FDA” + your topic of concern and I’ll add it to the next breakdown.   Sources to look up (by title) “The artificial sweetener erythritol and cardiovascular event risk” (Nature Medicine, 2023) “The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function…” (Journal of Applied Physiology, 2025) World Health Organization guideline: “Use of non-sugar sweeteners” (May 15, 2023) Cleveland Clinic summary on thrombosis/platelet reactivity (Aug 2024) 🔥 Subscribe for no-BS biohacking & longevity drops Follow on IG @Ultimatebiohacker10X For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies. And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications. #Erythritol #ZeroSugar #Keto#BloodBrainBarrier #StrokeRisk #EndothelialHealth #CardiovascularHealth #SugarAlcohol #ArtificialSweeteners #NutritionScience #MetabolicHealth #Inflammation #OxidativeStress #NitricOxide #Thrombosis #HeartHealth #BrainHealth #Biohacking #Longevity #HumanPerformance #TheHuman50Project #UltimateBiohacker10X

    7 min
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Om

The Human 5.0 Project is the podcast where science meets self-optimization. Hosted by Ultimate Biohacker 10X, this show explores the real research, real data, and real dosing behind today’s most effective biohacking tools — from peptides, longevity molecules, and nootropics to recovery devices, lifestyle strategies, sleep optimization, training principles, and cutting-edge performance tech. Each episode breaks down complex biology into practical, actionable protocols you can use to improve energy, metabolism, cognition, and overall healthspan. No hype. No fluff. Just evidence-based insights for people who want to understand their bodies, upgrade their biology, and unlock their highest potential. If you’re ready to optimize your life one pathway at a time, you’re in the right place.

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  • Skapad av
    Ultimate Biohacker 10x
  • Aktiva år
    2 tn
  • Avsnitt
    106
  • Åldersgräns
    Vuxet innehåll
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    © Copyright 2025 All rights reserved.
  • Programmets webbplats
    The Human 5.0 Project

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