The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)

Sam Charrington
The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)

Machine learning and artificial intelligence are dramatically changing the way businesses operate and people live. The TWIML AI Podcast brings the top minds and ideas from the world of ML and AI to a broad and influential community of ML/AI researchers, data scientists, engineers and tech-savvy business and IT leaders. Hosted by Sam Charrington, a sought after industry analyst, speaker, commentator and thought leader. Technologies covered include machine learning, artificial intelligence, deep learning, natural language processing, neural networks, analytics, computer science, data science and more.

  1. 24 JUNI

    Building the Internet of Agents with Vijoy Pandey

    Today, we're joined by Vijoy Pandey, SVP and general manager at Outshift by Cisco to discuss a foundational challenge for the enterprise: how do we make specialized agents from different vendors collaborate effectively? As companies like Salesforce, Workday, and Microsoft all develop their own agentic systems, integrating them creates a complex, probabilistic, and noisy environment, a stark contrast to the deterministic APIs of the past. Vijoy introduces Cisco's vision for an "Internet of Agents," a platform to manage this new reality, and its open-source implementation, AGNTCY. We explore the four phases of agent collaboration—discovery, composition, deployment, and evaluation—and dive deep into the communication stack, from syntactic protocols like A2A, ACP, and MCP to the deeper semantic challenges of creating a shared understanding between agents. Vijoy also unveils SLIM (Secure Low-Latency Interactive Messaging), a novel transport layer designed to make agent-to-agent communication quantum-safe, real-time, and efficient for multi-modal workloads. The complete show notes for this episode can be found at ⁠https://twimlai.com/go/737.

    56 min

  2. 17 JUNI

    LLMs for Equities Feature Forecasting at Two Sigma with Ben Wellington

    Today, we're joined by Ben Wellington, deputy head of feature forecasting at Two Sigma. We dig into the team’s end-to-end approach to leveraging AI in equities feature forecasting, covering how they identify and create features, collect and quantify historical data, and build predictive models to forecast market behavior and asset prices for trading and investment. We explore the firm's platform-centric approach to managing an extensive portfolio of features and models, the impact of multimodal LLMs on accelerating the process of extracting novel features, the importance of strict data timestamping to prevent temporal leakage, and the way they consider build vs. buy decisions in a rapidly evolving landscape. Lastly, Ben also shares insights on leveraging open-source models and the future of agentic AI in quantitative finance. The complete show notes for this episode can be found at https://twimlai.com/go/736.

    1 tim

  3. 10 JUNI

    Zero-Shot Auto-Labeling: The End of Annotation for Computer Vision with Jason Corso

    Today, we're joined by Jason Corso, co-founder of Voxel51 and professor at the University of Michigan, to explore automated labeling in computer vision. Jason introduces FiftyOne, an open-source platform for visualizing datasets, analyzing models, and improving data quality. We focus on Voxel51’s recent research report, “Zero-shot auto-labeling rivals human performance,” which demonstrates how zero-shot auto-labeling with foundation models can yield to significant cost and time savings compared to traditional human annotation. Jason explains how auto-labels, despite being "noisier" at lower confidence thresholds, can lead to better downstream model performance. We also cover Voxel51's "verified auto-labeling" approach, which utilizes a "stoplight" QA workflow (green, yellow, red light) to minimize human review. Finally, we discuss the challenges of handling decision boundary uncertainty and out-of-domain classes, the differences between synthetic data generation in vision and language domains, and the potential of agentic labeling. The complete show notes for this episode can be found at https://twimlai.com/go/735.

    57 min

  4. 5 JUNI

    Grokking, Generalization Collapse, and the Dynamics of Training Deep Neural Networks with Charles Martin

    Today, we're joined by Charles Martin, founder of Calculation Consulting, to discuss Weight Watcher, an open-source tool for analyzing and improving Deep Neural Networks (DNNs) based on principles from theoretical physics. We explore the foundations of the Heavy-Tailed Self-Regularization (HTSR) theory that underpins it, which combines random matrix theory and renormalization group ideas to uncover deep insights about model training dynamics. Charles walks us through WeightWatcher’s ability to detect three distinct learning phases—underfitting, grokking, and generalization collapse—and how its signature “layer quality” metric reveals whether individual layers are underfit, overfit, or optimally tuned. Additionally, we dig into the complexities involved in fine-tuning models, the surprising correlation between model optimality and hallucination, the often-underestimated challenges of search relevance, and their implications for RAG. Finally, Charles shares his insights into real-world applications of generative AI and his lessons learned from working in the field. The complete show notes for this episode can be found at https://twimlai.com/go/734.

    1 tim 25 min

  5. 28 MAJ

    Google I/O 2025 Special Edition

    Today, I’m excited to share a special crossover edition of the podcast recorded live from Google I/O 2025! In this episode, I join Shawn Wang aka Swyx from the Latent Space Podcast, to interview Logan Kilpatrick and Shrestha Basu Mallick, PMs at Google DeepMind working on AI Studio and the Gemini API, along with Kwindla Kramer, CEO of Daily and creator of the Pipecat open source project. We cover all the highlights from the event, including enhancements to the Gemini models like thinking budgets and thought summaries, native audio output for expressive voice AI, and the new URL Context tool for research agents. The discussion also digs into the Gemini Live API, covering its architecture, the challenges of building real-time voice applications (such as latency and voice activity detection), and new features like proactive audio and asynchronous function calling. Finally, don’t miss our guests’ wish lists for next year’s I/O! The complete show notes for this episode can be found at https://twimlai.com/go/733.

    26 min

  6. 21 MAJ

    RAG Risks: Why Retrieval-Augmented LLMs are Not Safer with Sebastian Gehrmann

    Today, we're joined by Sebastian Gehrmann, head of responsible AI in the Office of the CTO at Bloomberg, to discuss AI safety in retrieval-augmented generation (RAG) systems and generative AI in high-stakes domains like financial services. We explore how RAG, contrary to some expectations, can inadvertently degrade model safety. We cover examples of unsafe outputs that can emerge from these systems, different approaches to evaluating these safety risks, and the potential reasons behind this counterintuitive behavior. Shifting to the application of generative AI in financial services, Sebastian outlines a domain-specific safety taxonomy designed for the industry's unique needs. We also explore the critical role of governance and regulatory frameworks in addressing these concerns, the role of prompt engineering in bolstering safety, Bloomberg’s multi-layered mitigation strategies, and vital areas for further work in improving AI safety within specialized domains. The complete show notes for this episode can be found at https://twimlai.com/go/732.

    57 min

  7. 13 MAJ

    From Prompts to Policies: How RL Builds Better AI Agents with Mahesh Sathiamoorthy

    Today, we're joined by Mahesh Sathiamoorthy, co-founder and CEO of Bespoke Labs, to discuss how reinforcement learning (RL) is reshaping the way we build custom agents on top of foundation models. Mahesh highlights the crucial role of data curation, evaluation, and error analysis in model performance, and explains why RL offers a more robust alternative to prompting, and how it can improve multi-step tool use capabilities. We also explore the limitations of supervised fine-tuning (SFT) for tool-augmented reasoning tasks, the reward-shaping strategies they’ve used, and Bespoke Labs’ open-source libraries like Curator. We also touch on the models MiniCheck for hallucination detection and MiniChart for chart-based QA. The complete show notes for this episode can be found at https://twimlai.com/go/731.

    1 tim 1 min

  8. 6 MAJ

    How OpenAI Builds AI Agents That Think and Act with Josh Tobin

    Today, we're joined by Josh Tobin, member of technical staff at OpenAI, to discuss the company’s approach to building AI agents. We cover OpenAI's three agentic offerings—Deep Research for comprehensive web research, Operator for website navigation, and Codex CLI for local code execution. We explore OpenAI’s shift from simple LLM workflows to reasoning models specifically trained for multi-step tasks through reinforcement learning, and how that enables agents to more easily recover from failures while executing complex processes. Josh shares insights on the practical applications of these agents, including some unexpected use cases. We also discuss the future of human-AI collaboration in software development, such as with "vibe coding," the integration of tools through the Model Control Protocol (MCP), and the significance of context management in AI-enabled IDEs. Additionally, we highlight the challenges of ensuring trust and safety as AI agents become more powerful and autonomous. The complete show notes for this episode can be found at https://twimlai.com/go/730.

    1 tim 7 min
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Machine learning and artificial intelligence are dramatically changing the way businesses operate and people live. The TWIML AI Podcast brings the top minds and ideas from the world of ML and AI to a broad and influential community of ML/AI researchers, data scientists, engineers and tech-savvy business and IT leaders. Hosted by Sam Charrington, a sought after industry analyst, speaker, commentator and thought leader. Technologies covered include machine learning, artificial intelligence, deep learning, natural language processing, neural networks, analytics, computer science, data science and more.

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