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  • All-In with Chamath, Jason, Sacks & Friedberg
    All-In with Chamath, Jason, Sacks & Friedberg

    1

    All-In with Chamath, Jason, Sacks & Friedberg

    All-In Podcast, LLC

  • Acquired
    Acquired

    2

    Acquired

    Ben Gilbert and David Rosenthal

  • Dwarkesh Podcast
    Dwarkesh Podcast

    3

    Dwarkesh Podcast

    Dwarkesh Patel

  • Lex Fridman Podcast
    Lex Fridman Podcast

    4

    Lex Fridman Podcast

    Lex Fridman

  • Hard Fork
    Hard Fork

    5

    Hard Fork

    The New York Times

  • 罗永浩的十字路口
    罗永浩的十字路口

    6

    罗永浩的十字路口

    罗永浩的十字路口

  • 硅谷101
    硅谷101

    7

    硅谷101

    硅谷101

Essentials

  • Hard Fork
    Technology
    Technology

    Every two weeks

  • The Vergecast
    Technology
    Technology

    Updated twice weekly

  • There Are No Girls on the Internet
    Technology
    Technology

    Updated weekly

  • Endless Thread
    Technology
    Technology

    Updated weekly

  • Land of the Giants
    Business
    Business

    Weekly series

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    Business News
    Business News

    Updated weekly

  • Uncanny Valley | WIRED
    Technology
    Technology

    Updated weekly

  • Elon's Anthropic Deal, The Next AI Monopoly?, "FDA for AI" Panic, Trading the AI Boom

    1 DAY AGO

    1

    Elon's Anthropic Deal, The Next AI Monopoly?, "FDA for AI" Panic, Trading the AI Boom

    (0:00) Bestie intros! Thoughts on the LA mayor election (4:38) SpaceX-Anthropic deal, Elon Web Services, SpaceX IPO valuation, Anthropic's insane growth trajectory (26:48) Is Anthropic the next great monopoly? Early signals or major overreaction? (35:21) "FDA for AI" freakout, how the White House thinks about AI safety (52:01) Flipping AI's negative perception: Giving, healthcare and education innovation (1:00:04) Trading the AI market, state of the economy Apply for Summit 2026: https://allin.com/events Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg https://x.com/altcap Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://x.com/WallStreetApes/status/2052413443739951366 https://www.anthropic.com/news/higher-limits-spacex https://x.com/elonmusk/status/2052073463029055926 https://x.com/shaunmmaguire/status/2052075296002625942 https://x.ai/news/anthropic-compute-partnership https://www.realtor.com/news/trends/nvidia-pultegroup-span-date-center-backyard https://www.gradesaver.com/there-will-be-blood/study-guide/a-brief-history-of-standard-oil https://www.nytimes.com/2026/05/04/technology/trump-ai-models.html https://x.com/SusieWiles47/status/2052192419718783246 https://www.nytimes.com/2026/05/05/business/dealbook/trump-ai-regulation.html https://www.whitehouse.gov/wp-content/uploads/2026/03/03.20.26-National-Policy-Framework-for-Artificial-Intelligence-Legislative-Recommendations.pdf https://x.com/ahall_research/status/2052042535661691282 https://x.com/SenSanders/status/2052116733683470556

    1 day ago

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    1hr 22min
  • Can the U.S. Rein in Prediction Markets? + Joanna Stern on Her Year of A.I. Experiments + Our Producer Goes to Attention School

    2 DAYS AGO

    2

    Can the U.S. Rein in Prediction Markets? + Joanna Stern on Her Year of A.I. Experiments + Our Producer Goes to Attention School

    This week we’re taking another look at prediction markets and a new series of scandals. Is Congress finally ready to rein them in? Then, the journalist Joanna Stern returns to the show to discuss her new book “I Am Not A Robot,” all about turning her life over to a chatbot for a year. And finally, Hard Fork’s Rachel Cohn reports back on her month attending classes at the Strother School of Radical Attention, the center of a movement to resist the commodification of attention by technology companies.   Guests:  Joanna Stern, chief everything officer at New Things Rachel Cohn, producer of “Hard Fork”   Additional Reading: Soldier Used Classified Information to Bet on Maduro’s Ouster, U.S. Says Soldier Pleads Not Guilty in $400,000 Betting Case Over Maduro’s Ouster French weather service alerts police to tampering after suspicious Polymarket bets The Multi-Trillion-Dollar Battle for Your Attention Is Built on a Lie   We want to hear from you. Email us at hardfork@nytimes.com. Find “Hard Fork” on YouTube and TikTok. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    2 days ago

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    1hr 12min
  • 蔡康永×罗永浩!在残酷的世界寻找自在与和解、保持慈悲与真实

    29 APR

    3

    蔡康永×罗永浩!在残酷的世界寻找自在与和解、保持慈悲与真实

    《十字路口》播客节目简介本节⽬是⼀档由罗永浩主持的深度播客类节⽬,每集长达三到五个小时。我们与时代浪潮中的⼈物展开对话,聚焦于科技与⼈⽂领域,讲述个体命运故事,探讨时代发展趋势。 本期嘉宾:蔡康永 《罗永浩的十字路口》第二十六期。这次请到的嘉宾,是我的偶像,整个华语主持界公认最会说话的人——蔡康永。蔡康永和小S联合主持的近3000期《康熙来了》,是全球华人娱乐世界的精神避风港,是中文综艺界前无古人后无来者的绝对标杆,也是全球非中文世界人民永远的人生缺憾。在文艺界,大家总讨论什么样的作品能够真正打败时间,但我相信从来没有人想过,一个通常被认为不入流的电视综艺节目,竟然能一口气把上世纪的六零后到新世纪的零零后,五代人全部搞定,而且借助短视频平台,《康熙来了》正在奇迹般地,不可阻挡地,海量转化一零后的年轻观众。蔡康永老师的情商课系列三部曲也是整个中文世界的超级畅销书,我的桌上放的,就是他情商三部曲的最后一本《你愿意,人生就会值得》。很多人误以为他的书是心灵鸡汤,其实这是一个非常大的误解。蔡康永老师的文字跟心灵鸡汤最大的区别是,“它会在承认衰亡和虚无的前提下探讨积极选择,这使得他的作品不是那种麻痹神经的廉价迷幻药,而是现代人在精神荒野中行路时的罗盘。”这次的对谈,我有幸和蔡康永老师聊了足足四个多小时,我们聊到了很多他从未公开触碰过的话题和内容,关于他的创作和生活的近况,关于敏感的心灵如何在时代剧变的背景下自处,关于直面中老年以及死亡的地狱话题,以及我们该如何提前练习跟这个世界优雅地告别等等。虽然谈到了很多全新的话题,但他还是你熟悉的那个独一无二的、艺人外壳、知识分子底色的蔡康永,还是那个在残酷的世界平静地寻找自在与和解、保持慈悲和真实的敏感灵魂。 【你将听到】 00:02:33聊聊近况00:13:11仍在写作00:23:45两老头论片00:33:28回应《康熙》不好看00:46:22烂书推荐语00:53:16绝非心灵鸡汤01:10:42电影票房扑街01:23:42《康熙来了》01:48:43艺术展02:06:05深入讨论AI02:20:12中年心理危机02:41:13遗嘱、死亡和葬礼03:13:07理想的告别03:34:32推荐嘉宾 欢迎关注: 微博 @罗永浩的十字路口 B站 @罗永浩的十字路口 抖音 @罗永浩的十字路口 小红书 @罗永浩的十字路口 商务合作:欢迎发送邮件至 jayci_chen@163.com

    29 Apr

    •
    3h 36m
  • #496 – FFmpeg: The Incredible Technology Behind Video on the Internet

    3 DAYS AGO

    4

    #496 – FFmpeg: The Incredible Technology Behind Video on the Internet

    Jean-Baptiste Kempf is lead developer of VLC and president of VideoLAN. Kieran Kunhya is a longtime FFmpeg contributor, codec engineer, and the person behind the now-infamous FFmpeg account on X. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep496-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/ffmpeg-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions, videos or call-in: https://lexfridman.com/ama Hiring – join our team: https://lexfridman.com/hiring Other – other ways to get in touch: https://lexfridman.com/contact EPISODE LINKS: FFmpeg on X: https://x.com/FFmpeg FFmpeg: https://ffmpeg.org/ VideoLAN (VLC): https://www.videolan.org/ VideoLAN on X: https://x.com/videolan Jean-Baptiste’s Website: https://jbkempf.com/ Jean-Baptiste’s LinkedIn: https://www.linkedin.com/in/jbkempf/ Jean-Baptiste’s GitHub: https://github.com/jbkempf Kieran’s X: https://x.com/kierank_ Kieran’s LinkedIn: https://bit.ly/3OORhmC Kieran’s GitHub: https://github.com/kierank SPONSORS: To support this podcast, check out our sponsors & get discounts: Larridin: Measure AI adoption in your business. Go to https://larridin.com Blitzy: AI agent for large enterprise codebases. Go to https://blitzy.com/lex BetterHelp: Online therapy and counseling. Go to https://betterhelp.com/lex Fin: AI agent for customer service. Go to https://fin.ai/lex LMNT: Zero-sugar electrolyte drink mix. Go to https://drinkLMNT.com/lex Perplexity: AI-powered answer engine. Go to https://perplexity.ai/ OUTLINE: (00:00) – Introduction (03:00) – Sponsors, Comments, and Reflections (10:48) – Weirdest things VLC opens (15:12) – How video playback works (24:33) – Video codecs and containers (35:20) – FFmpeg explained (56:20) – Linus Torvalds (1:00:59) – Turning down millions to keep VLC ad-free (1:15:17) – FFmpeg & Google drama (1:34:31) – FFmpeg developers (1:41:08) – VLC and FFmpeg (1:45:42) – History of FFmpeg (1:48:59) – Reverse engineering codecs (2:02:14) – FFmpeg testing (2:06:21) – Assembly code (handwritten) (2:30:39) – Rust programming language (2:39:55) – FFmpeg and Libav fork (2:48:17) – Open source burnout (2:56:04) – x264 and internet video (3:09:20) – Video compression basics (3:16:17) – CIA and fake VLC (3:26:52) – Ultra low latency streaming (3:44:20) – AV2 codec and video patents (3:54:12) – VLC backdoors (4:04:27) – Video archiving (4:11:04) – Future of FFmpeg and VLC

    3 days ago

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    4h 24m
  • David Reich – Why the Bronze Age was an inflection point in human evolution

    2 DAYS AGO

    5

    David Reich – Why the Bronze Age was an inflection point in human evolution

    David Reich is back. He and collaborator Ali Akbari just published a paper that overturns a long-standing consensus about human evolution — that natural selection has been dormant in our species since the agricultural revolution. By scaling ancient DNA sequencing and developing a new statistical method, they found that selection has actually sped up. Selection went especially bonkers during the Bronze Age (around 3,000 years ago). That’s when gene frequencies for everything from immune function to body fat to intelligence were most in flux. Over the last 10,000 years, selection pushed the genetic predictor of cognitive performance up by roughly a full standard deviation — most of it between 4,000 and 2,000 years ago. After we finished recording, David sketched out on a whiteboard his new heretical model about who the Neanderthals really were. Luckily, I took out my iPhone and managed to record it. He thinks the standard story (that Neanderthals are some separate archaic lineage we interbred with a little) just doesn’t fit the evidence. Instead, he proposes that Neanderthals are essentially genetically-swamped modern humans. A small population somewhere around the Caucasus invented Middle Stone Age technology roughly 300,000 years ago and expanded outward. The ones that moved into Europe interbred with local archaic humans, got genetically swamped, and became Neanderthals. The same expansion went into Africa, met much more diverged archaic Africans, and that mixture became us. This means Neanderthals and modern humans share the same cultural ancestry — the only difference is which archaic humans they mixed with afterward. David is a brilliant and rigorous scholar. It was a real delight to learn from him again. Watch on YouTube; read the transcript. Sponsors * Cursor was super useful as I prepped for this episode. Whenever I had a question, I’d have Cursor kick off a few different models simultaneously and then compare their responses. I found that this led to better results than I could get out of any individual LLM. If you’ve only used Cursor for coding, you should try using it for research. Check it out at cursor.com/dwarkesh * Jane Street uses an internal currency called “hive bucks” to allocate compute through a real-time auction – and anyone can change anyone else’s bids or even kill their jobs! Everyone just trusts each other to act in the firm’s best interest, which is what lets the system work in the first place. If this weird and high-trust culture sounds like your kind of thing, Jane Street’s hiring at janestreet.com/dwarkesh * Crusoe’s ML infra team built fastokens, an open-source tokenizer that delivers a ~9x speedup over Hugging Face and up to 40% faster time-to-first token – on real production workloads! Crusoe achieved these results by parallelizing things and using some clever engineering to handle duplicates without cross-thread coordination. Learn more at crusoe.ai/dwarkesh Timestamps (00:00:00) – Ancient DNA suggests strong selection over last 10,000 years (00:15:45) – Natural selection intensified during the Bronze Age (00:35:02) – Why didn’t evolution max out intelligence? (00:57:21) – Evolution is limited by time, not population size (01:09:02) – Why no farming before the Ice Age? (01:17:13) – The Neanderthal puzzle David can’t stop thinking about (01:54:10) – The methodology behind this breakthrough Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe

    2 days ago

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    2h 13m
  • Ferrari

    13 APR

    6

    Ferrari

    Ferrari is the pinnacle of luxury scarcity — across its entire 79-year history, the company has sold just 330,000 cars at an average price today of $500,000. For context, Hermès sells that many Birkins and Kellys roughly every 2 years, and Rolex moves that many watches every 3 months. And yet this ultimate luxury product also lives under the same roof with a widely beloved professional sports team… one with 400 million rabid fans from all walks of life who live and die by the Scuderia’s performance every F1 race weekend! How is it possible that these two seemingly contradictory customer bases can coexist within the same company? And far from destroying each other’s value, only reinforce it? The answer, it turns out, is a beautiful, bloody, tragic and romantic opera that spans two families and three generations — and just might be one of the best tales we’ve ever told on Acquired. Buckle up for the story of Ferrari. Sponsors: Many thanks to our fantastic Spring '26 Season partners: J.P. Morgan PaymentsVercelServiceNowStatsigLinks: Sign up for email updates, get out takeaways and research photos from each episode, and vote on future topics!Our Ferrari "episode preview" in WSJEnzo Ferrari by Luca Dal MonteSeeing Red on IMDbGo Like Hell by A.J. BaimeStephen Wilmot's great WSJ piece on FerrariFerrari factory tourWorldly Partners' Multi-Decade Ferrari StudyAll episode sourcesCarve Outs: Ford v FerrariMaison Wheat sweatersCraighill scissorsAmazon grocery serviceTravelpro Altitude backpackMore Acquired: Get email updates and vote on future episodes!Join the SlackCheck out the latest swag in the ACQ Merch Store!00:00:00 Start00:01:08 Intro00:06:11 Enzo Ferrari's Early Life & Tragedies (1898-1919)00:12:39 Scuderia Ferrari: Enzo's Racing Dream (1920-1933)00:25:08 The Prancing Horse & Ferrari's Branding00:35:41 First Ferrari Road Cars & Le Mans Victory (1947-1949)00:51:31 F1 & The Tragedies of Enzo's Life (1950s)01:14:03 Ford vs. Ferrari: The Le Mans Rivalry (1963-1966)01:21:24 Enzo Sells 50% to Fiat (1969)01:29:10 Luca di Montezemolo's Return to F1 Glory (1971-1976)01:52:40 Ferrari's "Pepsi Challenge" and how Luca rescued the company (1991)02:27:41 Post-IPO Ferrari: New Models & Growth (2015-Present)02:48:24 The FUV Purosangue & Model Range03:07:16 Ferrari Luce: The EV Future with Jony Ive03:12:37 Ferrari Today by the Numbers03:29:39 Analysis03:50:04 Carve-Outs + Thank Yous ‍Note: Acquired hosts and guests may hold assets discussed in this episode. This podcast is not investment advice, and is intended for informational and entertainment purposes only. You should do your own research and make your own independent decisions when considering any financial transactions.

    13 Apr

    •
    3h 59m
  • E235|20年内CAR-T治愈癌症?与刘诚博士聊聊癌症治疗的底层哲学

    1 DAY AGO

    7

    E235|20年内CAR-T治愈癌症?与刘诚博士聊聊癌症治疗的底层哲学

    近年来,癌症治疗正迎来多个技术平台并行演进、加速迭代的新阶段:从ADC、双特异性抗体、放射性配体疗法,到细胞治疗,整个行业都在经历一轮底层技术工具的升级。其中,CAR-T是最具范式转换意义的一类疗法——它首次在部分血液肿瘤中,把“利用工程化改造的免疫细胞精准清除癌细胞”带入了临床现实。更值得关注的是,2025年以来,跨国药企的押注明显转向体内CAR-T:阿斯利康、艾伯维、百时美施贵宝和礼来等公司,先后收购了仍处于临床前或早期临床阶段的相关企业;其中金额最大的一笔,是礼来于2026年4月20日宣布收购Kelonia,交易总额最高达70亿美元。 为什么大药企会在这个时点密集下注?CAR-T到底是一种什么样的治疗方式?它会成为改写癌症治疗格局的关键武器吗?本期节目,我们有幸邀请到深耕CAR-T与细胞治疗领域二十多年、也是体外CAR-T领域专利布局最丰富的亚裔科学家之一的刘诚博士,和我们一起回顾CAR-T与癌症治疗的发展脉络,拆解这项技术的突破、局限与未来。节目最后,刘诚博士还从更大的视角谈到了癌症本身以及癌症治疗的底层逻辑,或许也会帮助我们重新理解这种疾病。 【主播】 Yushan,硅谷101特约研究员,生物医药行业从业者 泓君,硅谷101创始人,播客主理人 【嘉宾】 刘诚,美国Eureka Therapeutics创始人兼CEO,Estrella Immunopharma(Nasdaq上市公司)创始人兼CEO,JW Therapeutics(药明巨诺,香港上市公司)董事会主席 【你将听到】 02:48 CAR-T(嵌合抗原受体T细胞疗法):用患者自己的免疫细胞治疗自身癌症,这个观念本身就是一场革命 05:56 CAR-T像一艘军舰:嵌合抗原受体像导航系统,用来寻找癌细胞表面的靶点蛋白(抗原) 06:45 体外CAR-T的制作过程高度个性化,因此治疗成本很高 10:38 CAR-T的疗效相比传统癌症疗法强在哪里 13:33 体外自体CAR-T的常规制备接近一个月,快速制备技术FasTCAR可将时间加快一周左右 14:30 异体CAR-T:利用供体免疫细胞缩短治疗时间,但过去几年整体疗效表现有限 17:19 体内CAR-T:仍然利用自体免疫细胞治病,但细胞改造过程在患者体内完成 18:19 体内CAR-T在概念上很理想,但技术实现非常复杂 21:35 CAR-T的现实挑战:目前仍主要对于血液肿瘤有效 22:55 体外CAR-T制备成本约15万美元;体内CAR-T有望将成本降低约10倍;中国制造成本大约是美国的40% 25:48 为什么CAR-T治疗实体瘤更难 30:17 肿瘤微环境和免疫抑制的存在,进一步限制了免疫细胞治疗实体瘤 32:01 诺奖得主Jennifer Doudna参与创立的Azalea:希望通过CRISPR技术提升体内CAR-T的一致性与可靠性 34:07 人体免疫系统为什么会有免疫抑制功能 38:42 CAR-T诞生之初主要用于末线肿瘤;随着疗效逐步验证,开始进入更前线、惠及更多患者 41:26 CAR-T的关键价值在于一部分患者能够获得长期缓解;如何解决其余复发患者的问题,是当前研究重点 43:04 脱靶效应和髓外肿瘤,被认为是CAR-T治疗后复发的可能根源 44:07 细胞因子风暴等不良反应,限制了CAR-T的应用和推广 48:12 为什么中国在CAR-T领域走在全球前列:研发基础、监管环境、患者资源与医疗体系效率 53:29 体内CAR-T更偏工程应用范畴;在这类技术的追赶和产业化上,中国具备明显优势 54:58 CAR-T在国内存在两条监管路径:药品审批和医疗技术管理并存 58:36 如何理解人体细胞之间的分工与协作 59:26 如何理解癌细胞在人体内是一种怎样的存在 1:02:03 癌症治疗的基本思路,是尽可能有效地区分并杀死癌细胞 1:02:24 如何理解癌症的不同疗法与治疗思路 1:04:39 为什么CAR-T可能是治疗癌症最强的武器之一 1:06:07 CAR-T的未来发展方向:从血液瘤扩展到实体瘤 1:06:32 体外CAR-T的优势是可控性和质量;体内CAR-T试图解决的是成本和商业化问题,未来更可能是并存而不是替代 1:07:47 癌症可以被治愈吗?刘诚博士的判断:“最多20年” 1:08:39 如何定义“治愈”:不要死于癌症 【相关名词解释】 T细胞:免疫系统中负责识别并清除异常细胞的一类白细胞 CAR-T:把T细胞工程化改造后,用来更精准识别和杀伤癌细胞的细胞疗法 体外CAR-T:把患者的T细胞取出,在体外完成改造后再回输体内 免疫原性:一种物质引发人体免疫反应的能力 基因编辑:对细胞DNA进行定点修改的技术 抗体:能特异性识别某个目标分子的免疫蛋白 抗原:能被免疫系统识别的分子标记 靶点:药物或免疫细胞作用的具体分子目标 嵌合受体:人工设计的受体,把不同功能模块拼接在一起,用来让细胞识别特定目标 Leukapheresis:通过机器从血液中分离并采集白细胞的过程 CD19:B细胞表面常见的一种蛋白,也是多种CAR-T疗法的重要靶点 ALL:急性淋巴细胞白血病,一类进展较快的血液系统恶性肿瘤 QA/QC:质量保证与质量控制,用来确保产品生产过程和最终质量符合标准 FasTCAR:一种加快CAR-T制备流程的技术平台,目标是缩短生产时间 异体CAR-T(allogeneic CAR-T):使用供体而非患者本人来源的T细胞制备的CAR-T 自体CAR-T(autologous CAR-T):使用患者本人T细胞制备的CAR-T GVHD:移植物抗宿主病,指移植来的免疫细胞反过来攻击患者自身组织 慢病毒:一类常用于基因递送的病毒载体,可把目的基因导入细胞 载体:把基因编辑工具或治疗性基因送入细胞的递送工具 Complete response:完全缓解,指经过治疗后已检测不到明确的肿瘤证据 血液瘤/实体瘤:血液瘤发生在血液、骨髓或淋巴系统;实体瘤是在器官或组织中形成肿块的肿瘤 浸润:肿瘤细胞或免疫细胞进入并扩散到周围组织的过程 肿瘤微环境:肿瘤周围由免疫细胞、血管、基质和信号分子共同构成的局部生态系统 免疫抑制:免疫系统的攻击能力被压低,导致其更难清除癌细胞或病原体 CRISPR:一种可对DNA进行定点剪切和修改的基因编辑工具 去分化:细胞失去原有成熟特征,变得更像早期或更原始状态的过程 Treg:调节性T细胞,主要作用是抑制过强的免疫反应、维持免疫平衡 一线/末线治疗:一线是首选初始治疗;末线是前面多种方案失败后使用的后续治疗 PFS / EFS:PFS是无进展生存期,指疾病未恶化的时间;EFS是无事件生存期,除进展外还会把复发、治疗失败或死亡等算作事件 髓外肿瘤:发生在骨髓外部组织或器官的血液系统肿瘤病灶 CRS:细胞因子释放综合征,是免疫治疗后因炎症因子大量释放引起的全身炎症反应 ICANS:免疫效应细胞相关神经毒性综合征,是CAR-T等治疗后出现的神经系统不良反应 CDE:国家药品监督管理局药品审评中心,负责药品注册申请的技术审评 IIT:研究者发起的临床试验,由医院或研究者主导开展 818号令:中国国务院发布的《生物医学新技术临床研究和临床转化应用管理条例》,自2026年5月1日起施行,是针对细胞治疗、基因编辑等前沿生物医学技术的重要监管规则 Carl June:美国宾夕法尼亚大学的肿瘤学家和科学家,被广泛视为CAR-T疗法的先驱人物之一 小分子:一类分子量较小、通常可进入细胞内部发挥作用的药物 ADC:抗体偶联药物,用抗体把细胞毒药物更精准地送到肿瘤细胞 Toxin:毒素,在ADC等药物中通常指用于杀伤细胞的细胞毒载荷 伽马刀:利用高剂量聚焦射线精准破坏病灶的放射治疗设备,并不是真正的“刀” 【监制】 泓君 【后期】 Amei 【运营】 朱婕 【BGM】 The Vindicator Waltz - FormantX Pulse Runner - Helmut Schenker My Moon and Your Sun - Hampus Naeselius 【在这里找到我们】 公众号:硅谷101 收听渠道:Apple Podcast|Spotify|小宇宙|喜马拉雅|蜻蜓FM|荔枝FM|网易云音乐|QQ音乐 其他平台:YouTube|Bilibili 搜索「硅谷101播客」 联系我们:podcast@sv101.net Special Guest: 刘诚.

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  • Czechia
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  • Montenegro
  • Nederland
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  • Norway
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  • United Kingdom

Latin America and the Caribbean

  • Anguilla
  • Antigua and Barbuda
  • Argentina (Español)
  • Bahamas
  • Barbados
  • Belize
  • Bermuda
  • Bolivia (Español)
  • Brasil
  • Virgin Islands, British
  • Cayman Islands
  • Chile (Español)
  • Colombia (Español)
  • Costa Rica (Español)
  • Dominica
  • República Dominicana
  • Ecuador (Español)
  • El Salvador (Español)
  • Grenada
  • Guatemala (Español)
  • Guyana
  • Honduras (Español)
  • Jamaica
  • México
  • Montserrat
  • Nicaragua (Español)
  • Panamá
  • Paraguay (Español)
  • Perú
  • St. Kitts and Nevis
  • Saint Lucia
  • St. Vincent and The Grenadines
  • Suriname
  • Trinidad and Tobago
  • Turks and Caicos
  • Uruguay (English)
  • Venezuela (Español)

The United States and Canada

  • Canada (English)
  • Canada (Français)
  • United States
  • Estados Unidos (Español México)
  • الولايات المتحدة
  • США
  • 美国 (简体中文)
  • États-Unis (Français France)
  • 미국
  • Estados Unidos (Português Brasil)
  • Hoa Kỳ
  • 美國 (繁體中文台灣)