a16z Podcast

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

  1. America's Autism Crisis and How AI Can Fix Science with NIH Director Jay Bhattacharya

    3 HR AGO

    America's Autism Crisis and How AI Can Fix Science with NIH Director Jay Bhattacharya

    Dr. Jay Bhattacharya is one of the country’s top medical experts and a 24-year professor of medicine at Stanford. After being censored and deplatformed during COVID for his role in opposing harsh lockdowns, he was appointed Director of the National Institutes of Health by President Trump in 2025. a16z General Partners Erik Torenberg, Vineeta Agarwala, and Jorge Conde join Dr. Bhattacharya to discuss the administration’s role in tackling the autism crisis, how to restore public trust in health authorities, how to make the NIH more dynamic and efficient, and how to streamline publishing and restore academic freedom. Timecodes:  0:00 Introduction 1:30 Autism Initiative & New Research 2:45 Drug Discoveries: Leucovorin & Tylenol Caution 4:35 Preterm Birth & Broader Health Initiatives 5:45 The Replication Crisis in Science 8:50 Reforming NIH Funding & Scientific Culture 14:00 Allocation vs. Execution at NIH 17:30 Political & Scientific Decision-Making 22:30 Addressing Life Expectancy & Chronic Disease 27:00 Supporting Early Career Investigators 34:50 Academic Freedom & Open Science 37:30 Rebuilding Public Trust in Public Health 41:00 Communicating Science Amid Uncertainty 47:50 NIH Priorities: Nutrition, Chronic Disease, AI 50:00 The Future of AI in Science & Medicine 53:30 Advice for Rising Scientists 55:00 The Role and Limits of AI in Science   Resources: Find Dr. Bhattacharya on X: https://x.com/DrJBhattacharya and https://x.com/NIHDirector_Jay Find Erik on X: https://x.com/eriktorenberg Find Jorge on X: https://x.com/JorgeCondeBio Find Vineeta on X: https://x.com/vintweeta Learn more about the NIH: https://www.nih.gov/ Stay Updated: Find a16z on X Find a16z on LinkedIn Listen to the a16z Podcast on Spotify Listen to the a16z Podcast on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    58 min
  2. Dylan Patel on the AI Chip Race - NVIDIA, Intel & the US Government vs. China

    1 DAY AGO

    Dylan Patel on the AI Chip Race - NVIDIA, Intel & the US Government vs. China

    Nvidia’s $5 billion investment in Intel is one of the biggest surprises in semiconductors in years. Two longtime rivals are now teaming up, and the ripple effects could reshape AI, cloud, and the global chip race. To make sense of it all, Erik Torenberg is joined by Dylan Patel, chief analyst at SemiAnalysis, joins Sarah Wang, general partner at a16z, and Guido Appenzeller, a16z partner and former CTO of Intel’s Data Center and AI business unit. Together, they dig into what the deal means for Nvidia, Intel, AMD, ARM, and Huawei; the state of US-China tech bans; Nvidia’s moat and Jensen Huang’s leadership; and the future of GPUs, mega data centers, and AI infrastructure.   Resources:  Find Dylan on X: https://x.com/dylan522p Find Sarah on X: https://x.com/sarahdingwang Find Guido on X: https://x.com/appenz Learn more about SemiAnalysis: https://semianalysis.com/dylan-patel/   Stay Updated:  If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on X Find a16z on LinkedIn Listen to the a16z Podcast on Spotify Listen to the a16z Podcast on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    1h 40m
  3. 2 DAYS AGO

    Charlie Kirk and the Rise of Political Violence

    In this episode of Honestly with Bari Weiss, we share a special conversation featuring a16z general partner Katherine Boyle in the wake of Charlie Kirk’s shocking assassination. Katherine reflects on what courage means in a culture where words and debate are increasingly met with violence. Drawing on faith, history, and her own response to recent tragedies, she discusses the idea of martyrdom, not only in its most extreme sense, but also in the small, everyday choices to speak the truth despite risk.   Timecodes:  0:00  Introduction  0:49  Remembering Charlie Kirk 2:46  The Meaning of Martyrdom 4:49  Courage and the Choice We Face 9:16  Returning to Normalcy 10:35  The Age of Extremes 12:15 Words, Violence, and the Next Generation 14:10  Reclaiming the Center 18:18  The Power and Danger of Rhetoric 21:55  The Call to Speak Up   Resources:  Listen to more from Honestly: https://podcasts.apple.com/za/podcast/honestly-with-bari-weiss/id1570872415 Find Bari on X: https://x.com/bariweiss Find Katherine on X: https://x.com/KTmBoyle   Stay Updated:  If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on X Find a16z on LinkedIn Listen to the a16z Podcast on Spotify Listen to the a16z Podcast on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    24 min
  4. The Death of Search: How Shopping Will Work In The Age of AI

    6 DAYS AGO

    The Death of Search: How Shopping Will Work In The Age of AI

    The web is unhealthy, and AI agents are about to rewrite how we shop. In this episode, a16z General Partner Alex Rampell and Partner Justine Moore explore how AI agents will change commerce and the implications for Google’s business model, affiliate marketing, online shopping, and more.   Timecodes:  0:00 Introduction  0:12 The Role of AI Agents in Commerce 1:28 Affiliate Marketing & Impulse Buys 4:02 Observing Consumer Behavior & AI 6:08 Dynamic Pricing & E-commerce Trends 7:20 Online vs. Offline Shopping Behaviors 10:09 The Challenge of Attribution in Commerce 12:19 Aggregators, Brands, and Business Models 15:24 Trend Cycles & Single SKU Retailers 17:49 Google, Search, and the Freemium Model 22:41 The Unhealthy Web & Commercialization 26:04 Video Reviews & Trust in Commerce 29:10 The Costco Model & Consumer Trust 33:15 AI’s Impact on Different Types of Purchases 39:56 The Future: Specialized Shopping Agents 40:16 Opportunities for New Durable Companies 44:18 The Merchant Side: Infrastructure for AI Agents   Resources:  Read the article: http://a16z.com/ai-x-commerce/ Find Alex on X: https://x.com/arampell Find Justine on X: https://x.com/venturetwins   Stay Updated:  If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on X Find a16z on LinkedIn Listen to the a16z Podcast on Spotify Listen to the a16z Podcast on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    45 min
  5. How OpenAI Built Its Coding Agent

    16 SEPT

    How OpenAI Built Its Coding Agent

    OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software? In this episode, General Partner Anjney Midha goes behind the scenes with one of Codex’s product leads- Alexander Embiricos - to unpack its origin story, why its PR success rate is so high, the safety challenges of autonomous agents, and what this all means for developers, students, and the future of coding.   Timecodes: 0:00 Intro: The Vision for AI Agents 1:25 Codex’s Origin and Naming 3:20 Early Prototypes and Agent Form Factors 6:00 Cloud Agents: Safety and Security 9:40 Prompt Injection and Attack Vectors 12:00 PR Merging: Metrics and Transparency 17:00 The Future of Code Review and Automation 20:00 User Adoption: Internal vs. External Surprises 22:00 Multi-Turn Interactions and Product Learnings 29:30 Best-of-N, Slot Machine Analogy, and Creativity 33:00 Human Taste, Iteration, and Collaboration 40:00 AI’s Impact on Software Engineering Careers 45:00 Education, CS Degrees, and AI Integration 49:00 Prototyping, Hackathons, and Speed to Magic 55:00 Legacy Code, Modernization, and Global Adoption 1:00:00 Enterprise, Security, and Air-Gapped Environments 1:05:00 Product Roadmap and Future of Codex 1:10:00 Advice for Founders and Startups 1:15:00 Education Reform and Project-Based Learning 1:20:00 Hiring, Building, and New Grad Advice   Resources:  Find Alex on X: https://x.com/embirico Find Anjney on X: https://twitter.com/AnjneyMidha   Stay Updated:  If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on X Find a16z on LinkedIn Listen to the a16z Podcast on Spotify Listen to the a16z Podcast on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    1h 20m
  6. 12 SEPT

    Ben Horowitz: Why Hesitation is a CEO’s Worst Enemy

    In this conversation from Lenny’s Podcast, Ben Horowitz joins Lenny to discuss the psychological muscle every founder needs, why hesitation can be fatal for CEOs, when it’s time to replace a founder, and how to normalize failure while building confidence. They also explore the Databricks founding story, investing in Adam Neumann after WeWork, whether AI is in a bubble, where the real opportunities lie, and Ben’s work with the Paid in Full Foundation supporting hip-hop pioneers. The result is a candid look at leadership, product management, and what it takes to build enduring companies.   Timecodes:  00:00 Introduction  00:22 The Psychology of Leadership & Decision-Making 02:41 Leadership lessons from Shaka Senghor 07.56 Struggle, Pain, and Growth as a CEO  10:15 Running toward fear and why hesitation kills companies 19:35 Who shouldn’t start a company 22:36 The Databricks story: thinking bigger 24:54 Managerial leverage and CEO psychology 28:06 When founders should be replaced as CEOs 31:20 Normalizing failure for CEOs 37:57 Counterintuitive lessons about building companies 42:31 “Good Product Manager/Bad Product Manager” 48:21 Product managers as leaders 51:16 Why a16z invested in Adam Neumann after WeWork 56:23 Is AI in a bubble? 01:02:43 The biggest opportunities in AI 01:12:51 Why U.S. leadership in AI matters 01:18:53 The Paid in Full Foundation for hip-hop pioneers 01:23:18 Lightning round: book recommendations, products, and life mottos   Resources:  Find Ben on X: https://x.com/bhorowitz Find Ben on LinkedIn: https://www.linkedin.com/in/behorowitz/ Watch more of Lenny’s Podcast: https://www.youtube.com/@LennysPodcast Check out Lenny’s newsletter here: https://www.lennysnewsletter.com   Stay Updated:  Find a16z on X: https://x.com/a16z  Find a16z on LinkedIn: https://www.linkedin.com/company/a16z  Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX?si=3E8B3qT9TyiwAHJ7JnaKbg Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on X Find a16z on LinkedIn Listen to the a16z Podcast on Spotify Listen to the a16z Podcast on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    1h 36m
  7. Inside the $13T Mortgage Machine

    11 SEPT

    Inside the $13T Mortgage Machine

    The $13T U.S. mortgage market serves 50M homeowners but still runs on decades-old software.  In this episode, a16z GP Angela Strange hosts Tim Mayopoulos (ex-CEO of Fannie Mae and ex-president of Blend), Mike Yu (co-founder and CEO of Vesta), and Andrew Wang (co-founder and CEO of Valon) to unpack why standardization and regulation slow change, and how modern loan-origination and servicing platforms, cleaner data, and AI can cut costs, boost transparency, and reduce errors. They also discuss policy levers that could speed innovation and what a true one-tap mortgage could look like.   Timecodes:  00:00 Introduction  00:59 The Scale and Structure of the US Mortgage Market 01:33 Why Mortgage Tech is Slow to Change 02:00 Challenges of Standardization and Regulation 03:41 The Human Side of Home Buying 07:43 Old Software and Its Impact on Homeowners 11:16 Data Transparency and Capital Markets 13:17 Building New Mortgage Infrastructure: LOS and Servicing 16:22 Operational Challenges and Opportunities in Servicing 22:04 Driving Digital Adoption at Fannie Mae 25:15 Modernizing Data and Appraisals 28:27 Core Replacement vs. Wrappers: Tech Strategies 35:29 AI in Mortgage: Today and Tomorrow 40:42 AI, Regulation, and the Future of Compliance 43:54 Advice for Lenders Preparing for an AI Future 47:49 Visions for the Future of Mortgages   Resources:  Find Angela on X: https://x.com/astrange Find Tim on LinkedIn: https://www.linkedin.com/in/timothy-j-mayopoulos-56972a45/ Find Andrew on LinkedIn: https://www.linkedin.com/in/wangandrewd/ Find Mike on LinkedIn: https://www.linkedin.com/in/mikeyu1/   Stay Updated:  Find a16z on X: https://x.com/a16z  Find a16z on LinkedIn: https://www.linkedin.com/company/a16z  Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX?si=3E8B3qT9TyiwAHJ7JnaKbg Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

    55 min

Ratings & Reviews

4.2
out of 5
18 Ratings

About

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

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