Peptides Explained

John Garrett

Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more. Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they're popular, what the research shows, and the real risks and side effects — all in plain language. No bro science. No hype. Just clear, foundational education. For informational purposes only. Not medical advice. For Research Peptides; Offlinepeptides.com/ref/johngarrett/ https://www.skool.com/peptides-explained-15

  1. 1 day ago

    CJC-1295 Deep Dive: What the Human Evidence Actually Shows

    True-Sciences.com Use Code Pep20 for 20% off. A careful look at CJC-1295: the growth-hormone pathway, the distinction between DAC and no-DAC naming, what small human studies measured, the terminated Phase 2 trial, current FDA compounding information, the unproven CJC-1295/ipamorelin combination claims, and WADA's 2026 rules. The evidence supports a hormone effect for the long-acting DAC-modified compound; it does not establish the benefits often marketed for consumer products. Educational content only; not medical advice. Snapshot checked October 19, 2026.

  2. 1 day ago ·  Bonus

    You Might Also Like: The Questlove Show

    Introducing E-40 from The Questlove Show. Follow the show: The Questlove Show A real tycoon is in the building. Questlove sits down with Vallejo’s own E-40, the Yay Area legend who was selling records out of his trunk back when getting a major-label deal felt impossible. He built his own label, financed his projects independently, and gave Hip-Hop an entire dictionary of slang and similes. Now, with Turning My Money Over—a historic 40-song quadruple album—Earl Stevens isn’t slowing down. E-40 talks about growing up on Magazine Street in Vallejo’s Hillside neighborhood, the New York and Bay Area rappers who shaped his voice, and the year at Grambling State that taught him how to make it on his own. He explains how The Click navigated distribution through consignment sheets, mom-and-pop stores, and even rim shops—and how VHS duplication helped change the game for independent artists. 40 Water recalls his dealings with Tupac, advocates for members of the Hieroglyphics crew, and shares how being doubted by a room full of DJs decades ago only pushed him to go harder. See omnystudio.com/listener for privacy information. DISCLAIMER: Please note, this is an independent podcast episode not affiliated with, endorsed by, or produced in conjunction with the host podcast feed or any of its media entities. The views and opinions expressed in this episode are solely those of the creators and guests. For any concerns, please reach out to team@podroll.fm.

    You Might Also Like: The Questlove Show

  3. 6 days ago

    The Silent Killer in Your Kitchen? Seed Oils, Inflammation & What to Cook With Instead with Cherie Calbom

    Seed oils may be hiding in more of your everyday foods than you realize. In this episode of Peptides Explained, host John talks with Cherie Calbom, MS—known as the Juice Lady—about seed oils, cooking fats, inflammation, and how to make more informed choices at the grocery store and when dining out.Cherie discusses how common seed oils are processed, why she recommends checking ingredient labels, and which alternatives she uses, including olive oil, avocado oil, coconut oil, ghee, and beef tallow. They also talk about omega-6 and omega-3 balance, cooking with different fats, and practical ways to make food swaps without giving up flavor.The conversation explores the history of seed oils and changing ideas about dietary fat and cholesterol. Cherie shares tips for spotting oils in packaged foods and describes resources for people who want to learn more, including her book The Truth About Seed Oils. Topics include: seed oils, cooking fats, inflammation, omega-6 and omega-3, food labels, nutrition, and healthy cooking.

  4. 19 Oct

    Retatrutide: Is It Time to Panic? Lilly's Lawsuits, the Science, and What Happens Next

    Eli Lilly is taking legal action against businesses selling products labeled retatrutide. What do the lawsuits actually establish—and what don't they? John Garrett separates pending legal allegations from court findings, reviews the human trial evidence for the investigational triple agonist, and explains why molecular identity, purity, and pharmaceutical equivalence are not interchangeable. We also examine FDA restrictions, consumer safety, and the implications for clinics, vendors, and independent educators. Educational only; not medical or legal advice. Retatrutide is not FDA-approved. Sources: NEJM DOI 10.1056/NEJMoa2301972; FDA unapproved GLP-1 drug concerns; ClinicalTrials.gov NCT05929066 and NCT05882045.

  5. 14 Oct

    Can Peptides Protect the Brain From Vascular Damage?

    Can peptide biology protect the brain from vascular damage? John follows a question that started with Vesugen into the biology of vascular cognitive impairment—endothelial dysfunction, hypoperfusion, blood-brain-barrier injury, mitochondrial stress, inflammation and neuronal damage. The episode maps Cerebrolysin, SS-31/elamipretide, ARA-290/cibinetide, Semax, Vesugen and GLP-1 receptor agonists onto different points in that cascade, then asks the question that matters: what does the human evidence actually support? Cerebrolysin provides the biggest surprise, with randomized vascular-dementia trials—but still low-certainty evidence. Educational only; not medical advice.

  6. 12 Oct

    What the Heck Is Visceral Fat? (And Why People Keep Getting It Wrong)

    Everyone keeps calling belly fat "visceral fat." That is not how anatomy works. In this crossover episode, John breaks down the difference between visceral and subcutaneous fat, why visceral adipose tissue matters metabolically, how it is actually measured, what waist circumference can and cannot tell you, and what the evidence says about GLP-1 therapies and tesamorelin.

  7. 7 Oct

    Vesugen and Vascular Aging: Interesting Biology or Overhyped Claim?

    Vesugen is only three amino acids long: lysine, glutamate, and aspartate — KED. Yet it is promoted as a vascular bioregulator that may support endothelial health and even "rejuvenate" aging blood vessels. In this episode, John Garrett looks at what the endothelial research actually measured, the proposed gene-regulation mechanism, a small human blood-flow report, and the large gap between an interesting cell signal and a proven cardiovascular therapy. No hype. No dismissal. Just the biology, the evidence, and what remains unknown. INSTAGRAM CAPTION Three amino acids. K. E. D. And somehow that became a claim about "rejuvenating" aging blood vessels. Vesugen is one of the more interesting Khavinson bioregulator peptides because there is actual published endothelial-cell research behind the concept. But there is a big difference between: changing a cell marker improving endothelial function and preventing cardiovascular disease. In the new episode of Peptides Explained, I break down the mechanism, the human signal, the evidence gaps, and the question that matters most: Can Vesugen actually make aging blood vessels younger — or is the marketing way ahead of the science? Educational only. Not medical advice. #PeptidesExplained #Vesugen #KEDPeptide #Peptides #Longevity #VascularHealth #EndothelialHealth #CardiovascularHealth #HealthyAging #Biohacking #PeptideScience #MedicalScience

  8. 5 Oct

    FLGR-242 Explained: Smarter Follistatin—or Unproven Hype?

    FLGR-242 is being called a smarter, longer-acting follistatin. John examines the advertised construct, the activin-sparing and 19-day half-life claims, the difference between pathway evidence and product evidence, and why transformation photos cannot establish pharmacology or safety.

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About

Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more. Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they're popular, what the research shows, and the real risks and side effects — all in plain language. No bro science. No hype. Just clear, foundational education. For informational purposes only. Not medical advice. For Research Peptides; Offlinepeptides.com/ref/johngarrett/ https://www.skool.com/peptides-explained-15

Information

  • Creator
    John Garrett
  • Years Active
    2026
  • Episodes
    62
  • Rating
    Explicit
  • Copyright
    © 2026
  • Show Website
    Peptides Explained

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