From First Principles

Krishna Choudhary and Lester Nare
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From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

  1. 4 GÜN ÖNCE

    Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)

    Hosted by Lester Nare and Krishna Choudhary, this episode jumps from plant biochemistry to quantum metrology to cancer evolution. We start with a University of York breakthrough that solves a ~50-year mystery in alkaloid biosynthesis—identifying the “missing” enzyme behind a key asymmetric step plants use to build powerful defensive (and pharmaceutically useful) molecules. Then we go deep on quantum sensing with entangled atomic clouds, showing how correlated measurements can beat the standard quantum limit. Finally, we close with ALFA-K, a new tool that maps local fitness landscapes to predict how aneuploid cancers may evolve under pressure from therapy. Summary Plants making medicines — the “phantom enzyme” in alkaloid biosynthesis and why solving this pathway matters for scalable drug production.Quantum measurements with entangled atom clouds — squeezed/entangled states, noise reduction, and why correlations unlock better sensing.Predicting cancer evolution — ALFA-K and measurable fitness landscapes for aneuploidy-driven trajectories under treatment.Show Notes Story 1 — Plant alkaloid biosynthesis (University of York)Paper — New PhytologistStory 2 — Quantum measurements with entangled atomic clouds (University of Basel)Paper — ScienceStory 3 — Alpha-K (Moffitt Cancer Center)Paper — Nature Communications

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  2. 4 ŞUB

    Artemis II, Apollo, and the Physics of Going Back to the Moon (EP. 24)

    Hosted by Lester Nare and Krishna Choudhary, this episode is a full-spectrum moonshot: why Artemis II matters, how the mission actually works (SLS, Orion, translunar injection, free-return trajectories), and a first-principles teardown of the most common Apollo “hoax” claims—Van Allen belts, waving flags, shadows, and “why aren’t there stars?” We also run a quick Rundown of wild science headlines (ancient cave art, elevation-dependent warming, dogs and vocabulary, and peptide bonds in deep space), before coming back to the core question: what it takes to send humans safely around the Moon—again. Summary Artemis II mission profile — what “free return” means, why TLI timing matters, and what Orion is doing in high Earth orbit before the Moon.SLS vs Saturn V — the engineering and risk trade-offs behind modern human-rated heavy lift.Apollo myths, explained — radiation belts, camera exposure physics, and why the “flag,” “shadows,” and “no stars” arguments don’t survive basic mechanics and optics.Proof Apollo happened — retroreflectors, orbital imagery, and the reality that the world was watching.Show Notes NASA Artemis ProgramNASA Orion SpacecraftNASA Space Launch System (SLS)NASA Apollo 11 Mission Overview

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  3. 27 OCA

    JWST’s “Little Red Dots,” TimeVaults, and the Dawn of Math (EP. 23)

    Hosted by Lester Nare and Krishna Choudhary, this episode runs from JWST’s “Little Red Dots” (and what they imply about early supermassive black holes), to a TimeVault method for recording gene expression over time, to 8,000-year-old Halaf pottery that may encode geometric sequences — plus a quick Cloud9 follow-up on the “starless dark-matter halo” debate. Summary JWST’s Little Red Dots — why these compact red sources don’t behave like normal galaxies or quasars, and how an ionized-gas “cocoon” model could reconcile the data.TimeVaults — a genetically encoded “vault” that protects RNA long enough to capture time-series biology, not just snapshots.Math before numbers — Halafian motifs that appear to follow geometric sequences (4–8–16–32–64) and what that suggests about early cognition.Cloud9 update — what new data would actually settle RELHIC vs. “dark galaxy.” Show Notes JWST “Little Red Dots” (Nature)TimeVaults (Science)Halaf pottery + prehistoric mathematical thinking (Journal of World Prehistory)Cloud9 / RELHIC follow-up (arXiv)

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  4. 20 OCA

    Cloud9 Dark Matter Halo, Jellyfish Sleep, and String Theory Hidden in Nature (EP. 22)

    Hosted by Lester Nare and Krishna Choudhary, this episode runs from the deep math of string theory to the biology of sleep—then out to a starless “ghost cloud” that may be a naked dark-matter halo. We open with a Nature paper showing that physical networks in nature (brains, blood vessels, fungal networks) appear to organize like energy-minimizing surfaces—spitting out the same branching rules you see in soap films and (surprisingly) in the mathematics behind string theory. Then we hit a neuroscience twist: even simple jellyfish need sleep—and the evidence points to sleep as a repair cycle for DNA damage. We close with Cloud9, a newly characterized, starless gas cloud that could be a rare “reionization-limited” RELHIC—potentially exposing a dark matter halo without the glare of stars. Summary String theory… in your body? Why real-world transport networks converge toward minimal-energy geometry—and what that has to do with string-theory math and 120° branching angles. Jellyfish need sleep (and it’s not optional): Evidence that sleep pressure tracks cellular stress and DNA damage repair—even in a brainless animal. Cloud9: A nearby starless cloud that may be a dark matter halo in plain sight—plus what it implies about “missing” galaxies and the post-reionization universe. The Rundown: iron asteroids, artificial metabolism (ReForm), scalable helper T-cells from stem cells, and NASA’s Pandora exoplanet mission. Show Notes Physical networks / string-theory-like math (Nature)Jellyfish sleep & DNA repair (Nature Communications)Cloud9 (Astrophysical Journal Letters)

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  5. 12 OCA

    Roman Concrete, Brain “Cognitive Legos,” DeepSeek, and Econophysics (EP. 21)

    Hosted by Lester Nare and Krishna Choudhary, this episode jumps from ancient engineering to modern AI and markets. We start with the newly uncovered Pompeii worksite that finally shows how Romans mixed their concrete — and why it “self-heals.” Then we pivot into a Princeton neuroscience idea that the brain builds complex thought like LEGO bricks (compositional neural subspaces). From there, we break down DeepSeek’s “manifold-constrained hyperconnections” as a stability mechanism for scaling deep nets. And we close with econophysics: a Physical Review Letters result arguing the square-root law of market impact is strictly universal across stocks and time. Summary Roman concrete’s missing step — Pompeii evidence for “hot mixing,” lime clasts, and why cracks can heal themselves for millennia.Cognitive LEGOs — a compositionality framework where brains reuse shared neural subspaces to assemble new tasks.DeepSeek’s scaling trick — constraining hyperconnections to a stable manifold to avoid vanishing/exploding signals.The universal market law — PRL evidence that price impact follows a square-root rule across stocks, traders, and decades. Show Notes ⁠Roman Concrete (Pompeii worksite) — Nature Communications (2025)⁠⁠Hot Mixing & Lime Clasts — Science Advances (2023)⁠⁠Compositional Neural Subspaces (“Cognitive LEGOs”) — Nature (2025)⁠⁠mHC: Manifold-Constrained Hyper-Connections — arXiv⁠⁠Square-Root Law of Market Impact (Universality) — Physical Review Letters⁠⁠Artemis II Countdown Demonstration Test — NASA

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  6. 23.12.2025

    The Physics Behind Fusion’s Biggest Problem (Season Finale) (EP. 20)

    Hosted by Lester Nare and Krishna Choudhary, this Season Finale closes out Season 1 with a deep dive into the physics behind fusion’s biggest bottleneck: fast magnetic reconnection. We unpack why classic models predicted reconnection should be slow, why nature (and tokamaks) disagree, and how modern “plasmoid” reconnection helps explain solar flares, plasma instabilities, and the real engineering challenges fusion reactors face. Then we run a full Season 1 recap — our favorite episodes, biggest scientific moments, and the corrections and lessons we’re taking into Season 2. Summary Fusion’s biggest problem — magnetic reconnection, why the Sweet–Parker model breaks down at scale, and how plasmoid instability enables fast reconnection.From the Sun to tokamaks — how reconnection drives solar flares, space weather, and plasma confinement limits in fusion devices.Season 1 leaderboard — our top episodes and the breakthroughs that stuck: astronomy, biology, AI, quantum, and the history of science.Corrections + what’s next — what we fixed, what we learned, and how Season 2 evolves the format.

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  7. 04.12.2025

    The Race to the Double Helix — Watson, Crick, Franklin & the Real Story of DNA (EP. 19)

    Hosted by Lester Nare and Krishna Choudhary, this single-story deep dive tells the full story of how humanity uncovered the structure of DNA — and the human tensions that shaped it. From Mendel’s pea-plant mathematics to Rosalind Franklin’s groundbreaking x-ray crystallography, from Cavendish–King’s College rivalries to the famous Photo 51, this episode follows the scientific and ethical arc behind one of the most important discoveries in modern biology. Summary Before DNA — Mendel’s inheritance laws, Miescher’s nuclein, Levene’s early models, and why scientists initially believed proteins carried heredity.The turning point — Griffith’s transformation experiment and the Avery–MacLeod–McCarty proof that DNA is the genetic material.The physics connection — Schrödinger’s What Is Life? and the idea of an “aperiodic crystal” inspiring Watson, Crick, and a generation of physicists to enter biology.Two labs, one race — Cavendish vs. King’s College, Wilkins vs. Franklin, and the clash of personalities, methods, and interpretations.Photo 51 — Franklin and Gosling’s pivotal diffraction image revealing the helical structure of DNA.The model — base pairing, antiparallel strands, and why the double helix immediately explained replication.Recognition & legacy — the 1953 Nature papers, the 1962 Nobel Prize, Franklin’s omission, and Watson’s later controversies reshaping his legacy.Show Notes Mendel (1866) — Pea Plant GeneticsGriffith (1928) — TransformationAvery–MacLeod–McCarty (1944)Schrödinger — What Is Life?Franklin’s Photo 51Watson & Crick (1953)

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  8. 27.11.2025

    3I/ATLAS Explained, Forensic Fingerprints & Alzheimer’s Breakthrough (EP. 18)

    Hosted by Lester Nare and Krishna Choudhary, this episode spans astrophysics, forensic chemistry, and neuroimmunology. We begin with a deep dive into 3I/ATLAS, only the third confirmed interstellar object to ever pass through our solar system — larger and stranger than ‘Oumuamua and Borisov, with new imagery released as NASA reopened operations. Then we break down a true-crime forensic breakthrough from Maynooth University that reveals how to recover fingerprints from fired bullet casings — a technique that could radically accelerate criminal investigations. And we close with a Max Planck Institute discovery identifying a regulatory microglial state in the brain that may finally clarify why Alzheimer’s develops — and how immune dysfunction, not just plaques, drives the disease. Summary The third interstellar visitor — 3I/ATLAS joins ‘Oumuamua and Borisov as only the third object ever observed entering the solar system from interstellar space, with new NASA imagery revealing structure, trajectory, and compositional clues. A forensic chemistry breakthrough — researchers at Maynooth University develop a technique to retrieve latent fingerprints from fired shell casings, combining heat-stable organic residues with spectroscopic imaging. A new model of Alzheimer’s — Max Planck Institute scientists uncover a microglial “regulatory” state (a T-reg–like analogue) activated through CD28-dependent pathways, reshaping how the field thinks about plaques, neuroinflammation, and therapeutic targets. Show Notes 3I/ATLAS — Interstellar Object Updates (NASA / JPL)Forensic Chemistry: Fingerprints on Fired Casings (Maynooth University)Alzheimer’s Microglia Study — Max Planck Institute / Univ. of Cologne

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Hakkında

From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

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  • Yaratıcı
    Krishna Choudhary and Lester Nare
  • Aktif Yıllar
    2025 - 2026
  • Bölümler
    25
  • Sınıflandırma
    Uygunsuz
  • Telif Hakkı
    © Krishna Choudhary and Lester Nare
  • Şovun Web Sitesi
    From First Principles

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