Y Combinator

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4月29日

How to Build the Future: Demis Hassabis

Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads Google DeepMind, pushing toward the same goal he set as a teenager: AGI. On this special live episode of How to Build the Future, he sat down with YC's Garry Tan to talk about what still needs to happen to get us to AGI, his advice for founders on how to stay ahead of the curve and what the next big scientific breakthroughs might be. Chapters:00:00 — Intro00:46 — Demis Hassabis: From Chess Prodigy to DeepMind01:48 — What’s Missing Before We Get To AGI?03:36 — Why Memory Is Still Unsolved06:14 — How AlphaGo Shaped Gemini08:06 — Why Smaller Models Are Getting So Powerful10:46 — The 1000x Engineer12:40 — Continual Learning and the Future of Agents13:32 — Why AI Still Fails at Basic Reasoning15:33 — Are Agents Overhyped or Just Getting Started?18:31 — Can AI Become Truly Creative?20:26 — Open Models, Gemma, and Local AI22:26 — Why Gemini Was Built Multimodal24:08 — What Happens When Inference Gets Cheap?25:24 — From AlphaFold to the Virtual Cells28:24 — AI as the Ultimate Tool for Science30:43 — Advice for Founders33:30 — The AlphaFold Breakthrough Pattern35:20 — Can AI Make Real Scientific Discoveries?37:59 — What to Build Before AGI ArrivesApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs

4月29日

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41 分鐘
6 天前

Beyond Bigger Models: Recursion As The Next Scaling Law In AI

A 7-million parameter model outperforming models a thousand times its size on tasks like ARC Prize. That's what recursive reasoning unlocks.In this episode of Decoded, YC's Ankit Gupta and Francois Chaubard break down two recent papers on recursive AI models, HRMs and TRMs, that are achieving state-of-the-art results with a fraction of the parameters of today's largest models.They explain why standard LLMs hit a fundamental ceiling on certain reasoning tasks, how recursion at inference time gives small models the compute depth to break through it, and what happens when you combine these ideas with the power of large-scale foundation models.

6 天前

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38 分鐘
4月25日

The $9B Startup That Wants to Create a Billion New Developers

Replit is the leading no-code app builder for consumers and enterprise, letting anyone with an idea build real, deployed software using natural language. The company just raised a $400 million Series D at a $9 billion valuation.In this episode of Founder Firesides, co-founder and CEO Amjad Masad sat down with YC's Andrew Miklas to talk about Replit's 10-year journey from browser IDE to vibe coding platform, why the people getting the most value aren't traditional developers but founders and domain experts closest to the problem, and what Agent 4 unlocks with parallel agents, built-in design, and the ability to run your entire company on Replit.

4月25日

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39 分鐘
4月16日

The GPT Moment for Robotics Is Here

Physical Intelligence is building a foundation model that can control any robot to do any task — what the team describes as the GPT-1 moment for robotics. The company's cross-embodiment approach trains across many different robot platforms, and recent results show tasks being performed zero-shot that last year required hundreds of hours of data collection. In this episode of The Lightcone, co-founder Quan Vuong sat down with Garry, Jared, Diana, and Harj to talk about why robotics is finally ready for its scaling moment, how PI runs its models in the cloud rather than on-device, and the playbook for what Quan sees as a Cambrian explosion of vertical robotics companies.

4月16日

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49 分鐘
4月24日

The Playbook For Building An AI Native Company

AI isn't just making teams more productive. It's changing how companies should be built. In this episode of Startup School, YC Partner Diana Hu explains what it means to build an AI-native company, where AI isn't just a tool but the operating system your company runs on. She breaks down how to make your company queryable so agents can improve across every function, why management hierarchies break down when an intelligence layer replaces human middleware, and why early-stage founders have a massive edge in building this way from day one.

4月24日

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10 分鐘
4月22日

Stripe Head of Design Katie Dill Breaks Down Their New Website

Even the most successful websites eventually need a redesign. Take Stripe for example. After six years with the same homepage, they recently unveiled a brand new site that reflects how the fintech giant has evolved over the past few years. So when is the time right for a new landing page? And what should you prioritize in the redesign? In this episode of Design Review YC’s Aaron Epstein sat down Stripe’s Head of Design Katie Dill to pull the curtain back on their high profile redesign and to discuss how their team is evolving in a world dominated by new AI design tools.

4月22日

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44 分鐘
2月21日

The AI Agent Economy Is Here

With the takeoff of OpenClaw and MoltBook, a new agent-driven economy is taking shape. In this episode of the Lightcone, we took a look at the explosive growth of AI dev tools and whether the time has come for builders to make something agents want.

2月21日

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23 分鐘
2月7日

OpenClaw And The Future Of Personal AI Agents

You’ve probably already heard all about OpenClaw (formerly Clawdbot/Moltbot). The viral sensation is an open-source AI assistant that runs on your own device, connects with messaging apps you already use, and goes beyond chat to actually execute tasks like managing your email, calendars, files, workflows, and more. Now meet the man behind it. YC’s Raphael Schaad sat down with Peter Steinberger, the creator of OpenClaw, to discuss the “aha” moment behind the viral personal AI agent, why local-first agents could replace many of today’s apps, and how personal agents will reshape the future of software. Chapters: 00:00 – OpenClaw takes over the internet 00:44 – Life after going viral 01:28 – Why OpenClaw took off, what sets it apart 02:56 – Bots talking to bots (and hiring humans) 04:11 – From “God AI” to swarm intelligence 05:07 – Peter’s original “aha” moment 06:38 – Rebuilding the agent as a conversation 07:38 – The moment it exceeded expectations 10:21 – Are apps going to disappear? 12:31 – Memory, data silos, and ownership 14:39 – The privacy reality of personal agents 15:05 – Letting the bot loose in public Discord 16:55 – Giving an agent a personality 18:19 – Contrarian building philosophy 20:09 – CLIs vs MCPs 21:28 – Building for humans first 21:46 – The road ahead Apply to Y Combinator: https://www.ycombinator.com/apply Work at a startup: https://www.ycombinator.com/jobs

2月7日

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23 分鐘
2月17日

Inside Claude Code With Its Creator Boris Cherny

A very special guest on this episode of the Lightcone! Boris Cherny, the creator of Claude Code, sits down to share the incredible journey of developing one of the most transformative coding tools of the AI era.

2月17日

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50 分鐘
1月14日

How To Get Your First Customers

When you're starting out, it isn’t enough to just build a minimum viable product. You also need a minimum evolvable product - one that can adapt to the needs of those critical early customers. In this episode of Main Function, YC General Partner Ankit Gupta offers an update to the classic MVP playbook. He’ll outline strategies for getting your first customers, the power of adaptability and how feedback from early users will ultimately shape the future of your product and your company. Apply to Y Combinator: https://www.ycombinator.com/apply Work at a startup: https://www.ycombinator.com/jobs Chapters: 00:00 – The Minimum Evolvable Product 00:46 – Finding the First Believers 01:29 – Counterintuitive Rules To Get Early Users 02:10 – Learn Fast, Don’t Fear Churn 02:52 – How Early Users Shape the Market You Enter 04:22 – Tesla Case Study 05:14 – How To Build To Evolve

1月14日

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6 分鐘

Make something people want.