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  • Why Medical AI Needs a Referee | Protege's Engy Ziedan

    24 Aug

    Why Medical AI Needs a Referee | Protege's Engy Ziedan

    Daisy Wolf and Eva Steinman are joined by Engy Ziedan, co-founder and Chief Scientific Officer of Protege, to discuss why medical AI has a measurement problem, and why scoring well on a benchmark doesn't necessarily mean a model is ready for the hospital. Engy explains why healthcare AI needs independent evaluations that go beyond static exams and measure how models actually perform in real-world clinical workflows. They explore the risks of subtle bias and misalignment, why the same model can rank differently depending on how it's prompted or tested, and what happens as AI becomes more personalized and changes faster than traditional healthcare quality systems can keep up. The conversation also gets into Protege's role as an independent evaluator, how contaminated training data can undermine benchmarks, and why the future of medical AI may require continuous monitoring rather than occasional testing.   Resources: Read our insights piece: https://www.a16z.news/p/the-oracle-problem-an-invisible-bottleneck Follow Engy Ziedan on X: https://x.com/engyziedan Follow Daisy Wolf on X: https://x.com/daisydwolf Follow Eva Steinman on X: https://x.com/evajsteinman Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  • Anthropic’s new Fable 5.1, OpenAI Astra Release

    11 hr ago ·  Video

    Anthropic’s new Fable 5.1, OpenAI Astra Release

    In this episode, we explore Anthropic's new release of Fable 5.1 and OpenAI's latest offering, Astra. Discover the features, improvements, and implications of these advancements in AI technology. Show Links Get the top 80+ AI Models for $8.99 at AI Box: ⁠⁠https://aibox.aiHow I Grow and Scale My Business with AI: https://www.skool.com/aihustleGet the AI Chat Daily Newsletter: https://www.aichatdaily.com/newsletter

  • Steve Jobs in 2010, at D8.

    01/06/2010 ·  Video

    Steve Jobs in 2010, at D8.

    Steve Jobs at the D: All Things Digital Conference (Video)

  • #501 – DHH: Future of Programming, AI, Agentic Engineering, Vibe Coding & Linux

    26 Aug

    #501 – DHH: Future of Programming, AI, Agentic Engineering, Vibe Coding & Linux

    DHH is the creator of Ruby on Rails, Omarchy Linux, CTO of 37signals, and a racecar driver. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep501-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/dhh-2-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions, videos or call-in: https://lexfridman.com/ama Hiring – join our team: https://lexfridman.com/hiring Other – other ways to get in touch: https://lexfridman.com/contact EPISODE LINKS: DHH’s X: https://x.com/dhh DHH’s Blog: https://world.hey.com/dhh Omarchy: https://omarchy.org Ruby on Rails: https://rubyonrails.org 37signals: https://37signals.com SPONSORS: To support this podcast, check out our sponsors & get discounts: Wispr Flow: AI-powered voice dictation app. Go to https://wisprflow.ai/lex Blitzy: AI agent for large enterprise codebases. Go to https://blitzy.com/lex NetSuite: Business management software. Go to http://netsuite.ai/lex Shopify: Sell stuff online. Go to https://shopify.com/lex LMNT: Zero-sugar electrolyte drink mix. Go to https://drinkLMNT.com/lex Plaud: AI-powered note-taking devices and software. Go to https://plaud.ai/lex Higgsfield AI: AI-based video generation, filmmaking, and creative studio. Go to https://higgsfield.ai Perplexity: AI-powered answer engine. Go to https://perplexity.ai/ OUTLINE: (00:00) – Introduction (01:14) – Sponsors, Comments, and Reflections (08:56) – Programming with AI agents (24:14) – How software will change (33:30) – AI impact on open source (43:21) – Building Omarchy Linux distro (53:05) – Vibe coding vs agentic engineering (1:06:06) – The end of manual programming (1:16:24) – Advice for programmers (1:28:31) – Surviving Internet Hate (1:37:46) – Programming setup for AI Agents (1:50:11) – Obsessing about speed (2:13:06) – Voice prompting vs typing (2:27:05) – Best AI coding models (2:43:55) – Best AI coding harnesses (2:56:57) – AI video generation and filmmaking (3:16:28) – Fatherhood (3:44:35) – Linux will win the desktop (3:55:51) – PewDiePie (4:05:25) – Future of programming (4:28:18) – Politics and immigration (4:59:55) – Longevity, over-optimization, and fear of death (5:11:38) – Eternal recurrence and future of human civization

  • The Spy

    17/08/2021

    The Spy

    Igor works as a private investigator in NYC. He’s often sitting in cars keeping a distant eye on someone with binoculars. Or following someone through the busy streets of New York. In this episode we hear about a time when Igor was on a case but sensed that something wasn’t right. Sponsors Support for this show comes from Exabeam. Exabeam lets security teams see what traditional tools can’t, with automated threat detection and triage, complete visibility across the entire IT environment and advanced behavioral analytics that distinguishes real threats from perceived ones, so security teams stay ahead and businesses keep moving — without fear of the unknown. When the security odds are stacked against you, outsmart them from the start with Exabeam. Learn more at https://exabeam.com/DD. Support for this show comes from Blinkist. They offer thousands of condensed non-fiction books, so you can get through books in about 15 minutes. Check out Blinkist.com/DARKNET to start your 7 day free trial and get 25% off when you sign up. View all active sponsors. Sources Article: The Case of the Bumbling Spy Podcast: The Catch and Kill Podcast with Ronan Farrow

  • Zero Day Brokers

    03/08/2021

    Zero Day Brokers

    Zero day brokers are people who make or sell malware that’s sold to people who will use that malware to exploit people. It’s a strange and mysterious world that not many people know a lot about. Nicole Perlroth, who is a cybersecurity reporter for the NY Times, dove in head first which resulted in her writing a whole book on it. Affiliate link for book: This is How They Tell Me The World Ends (https://www.amazon.com/gp/product/1635576059/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=1635576059&linkCode=as2&tag=tunn01-20&linkId=0aa8c966d98b49a7927bfc29aac76bbe) Audiobook deal: Try Audible Premium Plus and Get Up to Two Free Audiobooks (https://www.amazon.com/Audible-Free-Trial-Digital-Membership/dp/B00NB86OYE/?ref_=assoc_tag_ph_1485906643682&_encoding=UTF8&camp=1789&creative=9325&linkCode=pf4&tag=tunn01-20&linkId=31042b955d5e6d639488dc084711d033) Sponsors Support for this show comes from IT Pro TV. Get 65 hours of free training by visiting ITPro.tv/darknet. And use promo code DARKNET. Support for this show comes from Privacy.com. Privacy allows you to create anonymous debit cards instantly to use for online shopping. Visit privacy.com/darknet to get a special offer. View all active sponsors. Sources Nicole’s Book: This is How They Tell Me the World Ends https://www.nytimes.com/2013/01/31/technology/chinese-hackers-infiltrate-new-york-times-computers.html

  • What the AI overlords get wrong about being alive

    1 day ago

    What the AI overlords get wrong about being alive

    Elizabeth Lopatto recently wrote about Mark Zuckerberg's 6,500-word AI manifesto in her piece, "Mark Zuckerberg doesn't understand how to live." Today, she joins guest host David Imel and senior wearables reviewer Victoria Song for a freewheeling discussion about what happens when we let AI make decisions for us. Further reading: Mark Zuckerberg doesn't understand how to live Dyson made a camera-equipped toothbrush that flosses for you Markiplier is now GoPro’s biggest shareholder GoPro has been acquired and is getting into ‘defense, government, robotics and aerospace’ John Ternus is now the CEO of Apple Subscribe to The Verge for unlimited access to theverge.com, subscriber-exclusive newsletters, and our ad-free podcast feed. We love hearing from you! Email your questions and thoughts to vergecast@theverge.com or call us at 866-VERGE11. Learn more about your ad choices. Visit podcastchoices.com/adchoices

  • Inside Moderna’s Personalized Cancer Vaccine

    1 day ago

    Inside Moderna’s Personalized Cancer Vaccine

    a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Merck’s individualized treatment for melanoma, after more than a decade of work on personalized cancer vaccines. Stéphane explains how the treatment works by sequencing an individual patient’s tumor and healthy cells, identifying the mutations most relevant to their cancer, and encoding up to 34 of them into an mRNA designed specifically for that patient. Rather than simply unleashing the immune system, the goal is to teach it exactly what to recognize and attack. They also unpack the engineering challenge of manufacturing a different medicine for every patient, how Moderna has brought the process down to roughly 42 days from biopsy to treatment, and what it would take to manufacture personalized medicines at scale. Finally, Stéphane looks beyond melanoma to lung, kidney, bladder, pancreatic, and gastric cancers, as well as Moderna’s longer-term work applying mRNA to rare genetic and autoimmune diseases.   Resources: Follow Stéphane Bancel on LinkedIn: https://www.linkedin.com/in/st%C3%A9phane-bancel-8185251/ Follow Jorge Conde on X: https://x.com/JorgeCondeBio       Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  • Garry Tan on Taste, Agents and Founder Ambition

    12 Aug

    Garry Tan on Taste, Agents and Founder Ambition

    Anish Acharya is joined by Garry Tan, President and CEO of Y Combinator, for a conversation about how AI is rewriting the startup playbook, why founders should be more ambitious than ever, and what two decades of Silicon Valley booms, busts, and missed opportunities have taught Garry about building what's next. Garry reflects on turning down an early opportunity to join Palantir, why chasing what's "hot" is often the wrong strategy, and why the best ideas tend to begin with people pursuing strange, earnest obsessions outside the mainstream. They also explore how AI changes the economics of company building, why traditional SaaS may be losing its advantage, and how tiny teams equipped with hundreds of agents can build businesses at a scale that once required entire organizations. The conversation goes deeper into agentic companies, taste and agency, why "a markdown file is an employee," and how AI could remove layers of bureaucracy that have historically limited organizations. Garry and Anish also discuss the future of consumer AI, the coming "harness wars," why AI adoption may take longer than Silicon Valley expects, and what the next generation of founders can build with intelligence that was unimaginable just a few years ago.   Resources: Follow Garry Tan on X: https://x.com/garrytan Follow Anish Acharya on X: https://x.com/illscience Follow Y Combinator on X: https://x.com/ycombinator Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  • Write better requirements or pay for it later

    5 days ago

    Write better requirements or pay for it later

    Have you ever handed off a feature request with barely any detail and expected the developer to just figure it out? In the latest episode of the No Compromises podcast, we discuss why writing clear requirements is one of the most valuable things a business can do before development starts. We make the case that even imperfect requirements beat none at all because they determine where the discovery happens, closer to the finish line rather than somewhere in the middle of the country. We also cover why letting AI write your requirements for you is a trap, and how AI can help you review and cross-check requirements instead. And why the more detail you put in upfront, the less money you spend on surprises later. (02:53) - Good requirements let you build start to finish (05:10) - Imperfect requirements still beat having none (07:36) - Why AI should not write your requirements (09:09) - Using AI to cross-check requirements instead (10:46) - Silly bit Have a messy real-world project you're working through? Join the No Compromises community and talk it through with other developers.Subscribe to the Mastering Laravel newsletter for practical insights that help you communicate better with your development team.

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