BMJ Podcasts

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22 THG 4

Radiologically isolated syndrome: managing the preclinical phase of MS

What should a neurologist do when a routine MRI for migraine reveals incidental white matter lesions that look remarkably like Multiple Sclerosis (MS), despite the patient having no neurological symptoms? The Editors' Choice paper for the April 2026 issue of Practical Neurology is a practical guide to the clinical diagnosis and management of radiologically isolated syndrome (RIS). Author Dr. Audrey Reynolds¹ joins PN podcast editor Dr. Amy Ross Russell to discuss her work on how updated diagnostic criteria and advanced imaging markers now enable a more proactive, biological approach to the disease. Their discussion highlights the importance of risk stratification - using tools like CSF analysis and spinal imaging - to identify those most likely to benefit from early intervention with disease-modifying therapies. They also examine the delicate balance between preventing future disability and avoiding misdiagnosis in this rapidly evolving area of neurology. Read the paper: Radiologically isolated syndrome: a practical guide. (1) St Vincent’s University Hospital, Dublin; University College Dublin, Ireland Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest episodes. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. This episode was hosted by PN's podcast editor Dr. Amy Ross Russell. Production by Amy Ross Russell and Brian O'Toole. Editing by Brian O'Toole. Thank you for listening.

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31 phút
5 NGÀY TRƯỚC

MS drug controversy, adoption outcomes in Sweden, and the multi-factorial reality of Alzheimer’s

A blockbuster MS drug undergoes FDA re-evaluation. We explore the story of Ocrelizumab, a treatment for primary progressive multiple sclerosis, following a patient petition that highlighted internal disagreements among agency reviewers regarding its efficacy. We look to Sweden, where new research involving sibling pairs separated by adoption investigates how early-life environments shape long-term health and social outcomes. Finally, we revisit the dominant medical narrative on Alzheimer’s disease. Why is it so difficult to move towards comprehensive treatments? Has the focus on amyloid plaques hindered our understanding of other critical factors like vascular health and social inequality? Peter Doshi is a senior editor at The BMJ and an associate professor of pharmaceutical health services research at the University of Maryland. Erik Peterson is an associate professor at the Karolinska Institute in Stockholm, specializing in psychiatric epidemiology and adoption studies. Carol Brayne is a professor emerita of public health medicine at the University of Cambridge and a leading expert in the epidemiology of dementia. Reading List: Multiple sclerosis: Could Roche's bestselling drug Ocrevus be doing more harm than good in women with primary progressive MS? Home environment conditions during childhood and psychosocial outcomes across three generations in Sweden: population based adoption-discordant sibling comparison study

5 ngày trước

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39 phút
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Breathwork in Athletes, friend or foe? Join Professor James Hull and guests for answers. EP#586

Professor James Hull is joined by Dr Eric Harbour and Professor Hege Clemm to discuss the fast growing trend of “breathwork’ in athletes and whether this is a useful novel area of interest or if it is a potentially dangerous fad. Listen in for a lively discussion! Info: Please find relevant references for further information below: Dr Eric Harbour recommends: Breath Tools review: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.813243/full Breath tools website: https://www.breathtools.com/ Lancet review mentioned: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00437-0/fulltext Prof. Hege Clemm recommends: IOC consensus BJSM: https://bjsm.bmj.com/content/bjsports/56/19/1066.full.pdf https://bjsm.bmj.com/content/bjsports/56/19/1089.full.pdf Prof. James Hull has some resources in here: www. breathetowin.co.uk

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It is not all about strength! Rethinking the role of exercise for musculokeletal pain relief with Dr. Jared Powell. EP#585

In this episode, Dr. Jared Powell invites us to reflect on the mechanistic assumptions underlying exercise-based rehabilitation for musculoskeletal pain relief, based on his editorial recently published in BJSM. It’s a great conversation that explores questions such as: Why are these patients getting better? How can we help those who do not respond to exercise? What should be the next steps in research, and what should we be exploring in future clinical trials? Should we offer exercise to all patients with musculoskeletal pain? And how do we explain to patients that recovery may not be all about strength? Press play and enjoy!

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26 phút
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Pulmonary embolism

Pulmonary embolism is common and important. So it is vital that we get the diagnosis and management of this condition right. To find out more about this condition, please do listen to this BMJ Best Practice podcast interview with Scott Woller, Director of the Thrombosis Clinic, Intermountain Medical Center and Professor of Medicine at the University of Utah. For more on pulmonary embolism, visit BMJ Best Practice. Competing interests: SCW declares that he is expecting to receive funding of an investigator initiated grant from Janssen Pharmaceuticals to Intermountain Health - with no direct compensation to himself.

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28 phút
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Simulation training in Cardiology - a missed opportunity?

In this episode of the Heart podcast, Digital Media Editor, Professor James Rudd, is joined by Dr Stephen Hamshere from Bart's Hospital in London, UK. They discuss what simulation training entails, how it can help fill gaps in specialist training and what the future state might look like. If you enjoy the show, please leave us a positive review wherever you get your podcasts. It helps us to reach more people - thanks! Link to published paper: https://heart.bmj.com/content/early/2025/11/19/heartjnl-2025-326598.long

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18 phút
$Bone health in Neurology: managing the fracture risk$

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Bone health in Neurology: managing the fracture risk

In this Practical Neurology bonus international podcast linked to the February issue, host Alasdair Coles (Cambridge, UK) is joined by movement disorder specialist Dr. Ashley Paul (Johns Hopkins, US) and epilepsy expert Dr. Lata Vadlamudi (Brisbane, Australia) to discuss the integration of bone health into neurology clinics. They discuss the identification of osteoporosis in patients on steroids or anti-seizure medications and evaluate the use of FRAX assessment tools for neurological populations. They also address the implementation of screening protocols and checklists to prevent fragility fractures. Read the related paper: Osteoporosis and fracture risk: a practical guide for neurologists Participants: Professor Alasdair Coles is Head of Department for Clinical Neuroscience and also Co-Director of the Cambridge Centre for Myelin Repair, UK. Associate Professor Lata Vadlamudi, Senior Staff Specialist in Neurology at the Royal Brisbane and Women's Hospital, Australia. Dr. Ashley Paul, Assistant Professor of Neurology in the Division of Movement Disorders at Johns Hopkins University, USA. Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Letícia Amorim. Thank you for listening.

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33 phút
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Head knocks in athletes, the clock drawing test, and generic medications - Editors' Highlights April 2026

As with any Darwinian subject, neurology is under constant evolution. This podcast for the April 2026 issue of Practical Neurology has co-editors Phil Smith and Geraint Fuller taking a look at some intriguing specimens from the neurological field. Populating the menagerie for this episode are the "reversed clock phenomenon", a new study on brain problems in retired sportspersons, a practice guide for biosimilar drugs, and a look at GLP-1 drugs. Also found inside are the "nocebo effect", radiologically isolated syndrome for multiple sclerosis identification, and a weighing up of stenting vs shunting. Read the issue: https://pn.bmj.com/content/26/2/103 Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Brian O'Toole. Thank you for listening.

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41 phút
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The Trump administration is an international health emergency

Covid 19 was the last Public Health Emergency of International Concern (PHEIC). Our guests in this podcast think that the Trump Administration should be declared the next one. Joining Kamran Abbasi are, Fatima Hassan, human rights lawyer and Director of the Health Justice Initiative in South Africa, and Matthew Herder, Director of the Health Justice Institute at Dalhousie University in Canada explain why they think that the actions and consequences of the Whitehouse meet the bar for WHO to delcare an emergency We examine the global consequences of recent US policy shifts, including: The withdrawal from the World Health Organization (WHO) and its implications for international health governance. Significant funding cuts to global health programs, including PEPFAR and the CDC, and how these disruptions affect life-saving HIV and TB treatments in the Global South. The rise of "unhinged nationalism" in health policy, from North American measles outbreaks to the extraction of trade concessions in exchange for medical aid. The role of US health leadership in fueling vaccine hesitancy and dismantling scientific research at the NIH. Reading list: Trump and his administration as a public health emergency of international concern Why the expanded global gag rule is a deadly triple tripwire for recipients of US foreign aid The power of the markets: the scandal that keeps on taking

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51 phút
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Recurring migraine, and unintentional weight loss - Case Reports February 2026

What unsuspecting dangers lie within a garden compost bin? The Case Reports team are back to uncover a new pair of neurological mysteries. The first case this episode (1:24) comes from Edinburgh, centred on an 88-yo woman who presents with headache and eye-pain on her right side. She receives an early diagnosis of migraine, but returns a few weeks later with intermittent vomiting and subsequent progressive visual loss. https://pn.bmj.com/content/26/1/83 The second case (19:51) from Wessex features a common presentation of tingling feet, with a 62-yo man who develops gait instability. More curious are a significant drop in his weight, as well as a scaly patch on his chest. https://pn.bmj.com/content/26/1/63 The case reports discussion is hosted by Prof. Martin Turner¹, who is joined by Dr. Ruth Wood² and Dr. Babak Soleimani³ for a group examination of the features of each presentation, followed by a step-by-step walkthrough of how the diagnosis was made. These case reports and many others can be found in the October 2025 issue of the journal. (1) Professor of Clinical Neurology and Neuroscience at the Nuffield Department of Clinical Neurosciences, University of Oxford, and Consultant Neurologist at John Radcliffe Hospital. (2) Clinical Lecturer in Neurology at the Institute of Cognitive Neuroscience, University College London, and an Honorary Neurology SpR at the National Hospital for Neurology and Neurosurgery. (3) Clinical Research Fellow, Oxford Laboratory for Neuroimmunology and Immunopsychiatry, Nuffield Department of Medicine, University of Oxford Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://bit.ly/4aXF46i). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Brian O'Toole. Thank you for listening.

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39 phút

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