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4일 전
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2023. 05. 01.
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2022. 04. 20.

3월 24일

ILD for the rheumatologist: Digging through the past and making sense of the present

In this week's episode we interview Joseph Parambil, MD, staff member in the department of pulmonary, allergy and critical care medicine at Cleveland Clinic, about the current challenges of interstitial lung disease, or ILD. · Intro by Adam J. Brown, MD 0:12 · Welcome back Joseph Parambil, MD 0:32 · But first, some medical history on ILD 1:04 · ILD vs. IPF 2:26 · A quick aside into silicosis and bleomycin 4:27 · Trying to describe pulmonary fibrosis 5:23 · The different types of ILD 9:44 · Finding a slow progression of disease and autoimmune conditions 10:59 · Pulmonary fibrosis diagnoses in 1963 14:41 · The modern era of ILD 16:22 · Nonspecific interstitial pneumonia 20:12 · Handing things over to Dr. Parambil 23:01 · Helping rheumatologists understand ILD/The alphabet soup 24:34 · The shift from biopsies and using immunosuppression 33:07 · Is the workup similar for UIP and NSIP? 35:26 · Is there a standard protocol for workup in terms of serologies? 36:30 · The danger of choosing the wrong treatment 38:43 · Immunosuppression in patients with pulmonary hypertension and ILD 40:52 · UIP and ANCA vasculitis 42:12 · Compared to ten years ago, how are we doing with treatments? 43:10 · Where are we with lung transplants? 50:49 · Looking at hematopoietic stem cell transplants 53:24 · The importance of early diagnosis 54:14 · Antifibrotic medicines 56:15 · Chronic and acute interstitial lung diseases 58:41 · Thank you, Dr. Parambil 1:03:54 · A conclusion from Dr. Brown 1:04:20 · Thank you for listening 1:04:55 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Joseph Parambil, MD, is a staff member in the Respiratory Institute and the director of the HHT Center of Excellence and the Vascular Anomalies Center at the Cleveland Clinic. He is associate professor of medicine at Cleveland Clinic's Lerner College of Medicine. He is certified by the American Board of Internal Medicine with additional specialty certification in pulmonary medicine and critical care medicine. References: Homolka J. CMAJ. 1987;PMID:3315158 Liebow A, et al. : "Frontiers of Pulmonary Radiology." The interstitial pneumonias, pp. 102-141. 1969. Grune & Stratton. Liebow A, et al. Calif Med. 1969;PMID:PMC1501512 Noble PW, et al. Am J Respir Cell Mol Biol. 2005;doi:10.1165/rcmb.F301 Scadding JG, et al. Thorax. 1967;doi:10.1136/thx.22.4.291 Disclosures: Brown and Parambil report no relevant financial disclosures.

3월 24일

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1시간 5분
4일 전

The politics and future of telehealth with Kyle Zebley

In this episode, Kyle Zebley, CEO of the American Telemedicine Association, or ATA, discusses telemedicine's role in current health policy, innovation in virtual care and more. · Intro 0:56 · Kyle Zebley 1:03 · What is the distinction between telehealth and telemedicine? 1:37 · Tell us about where you grew up and your upbringing. 2:36 · How did your interest in telehealth and virtual care develop? 7:18 · Was joining the ATA your first shift from working for the government to going into the private sector/a nongovernment role? 11:37 · Is telehealth now evenly distributed throughout the U.S., or are there still areas where it is not being utilized? 16:23 · Discussion on health care worker shortages and issues with distribution, and whether telehealth is part of the solution. 19:10 · Who is pushing back against telehealth? 21:01 · Why can't we get a long-term solution to these issues? 26:11 · Can you share your perspective on the October 2025 government shutdown, and why telehealth flexibility was involved? 30:10 · What are the telehealth innovations that you are most excited about? 35:53 · Is AI-driven technology something the ATA is thinking about and navigating? 41:09 · Thanks for listening 47:28 Kyle Zebley is CEO of the American Telemedicine Association (ATA), leading efforts to advance health care innovation and the transformation of health care through virtual care, digital health and AI-driven models. We'd love to hear from you! Send your comments/questions to guttalkpodcast@healio.com. Follow us on X @HealioGastro @sameerkberry @umfoodoc. Disclosures: Berry, Chey and Zebley report no financial disclosures.

4일 전

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48분
2월 24일

Healio Community Book Club: A conversation between Leonard Calabrese, DO and Kevin Tracey, MD, author of The Great Nerve

This special edition episode features the latest installment of Healio Community's book club. Physician author Kevin J. Tracey, MD, discussed his book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes in which he explores the potential of stimulating the vagus nerve to treat rheumatoid arthritis and other diseases. · Intro by Adam J. Brown, MD 0:14 · A warm welcome from Leonard H. Calabrese, DO 0:25 · Introducing Kevin J. Tracey, MD 0:58 · The connection between the brain and the immune system 3:25 · Where was the switch that combined neural networks and immune response? 5:55 · A brief summary of the main parts of The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes 9:18 · The science of vagal nerve stimulation 11:03 · What are the pros and cons of different strategies of stimulating the vagus nerve? 16:28 · Different inflammatory responses to implant devices 17:35 · Data on vagus nerve stimulation 21:38 · Adopting new technology 25:40 · Enhancing immune health through brain health 28:35 · Wellness behaviors 32:55 · A motivated patient 36:16 · Thank you, Dr. Tracey 38:03 · Thanks for listening 39:26 Don't miss out! To engage in future conversations like this with physician authors on Healio Community, register here. We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

2월 24일

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40분
2025. 11. 25.

The history of giant cell arteritis: Infections, injections and the man who couldn't wear a hat

What does a goiter and syphilis have in common with the first descriptions of giant cell arteritis? Join us as we dive into the history of the most common type of vasculitis! Intro 0:13 GCA at ACR 2025 00:30 How Brown has approached framing this episode 1:01 A primer leading us to GCA 3:15 Let's get to the story 4:02 The man who couldn't wear a hat 4:57 Dr. Bayard Horton's 7:40 A tangent on cluster headaches 8:27 Let's get back to GCA 13:16 The first temporal artery biopsy 14:28 Vision loss and other puzzle pieces of GCA 16:27 What about jaw claudication? 21:15 Could GCA be transmissible? Injecting ground temporal arteries into healthy volunteers 24:13 Oxygen? Histamines? Adrenal cortical extract? Looking for GCA treatments 26:55 Steroids and GCA 28:40 A quote from the 1959 Mayo Clinic Board of Governors 32:24 Extracranial involvement in GCA 33:24 When did we recognize aorta involvement? Syphilis enters the picture 35:08 A recap of the history of GCA 41:25 Thanks for listening 42:19 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Boes CJ, Cephalalgia. 2007;doi:10.1111/j.1468-2982.2007.01238.x Cummer CL, et al. JAMA. 1912;doi:10.1001/jama.1912.04270080101004 Horton BT, Proc Cent SOC Clin Res. 1946 Sproul EE, et al. Am J Pathol. 1937;PMID: 19970328 Disclosures: Brown reports no relevant financial disclosures.

2025. 11. 25.

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43분
1월 29일

Celebrating 101 episodes of Healio Rheuminations with Dr. Leonard Calabrese

To celebrate 101 episodes, I sit with Leonard H. Calabrese, DO, to discuss his unique career in Rheumatology, spanning immunology, HIV, MECFS, IRES, CNS vasculitis and more. We also discuss how medical history shaped our careers. · Intro 0:12 · Welcome Leonard H. Calabrese, DO 3:11 · A quick friendship begins over medical history 4:14 · How Healio Rheuminations began and where the show is now 5:38 · How Dr. Calabrese got interested in medical history 7:11 · Serotherapy 10:52 · Why patients get certain diseases 12:33 · Dr. Calabrese's career trajectory 14:43 · One day in 1981… 17:52 · A few things happened in the 90's 20:20 · Tell us about CNS vasculitis 21:53 · Don't be afraid to reinvent yourself 24:30 · Checkpoint inhibitors 25:09 · How do you keep up? 26:43 · Placebo science 28:25 · Do you think we'll ever be able to answer where diseases come from? 29:33 · Thank you, Dr. Calabrese 31:01 · Thanks for listening 31:26 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

1월 29일

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32분
4월 6일

Live from Hawaiian Eye 2026 with Baruch D. Kupperman, MD, PhD, and L. Jay Katz, MD

In this episode of Eyeluminaries, John A. Hovanesian, MD, FACS, and Jim Mazzo are live from Hawaiian Eye 2026, with guests Baruch D. Kuppermann, MD, PhD and L. Jay Katz, MD. They discuss everything from their unique career journeys to the current treatments and procedures in eye care. Welcome to Eyeluminaries 00:10 Recap of AAO episode 00:34 Intro of Baruch D. Kuppermann, MD, PhD 01:28 What made you enter retina and how has your career evolved? 03:02 The Gavin Herbert Eye Institute 06:02 What are your other interests? 12:09 Nonprofit work and the Armenian EyeCare Project 13:07 Intro of L. Jay Katz, MD 17:14 How did you get into glaucoma? 18:03 How are things going to evolve in treatment and procedures? 20:28 What was the driving force behind leaving academia and working with Glaukos? 25:01 Tell us a favorite Tom Burns story! 26:44 Thank you! 29:50 Baruch D. Kuppermann, MD, PhD, is the Roger F. Steinert Professor, Chair of the Department of Ophthalmology, and Director of the Gavin Herbert Eye Institute at the University of California, Irvine. L. Jay Katz, MD, is the chief medical officer at Glaukos. We'd love to hear from you! Send your comments/questions to eyeluminaries@healio.com. Follow John Hovanesian on X @DrHovanesian.

4월 6일

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30분
2025. 09. 29.

Don't forget the toes: Managing patients with ANCA vasculitis

Active or not active, that is the question. In this week's episode we interview Alexandra Villa-Forte, MD, MPH, a staff physician in the Center for Vasculitis Care and Research at Cleveland Clinic and a leading vasculitis expert, on a pragmatic approach to recognizing disease activity in patients with ANCA vasculitis. · Intro 0:01 · Welcome Alexandra Villa-Forte, MD, MPH 0:10 · Dr. Brown sketches a potential patient that may be seen in practice 0:40 · How are you monitoring patients' kidneys? 1:28 · How reliable are 'no casts' results in urinalysis tests? 4:15 · What is happening in the glomeruli? 5:23 · The importance of monitoring the urinalysis of patients with ANCA vasculitis 7:06 · Symptoms to watch for when tapering off medications 7:43 · Different scenarios with lung symptoms 9:35 · Evaluating patients with GPA; looking at the nose, ear and sinuses 12:20 · Neurologic symptoms in ANCA vasculitis 14:24 · Laboratory monitoring 15:52 · Should ANCA titers be a part of routine vasculitis monitoring? 17:05 · What is your approach using PJP prophylaxis in ANCA-associated vasculitis? 18:05 Thank you, Dr. Villa-Forte! 20:25 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Disclosures: Brown reports no relevant financial disclosures. Healio was unable to confirm relevant financial disclosures for Villa-Forte at the time of publication.

2025. 09. 29.

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22분
2025. 10. 13.

The Unnecessarily Complex Story of Rheumatoid Factor

The story of rheumatoid factor could be a 10 minute episode, but in this episode, we dig deep into the history of the lab techniques leading up to this discovery…that happened twice. Intro 0:15 Rheumatoid factor quick background and history 00:36 Rheumatology blood tests 3:02 What is Rheumatoid factor? 3:49 Spiderman and latex agglutination: Testing for rheumatoid factor 4:50 The double discovery of rheumatoid factor 8:03 Putting agglutination on the medical map in 1896 10:08 Pop Quiz! 11:21 Serotherapy 13:10 When did we start using agglutination for testing? 14:17 First discovery of blood groups 14:50 The complement fixation test 17:22 Testing for syphilis with complement fixation and agglutination 21:01 The first discovery of rheumatoid factor 24:11 We forget about rheumatoid factor 27:44 Rediscovering rheumatoid factor 28:20 Analytical ultracentrifugation 32:50 What rheumatoid factor is used for 36:01 Thanks for listening 38:22 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Assadian O et al. Wien Klin Wochenschr. 2010;doi:10.1007/s00508-009-1297-1 Edelman GM, et al. J Exp Med. 1958;doi:10.1084/jem.108.1.105 Franklin EC, et al. J Exp Med. 1957;doi:10.1084/jem.105.5.425 Fraser KJ. Semin Arthritis Rheum. 1988;doi:10.1016/0049-0172(88)90035-2 Jonsson R. Ann Rheum Dis. 2020;doi:10.1136/annrheumdis-2019-216822 Mohd Noor NH, et al. Cureus. 2024;doi:10.7759/cureus.68903 Tan EM, et al. J Exp Med. 2016;doi:10.1084/jem.20160792 Disclosures: Brown reports no relevant financial disclosures.

2025. 10. 13.

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39분
2025. 05. 30.

History of polymyalgia rheumatica: The origin of the pain & link to giant cell arteritis

In this episode, we dive into the history of polymyalgia rheumatica, how it was discovered and its link to giant cell arteritis. Intro 0:01 In this episode 0:10 What is polymyalgia rheumatica (PMR)? 0:24 The history of PMR 02:12 PMR in the 1950s: A formally recognized disease 04:52 What was probably PMR in the 1880s 06:27 Naming PMR: Senile rheumatic gout 07:26 1957: The witch's shot and finally landing on polymyalgia rheumatica 08:30 Where is PMR coming from? 14:42 Injecting joins with saline 16:39 A biopsy study in 1964 19:54 Technetium bone scintigraphy in 1971 and bone scan history 23:01 First look at a PMR ultrasound in 1993 27:00 1997: First use of MRI on PMR patients in Italy 27:49 Going back to 1962: PMRs association with giant cell arteritis 30:40 A paper on muscular involvement in giant cell arteritis: 80-year-old 'robust' partially blind seaman 32:15 First systematic approach: The link between PMR and giant cell arteritis 35:14 80 cases of PMR 38:13 Swedish autopsy studies 41:07 Introduction of advanced imaging in the 1990s 42:40 Summing up PMR through the decades 43:28 That is the end! 45:25 Thanks for listening 45:50 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bruk MI. Ann Rheum Dis. 1967;doi:10.1136/ard.26.2.103. Cantini F, et al. J Rheumatol. 2001;28(5):1049-55. De Miguel E, et al. Rheumatology (Oxford). 2024;doi:10.1093/rheumatology/kead189. Dixon AS, et al. Ann Rheum Dis. 1966;doi:10.1136/ard.25.3.203. Hamrin B, et al. Ann Rheum Dis. 1968;doi:10.1136/ard.27.5.397. Salvarani C, et al. Ann Intern Med. 1997;doi:10.7326/0003-4819-127-1-199707010-00005. Shah S, et al. Rheumatology (Oxford). 2025;doi:10.1093/rheumatology/keae569. Disclosures: Brown reports no relevant financial disclosures.

2025. 05. 30.

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46분
2025. 11. 19.

Innovations in GI Cancer Screening with Paul Limburg, MD

In this podcast episode, Paul Limburg, MD, MPH, discusses the movement from academics to industry, developments in colorectal cancer screening tools and more. • Intro 1:11 • Paul Limburg, MD, MPH 1:17 • How did your early influences and childhood years lead you to become interested in gastroenterology and the career you have today? 1:34 • Who were your early inspirations? 2:14 • How did you transition from a career in academics and sciences to a life on the commercial side? 3:34 • How did your role at Exact Sciences come about? 5:58 • Was it a hard decision to take a new position? 7:47 • Chey and Limburg on the joy of advancing science and innovation. 9:03 • Were there any cultural differences that shocked you about the ways work is done in your previous and current positions? 10:10 • Do you see Exact outsourcing scientific research as the company grows? 12:12 • What does a typical day look like for you at Exact? […] What are you responsible of as the leading physician? 13:28 • From a product standpoint, what is ahead on the roadmap for Exact Sciences? […] What are you most excited about regarding next-generation multi-target stool testing and its impact? 15:14 • How do you respond to gastroenterologists' skepticism and concerns surrounding stool-based screening? 21:15 • What about addressing the concerns surrounding how we can ensure patients with a positive FIT test go in for a colonoscopy? 23:22 • How much of an issue are language barriers when it comes to screening tools? 28:11 • Can you talk about how Exact Sciences are using AI and the evolution of the microbiome internally or in product development? 29:42 • Do you see a future for stool-based testing in between/in combination with colonoscopies? 32:59 • Have you noticed differences in sensitivity and specificity based on age? 34:07 • What are your thoughts on making these tools available in a direct-to-consumer offering? […] How do you make these screening tools more readily available while weighing the usage risks? 35:08 • What is the rate of patients who have a positive stool-based test getting a colonoscopy? 38:44 • If you were talking to a GI fellow deciding to make the jump to industry, what do you tell them? 41:58 • Thank you, Paul 44:55 • Thanks for listening 45:21 Paul J. Limburg, MD, MPH, is chief medical officer for screening at Exact Sciences and emeritus professor of Medicine at Mayo Clinic. We'd love to hear from you! Send your comments/questions to guttalkpodcast@healio.com. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Dr. Limburg, follow @limburg_paul and @ExactSciences on X. Disclosures: Chey and Berry report no relevant financial disclosures. Limburg reports he is an employee of Exact Sciences.

2025. 11. 19.

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45분

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