Apple Podcast：NephJC Podcast 節目

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10月18日

FF 74: Amino Acids for AKI

The Filtrate: Jennie Lin Joel Topf Josh Waitzman Swapnil Hiremath With Special Guests Pedro Teixeira Jay Koyner Editor Sophia Ambruso Show Notes The article: A Randomized Trial of Intravenous Amino Acids for Kidney Protection NephJC Summary KDIGO Clinical Practice Guideline for Acute Kidney Injury (PDF) Steve Coca study Evaluation of Short-Term Changes in Serum Creatinine Level as a Meaningful End Point in Randomized Clinical Trials (PubMed) Using Nephrocheck to prevent AKI: Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial (PubMed) Brenner’s Review of protein intake and renal hemodynamics: Dietary Protein Intake and the Progressive Nature of Kidney Disease: — The Role of Hemodynamically Mediated Glomerular Injury in the Pathogenesis of Progressive Glomerular Sclerosis in Aging, Renal Ablation, and Intrinsic Renal Disease (NEJM) Husain-Syed a look at preoperative renal functional reserve and risk of AKI: Preoperative Renal Functional Reserve Predicts Risk of Acute Kidney Injury After Cardiac Operation (PubMed) Dana Fuhrman review of renal functional reserve: The Role of Renal Functional Reserve in Predicting Acute Kidney Injury (PubMed) Use of SGLT2i prevented AKI in the placebo controlled trials. Clinical Adverse Events Associated with Sodium-Glucose Cotransporter 2 Inhibitors: A Meta-Analysis Involving 10 Randomized Clinical Trials and 71 553 Individuals (PubMed) Assessment of P values for demographic data in randomized controlled trials (PubMed) Tubular Secretions Swapnil The Lord of the Rings: Rings of Power Season 2 on Amazon Prime (Wikipedia) Josh Fortnite (Website) Pedro CRRT Academy at University of Alabama Birmingham (Website) Jay Koyner Slow Horses on AppleTV (Wikipedia) Jennie Linn #KidneyWk Run Club Friday 10/25 at 6:15 am PST Meet in front of Sally’s Fish House ~2 miles. Easy pace (10-12 min/mile) (Strava) Joel Topf Your Honor on Netflix (Wikipedia)

10月18日

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1 小時 33 分鐘
2021/01/25

Chapter One: Introduction to Renal Function

The Channel Gang discusses the name of their new podcast and then discuss chapter one of The Book.

2021/01/25

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1 小時 5 分鐘
6月15日

FF 72: Nefecon for IgAN, The NefIgArd part B trial

Nefecon, coated budesonide, is the first drug labelled for IgA nephropathy and the approval path, 9-month reduction in proteinuria followed by 2 year GFR data set the stage for the GN renaissance we are currently living through.

6月15日

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1 小時 32 分鐘
6月1日

FF 71: Semaglutide for diabetic nephropathy FLOW

On May 24th, at the ERA meeting in Stockholm Sweden (this will not be the last GLP1ra talk at Stockholm), Vlado Perkovic presented the previously spoiled results of FLOW. In addition to simultaneous publication in the NEJM, it made the front page in newspapers around the world. As one headline writer said, “Is there anything Ozempic can’t do?”

6月1日

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1 小時 24 分鐘
8月17日

Chapter 15 part 2 — Clinical Use of Diuretics

References Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice Melanie is in love with this paper that shows that sodium retention Bumetanide and furosemide in heart failure everyone agreed that we love this classic paper from Craig Brater on diuretics (and the source of figure 15-6). Lety referenced the Cr x 20 formula, a strategy to multiply the serum creatinine by 20 to estimate the initial furosemide dose. We agreed that this is more appropriate than the House of God formula of age + BUN = dose (which may be so much higher). Joel shared this excellent report Diuretic Optimization Strategies Evaluation (DOSE) trial: https://www.nejm.org/doi/full/10.1056/nejmoa1005419 Amy shared how much she likes the two hour urine sodium (or random urine sodium) Rapid and Highly Accurate Prediction of Poor Loop Diuretic Natriuretic Response in Patients With Heart Failure - PMC Anna shared this paper which suggests that urinary sodium is more closely linked to outcome compared to urine volume Natriuretic Response Is Highly Variable and Associated With 6-Month Survival: Insights From the ROSE-AHF Trial and the study showing Substantial Discrepancy Between Fluid and Weight Loss During Acute Decompensated Heart Failure Treatment Josh worried about obstructive sleep apnea and nocturia: Sleep disordered breathing and nocturnal polyuria: nocturia and enuresis. WAITING FOR JOSH JC mentioned this report from a group in the Netherlands regarding solute load and urine volume Determinants of Urine Volume in ADPKD Patients Using the Vasopressin V2 Receptor Antagonist Tolvaptan We also considered CLICK trail Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease | NEJM (and here’s the Freely Filtered Podcast on this topic- a really great episode! Freely Filtered 040: Double CLICK for BP control in CKD stage 4 — NephJC Roger shared these articles on albumin and furosemide: Co-administration of albumin-furosemide in patients with the nephrotic syndrome and Albumin and Furosemide Combination for Management of Edema in Nephrotic Syndrome: A Review of Clinical Studies - PMC. This is an interesting study that showed that the serum and urine albumin does not predict of the response to loop diuretics.Serum and Urine Albumin and Response to Loop Diuretics in Heart Failure | American Society of Nephrology JC”s abstract on use of loop diuretics in hepatorenal syndrome type 1 was ultimately published in the American Journal of the Medical Sciences: https://doi.org/10.1016/S0002-9629(23)00623-7 Defining the role of albumin infusion in cirrhosis-associated hyponatremia this article explores the Gibbs-Donan Effect that Amy loves teaching us about. Distal Convoluted Tubule | American Society of Nephrology Figure 1 is a favorite (and a prerequisite to friendship with melanie) There is also a nice discussion of diuretic resistance in this year’s Nephmadness #NephMadness 2022: Cardiorenal Region – AJKD Blog Josh is excited about starting an SGLT2 inhibitor for acute heart failure and Anna mentions this article about how they may prevent AKI: The SGLT2 Inhibitor Empagliflozin Might Be a New Approach for the Prevention of Acute Kidney Injury Josh remembered this Tweetorial from Avi Cooper on the direct effect of furosemide: https://twitter.com/avrahamcoopermd/status/1292134482812604418?lang=en Roger reminded us about the practice of using bedrest for heart failure: Prolonged Bed Rest in the Treatment of the Dilated Heart and rotating tourniquets Effectiveness of Congesting Cuffs ("Rotating Tourniquets") in Patients with Left Heart Failure | Circulation and Rotating Tourniquets for Acute Cardiogenic Pulmonary Edema | JAMA Amy’s Voice of God: SGLT2i use in ADHF CCJM: https://www.ccjm.org/content/91/1/47 EMPA AHF: https://pubmed.ncbi.nlm.nih.gov/38569758/ Joel’s Voice of God The ADVOR Trial: https://www.nejm.org/doi/full/10.105

8月17日

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1 小時 36 分鐘
2021/02/28

Chapter 2 part 1

Back by popular demand…all two of you…the second chapter of The Clinical Physiology of Acid Base and Electrolyte Disorders.

2021/02/28

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1 小時 29 分鐘
3月16日

FF 68: Inpatient hypertension

Beep Beep. Hey intern the patient’s blood pressure is 160/95. Do you want to do something. No. The answer is no. But honestly we have all been guilted into ordering some clonidine or god forbid some IV hydralazine. Stop it. Just stop it. Join the filtrate as we dissect a recent study looking at this issue with the lead author.

3月16日

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1 小時 28 分鐘
2021/03/29

Chapter 2 Part 2

The exciting conclusion to Chapter Two: Renal Circulation and Glomerular Filtration Rate

2021/03/29

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1 小時 38 分鐘
4月22日

FF 69:DUPLEX Sparsentan, it’s no Acthar Gel

FSGS is hard and the data sucks. But here comes sparsentan fresh off its win in the PROTECT trial for IgA Nephropathy. Can it pull another rabbit out of the hat for patients that suffer from FSGS or are we doomed to forever treating our patients with Acthar® Gel?

4月22日

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1 小時 42 分鐘
2021/06/23

Chapter 4: The Loop of Henle and Counter Current Exchange

Show notes with a full set of references are available here: http://www.rosebook.club/episodes/2021/6/22/chapter-four Also, please fill out our listener survey: https://forms.gle/DVdcJikKZkzY56mXA

2021/06/23

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1 小時 44 分鐘

NephJC’s mission is to increase free open access medical education (FOAMed) pertaining to nephrology, hypertension, and transplantation. NephJC does this primarily by hosting Twitter chats about the latest high impact research in nephrology and related fields. NephJC also participates, sponsors, and supports activities that strengthen the Nephrology social network. One of the primary ways NephJC supports the Nephrology social network is through the Nephrology Social Medial Collective (NSMC). The NSMC internship is training health care professionals to utilize and contribute to the nephrology social network.

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熱門節目

FF 74: Amino Acids for AKI

Chapter One: Introduction to Renal Function

FF 72: Nefecon for IgAN, The NefIgArd part B trial

FF 71: Semaglutide for diabetic nephropathy FLOW

Chapter 15 part 2 — Clinical Use of Diuretics

Chapter 2 part 1

FF 68: Inpatient hypertension

Chapter 2 Part 2

FF 69:DUPLEX Sparsentan, it’s no Acthar Gel

Chapter 4: The Loop of Henle and Counter Current Exchange

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