SIGNIFICANT.

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Channel • 2 Shows

Science

Science

Updated Biweekly
Science

Science

Updated Biweekly

12/01/2024

Catalysts and Craters: The Collision of Science and Industry (Pt. 1)

In this episode of ⁠SIGNIFICANT⁠, we explore two astonishing tales where science and industry collided – with world-altering consequences. First, the untold story of how Pemex geologist Glen Penfield uncovered clues to the Chicxulub impact crater decades before its role in the extinction of the dinosaurs was recognized—a discovery delayed by corporate priorities and scientific blind spots. Then, we delve into the legacy of Thomas Midgley Jr., whose groundbreaking innovations - tetraethyl lead and CFCs - once solved pressing problems but left catastrophic environmental and public health legacies. These stories reveal the uneasy, often dangerous, partnership between science and industry; and the unintended consequences that have shaped our world. Explore these stories and more at ⁠significant-podcast.com⁠.

12/01/2024

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39 min
11/03/2024

Should Everybody Be On A GLP-1?

Semaglutide and tirzepatide have reshaped diabetes and weight-loss treatment, but could these drugs hold even greater potential? Join Dr. David S. Filippi—and his AI friends—on a quick journey into emerging data, revealing mechanisms, benefits, and mysteries of these breakthrough medications. Are they the most significant drugs of our time? Listen in and decide. Visit us at significant-podcast.com. Note: Signet is a brief, AI-generated summary of the Significant Podcast and may contain amusing or unexpected errors.

11/03/2024

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13 min
02/16/2025

Stranger Tongues, Stranger Tides

Communication isn’t just words—it’s connection. This episode starts with a blue jay who taught me a lesson in language, moves through my autistic son’s search for a voice, explores science’s efforts to talk to animals, and stretches all the way to messages we’ve sent to the stars. From backyards to deep space, who—or what—is really listening? This one’s personal.

02/16/2025

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1h 1m
01/12/2025

Cenotes of the Yucatán: Secrets of Life and Water

Join your intrepid guide, Dr. David Filippi, on a deep dive - literally - into the Cenotes of the Yucatán. In this episode, we explore the geological origins of these breathtaking natural wonders, shaped by the cataclysmic Chicxulub impact 66 million years ago. Learn how blind cavefish have evolved extraordinary adaptations to thrive in their resource-scarce, lightless underwater worlds, and discover how these ecosystems mirror challenges faced by humanity and even artificial intelligence. Through science, storytelling, and thought-provoking parallels, this episode is as mind-expanding as it is immersive. Learn more about Significant and find additional resources at significant-podcast.com. Take the plunge—you won’t want to miss it!

01/12/2025

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47 min
12/29/2024

The Alien Hand and the Shattered World

How does the brain construct our sense of self—and what happens when it breaks apart? Come along for the ride as Dr. David Filippi delves into haunting case histories: from the phenomenon of alien hand syndrome to the story of Lev Zasetsky - The Man with a Shattered World - a man lost in a world his mind could no longer piece together. Along the way, we explore groundbreaking insights from neuroscience and ask: What can these stories teach us about embodied cognition, adaptation, and even artificial intelligence? Join us on a journey that spans the boundaries of science, philosophy, and technology—and challenges us to rethink what it means to truly understand. Visit us on the web at significant-podcast.com.

12/29/2024

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42 min
12/29/2024

The Alien Hand and the Shattered World

How does the brain construct our sense of self—and what lessons can artificial intelligence learn from the ways it falters? In this 17-minute Signet episode, we dive into the phenomenon of embodied cognition, exploring how sensory integration, movement, and spatial awareness are fundamental to both human identity and intelligent systems. From the haunting case of Lev Zasetsky’s shattered world to the challenges of training AI in physical and social contexts, this episode bridges the gaps between neurology, philosophy, and technology. What would it take for machines to navigate the world with human-like understanding? Join us as we distill the mysteries of cognition into a concise, thought-provoking journey through the mind and its possibilities. Visit us on the web at significant-podcast.com.

12/29/2024

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17 min
12/11/2024

Catalysts and Craters: The Collision of Science and Industry (Pt. 1)

We explore two astonishing tales where science and industry collided with world-altering consequences. First, the untold story of how Pemex geologists uncovered clues to the Chicxulub impact crater decades before its role in the extinction of the dinosaurs was recognized—a discovery delayed by corporate priorities and scientific blind spots. Then, we delve into the legacy of Thomas Midgley Jr., whose groundbreaking innovations in tetraethyl lead and CFCs solved pressing problems of his time but left catastrophic environmental and public health legacies. These stories reveal the uneasy, often dangerous, partnership between science and industry and the unintended consequences that have shaped our world. Learn more at https://significant-podcast.com.

12/11/2024

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14 min
12/15/2024

Nobels, Nitrogen, Nutrition: The Nexus of Science and Industry (pt. 2)

In this episode of ⁠⁠SIGNET⁠⁠, we distill three transformative moments in science and industry into just 19 minutes. From Fritz Haber and Carl Bosch’s ammonia synthesis that fed billions and armed nations, to the discovery of penicillin and the global collaboration that made it a lifesaver, to Norman Borlaug’s Green Revolution and its lasting impact on humanity—this episode delivers the highlights of innovation and consequence. Perfect for curious minds short on time. Tune in now at ⁠⁠significant-podcast.com⁠⁠.

12/15/2024

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19 min
11/17/2024

Tackling CTE: Inside the NFL’s Concussion Crisis

Signet distills the latest episode of Significant, where Dr. David Filippi - and his AI friends - explore the NFL’s concussion crisis. From the science, to the personal stories, to the cultural shifts impacting the game, it's all here - in 13 minutes. For the full experience, visit significant-podcast.com. Note: Signet is an AI-generated summary of the Significant Podcast and may contain amusing or unexpected errors.

11/17/2024

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12 min
01/12/2025

Cenotes of the Yucatán: Secrets of Life and Water

Take a deep dive - literally - into the Cenotes of the Yucatan with your hosts, Anna Coluthon and Perry Prosdokian. SIGNET is an AI-assisted summary of Drs David Filippi's SIGNIFICANT podcast. This one clocks in at 15 minutes, so you're shaving 32 minutes off your valuable ear time. But for this one, I gotta be honest - if you ain't SIGNIFICANT, what exactly is you doin', baba? Learn more at significant-podcast.com.

01/12/2025

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16 min

Welcome to the home of Significant, a thought-provoking podcast by Dr. David Filippi that explores the wonders of science, industry, and the intricate art of discovery. Significant dives into the pivotal ideas shaping our world, blending science, history, and culture with an eye on the future. Hosted by polymath/neurologist Dr. David Filippi, each episode explores the stories behind game-changing discoveries, technologies, and thinkers, from consciousness to concussions and beyond. Join us as we unravel the mysteries of the past, present, and future. Join us at significant-podcast.com for more content, episode archives, and everything you need to keep your curiosity alive. No matter where you start, you're in for a journey of insight, humor, and a fresh perspective on the world. Stay curious. Stay courageous. Stay Significant!

Website

SIGNIFICANT.

Top Shows

Catalysts and Craters: The Collision of Science and Industry (Pt. 1)

Should Everybody Be On A GLP-1?

Stranger Tongues, Stranger Tides

Cenotes of the Yucatán: Secrets of Life and Water

The Alien Hand and the Shattered World

The Alien Hand and the Shattered World

Catalysts and Craters: The Collision of Science and Industry (Pt. 1)

Nobels, Nitrogen, Nutrition: The Nexus of Science and Industry (pt. 2)

Tackling CTE: Inside the NFL’s Concussion Crisis

Cenotes of the Yucatán: Secrets of Life and Water

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