SKRAPS Studio

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Canal • 2 programas

Ciencias de la vida

Ciencias de la vida

12/03/2025
Documentales

Documentales

21/12/2021

29/09/2021

Episode 2: Mescaline: The OG of Psychedelics

Peyote crosses the border and causes a riot. Drug companies want their taste, and psychedelics reach the social elite. What could possibly go wrong? In episode two of PsychedeRx, Peyote comes north to the good old US of A. And it’s not just for religious ceremonies anymore, either. Spanish conquistadors and European explorers, seeking to dominate the indigenous tribes, used Peyote to show force by banning its use and denying the tribes their spiritual practices. And we all know what happens when prohibitions are imposed - the use doesn’t stop, it just gets moved underground. James Mooney, an ethnographer dispatched by the Smithsonian Institute, is one of our best resources for this era. He committed to his diary first-hand accounts of the use of and backlash against peyote in tribal rituals. As Peyote moved north, albeit underground, it became the catalyst for a series of events that were bloodier than an episode of Dexter. Wovoka and the Ghost Dance were the turning point. The execution of Sitting Bull led to the massacre at Wounded Knee - and it was all over peyote and freedom of religion - ain’t that an ironic twist? Episode two also sheds light on the earliest interventions of the drug companies like Merck and Parke-Davis and their part in our little psychedelic drama. Arthur Heffter separates the resins from the alkaloids and isolates the first real information on dosing. We get a close-up look at how the psychiatrists and psychologists got involved - where they got it right, and where they got it all wrong. Psychedelics also make their way into the world of the social elites through folks like Aldous Huxley and Ken Kesey. We’ll close out this week with our first peek at LSD. So remember to “Turn on, tune in, and drop out.” This documentary series is made possible by our kind donors. Kindly help us by donating to our cause of disseminating factual stories of science, scientists and innovations at https://skrapspodcast.com/donate/ This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

29/09/2021

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1 h 1 min
12/03/2025

And then came the microelectrode...!

How do we even know what constitutes the heart beat? What was the reason for all those abnormal rhythms of the heart? Why does it happen? The answer lies in the small, cylindrical glass tube called the micropipetter, which was used to create a microelectrode. Here it is, on how the microelectrode changed the face of cardiology. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Show Credits Created & Produced by: Arun Sridhar Social Media: Twitter: @skrappyscienceWhatsapp Channel for announcementsInstagram Profile: FibrillatorySkraps If you like to help us with our production costs, you can visit HERE

12/03/2025

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18 min
01/04/2023

Sympathetically, Un-sympathetic

This is conclusion of the mini-series! In this episode, we uncover the question, is the "cholinergic anti-inflammatory reflex" nerves entirely vagal? The answer is not so straightforward. Building on good work by Davide Martelli and Robin McAllen, we uncover crucial role of the efferent arm of the reflex to "also" be sympathetic. And at the end, we also talk about the importance of understanding the referral and implantation pathway and why we remain muted in the ability of neuromodulation for immune-inflammation to be uptaken widely anytime soon. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Show Credits Created & Produced by: Arun Sridhar Editing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam Social Media: Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter Feed You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

01/04/2023

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42 min
31/01/2023

Las Vagus, Baby!!

What happens in the vagus, stays in vagus?? Not with us at SKRAPS. “Science Is a Team Sport” If we truly mean this - I mean, really and truly mean that science is a group effort and not the effort of one person, let’s really dive in to this and embrace our opportunities to set the record straight. And I mean let’s start right now! As we endeavor to understand The Wanderer, we must also strive to understand the contributors - and not just the marquee names. We hope to shed light on the nerve, the possibilities, the history, and all of the major players - not just a solo artist. After all, as we near the end of another American football season, I think we can appreciate that Joe Montana was better because of Jerry Rice - Troy Aikman thrived with Michael Irvin, and Tom Brady is the GOAT because of his myriad weapons. Let’s be true to our intent to make science a team sport and go beyond the lip service. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Show Credits Created & Produced by: Arun Sridhar Editing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam Social Media: Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter Feed You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE or you can buy us a coffee - here

31/01/2023

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53 min
15/02/2023

The Inflammation

With the set up of how vagus signalling was deduced by careful and meticulous experiments of Linda Watkins, who built on some amazing results from Hugo Besedovsky, we turn our attention to how the hypothesis moved from tackling acute inflammatory models (e.g. Sepsis) to chronic inflammatory models and disease conditions like Rheumatoid Arthritis. We are joined by Tony Arnold, ex-CEO of SetPoint Medical and Dr. Paul-Peter Tak who pioneered the clinical trials in Rheumatoid Arthritis and Inflammatory Bowel Disease. Also, we cover some shocking moral plaigiarism from Feinstein Institute and Dr. Kevin Tracey in managing their public image. We now know that he was not the single pioneer of the transition to Arthritis and IBD trials as the news media claims or potrays him to be. It actually had many people's hand, especially Paul-Peter Tak's. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Show Credits Created & Produced by: Arun SridharEditing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam Social Media: Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter Feed You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

15/02/2023

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46 min
19/10/2021

Episode 5: Basic Pharmacology of Serotonin & Psychedelics

We’ve spent some time already on the definition of psychedelic - and we’ll spend more time before this series is over. But, Skraps is a podcast whose roots are run deep in the sciences, we couldn’t ignore the topic of the basic pharmacology of psychedelics. This episode is a primer for citizen scientists and holds some intriguing information for the bonafide scientists among us. As always, we don’t just deliver science, we are going to start with core science and intertwine the stories of the people who made the discoveries - ultimately ending with an understanding of how psychedelics work. We’ll feature the work of Dr. Joanna Neill, a pharmacologist and Chair of the Psychedelics Working Group for Drug Science UK. Dr. Bryan Roth also joins us; Bryan is a professor of pharmacology at the University of North Carolina studying psychedelics with a pretty serious DARPA grant. For a special treat, you’ll get to hear JoJo absolutely butcher some basic biology and pharmacology terms. Please DM Arun and let him know that you’d like to get the bonus out-takes of PsychedeRx. This podcast series is made possible by kind donations. If you wish to donate to our cause of spreading factual stories of science, scientists and innovations, please click here: https://skrapspodcast.com/donate/ This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

19/10/2021

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1 h 31 min
21/12/2021 · CONTENIDO EXTRA

Bonus Episode No.3: What's a trip really like?

If you’ve listened to the PsychedRx series, or ever contemplated experiencing psychedelics, you’ve probably asked yourself what a trip is really like. Well, I’d very much like to tell you what it’s like, but it’s much like trying to describe an exact shade of purple velvet. It’s deep, rich, bright, dark, it changes as the light shifts. When you touch it, everything changes. It’s different in the morning than it is at night. It’s simultaneously warm and cool, comforting and challenging, but it’s something you can’t fully appreciate or describe without seeing it in person. For additional exploration and examination, we’ve engaged a first-rate scientist and psychonaut of sorts to help us understand, as best we can… With that, we’d like to thank Juan for sharing his experiences and perspectives with us. We’d also like to thank all of our participants for their time, dedication, talent, and insights. Finally, we’d like to thank each of you for taking this journey with us. Hazzah! This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

21/12/2021 · Contenido extra

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42 min
13/08/2021

#PsychedeRx Episode 8: New Frontiers in Psychedelics for Addiction and Depression

Zeus gave Sisyphus the eternal punishment of forever rolling a boulder up a hill in the depths of Hades for his crimes of being a trickster and twice cheating death. “Then I witnessed the torture of Sisyphus, as he wrestled with a huge rock with both hands. Bracing himself and thrusting with hands and feet he pushed the boulder uphill to the top. But every time, as he was about to send it toppling over the crest, its sheer weight turned it back, and once again towards the plain the pitiless rock rolled down. So once more he had to wrestle with the thing and push it up, while the sweat poured from his limbs and the dust rose high above his head. (Odyssey, Book 11:593)” His tale sounds woefully close to the trials of addiction and depression. Just when you see the light, just when the journey appears as though it will end in success and the completion of a herculean task, life turns that boulder right around and sends you back to the foot of the mountain - only to start the task all over again with nothing more than your corporeal toolkit. But what if Sisyphus had real tools? Not just his hands and brute strength, but genuine tools like levers and pulleys? What if he had a partner to help him brace the boulder while he lassoed it with the rope that could be manipulated to make the work of one man equal to two? and to mitigate the back-roll? Depression and addiction, much like PTSD from episode seven, have benefitted little from new discoveries. The tool kits haven’t changed much lately while the rates of incidence climb without check. Is there a way that psychedelics can offer a good old fashioned Craftsman-style revolution? We talk with Celia Morgan (https://psychology.exeter.ac.uk/staff/profile/index.php?web_id=Celia_Morgan), Laurie Higbed (https://theorg.com/org/awakn-life-sciences/org-chart/laurie-higbed ) and others about where the research stands. We’ll walk through the history of psychedlics in addiction and depression, and we’ll hear from people like Mary Ann Dimond with a poignant reminder that these are not problems, not boulders, not numbers, but people who are struggling, people who are loved, and all to often, people who are gone.

13/08/2021

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1 h 19 min
01/11/2022

BCI's On The Grill 🥩 - Candid Questions in Bioelectronic Medicines (Part 2)

What Is a BCI? And just as importantly, what isn’t a BCI? This is an unusual episode and an incredibly fun one. Arun and JoJo enlisted some of the field’s top folks to talk through what’s in and what’s out in this exciting field. Amy Kruse is a general partner at Prime Movers Lab and a self-professed Founder turned Funder (and a neuroscientist by training), Matt Angle is the founder and CEO of Paradromics - developing high data rate BCIs, and Marcus Gerhardt is the co-founder and CEO of Blackrock Neurotech and is hoping that their BCIs will disrupt the standard for patient care for the 600 million people that suffer from neurological disorders. This episode has it all - technical glitches, laughter, ruffled feathers (Arun’s specialty), and some tantalizing discussions around definitions, dystopia, and delivering on the promise of this incredible technology. Arun picks at and Matt defends the valuations of BCI companies - replete with funny characters and great voice acting. Amy chimes in with her point of view (plot twist: she’s on the side of massive market potential) while Marcus makes the claim that BCI companies are, in fact, under valued. In short, this episode is pretty much your best chance at eavesdropping on a tantalizing conversation among some truly brilliant people on a fascinating topic. SKRAPS is your podcast, where we on your behalf explores unsaid, under-appreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Show Credits Created & Produced by: Arun Sridhar & JoJo PlattEditing: Arun Sridhar Social Media: Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter FeedJoJo's Twitter Feed You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

01/11/2022

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1 h 22 min
29/05/2022

Sleep Apnea: ft. Napoleon, Churchill, Brahms, Stalin & Queen Victoria

“Laugh and the world laughs with you. Snore and you sleep alone” is a famous quote from the author Anthony Burgess. Sleep Apnea affects 425 million adults over the age of 40. Yet, good treatments are unavailable. In this episode we address how Bioelectronic Medicines helps to alleviate the problem. Links as promised: Inspire Medical - the first hypoglossal nerve stimulation product on the market. Kingman Strohl’s lecture A Ted Talk on Didgeridoo SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Show Credits Created & Produced by: Arun Sridhar & JoJo PlattEditing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam Social Media: Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter FeedJoJo's Twitter Feed You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

29/05/2022

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1 h 18 min

SKRAPS Studio explores the stories sparks of scientific brilliance in science and innovation through its interview based podcast (SKRAPS Podcast) and its scripted narrative audio documentary series.

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Top programas

Episode 2: Mescaline: The OG of Psychedelics

And then came the microelectrode...!

Sympathetically, Un-sympathetic

Las Vagus, Baby!!

The Inflammation

Episode 5: Basic Pharmacology of Serotonin & Psychedelics

Bonus Episode No.3: What's a trip really like?

#PsychedeRx Episode 8: New Frontiers in Psychedelics for Addiction and Depression

BCI's On The Grill 🥩 - Candid Questions in Bioelectronic Medicines (Part 2)

Sleep Apnea: ft. Napoleon, Churchill, Brahms, Stalin & Queen Victoria

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