SKRAPS Studio

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Documentário

21/12/2021
Ciências da vida

Ciências da vida

12/03/2025

19/10/2021

Episode 5: Basic Pharmacology of Serotonin & Psychedelics

We’ve spent some time already on the definition of psychedelic - and we’ll spend more time before this series is over. But, Skraps is a podcast whose roots are run deep in the sciences, we couldn’t ignore the topic of the basic pharmacology of psychedelics. This episode is a primer for citizen scientists and holds some intriguing information for the bonafide scientists among us. As always, we don’t just deliver science, we are going to start with core science and intertwine the stories of the people who made the discoveries - ultimately ending with an understanding of how psychedelics work. We’ll feature the work of Dr. Joanna Neill, a pharmacologist and Chair of the Psychedelics Working Group for Drug Science UK. Dr. Bryan Roth also joins us; Bryan is a professor of pharmacology at the University of North Carolina studying psychedelics with a pretty serious DARPA grant. For a special treat, you’ll get to hear JoJo absolutely butcher some basic biology and pharmacology terms. Please DM Arun and let him know that you’d like to get the bonus out-takes of PsychedeRx. This podcast series is made possible by kind donations. If you wish to donate to our cause of spreading factual stories of science, scientists and innovations, please click here: https://skrapspodcast.com/donate/ This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
29/09/2021

Episode 2: Mescaline: The OG of Psychedelics

Peyote crosses the border and causes a riot. Drug companies want their taste, and psychedelics reach the social elite. What could possibly go wrong? In episode two of PsychedeRx, Peyote comes north to the good old US of A. And it’s not just for religious ceremonies anymore, either. Spanish conquistadors and European explorers, seeking to dominate the indigenous tribes, used Peyote to show force by banning its use and denying the tribes their spiritual practices. And we all know what happens when prohibitions are imposed - the use doesn’t stop, it just gets moved underground. James Mooney, an ethnographer dispatched by the Smithsonian Institute, is one of our best resources for this era. He committed to his diary first-hand accounts of the use of and backlash against peyote in tribal rituals. As Peyote moved north, albeit underground, it became the catalyst for a series of events that were bloodier than an episode of Dexter. Wovoka and the Ghost Dance were the turning point. The execution of Sitting Bull led to the massacre at Wounded Knee - and it was all over peyote and freedom of religion - ain’t that an ironic twist? Episode two also sheds light on the earliest interventions of the drug companies like Merck and Parke-Davis and their part in our little psychedelic drama. Arthur Heffter separates the resins from the alkaloids and isolates the first real information on dosing. We get a close-up look at how the psychiatrists and psychologists got involved - where they got it right, and where they got it all wrong. Psychedelics also make their way into the world of the social elites through folks like Aldous Huxley and Ken Kesey. We’ll close out this week with our first peek at LSD. So remember to “Turn on, tune in, and drop out.” This documentary series is made possible by our kind donors. Kindly help us by donating to our cause of disseminating factual stories of science, scientists and innovations at https://skrapspodcast.com/donate/ This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
26/10/2021

Episode 6: Sparking the Psychedelic Renaissance

We discuss previously underappreciated personal stories of how the Psychedelic Renaissance was sparked since 1971. Description: 1971 was the year when drug prohibition came into force. Did we tell you the story of how the tables were turned against the prohibition of drugs? Or did we tell you the hurdles that were needed to be overcome. Well, that's exactly the point of the episode. We are here to bring to you how the road to psychedelic renaissance was built. And if you think, it came from overwhelming people with data, just like how a typical scientist thinks, you would be amazed at the personalities who paved the way, as much as the ones that broke it for themselves and for the world. We discuss the unconventional paths taken by Amanda Feilding of Beckley Foundation, Rick Doblin of MAPS - Multidisciplinary Association for Psychedelic Studies and more importantly, the trailblazers who initiated the clinical studies before anyone did - The Heffter Research Institute. We interview the original members - Dr. Mark Geyer of UCSD to tell us the never-reported personal stories of the creation of Heffter Research Institute and the Psilocybin studies. This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
06/10/2021

Episode 3: The Doors are Blown Open

Drug discovery doesn’t happen in a vacuum. So much of the world’s geopolitical activities affect what happens both inside and outside of the lab. Lysergic Acid Diethylamide was such a curious drug that there were seemingly no limits to how and when it would be tested. Episode three of PsychedeRx kicks off with an LSD-laden military training exercise. Don’t laugh. It really did happen and we have the tapes to prove it. All in the name of science, right? We bring back Mike Jay from Episode Two to bring some of the highlights from the lab of Albert Hoffman and how his cult-favorite bicycle “trip.” A day now celebrated around the world. But it wasn't a pleasant ride as the world sees it. We got the details on it from Hoffman's personal journal. We’ll see how Sandoz, the Swiss pharmaceutical company, passed out LSD to psychiatrists around the world in an attempt to find out just what the heck this chemical could really be used for - including as a possible cure for alcoholism. As always, we want you to listen in and ask the hard questions. Were these incidents that shaped the reputation and the future of these substances use or misuse? Were they inherently bad, or was it their handling that earned the demonized notoriety? Hoffman's Potion Documentary Link: CLICK HERE This podcast series is made possible by kind donations. If you wish to donate to our cause of spreading factual stories of science, scientists and innovations, please click here: https://skrapspodcast.com/donate/ This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
12/10/2021

Episode 4: Oh, LSD! My Problem Child

“Who knows what evil lurks in the heart of men? The Shadow knows!” But seriously - who knows? And are the men evil? Or is it their hearts? Or is it the means that they employ? Can their cause serve as cover? Can there be righteous justification for some of the horrendous things done in the name of self-preservation? In the short gap between World War II and the Cold War, America was battling new enemies, both foreign and domestic. How could that be? How could the superpower that conquered the Nazis and fought off attacks from the Pacific suffer internal moral and ethical turpitude? Fear. Fear causes people to do amazing and improbable things. Fear of an enemy, fear of an unknown. They are powerful motivators and ones that Syndey Gottlieb embraced with every fibre of his professional being. The same man whose family would have been Nazi victims engaged in some of the most insidious “experiments” known to man - experiments based on the knowledge and tutelage of the same Nazi scientists who deployed the gasses that would have killed his own family. Join us as New York Times reporter and prolific author, Stephen Kinzer introduces us to the most diabolical personalities of the psychedelic journey to date. This episode includes nothing short of the best Bourne thriller - with murder, mayhem, science, spies, brainwashing, and oh so much more. And then… let’s bring in Mr. LSD himself, Dr. Timothy Leary. All of this came to a pinnacle, and contributed to the 1971 war on drugs. Join us as we explore paranoia, brutality, recklessness and glorification of recreational use led to where we are today. This podcast series is made possible by kind donations. If you wish to donate to our cause of spreading factual stories of science, scientists and innovations, please click here: https://skrapspodcast.com/donate/ This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
24/11/2021

Episode 10: Investing in New Frontiers of the Psychedelic Renaissance

New molecules, new IP, new opportunities. How can investors be induced to support the massive, but necessary funds required to support the important and carefully regulated research necessary to bring psychedelic therapies to market. Not to be crass, but if something isn’t going to bring a profit, it’s unlikely to receive much funding, regardless of how much good it might do, certainly not enough to cover the massive costs of bringing a disruptive therapy to market. Companies like Cybin and Bright Minds Bio are looking at modifications to create new IP, improved efficacy, and new delivery mechanisms. With investment validations now taken care of, we need to address issues around delivery of care. Are we prepared to shift to a model of care that moves from weekly one-hour sessions to intensive, multi-hour sessions that require new paradigms that have never been tried? Before you answer, let us ask you another question: with between 11 and 20 out of every 100 US Veterans suffering from PTSD, how can we afford not to try? Clara Burtenshaw, co-founder of Neo Kuma Ventures created the first European Fund dedicated to psychedelics shared with us her motivations, both professional and personal, for focusing on this space. We visited with Wavepaths CEO Mendel Kaelen about their founding principles and objectives; we explore Kernel’s entre into the psychedelic research space, and we revisit Doug Drysdale, CEO of Cybin. These are the folks to watch for the future of psychedelic medicines and the healthcare revolution that is coming your way. It has been our pleasure to bring to you this series - this passion project to understand and share the opportunities, challenges, history, and future of psychedelic medicine. Humbly, Arun and JoJo This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
02/11/2021

Episode 7: PTSD and Psychedelics: Making "Unconventional" Conventional!

A cast will help a broken bone to heal, a tourniquet will help to stop the bleeding in a limb, an aspirin will alleviate a headache, time (and ice cream) will help to heal a broken heart. But how do you heal a broken mind? Post Traumatic Stress Disorder (PTSD) is but one of the psychiatric indications with inadequate, frequently ineffective treatment protocols, that has been in the psychedelic spotlight. There’s no shortage of heartbreaking stories about men and women who have dedicated their lives to the service of their countries and endured unfathomable trauma. Add to this population the other sources of PTSD like car accidents, witnessing or experiencing violence - or even the threat of violence, sustained stress in traumatic situations (hello, COVID frontline workers - I’m looking at you), and you have an explosion in an untreated or treatment refractory population. Enter psychedelics. In this episode, we are privileged to hear from Jesse Gould, a former Army Ranger, and Keith Abraham, a former member of the UK’s Parachute Regiment. These gentlemen both served their countries in combat tours in the Middle East and have suffered the invisible injuries of war. Each found his way to ayahuasca as a means of resolving his PTSD when pharmacological, talk therapy, and wholistic approaches failed him. Ayahuasca healed them when nothing else could; now, through their connected organizations - Heroic Hearts Project and Heroic Hearts Project UK - they are helping other veterans gain access to this highly promising combination therapy of psychedelics and psychiatry in what is now known as psychedelic-assisted psychotherapy. In addition, we explore the story of how MDMA assisted psychotherapy, pioneered by MAPS' pivotal trials were done in an interview with Dr. Jennifer Mitchell This episode will take you into the personal stories, the science, the history, the future, and the promise of psychedelic-assisted psychotherapy for PTSD. Grab a tissue, you’re going to need it. (And then go donate to Heroic Hearts Project so that we can help more people heal.) This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
22/09/2021

Episode 1: Psychedelics: The Fun, The Fantastical & the Facts!

Where were you on June 18, 1971? Did you know that was when Richard Nixon, the United Nations, and other world leaders changed the course of popular culture, scientific experimentation, and mind exploration for the next five decades? Did you know that substances that have the potential to change the way we treat myriad diseases and conditions - ones that have little or no reliable treatments today - were fated on that day to be imprisoned like Hannibal Lecter? Join us for the first of a series of Skraps Original episodes as we explore the use, misuse, and history of psychedelics. In this episode, we will cover the most important question of what these substances are, and begin to question why they were lumped in with other addictive substances by exploring the history of how curiosity-induced exploration on one side clashed with religious single-mindedness. This manifested itself in how these plant-based substances were viewed then and for centuries later, in the eyes of the western world. PsychedeRx will cover the ancient history of plant-based psychedelics including their religious, ceremonial, tribal uses and the dangers imposed by the European views of those uses. We’ll experience murder, mayhem, executions, displacement, and more. We’ll talk to psychedelic historian Mike Jay to get the full story of the full journey - one that started long before Nixon and other world powers set their limited, short-sighted fear loose upon the world. Subscribe to SKRAPS on your favourite podcast platform to make sure you don’t miss a minute of this riveting journey. PsychedeRx is brought to you by kind donations of our listeners. Please donate to our cause to disseminate factual stories of science, scientists and innovations at: https://skrapspodcast.com/donate/ This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
24/02/2025

Sudor Anglicus: The English Sweating Sickness

What connects Tudor England, Ann Boleyn, Henry the VIII, autonomic nervous system and a flash mob like wave of a deadly disease? There is only way to find out. Inspired by this paper and Dr. Ali Christy's X thread. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Created & Produced by: Arun Sridhar You can help us fund the production costs by donating as a one time or a recurring payment HERE
16/02/2021

S2 E5: The Fit and the Furious - TK Kozai from lab life to "Oh, no he didn't..."

TK Kozai is an Assistant Professor of Bioengineering at the University of Pittsburgh. You can check out his prolific research publications here, but don't miss out on the story behind the investigator as we take on the peer-review process, lab culture and contracts (get that heart rate up!), being an outsider to both of your own cultures, sleep and exercise, and InequalityInSTEM (which his wife aptly points out should be STEAM!) an effort driven by Dawn Taylor that TK whole-heartedly endorses. Believe me when I tell you, you'll understand the "Oh, no he didn't" when you hear this episode of SKRAPS.

SKRAPS Studio explores the stories sparks of scientific brilliance in science and innovation through its interview based podcast (SKRAPS Podcast) and its scripted narrative audio documentary series.

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SKRAPS Studio

Principais podcasts

Episode 5: Basic Pharmacology of Serotonin & Psychedelics

Episode 2: Mescaline: The OG of Psychedelics

Episode 6: Sparking the Psychedelic Renaissance

Episode 3: The Doors are Blown Open

Episode 4: Oh, LSD! My Problem Child

Episode 10: Investing in New Frontiers of the Psychedelic Renaissance

Episode 7: PTSD and Psychedelics: Making "Unconventional" Conventional!

Episode 1: Psychedelics: The Fun, The Fantastical & the Facts!

Sudor Anglicus: The English Sweating Sickness

S2 E5: The Fit and the Furious - TK Kozai from lab life to "Oh, no he didn't..."

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SKRAPS Studio

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