On this episode of the Bioactive Podcast, Dr. Riley Kirk is joined by Dr. Codi Peterson and Megan Mbengue to discuss their newly published paper on Cannabinoid Hyperemesis Syndrome (CHS). Drawing from their recently published research and clinical experience, they explore what CHS is, how it presents, and why it is often misunderstood or misdiagnosed. The conversation covers early warning signs, the prodromal phase, and the severe symptoms patients experience, including the challenges faced in emergency care settings. They also address common misconceptions around cannabis use patterns, frequency, and the role of THC in the development of CHS. They discuss key factors influencing CHS, including consumption methods such as vaping versus flower, rapid THC absorption, tolerance, and the impact of high-potency products. The discussion explores myths around pesticides, synthetic cannabinoids, and the importance of distinguishing correlation from causation in cannabis-related health outcomes. Additionally, they examine strategies for reducing risk, including tolerance breaks, balanced use, and patient education without stigma. The dialogue further highlights the importance of compassionate care, proper diagnosis, and the role of healthcare professionals in bridging the gap between cannabis use and medical understanding. Finally, they touch on future research directions, the importance of data collection, and how education can shape safer, more informed cannabis use. This is a conversation for anyone using cannabis regularly, healthcare professionals seeking to better understand CHS, or patients navigating unexplained symptoms. Whether you're exploring cannabis for wellness or working in clinical settings, this episode provides critical insight into responsible use, early warning signs, and the evolving science behind cannabis-related health outcomes. Chapters 00:00 CHS Is Real 00:58 Welcome And Guests 01:43 Publishing The Study 03:47 What Is CHS 05:04 ER Reality Check 06:17 Scromiting And Severity 09:16 Survey Size And Reach 10:48 Vapes Versus Flower 11:42 Use Patterns And Myths 15:55 Prodrome Phase Warning 18:13 Triggers And Cutting Down 23:41 Is THC The Culprit 26:06 Why Vapes Hit Faster 27:56 Vaping And THC Spikes 29:22 Pesticides Myth Busting 31:57 Tolerance Breaks And Balance 34:08 CHS Education Not Stigma 36:45 ER Diagnosis And Overdiagnosis 38:55 Who Gets CHS Demographics 41:22 Early Warning Signs 43:28 Synthetic Cannabinoid Risks 45:37 Whole Plant Over Isolates 50:02 Future Papers And Next Steps 51:57 Compassion And Closing Read the Research on CHS Cannabinoid Hyperemesis Syndrome Publication: https://journals.sagepub.com/doi/10.1177/25785125261421434?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Note: This publication is currently behind a paywall but will be available for free on Patreon. Sponsor Thank you to our sponsor Storz & Bickel! S&B makes medical-grade dry herb vaporizers which are some of my favorite products to use daily. If you want to check them out, head to storz-bickel.com and use code Riley10 for 10% off most items! Want Exclusive Content and Ad-Free Episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one. www.Patreon.com/Cannabichem 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, pharmacology, and plant medicine. Sign Up for Emails www.AppliedPharmacognosy.org Keep Up with Dr. Riley Kirk https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem https://www.appliedpharmacognosy.org/ Learn more about your ad choices. Visit megaphone.fm/adchoices
